Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population (original) (raw)
Abstract.
As one approach to exploring whether the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is associated with atherosclerosis, we genotyped 461 healthy Japanese individuals and studied the relationship of mt5178 A/C genotypes to serum lipid levels. Blood specimens were obtained after at least a 12-h fasting period from the subjects. The mt5178 A/C was genotyped by the polymerase chain reaction/restriction fragment length polymorphism method. The relative frequency of mt5178 A was 41.6% (192/461) and of mt5178 C was 58.4% (269/461). After adjustments for age and body mass index, the high-density lipoprotein cholesterol concentration in males carrying mt5178 A was significantly higher than that in males carrying mt5178 C (_P_=0.026). The tryglyceride (TG) concentration in females carrying mt5178 A was significantly lower than that in females carrying mt5178 C (_P_=0.012). This difference in the TG level between the two genotypes was more evident in postmenopausal females than in premenopausal females. Mt5178 A seems to have an antiatherogenic effect. This is the first genetic epidemiological report on the association of mt5178 A/C polymorphism with serum lipid levels in the Japanese population.
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Authors and Affiliations
- Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181–8611, Japan, , , , ,
Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Masao Yoshida, Yasuko Sekine, Yu Sumiya, Yoshiko Uchida & Yutaka Takashima - Department of Preventive Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, Japan, , , , ,
Koji Teruya & Nobuo Takeda
Authors
- Akatsuki Kokaze
- Mamoru Ishikawa
- Naomi Matsunaga
- Masao Yoshida
- Yasuko Sekine
- Koji Teruya
- Nobuo Takeda
- Yu Sumiya
- Yoshiko Uchida
- Yutaka Takashima
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Kokaze, A., Ishikawa, M., Matsunaga, N. et al. Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population.Hum Genet 109, 521–525 (2001). https://doi.org/10.1007/s004390100602
- Received: 17 May 2001
- Accepted: 22 August 2001
- Issue date: November 2001
- DOI: https://doi.org/10.1007/s004390100602