Pathological and molecular characterisation of peste des petits ruminants in Nubian ibex (Capra nubiana) in Israel (original) (raw)

Abstract

Peste des petits ruminants (PPR) is a devastating disease that generally affects sheep and goats, mostly in Asia, the Middle East and Africa. The disease has been declared a target for global eradication. Despite its high prevalence in domestic flocks and its high seroprevalence among wildlife, it is rarely reported as a fulminant disease in wild ruminant species (with the exception of Central Asia). In this report, we describe a severe PPR outbreak in a zoo herd of Nubian ibex (Capra nubiana), causing the deaths of 2/3 of the herd. The clinical onset was acute with morbid animals exhibiting lethargy and watery-to-bloody diarrhea and death usually within 48 h. The most consistent gross pathologic findings were hemorrhagic abomasitis and enteritis. Oral lesions and pulmonary lesions were rare. Histology revealed necrohemorrhagic enteritis and abomasitis with myriad nuclear and cytoplasmic viral inclusion bodies. Molecular examinations confirmed the diagnosis of PPR and determined that the causative agent belongs to lineage IV. Further molecular examination showed that the virus belongs to the Asian clade of lineage IV and is closely related to a virus described in Turkey.

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Funding

This study was funded by internal resources of the Kimron Institute.

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Author notes

1. Oran Erster
   Present address: Central Virology Laboratory, Israeli Ministry of Health, Sheba Medical Center, 5266202, Ramat Gan, Israel
2. Asaf Berkowitz and Oran Erster contributed equally to this work.

Authors and Affiliations

1. Division of Pathology, Kimron Veterinary Institute, Bet Dagan, 50250, Israel
   Asaf Berkowitz & Arieli Bouznach
2. Division of virology, Kimron Veterinary Institute, 50250, Bet Dagan, Israel
   Orly Friedgut, Velizar Bombarov, Marisol Guini-Rubinstein, Yehuda Stram, Avi Eldar & Oran Erster
3. Biblical zoo of Jerusalem, Derech Aharon Shulov 3, Jerusalem, Israel
   Nili Avni-Magen & Arie Litvak
4. Veterinary Clinic, 9 Meginay Hagalil Street, Rehovot, Israel
   Trevor Waner

Authors

1. Asaf Berkowitz
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2. Nili Avni-Magen
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3. Arieli Bouznach
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4. Trevor Waner
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5. Arie Litvak
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6. Orly Friedgut
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7. Velizar Bombarov
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8. Marisol Guini-Rubinstein
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9. Yehuda Stram
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10. Avi Eldar
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11. Oran Erster
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Correspondence toOran Erster.

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The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Since no studies with live animals were conducted in this work, an ethical approval was not required.

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Berkowitz, A., Avni-Magen, N., Bouznach, A. et al. Pathological and molecular characterisation of peste des petits ruminants in Nubian ibex (Capra nubiana) in Israel.Arch Virol 164, 1997–2003 (2019). https://doi.org/10.1007/s00705-019-04269-y

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• Received: 03 December 2018
• Accepted: 30 March 2019
• Published: 15 May 2019
• Issue Date: 01 August 2019
• DOI: https://doi.org/10.1007/s00705-019-04269-y