The significance of neuroinflammation in understanding Alzheimer’s disease (original) (raw)
H Akiyama S Barker S Barnum B Bradt J Bauer GM Cole NR Cooper P Eikelenboom M Emmerling BL Fiebich_et al._ (2000)ArticleTitleInflammation and Alzheimer’s disease_Neurobiol Aging_ 21 383–421Occurrence Handle10858586Occurrence Handle1:CAS:528:DC%2BD3cXktVSmt74%3D PubMedCAS Google Scholar
YM Arends C Duyckaerts JM Rozemuller P Eikelenboom J-J Hauw (2000)ArticleTitleMicroglia, amyloid and dementia in Alzheimer’s disease. A correlative study_Neurobiol Aging_ 21 39–47Occurrence Handle10794847Occurrence Handle1:STN:280:DC%2BD3c3ls12msQ%3D%3D PubMedCAS Google Scholar
T Arendt (2001)ArticleTitleAlzheimer’s disease as a disorder of mechanisms underlying structural brain self-organization_Neuroscience_ 102 723–765Occurrence Handle11182240Occurrence Handle1:CAS:528:DC%2BD3MXhtFalu7Y%3D PubMedCAS Google Scholar
KR Bales T Verina RC Dodel YS Du L Altstiel M Bender P Hyslop EM Johnstone SP Little DJ Cummins P Ricardo B Ghetti SM Paul (1997)ArticleTitleLack of apoliprotein E dramatically reduces amyloid β-peptide deposition_Nature Genet_ 17 263–264Occurrence Handle9354781Occurrence Handle1:CAS:528:DyaK2sXntVShsbk%3D PubMedCAS Google Scholar
C Bate R Veerhuis P Eikelenboom A Williams (2004)ArticleTitleMicroglia kill Aβ1-42 damaged neurons by a CD14 dependent process_Neuroreport_ 28 1427–1430 Google Scholar
RJ Bateman LY Munsell JC Morris R Swarm KE Yarasheski DM Holzman (2006)ArticleTitleHuman amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo_Nat Med_ 12 856–861Occurrence Handle16799555Occurrence Handle1:CAS:528:DC%2BD28Xms1eksLc%3D PubMedCAS Google Scholar
D Beher EE Clarke JD Wrigley AC Martin A Nadin I Churcher MS Shearman (2004)ArticleTitleSelected non-steroidal anti-inflammatory drugs and their derivates target γ-secretase at a novel site. Evidence for an allosteric mechanism_J Biol Chem_ 279 43419–43426Occurrence Handle15304503Occurrence Handle1:CAS:528:DC%2BD2cXot1yhtL4%3D PubMedCAS Google Scholar
EM Blalock JW Geddes KC Chen NM Porter WR Markesbery PW Landfield (2004)ArticleTitleIncipient Alzheimer’s disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses_Proc Natl Acad Sci USA_ 101 2173–2178Occurrence Handle14769913Occurrence Handle1:CAS:528:DC%2BD2cXhs1SrsL4%3D PubMedCAS Google Scholar
L Bouman (1934)ArticleTitleSenile plaques_Brain_ 57 128–142 Google Scholar
H Braak E Braak (1996)ArticleTitleStaging of Alzheimer’s disease-related neurofibrillary changes_Neurobiol Aging_ 16 271–278 Google Scholar
KC Breen (1992)ArticleTitleAPP-collagen interaction is mediated by a heparin bridge mechanism_Mol Chem Neuropathol_ 16 109–121Occurrence Handle1520400Occurrence Handle1:CAS:528:DyaK38Xkt1ersL4%3DOccurrence Handle10.1007/BF03159964 ArticlePubMedCAS Google Scholar
RP Brendza BJ Bacskai JR Cirrito KA Simmons JM Skoch WE Klunk CA Mathis KR Bales SM Paul BT Hyman DM Holtzman (2005)ArticleTitleAnti-β antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice_J Clin Invest_ 115 428–433Occurrence Handle15668737Occurrence Handle1:CAS:528:DC%2BD2MXhtFyjsbY%3D PubMedCAS Google Scholar
A Cagnin DJ Brooks AM Kennedy RN Gunn R Myers FE Turkheimer T Jones RB Banati (2001)ArticleTitleIn-vivo measurement of microglia in dementia_Lancet_ 358 461–467Occurrence Handle11513911Occurrence Handle1:STN:280:DC%2BD3MvmvVWjsw%3D%3D PubMedCAS Google Scholar
B Cannella CS Raine (1995)ArticleTitleThe adhesion molecule and cytokine profile of multiple sclerosis lesions_Ann Neurol_ 37 424–435Occurrence Handle7536402Occurrence Handle1:STN:280:DyaK2M3jtlOhug%3D%3D PubMedCAS Google Scholar
CW Cotman (1997)ArticleTitleBeta-amyloid peptide, peptide self-assembly, and the emergence of biological activities. A new principle in peptide function and the induction of neuropathology_Ann NY Acad Sci_ 814 1–16Occurrence Handle9160955Occurrence Handle1:CAS:528:DyaK1cXht1ygtbk%3D PubMedCAS Google Scholar
P del Rio-Hortega (1932) Microglia W Penfield (Eds) Cytology and cellular pathology of the nervous system PB Hoeber New York 483–534 Google Scholar
RB DeMattos MA O’dell M Parsadanian JW Taylor JA Harmony KR Bales SM Paul BJ Aronow DM Holtzman (2002)ArticleTitleClusterin promotes amyloid plaque formation and it is critical for neuritic toxicity in a mouse model of Alzheimer’s disease_Proc Natl Acad Sci USA_ 99 10843–10848Occurrence Handle12145324Occurrence Handle1:CAS:528:DC%2BD38Xmt1ChtLc%3D PubMedCAS Google Scholar
MG Dik C Jonker CE Hack JH Smit HC Comijs P Eikelenboom (2005)ArticleTitleSerum inflammatory proteins and cognitive decline in older patients_Neurology_ 64 1371–1377Occurrence Handle15851726Occurrence Handle1:CAS:528:DC%2BD2MXivFOgt7g%3D PubMedCAS Google Scholar
P Eikelenboom FC Stam (1982)ArticleTitleImmunoglobulins and complements factors in senile plaques_Acta Neuropathol (Berl)_ 57 239–242Occurrence Handle1:STN:280:DyaL3s%2FhvV2hug%3D%3D CAS Google Scholar
P Eikelenboom CE Hack JM Rozemuller FC Stam (1989)ArticleTitleComplement activation in amyloid plaques in Alzheimer’s disease_Virchows Arch B (Cell Pathol)_ 56 259–262Occurrence Handle1:STN:280:DyaL1M3isVWmsg%3D%3D CAS Google Scholar
P Eikelenboom JM Rozemuller G Kraal FC Stam PA McBride ME Bruce H Fraser (1991)ArticleTitleCerebral amyloid plaques in Alzheimer’s disease but not in scrapie-affected mice are closely associated with an chronic inflammatory process_Virchows Arch B (Cell Pathol)_ 60 329–336Occurrence Handle1:STN:280:DyaK387hs1CqtA%3D%3D CAS Google Scholar
P Eikelenboom SS Zhan W Kamphorst P Van der Valk JM Rozemuller (1994)ArticleTitleCellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer’s disease_Virchows Arch_ 424 421–427Occurrence Handle7515758Occurrence Handle1:STN:280:DyaK2c3msV2mtQ%3D%3D PubMedCAS Google Scholar
P Eikelenboom R Veerhuis (1996)ArticleTitleThe role of complement and activated microglia in the pathogenesis of Alzheimer’s disease_Neurobiol Aging_ 17 673–680Occurrence Handle8892339Occurrence Handle1:STN:280:DyaK2s%2FkslCiuw%3D%3D PubMedCAS Google Scholar
P Eikelenboom WJG Hoogendijk C Jonker W van Tilburg (2002)ArticleTitleImmunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer’s disease_J Psychiat Res_ 36 269–280Occurrence Handle12127594Occurrence Handle1:STN:280:DC%2BD38zot1Cqtg%3D%3D PubMedCAS Google Scholar
P Eikelenboom WA van Gool (2004)ArticleTitleNeuroinflammatory perspectives on the two faces of Alzheimer’s disease_J Neural Transm_ 111 281–294Occurrence Handle14991455Occurrence Handle1:CAS:528:DC%2BD2cXhsFequ7k%3D PubMedCAS Google Scholar
J El Khoury SE Hickman CA Thomas L Cao SC Silverstein J Loike (1996)ArticleTitleScavenger receptor mediated adhesion of micoglia to amyloid-β fibrils_Nature_ 382 716–719Occurrence Handle8751442Occurrence Handle1:CAS:528:DyaK28Xlt1ylt70%3D PubMedCAS Google Scholar
MJ Engelhart MI Geerlings J Meijer A Kilaan A Ruitenberg JC van Swieten T Stijnen A Hofman JC Witteman MMB Breteler (2004)ArticleTitleInflammatory proteins in plasma and the risk of dementia: the Rotterdam study_Arch Neurol_ 61 668–672Occurrence Handle15148142 PubMed Google Scholar
S Familian RS Boshuizen P Eikelenboom R Veerhuis (2006)ArticleTitleInhibitory effect of minocycline on amyloid-β fibril formation and human microglia activation_Glia_ 53 223–240 Google Scholar
K Fassbender S Walter S Kuhl R Landmann K Ishii T Bertsch AK Stalder F Muehlhauser Y Liu AJ Ulmer S Rivest A Lentschat E Guulbins M Jucker M Staufenbiel K Brechtel J Walter G Multhaup B Penke Y Adachi T Hartmann K Beyreuther (2004)ArticleTitleThe LPS receptor (CD14) links innate immunity with Alzheimer’s disease_Faseb J_ 18 203–205Occurrence Handle14597556Occurrence Handle1:CAS:528:DC%2BD2cXlvFymsg%3D%3D PubMedCAS Google Scholar
O Fischer (1907)ArticleTitleMiliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmässige Veränderung der Hirnrinde bei seniler Demenz_Monatsch f Psychiat u Neurol_ 22 361–372Occurrence Handle10.1159/000211873 Article Google Scholar
O Fischer (1910)ArticleTitleDie presbyophrene Demenz, deren anatomische Grundlage und klinische Abgrenzung_Z Ges Neurol u Psychiat_ 3 371–471Occurrence Handle10.1007/BF02893605 Article Google Scholar
L Gasparini E Ongini G Wenk (2004)ArticleTitleNon-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer’s disease: old and new mechanisms of action_J Neurochem_ 91 521–536Occurrence Handle15485484Occurrence Handle1:CAS:528:DC%2BD2cXpsFelsLo%3D PubMedCAS Google Scholar
JW Geddes DT Monaghan CW Cotman IT Lou RC Kim HC Chui (1995)ArticleTitlePlasticity of hippocampal circuitry in Alzheimer’s disease_Science_ 230 1179–1181 Google Scholar
JP Godbout J Chen J Abraham AF Richwine BM Berg KW Kelley RW Johnson (2005)ArticleTitleExaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system_FASEB J_ 19 1329–1331Occurrence Handle15919760Occurrence Handle1:CAS:528:DC%2BD2MXntlaqs7s%3D PubMedCAS Google Scholar
EA Grace J Busciglio (2003)ArticleTitleAberrant activation of focal adhesion proteins mediates fibrillar amyloid-β-induced neuronal dystrophy_J Neurosci_ 23 493–502Occurrence Handle12533609Occurrence Handle1:CAS:528:DC%2BD3sXovV2msQ%3D%3D PubMedCAS Google Scholar
EST Griffin LC Stanley C Ling L White V MacLeod LJ Perrot CL White C Araoz (1989)ArticleTitleBrain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer’s disease_Proc Natl Acad Sci_ 86 7611–7615Occurrence Handle2529544Occurrence Handle1:STN:280:DyaK3c%2FhslGhug%3D%3D PubMedCAS Google Scholar
JJM Hoozemans MK Brückner AJM Rozemuller R Veerhuis P Eikelenboom T Arendt (2002)ArticleTitleCyclin D1 and cyclin E are co-localized with cyclooxygenase-2 in pyramidal neurons in Alzheimer’s disease temporal cortex_J Neuropathol Exp Neurol_ 61 678–688Occurrence Handle12152783Occurrence Handle1:CAS:528:DC%2BD38XmsVansr8%3D PubMedCAS Google Scholar
JJM Hoozemans R Veerhuis AJM Rozemuller T Arendt P Eikelenboom (2004)ArticleTitleNeuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex_Neurobiol Dis_ 15 492–499Occurrence Handle15056456Occurrence Handle1:CAS:528:DC%2BD2cXivVKnu7w%3D PubMedCAS Google Scholar
JJM Hoozemans ES van Haastert R Veerhuis T Arendt W Scheper P Eikelenboom AJM Rozemuller (2005a)ArticleTitleMaximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer’s disease_J Neuroinflammation_ 2 27 Google Scholar
JJM Hoozemans R Veerhuis JM Rozemuller F Baas P Eikelenboom W Scheper (2005b)ArticleTitleThe unfolded protein is activated in Alzheimer’s disease_Acta Neuropathol_ 110 165–172Occurrence Handle1:CAS:528:DC%2BD2MXos1Cqur8%3D CAS Google Scholar
JJM Hoozemans SM Chafekar F Baas P Eikelenboom W Scheper (2006a)ArticleTitleAlways around, never the same: pathways of amyuloid-β induced neurodgeneration throughout the pathogenic cascade of Alzheimer’s_Curr Med Chem_ 13 2599–2605Occurrence Handle1:CAS:528:DC%2BD28Xps1Sktbg%3D CAS Google Scholar
JJM Hoozemans R Veerhuis JM Rozemuller P Eikelenboom (2006b)ArticleTitleNeuroinflammation and regeneration in the early stages of Alzheimer’s disease pathology_Int J Devl Neurosci_ 24 157–165Occurrence Handle1:CAS:528:DC%2BD28XhvVWnsrY%3D CAS Google Scholar
T Ishii S Haga (1984)ArticleTitleImmuno-electron-microscopic localization of complement in amyloid fibrils of senile plaques_Acta Neuropathol_ 63 296–300Occurrence Handle6382906Occurrence Handle1:STN:280:DyaL2czgtlWjtA%3D%3D PubMedCAS Google Scholar
S Itagaki PL McGeer H Akiyama S Zhu D Selkoe (1989)ArticleTitleRelationship of microglia and astrocytes to amyloid deposits of Alzheimer’s disease_J Neuroimmunol_ 24 173–182Occurrence Handle2808689Occurrence Handle1:STN:280:DyaK3c%2FjslGnsg%3D%3D PubMedCAS Google Scholar
N Iwata M Higuchi TC Saido (2005)ArticleTitleMetabolism of amyloid-β peptide and Alzheimer’s disease_Pharmacol Ther_ 108 129–148Occurrence Handle16112736Occurrence Handle1:CAS:528:DC%2BD2MXhtFKhsrrO PubMedCAS Google Scholar
PT Jantzen KE Connor G DiCarlo GL Wenk JL Wallace AM Rojiani D Coppola D Morgan MN Gordon (2002)ArticleTitleMicroglial activation and β-amyloid deposit reduction caused by nitric oxide-releasing ninsteroidal anti-inflammatory drug in amyloid precursor protein plus presenelin-1 transgenic mice_J Neurosci_ 22 2246–2254Occurrence Handle11896164Occurrence Handle1:CAS:528:DC%2BD38XisVGisbo%3D PubMedCAS Google Scholar
WL Klein GA Krafft CE Finch (2001)ArticleTitleTargetting small oligomers: the solution to an Alzheimer’s disease conundrum?Trends Neurosci2001 219–224 Google Scholar
EH Koo L Park DJ Selkoe (1993)ArticleTitleAmyloid-β protein as substrate interacts with extracellular matrix to promote neurite outgrowth_Proc Natl Acad Sci USA_ 90 1564–1568 Google Scholar
GE Landreth MT Heneka (2001)ArticleTitleAnti-inflammatory actions of peroxisome proliferator-activated receptor γ agonists in Alzheimer’s disease_Neurobiol Aging_ 22 937–944Occurrence Handle11755002Occurrence Handle1:CAS:528:DC%2BD3MXptFylu7k%3D PubMedCAS Google Scholar
GP Lim T Chu F Yang W Beech SA Frautschy GM Cole (2001)ArticleTitleThe curry spice curcumin reduces oxidative damage and amyloid pathology in Alzheimer transgenic mice_J Neurosci_ 21 8370–8377Occurrence Handle11606625Occurrence Handle1:CAS:528:DC%2BD3MXnvVeqs7g%3D PubMedCAS Google Scholar
PL McGeer S Itagaki H Tago EG McGeer (1987)ArticleTitleReactive microglia in patients with senile dementia of Alzheimer-type are positive for the histocompatibility glycoprotein HLA-DR_Neurosci Lett_ 79 195–200Occurrence Handle3670729Occurrence Handle1:STN:280:DyaL1c%2FjvFKrtg%3D%3D PubMedCAS Google Scholar
PL McGeer H Akiyama S Itgaki EG McGeer (1989)ArticleTitleImmune system response in Alzheimer’s disease_Can J Neurol Sci_ 16 516–527Occurrence Handle2804814Occurrence Handle1:STN:280:DyaK3c%2FivF2nuw%3D%3D PubMedCAS Google Scholar
JP Melchor R Pawlak S Strickland (2003)ArticleTitleThe tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-β (Aβ) degredation and inhibits Aβ-induced neurodegeneration_J Neurosci_ 23 8867–8871Occurrence Handle14523088Occurrence Handle1:CAS:528:DC%2BD3sXotFOntbY%3D PubMedCAS Google Scholar
D Morgan (2006)ArticleTitleModulation of microglial activation state following passive immunization in amyloid deposing transgenic mice_Neurochem Int_ 49 190–194Occurrence Handle16740342Occurrence Handle1:CAS:528:DC%2BD28XlvFGisrc%3D PubMedCAS Google Scholar
S Narindrasorasak DE Lowery RA Altman PA Gonzalez-DeWhitt BD Greenberg R Kisilevsky (1992)ArticleTitleCharacterization of high affinity binding between laminin and Alzheimer’s amyloid precursor proteins_Lab Invest_ 67 643–652Occurrence Handle1434542Occurrence Handle1:CAS:528:DyaK3sXps1Ghuw%3D%3D PubMedCAS Google Scholar
JA Nicoll D Wilkinson C Holmes P Steart H Markham RO Weller (2003)ArticleTitleNeuropathology of human Alzheimer’s disease after immunization with amyloid-β peptide; a case study_Nat Med_ 9 448–452Occurrence Handle12640446Occurrence Handle1:CAS:528:DC%2BD3sXisVOmu78%3D PubMedCAS Google Scholar
LNG Nilsson KR Bales G DiCarlo MN Gordon SM Paul H Potter (2001)ArticleTitleα-1 Antichymotrypsin promotes β-sheet amyloid plaque formation in a transgenic mouse model of Alzheimer’s disease_J Neurochem_ 21 1444–1451Occurrence Handle1:CAS:528:DC%2BD3MXjslCltLg%3D CAS Google Scholar
HS Nottet Y Persidsky VG Sasseville AN Nukuna P Bock H Zhai LR Sharer RD McComb S Swindels C Soderland HE Gentleman (1996)ArticleTitleMechanisms for the transendothelial migration of HIV-1-infected monocytes into the brain_J Immunol_ 156 1284–1295Occurrence Handle8558009Occurrence Handle1:CAS:528:DyaK28XmtlyitQ%3D%3D PubMedCAS Google Scholar
K Oshima H Akiyam K Tsuchiya H Kondo C Haga Y Shimomura E Iseki H Uchikado M Kato K Niizato H Arai (2006)ArticleTitleRelatively paucity of tau accumulation in the small areas with abundant Aβ42-positive caplliary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology_Acta Neuropathol_ 111 510–518Occurrence Handle16718347Occurrence Handle1:CAS:528:DC%2BD28XkvVCnu7Y%3D PubMedCAS Google Scholar
DM Paresce RN Ghosh FR Maxfield (1996)ArticleTitleMicroglial cells internalize aggregates of the Alzheimer’s disease amyloid-β-protein via a scavenger receptor_Neuron_ 17 553–565Occurrence Handle8816718Occurrence Handle1:CAS:528:DyaK28XlvFans70%3D PubMedCAS Google Scholar
VH Perry TA Newman C Cunningham (2003)ArticleTitleThe impact of systemic infection on the progression of neurodegenerative disease_Nat Rev Neurisci_ 4 103–112Occurrence Handle1:CAS:528:DC%2BD3sXot12itQ%3D%3D CAS Google Scholar
A Poulard-Barthelaix F Dubas W Jabbour I Maher J Emile (1986) An immunological view on the etiology and pathogenesis of Alzheimer’s disease A Bes (Eds) Senile dementia early detection John Libbey Eurotext, Paris 216–222 Google Scholar
A Pouplard J Emile (1985)ArticleTitleNew immunological findings in senile dementia_Interdiscipl Topics Geront_ 19 62–71 Google Scholar
WQ Qiu DM Walsh Z Ye K Vekrelis J Zhang MB Podlisny MR Rosner A Safavi LB Hersh DJ Selkoe (1998)ArticleTitleInsulin-degrading enzyme regulates extracellular levels of amyloid-β protein by degredation_J Biol Chem_ 273 32370–32738 Google Scholar
A Reichenberg R Yirmiya AM Schuld T Kraus M Haack A Morag T Pollmacher (2001)ArticleTitleCytokine-associated emotional and cognitive disturbances in humans_Arch Gen Psychiat_ 56 445–452 Google Scholar
KP Riley DA Snowdon WR Markesberry (2002)ArticleTitleAlzheimer’s neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study_Ann Neurol_ 51 567–577Occurrence Handle12112102 PubMed Google Scholar
BR Rock G Gekker S Hu WS Sheng M Cheeran JR Lokensgaard PK Peterson (2004)ArticleTitleRole of microglia in central nervous infections_Clin Microbiol Rev_ 17 942–964Occurrence Handle15489356Occurrence Handle1:CAS:528:DC%2BD2cXhtVSht7nP PubMedCAS Google Scholar
J Rogers J Luber-Narod SD Styren WH Civin (1988)ArticleTitleExpression of the immune system-associated antigen by cells of the human central nervous system. Relationship to the pathology of Alzheimer’s disease_Neurobiol Aging_ 9 339–349Occurrence Handle3263583Occurrence Handle1:STN:280:DyaL1M%2FktVCgtg%3D%3D PubMedCAS Google Scholar
J Rogers NR Cooper S Webster J Schulz PL McGeer SD Styren WH Civin L Brachova B Bradt I Lieberburg (1992)ArticleTitleComplement activation by β-amyloid in Alzheimer’s disease_Proc Natl Acad Sci USA_ 89 10016–10020Occurrence Handle1438191Occurrence Handle1:CAS:528:DyaK3sXitVektg%3D%3D PubMedCAS Google Scholar
JM Rozemuller P Eikelenboom ST Pals FC Stam (1989a)ArticleTitleMicroglial cells around plaques in Alzheimer’s disease express leucocyte adhesion of the LFA/1 family_Neurosci Lett_ 101 288–292Occurrence Handle1:CAS:528:DyaL1MXltFeisLY%3D CAS Google Scholar
JM Rozemuller P Eikelenboom FC Stam K Beyreuther CL Masters (1989b)ArticleTitleA4 protein in Alzheimer’s disease: primary and secondary cellular events in extracellular amyloid depostion_J Neuropathol Exp Neurol_ 48 647–663 Google Scholar
Saido TC, Overview-Aβ metabolism: From Alzheimer research to brain aging control (2003) In: Saido TC (ed) Aβ metabolism and Alzheimer’s disease. Landes Bioscience Georgetown, Texas USA, pp 1–16
D Schenk R Barbour W Dunn G Gordon H Grajeda T Guido K Hu J Huang K Johnson-Wood K Khan_et al._ (1999)ArticleTitleImmunisation with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse_Nature_ 400 173–177Occurrence Handle10408445Occurrence Handle1:CAS:528:DyaK1MXks1Khsbc%3D PubMedCAS Google Scholar
R Schmidt H Schmidt JD Curb K Masaki LR White LJ Launer (2002)ArticleTitleEarly inflammation and dementia: a 25-year follow-up of the Honolul-asian aging study_Ann Neurol_ 52 168–174Occurrence Handle12210786 PubMed Google Scholar
J Schnabel (1998) Forever youngSeriesTitleScience and the search for immortality Bloomsburry Publishing Plc London Google Scholar
LM Shaffer MD Dority R Gupta-Bansal RC Frederickson SG Younkin KR Brunden (1995)ArticleTitleAmyloid-β protein (Aβ) removal by neuroglial cells in the culture_Neurobiol Aging_ 16 737–745Occurrence Handle8532106Occurrence Handle1:CAS:528:DyaK2MXpsVShu7Y%3D PubMedCAS Google Scholar
AD Snow R Sekiguchi D Nochlin P Fraser K Kimata A Mizutani M Arai WA Schreier DG Morgan (1994)ArticleTitleAn important role of heparan sulphate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar β-amyloid in the rat brain_Neuron_ 12 219–234Occurrence Handle8292358Occurrence Handle1:CAS:528:DyaK2cXivFGrsLY%3D PubMedCAS Google Scholar
SW Snyder GT Wang L Barrett US Ladror D Casuto CM Lee GA Kraft RB Holzman TF Holzman (1994)ArticleTitleComplement C1q does not bind monomeric β-amyloid_Exp Neurol_ 128 136–142Occurrence Handle8070518Occurrence Handle1:CAS:528:DyaK2MXhsl2jsLw%3D PubMedCAS Google Scholar
WJ Streit (2002)ArticleTitleMicroglia as neuroprotective, immunocompetent cells of the CNS_Glia_ 40 133–139Occurrence Handle12379901 PubMed Google Scholar
GA Tennent LB Lovat MB Pepys (1995)ArticleTitleSerum amyloid-P component prevents proteolysis of the amyloid fibrils of alzheimer disease and systemic amyloidosis_Proc Natl Acad Sci USA_ 92 4299–4303Occurrence Handle7753801Occurrence Handle1:CAS:528:DyaK2MXls1alur0%3D PubMedCAS Google Scholar
AP Timmer (1925)ArticleTitleDer Anteil der Mikroglia und Makroglia am Afbau der senile Plaques_Z Neurol_ 98 43–58 Google Scholar
KP Townsend D Pratico (2005)ArticleTitleNovel therapeutic options for Alzheimer’s disease: focus on nonsteroidal anti-inflammatory drugs_FASEB J_ 19 1592–1601Occurrence Handle16195368Occurrence Handle1:CAS:528:DC%2BD2MXhtV2nu7rJ PubMedCAS Google Scholar
WA Van Gool PS Aisen P Eikelenboom (2003)ArticleTitleAnti-inflammatory therapy in Alzheimer’s disease: is hope still alive_J Neurol_ 250 788–792Occurrence Handle12883918Occurrence Handle1:STN:280:DC%2BD3szltFaiug%3D%3D PubMedCAS Google Scholar
J Van Horssen P Wesseling LP van den Heuvel RM de Waal MM Verbeek (2003)ArticleTitleHeparan sulphate proteoglycans in Alzheimer’s disease and amyloid-related disorders_Lancet Neurol_ 2 482–492Occurrence Handle12878436Occurrence Handle1:CAS:528:DC%2BD3sXmslamtbg%3D PubMedCAS Google Scholar
R Veerhuis MJ van Breemen JJM Hoozemans M Morbin J Ouladhadj F Tagliavini P Eikelenboom (2003)ArticleTitleAmyloid β-associated proteins C1q and SAP enhance the Aβ1-42 peptide-induced cytokine secretion by adult human microglia in vitro_Acta Neuropathol_ 105 135–144Occurrence Handle12536224Occurrence Handle1:CAS:528:DC%2BD3sXksVOhsw%3D%3D PubMedCAS Google Scholar
R Veerhuis RS Boshuizen A Familian (2005)ArticleTitleAmyloid associated proteins in Alzheimer’s and prion disease_Curr Drug Targets CNS Neurol Disord_ 4 325–348 Google Scholar
R Veerhuis A Familian P Eikelenboom (2006)ArticleTitleMinocycline attenuates the amyloid-β (Aβ) mediated activation of human microglia without affecting microglial Aβ phagocytosis in vitro_Alzheimer’s & Dementia_ 2 S607 Google Scholar
AK Vehmas CH Kawas WF Stewart JC Troncoso (2003)ArticleTitleImmune reactive cells in senile plaque and cognitive decline in Alzheimer’s disease_Neurobiol Aging_ 24 321–331Occurrence Handle12498966 PubMed Google Scholar
S Weggen JL Eriksen P Das SA Sagi R Wang CU Pietrzik KA Findl TE Smith MP Murphy T Bulter DE Kang N Marquez-Sterling TE Golde EH Koo (2001)ArticleTitleA subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity_Nature_ 414 212–216Occurrence Handle11700559Occurrence Handle1:CAS:528:DC%2BD3MXosFahsLc%3D PubMedCAS Google Scholar
S Weggen JL Eriksen SA Sagi CU Pietrzik V Ozols A Fauq TE Golde EH Koo (2003)ArticleTitleEvidence that nonsteroidal anti-inflammatory drugs decrease amyloid-β 42 production by direct modulation of γ-secretase activity_J Biol Chem_ 278 31831–31837Occurrence Handle12805356Occurrence Handle1:CAS:528:DC%2BD3sXmsVOntbY%3D PubMedCAS Google Scholar
S Webster J Rogers (1997)ArticleTitleRelative efficacies of amyloid-β peptide (Aβ) binding proteins in Aβ aggregation_J Neurosci Res_ 46 58–66 Google Scholar
SD Webster AJ Yang L Margol W Garzon-Rodriquez CG Glabe AJ Tenner (2000)ArticleTitleComplement component C1q modulates the phagocytosis of Aβ by microglia_Exp Neurol_ 161 127–138Occurrence Handle10683279Occurrence Handle1:CAS:528:DC%2BD3cXht1SgtL4%3D PubMedCAS Google Scholar
DM Wilcock A Rojiani A Rosenthal S Subbarao MJ Freeman MN Gordon D Morgan (2004)ArticleTitleO Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage_J Neuroinflammation_ 1 24Occurrence Handle15588287 PubMed Google Scholar
AE Williams A-M Van Dam P Eikelenboom H Fraser (1997)ArticleTitleImmunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incuabation period of mrine scrapie correlates with progressive PrP accumulations_Brain Res_ 754 171–180Occurrence Handle9134973Occurrence Handle1:CAS:528:DyaK2sXit1eiur8%3D PubMedCAS Google Scholar
T Wyss-Coray L Mucke (2002)ArticleTitleInflammation in neurodegenerative disease: a double-edged sword_Neuron_ 35 419–432Occurrence Handle12165466Occurrence Handle1:CAS:528:DC%2BD38Xmt12isrs%3D PubMedCAS Google Scholar
T Wyss-Coray F Yan AH Lin JD Lambris JJ Alexander RJ Quigg E Masliah (2002)ArticleTitleProminent neurodegeneration and increased plaque formation in complement inhibited Alzheimer’s mice_Proc Natl Acad Sci USA_ 99 10837–10842Occurrence Handle12119423Occurrence Handle1:CAS:528:DC%2BD38Xmt1ChtLY%3D PubMedCAS Google Scholar
K Yaffe K Lindquist BW Penninx EM Simonsick M Pahor S Kritchevsky L Launer L Kuller S Rubin T Harris (2003)ArticleTitleInflammation and cognition in well-functioning African–American and white elders_Neurology_ 61 76–80Occurrence Handle12847160Occurrence Handle1:STN:280:DC%2BD3szhvVSlsw%3D%3D PubMedCAS Google Scholar
K Yaffe A Kanaya K Lindquist EM Simonsick T Harris RI Shorr FA Tylavsky AB Newman (2004)ArticleTitleThe metabolic syndrome, inflammation, and risk of cognitive decline_JAMA_ 292 2237–2242Occurrence Handle15536110Occurrence Handle1:CAS:528:DC%2BD2cXpvVWms7s%3D PubMedCAS Google Scholar
SS Zhan W Kamphorst WE VanNostrand P Eikelenboom (1995a)ArticleTitleDistribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer’s disease and non-demented elderly_Acta Neuropathol (Berl)_ 89 356–362Occurrence Handle1:STN:280:DyaK2MzjsFWnsA%3D%3D CAS Google Scholar
SS Zhan R Veerhuis W Kamphorst P Eikelenboom (1995b)ArticleTitleDistribution of beta amyloid associated proteins in plaques in Alzheimer’s disease and in non-demented elderly_Neurodegeneration_ 4 291–297Occurrence Handle1:STN:280:DyaK287jtVyksw%3D%3D CAS Google Scholar
BV Zlokovic (2004)ArticleTitleClearing amyloid through the blood–brain barrier_J Neurochem_ 89 807–811Occurrence Handle15140180Occurrence Handle1:CAS:528:DC%2BD2cXksVyks7c%3D PubMedCAS Google Scholar
BV Zlokovic B Frangione (2003) Transport clearance hypothesis for Alzheimer’s disease and potential implications TC Saido (Eds) Aβ metabolism and Alzheimer’s disease Landes Bioscience Georgetown Texas, USA 117–125 Google Scholar