Parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients (original) (raw)

Summary.

Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them.

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Authors and Affiliations

1. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET),, , , , , , AR
   J. A. Serra
2. Hospital Sirio – Libanés, FACENE,, , , , , , AR
   R. O. Domínguez, A. L. Famulari & E. L. Bartolomé
3. Instituto de Oncología Angel H. Roffo (UBA),, , , , , , AR
   E. S. de Lustig
4. Laboratorio Especializado para las Investigaciones Clínicas (LEPLIC), and, , , , , , AR
   E. M. Guareschi
5. Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires, Argentina, , , , , , AR
   E. R. Marschoff

Authors

1. J. A. Serra
2. R. O. Domínguez
3. E. S. de Lustig
4. E. M. Guareschi
5. A. L. Famulari
6. E. L. Bartolomé
7. E. R. Marschoff

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Received October 5, 2000; accepted June 1, 2001

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Serra, J., Domínguez, R., de Lustig, E. et al. Parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients.J Neural Transm 108, 1135–1148 (2001). https://doi.org/10.1007/s007020170003

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• Issue date: October 2001
• DOI: https://doi.org/10.1007/s007020170003