Precursor genes of future pandemic influenza viruses are perpetuated in ducks nesting in Siberia (original) (raw)

Summary.

Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia in summer from 1996 to 1998. Phylogenetic analysis of the NP genes of the isolates in Siberia and those in Hokkaido, Japan on their flyway of migration from Siberia to the south in autumn revealed that they belong to the Eurasian lineage of avian influenza viruses. It is noted that the genes of the isolates in Siberia are closely related to those of H5N1 influenza virus strains isolated from chickens and humans in Hong Kong in 1997 as well as to those of isolates from domestic birds in southern China. The results indicate that influenza viruses perpetuated in ducks nesting in Siberia should have contributed genes in the emergence of the H5N1 virusin Hong Kong. Vaccine prepared from avirulent A/duck/Hokkaido/4/96 (H5N3) influenza virus was potent enough to protect mice from challenge with lethal dose of the pathogenic H5N1 virus [19]. Intensive surveillance study of aquatic birds especially in Siberia is, therefore, stressed to provide information on the future pandemic influenza virus strains and for vaccine preparation.

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Authors and Affiliations

1. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP
   K. Okazaki, A. Takada, M. Imai, H. Takakuwa, M. Hatta, H. Ozaki, T. Tanizaki, T. Nagano, A. Ninomiya & H. Kida
2. Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan, JP
   T. Ito
3. Far-Eastern Medical Association, Khabarovsk, Russia, RU
   V. A. Demenev
4. Department of Biology Resources, Ministry of Nature Protection, Yakutsk, Sakha Republic, Russia, RU
   M. M. Tyaptirganov
5. Veterinary Department, Ministry of Agriculture and Food, Yakutsk, Sakha Republic, Russia, RU
   T. D. Karatayeva
6. Ivanovsky Institute of Virology, Moscow, Russia, RU
   S. S. Yamnikova & D. K. Lvov

Authors

1. K. Okazaki
2. A. Takada
3. T. Ito
4. M. Imai
5. H. Takakuwa
6. M. Hatta
7. H. Ozaki
8. T. Tanizaki
9. T. Nagano
10. A. Ninomiya
11. V. A. Demenev
12. M. M. Tyaptirganov
13. T. D. Karatayeva
14. S. S. Yamnikova
15. D. K. Lvov
16. H. Kida

Additional information

Received August 24, 1999/Accepted January 7, 2000

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Okazaki, K., Takada, A., Ito, T. et al. Precursor genes of future pandemic influenza viruses are perpetuated in ducks nesting in Siberia.Arch. Virol. 145, 885–893 (2000). https://doi.org/10.1007/s007050050681

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• Published: 01 May 2000
• Issue date: May 2000
• DOI: https://doi.org/10.1007/s007050050681