Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population (original) (raw)

References

• Agarwal DP, Harada S, Goedde HW (1981) Racial differences in biological sensitivity to ethanol: the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes. Alcohol Clin Exp Res 5:12–16
  Google Scholar
• Agarwal DP, Goedde HW (1990) Pharmacogenetics of alcohol dehydrogenase (ADH). Pharmacol Ther 45:69–83
  Article CAS PubMed Google Scholar
• Borras E, Coutelle C, Rosell A, Fernández-Muixl F, Broch M, Crosas B, Hjelmqvist L, Lorenzo A, Gutiérrez C, Santos M, Szczepanek M, Heilig M, Quattrocchi P, Farrés J, Vidal F, Richart C, Mach T, Bogdal J, Jörnvall H, Seitz HK, Couzigou P, Parés X (2000) Genetic polymorphism of alcohol dependence in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology 31:984–989
  CAS PubMed Google Scholar
• Bosron WF, Magnes LJ, Li TK (1983) Kinetic and electrophoretic properties of native and recombined isoenzymes of human liver alcohol dehydrogenase. Biochemistry 22:1852–1857
  CAS PubMed Google Scholar
• Burnell JC, Li TK, Bosron WF (1989) Purification and steady-state kinetic characterization of human liver β3β3 alcohol dehydrogenase. Biochemistry 28:6810–6815
  CAS PubMed Google Scholar
• Chen C-C, Lu R-B, Chen Y-C, Wang M-F, Chang Y-C, Li T-K, Yin S-J (1999) Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 65:795–807
  Article CAS PubMed Google Scholar
• Chen WJ, Loh EW, Hsu YP, Chen CC, Yu JM, Cheng AT (1996) Alcohol-metabolizing genes and alcoholism among Taiwanese Han men: Independent effect of_ADH2_, _ADH3_and ALDH2. Br J Psychiatry 168:762–767
  CAS PubMed Google Scholar
• Dandre F, Cassaigne A, Iron A (1995) The frequency of the mitochondrial aldehyde dehydrogenase I2 (atypical) allele in Caucasian, Oriental and African black populations determined by the restriction profile of PCR-amplified DNA. Mol Cell Probes 9:189–193
  Article CAS PubMed Google Scholar
• Dawson E, Abecasis GR, Bumpstead S, Chen Y, Beare DM, Pabial J, Dibling T, et al. (2002) A first-generation linkage disequilibrium map of human chromosome 22. Nature 418:544–548
  CAS PubMed Google Scholar
• Farrés J, Wang X, Takahashi K, Cunningham SJ, Wang TT, Weiner H (1994) Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 269:13854–13860
  PubMed Google Scholar
• Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002) The structure of haplotype blocks in the human genome. Science 296:2225–2229
  CAS PubMed Google Scholar
• Goedde HW, Harada S, Agarwal DP (1979) Racial differences in alcohol sensitivity: a new hypothesis. Hum Genet 51:331–334
  CAS PubMed Google Scholar
• Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, Bhatia K, Chen LZ, Fang B, Lisker R, Paik YK, Rothhammer F, Saha N, Srivastava LM, Czeizel A (1992) Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 88:344–346
  CAS PubMed Google Scholar
• Groppi A, Begueret J, Iron A (1990) Improved methods for genotype determination of human alcohol dehydrogenase (ADH) at _ADH2_and ADH3 loci by using polymerase chain reaction-directed mutagenesis. Clin Chem 36:1765–1768
  CAS PubMed Google Scholar
• Hammer MF, Karafet TM, Redd AJ, Jarjanazi H, Santachiara-Benerecetti S, Soodyall H, Zegura S (2001) Hierarchical patterns of global human Y-chromosome diversity. Mol Biol Evol 18:1189–1203
  CAS PubMed Google Scholar
• Harada S, Agarwal DP, Goedde HW, Takagi S, Ishikawa B (1982) Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet 2:827
  CAS PubMed Google Scholar
• Harris EE, Hey J (1999) X chromosome evidence for ancient human histories. Proc Natl Acad Sci USA 96:3320–3324
  CAS PubMed Google Scholar
• Haseman JK, Elston RC (1972) The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3–19
  CAS PubMed Google Scholar
• Higuchi S, Muramatsu T, Shigemori K, Saito M, Kono H, Dufour MC, Harford TC (1992) The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. J Stud Alcohol 53:170–175
  CAS PubMed Google Scholar
• Hines LM, Stampfer MJ, Ma J, Gaziano JM, Ridker PM, Hankinson SE, Sacks F, Rimm EB, Hunter DJ (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. N Engl J Med 344:549–555
  Article CAS PubMed Google Scholar
• Jorde LB, Rogers AR, Bamshad M, Watkins WS, Krakowiak P, Sung S, Kere J, Harpending HC (1997) Microsatellite diversity and the demographic history of modern humans. Proc Natl Acad Sci USA 94:3100–3103
  CAS PubMed Google Scholar
• Kolman CJ, Bermingham E (1997) Mitochondrial and nuclear DNA diversity in the Chocó and Chibcha Amerinds of Panamá. Genetics 147:1289–1302
  CAS PubMed Google Scholar
• Kolman CJ, Bermingham E, Cooke R, Ward RH, Arias TD, Guionneau-Sinclair F (1995) Reduced mtDNA diversity in the Ngöbé Amerinds of Panamb. Genetics 140:275–283
  CAS PubMed Google Scholar
• Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D (1998) Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry 55:989–994
  CAS PubMed Google Scholar
• Long JC, Williams RC, Urbanek M (1995) An E-M algorithm and testing strategy for multiple-locus haplotypes. Am J Hum Genet 56:799–810
  PubMed Google Scholar
• Long JC, Knowler WC, Hanson RL, Robin, RW, Urbanek M, Moore E, Bennett PH, Goldman D (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216–221
  Article CAS PubMed Google Scholar
• Nakamura K, Iwahashi K, Matsuo Y, Miyatake R, Ichikawa Y, Suwaki H (1996) Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2. I. A comparison of the genotypes of_ALDH2_,ADH2, ADH3, and cytochrome P-450E1 between alcoholics and nonalcoholics. Alcohol Clin Exp Res 20:52–55
  CAS PubMed Google Scholar
• Neumark YD, Friedlander Y, Thomasson HR, Li T-K (1997) Association of the_ADH2*2_ allele with reduced ethanol consumption in Jewish men in Israel: A pilot study. J Stud Alcohol 59:133–139
  Google Scholar
• Novoradovsky A, Tsai S-J, Goldfarb L, Peterson R, Long JC and Goldman D (1995) Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: Detection of new ALDH2 alleles. Alcohol Clin Exp Res 19:1105–1110
  CAS PubMed Google Scholar
• Osier M, Pakstis AJ, Kidd JR, Lee J-F, Yin S-J, Ko H-C, Edenberg HJ, Lu R-B, Kidd KK (1999) Linkage disequilibrium at the _ADH2_and ADH3 loci and risk of alcoholism. Am J Hum Genet 64:1147–1157
  Google Scholar
• Osier M, Pakstis AJ, Soodyall H, Comas D, Goldman D, Odunsi K, Okonofua F, Parnas J, Schulz L, Bertranpetit J, Bonne-Tamir B, Lu R-B, Kidd JR, Kidd KK (2002) A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet 71:84–99
  Article CAS PubMed Google Scholar
• Peterson RJ, Goldman D, Long JC (1999) Nucleotide sequence diversity in non-coding regions of ALDH2 as revealed by restriction enzyme and SSCP analysis. Hum Genet 104:177–187
  Article CAS PubMed Google Scholar
• Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li TK, Conneally PM, Nurnberger JI Jr, Tischfield JA, Crowe RR, Cloninger CR, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H (1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81:207-215
  Article CAS PubMed Google Scholar
• Robin RW, Long JC, Rasmussen JK, Albaugh B, Goldman D (1998) Relationship of binge drinking to alcohol dependence, other psychiatric disorders, and behavioral problems in an American Indian tribe, Alcohol Clin Exp Res 22:518–523
  Google Scholar
• Saccone NL, Kwon JM, Corbett J, Goate A, Rochberg N, Edenberg HJ, Foroud T, Li T-K, Begleiter H, Reich T, Rice JP (2000) A genome screen of maximum number of drinks as an alcoholism phenotype. Am J Med Genet 96:632–637
  Article CAS PubMed Google Scholar
• S.A.G.E. (1994) Statistical analysis for genetic epidemiology, release 2.2. Computer program package available from the Department of Biometry and Genetics, LSU Medical Center, New Orleans
• Schwitters SY, Johnson RC, McClearn GE, Wilson JR (1982) Alcohol use and the flushing response in different racial-ethnic groups. J Stud Alcohol 43:1259–1262
  CAS PubMed Google Scholar
• Spitzer RL, Endicott J, Robins E (1989) Research Diagnostic Criteria (RDC) for a selected group of psychiatric disorders. New York, Department of Research Assessment and Training, New York Psychiatric Institute
• Suwaki H, Ohara H (1985) Alcohol-induced facial flushing and drinking behavior in Japanese men. J Stud Alcohol 46:196–198
  CAS PubMed Google Scholar
• Templeton AR, Boerwinkle E, Sing CF (1987) A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila. Genetics 117:343–351
  CAS PubMed Google Scholar
• Templeton AR, Sing CF, Kessling A, Humphries S (1988) A cladistic analysis of phenotype associations with haplotypes inferred from restriction endonuclease mapping. II. The analysis of natural populations. Genetics 120:1145–1154
  CAS PubMed Google Scholar
• Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li T-K, Wang SP, Lin YT, Lu RB, Yin SJ (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677–681
  CAS PubMed Google Scholar
• Thomasson HR, Crabb DW, Edenberg HJ, Li T-K (1993) Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 23:131–136
  CAS PubMed Google Scholar
• Tishkoff SA, Dietzsch E, Speed W, Pakstis AJ, Kidd JR, Cheung K, Bonné-Tamir B, Santachiara-Benerecetti S, Moral P, Krings M, Pääbo S, Watson E, Risch N, Jenkins T, Kidd KK (1996) Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. Science 271:1380–1387
  CAS PubMed Google Scholar
• Uhl GR, Liu Q-R, Walther D, Hess J, Naiman D (2001) Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet 69:1290–1300
  Article CAS PubMed Google Scholar
• Uhl GR, Liu Q-R, Naiman D (2002) Substance abuse vulnerability loci: converging genome scanning data. Trends Genet 18:420–425
  Article CAS PubMed Google Scholar
• Urbanek M, Goldman D, Long JC (1996) The apportionment of dinucleotide repeat diversity in Native Americans and Europeans: A new approach to measuring gene identity reveals asymmetric patterns of divergence. Mol Biol Evol 13:943–953
  CAS PubMed Google Scholar
• Wall TL, Thomasson HR, Ehlers CL (1995) Investigator-observed alcohol-induced flushing but not self-report of flushing is a valid predictor of ALDH2 genotype. J Stud Alcohol 57:267–272
  Google Scholar
• Wall TL, Garcia-Angrade C, Thomasson HR, Carr LG, Ehlers CL (1997) Alcohol dehydrogenase polymorphisms in Native Americans: Identification of the_ADH2*3_ allele. Alcohol Alcohol 32:129–132
  CAS PubMed Google Scholar
• Weir BS (1996) Genetic data analysis II. Sinauer Associates, Sunderland, Mass.
• Whitfield JB, Nightingale BN, Bucholz KK, Madden PAF, Heath AC, Martin NG (1998) ADH genotypes and alcohol use and dependence in Europeans. Alcohol Clin Exp Res 22:1463–1469
  CAS PubMed Google Scholar
• Williams RC, Knowler WC, Pettitt DJ, Long JC, Pokala DA, Polesky HF, Hackenberg RA, Steinberg AG, Bennett PH (1992) The magnitude and origin of European-American admixture in the Gila River Indian Community of Arizona: A union of genetics and demography. Am J Hum Genet 51:101–110
  CAS PubMed Google Scholar
• Wolff PH (1972) Ethnic differences in alcohol sensitivity. Science 175:449–450
  CAS PubMed Google Scholar
• Yin SJ, Han CL, Lee AI, Wu CW (1999) Human alcohol dehydrogenase family. Functional classification, ethanol/retinol metabolism, and medical implications. Adv Exp Med Biol. 463:265–274
  Google Scholar

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