Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis (original) (raw)

Abstract

Background

Clinical and immunological studies have consistently shown a relationship between atopic diathesis and idiopathic nephrotic syndrome (INS). However, no large population cohort study has yet to demonstrate the nature of the relationship between these disorders.

Methods

Claims data from a random selection of children representing half of the insured population in Taiwan were examined. During the period from 1998 to 2007, we identified 192,295 children aged <18 years with newly diagnosed atopic dermatitis (AD) and 769,169 frequency-matched controls. Incidence of INS and hazard ratios (HRs) were calculated.

Results

The AD cohort had a 2-fold higher overall incidence of INS than the non-AD cohort [7.20 vs. 3.60 per 100,000 person-years, respectively; 95 % confidence interval (CI) 1.50–2.66]. The HR for INS increased with age and was higher among females. The HR for INS was also higher in AD children with more medical visits per year, ranging from 0.94 for those having ≤3 visits to 38.6 for those having >6 visits (trend test P < 0.0001). In particular, the risk of INS clearly increased during the initial 5 years after AD onset.

Conclusions

Children with AD have a greater incidence and risk of developing INS and this risk increases with AD severity.

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Acknowledgments

This study was partially supported by the Bureau of Health Promotion, Taiwan Ministry of Health Welfare, R.O.C. (Taiwan) (DOH99-HP-1205), study project grants (DMR-103-036) from China Medical University Hospital, Taiwan Ministry of Health Welfare, Clinical Trial and Research Center for Excellence (DOH102-TD-B-111-004), China Medical University Hospital Cancer Research Center of Excellence (MOHW103-TD-B-111-03, Taiwan), and International Research-Intensive Centers of Excellence in Taiwan (I-RiCE) (NSC101-2911-I-002-303).

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Authors and Affiliations

  1. Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
    Chang-Ching Wei
  2. College of Medicine, China Medical University, Taichung, Taiwan
    Chang-Ching Wei & Te-Chun Shen
  3. Institute of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Jeng-Dau Tsai
  4. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
    Cheng-Li Lin
  5. Department of Public Health, China Medical University, Taichung, Taiwan
    Cheng-Li Lin
  6. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
    Te-Chun Shen
  7. Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, Taiwan
    Tsai-Chung Li
  8. Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan
    Tsai-Chung Li
  9. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    Chi-Jung Chung
  10. Department of Health Risk Management, College of Public Health, China Medical University, #91 Hsueh-Shih Road, Taichung City, 404, Taiwan
    Chi-Jung Chung

Authors

  1. Chang-Ching Wei
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  2. Jeng-Dau Tsai
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  3. Cheng-Li Lin
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  4. Te-Chun Shen
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  5. Tsai-Chung Li
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  6. Chi-Jung Chung
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Corresponding author

Correspondence toChi-Jung Chung.

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Wei, CC., Tsai, JD., Lin, CL. et al. Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis.Pediatr Nephrol 29, 2157–2163 (2014). https://doi.org/10.1007/s00467-014-2835-2

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