Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation (original) (raw)

• Abcouwer SF, Marjon PL, Loper RK, Vander Jagt DL (2002) Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress. Invest Ophthalmol Vis Sci 43:2791–2798
  PubMed Google Scholar
• Averous J, Bruhat A, Jousse C, Carraro V, Thiel G, Fafournoux P (2004) Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J Biol Chem 279:5288–5297
  Article PubMed CAS Google Scholar
• Bain PJ, LeBlanc-Chaffin R, Chen H, Palii SS, Leach KM, Kilberg MS (2002) The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase. J Nutr 132:3023–3029
  PubMed CAS Google Scholar
• Bode BP (2001) Recent molecular advances in mammalian glutamine transport. J Nutr 131:2475S–2485S
  PubMed CAS Google Scholar
• Bracy DS, Handlogten ME, Barber EF, Han HP, Kilberg MS (1986) Cis-inhibition, trans-inhibition, and repression of hepatic amino acid transport mediated by system A. J Biol Chem 261:1514–1520
  PubMed CAS Google Scholar
• Broer S (2002) Adaptation of plasma membrane amino acid transport mechanisms to physiological demands. Pflugers Arch 444:457–466
  Article PubMed CAS Google Scholar
• Brosnan JT (2003) Interorgan amino acid transport and its regulation. J Nutr 133:2068S–2072S
  PubMed CAS Google Scholar
• Chen H, Pan YX, Dudenhausen EE, Kilberg MS (2004) Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive bZIP transcription factors as well as localized histone acetylation. J Biol Chem 279:50829–50839
  Article PubMed CAS Google Scholar
• Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A (2007) The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res 35:5954–5965
  Article PubMed CAS Google Scholar
• Fernandez J, Lopez AB, Wang C, Mishra R, Zhou L, Yaman I, Snider MD, Hatzolgou M (2003) Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress. J Biol Chem 278:50000–50009
  Article PubMed CAS Google Scholar
• Gaccioli F, Huang CC, Wang C, Bevilacqua E, Franchi-Gazzola R, Gazzola GC, Bussolati O, Snider MD, Hatzoglou M (2006) Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eIF2alpha phosphorylation and cap-independent translation. J Biol Chem 281:17929–17940
  Article PubMed Google Scholar
• Gazzola GC, Franchi R, Saibene V, Ronchi P, Guidotti GG (1972) Regulation of amino acid transport in chick embryo heart cells I. Adaptive system of mediation for neutral amino acids. Biochim Biophys Acta 266:407–421
  Article PubMed CAS Google Scholar
• Gazzola RF, Sala R, Bussolati O, Visigalli R, Dall’Asta V, Ganapathy V, Gazzola GC (2001) The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression. FEBS Lett 490:11–14
  Article PubMed CAS Google Scholar
• Gjymishka A, Palii SS, Shan J, Kilberg MS (2008) Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. J Biol Chem 283:27736–27747
  Article PubMed CAS Google Scholar
• Handlogten ME, Kilberg MS, Christensen HN (1982) Incomplete correspondence between repressive and substrate action by amino acids on transport systems A and N in monolayered rat hepatocytes. J Biol Chem 257:345–348
  PubMed CAS Google Scholar
• Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6:1099–1108
  Article PubMed CAS Google Scholar
• Hu CA, Williams DB, Zhaorigetu S, Khalil S, Wan GH, Valle D (2008) Functional genomics and SNP analysis of human genes encoding proline metabolic enzymes. Amino Acids 35:655–664
  Article PubMed CAS Google Scholar
• Hyde R, Taylor PM, Hundal HS (2003) Amino acid transporters: roles in amino acid sensing and signalling in animal cells. J Biochem 373:1–18
  Article CAS Google Scholar
• Jousse C, Bruhat A, Ferrara M, Fafournoux P (2000) Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. J Nutr 130:1555–1560
  PubMed CAS Google Scholar
• Kilberg MS (1989) Measurement of amino acid transport by hepatocytes in suspension or monolayer culture. Methods Enzymol 173:564–575
  Article PubMed CAS Google Scholar
• Kilberg MS, Pan YX, Chen H, Leung-Pineda V (2005) Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr 25:59–85
  Article PubMed CAS Google Scholar
• Kimball SR, Jefferson LS (2005) Role of amino acids in the translational control of protein synthesis in mammals. Semin Cell Dev Biol 16:21–27
  Article PubMed CAS Google Scholar
• Kimball SR, Jefferson LS (2006) Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 136:227S–231S
  PubMed CAS Google Scholar
• Lee JI, Dominy JE Jr, Sikalidis AK, Hirschberger LL, Wang W, Stipanuk MH (2008) HepG2/C3A cells respond to cysteine-deprivation by induction of the amino acid deprivation/integrated stress response pathway. Physiol Genomics 33:218–229
  Article PubMed CAS Google Scholar
• Liao XH, Majithia A, Huang XL, Kimmel AR (2008) Growth control via TOR kinase signaling, an intracellular sensor of amino acids and energy availability, with crosstalk potential to proline metabolism. Amino Acids 35:761–770
  Article PubMed CAS Google Scholar
• Ling R, Bridges CC, Sugawara M, Fujita T, Leibach FH, Prasad PD, Ganapathy V (2001) Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A. Biochim Biophys Acta 1512:15–21
  Article PubMed CAS Google Scholar
• Lu PD, Harding HP, Ron D (2004) Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol 167:27–33
  Article PubMed CAS Google Scholar
• Mackenzie B, Erickson JD (2004) Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch 447:784–795
  Article PubMed CAS Google Scholar
• Palii SS, Chen H, Kilberg MS (2004) Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem 279:3463–3471
  Article PubMed CAS Google Scholar
• Palii SS, Thiaville MM, Pan YX, Zhong C, Kilberg MS (2006) Characterization of the amino acid response element within the human SNAT2 system A transporter gene. J Biochem 395:517–527
  Article CAS Google Scholar
• Perta-Kajan J, Twardowski T, Jakubowski H (2007) Mechanisms of homocysteine toxicity in humans. Amino Acids 32:561–572
  Article Google Scholar
• Riggs TR, Pan MW (1972) Transport of amino acids into the oestrogen-primed uterus. Enchancement of the uptake by a preliminary incubation. J Biochem 128:19–27
  CAS Google Scholar
• Sharp JW, Ross-Inta CM, Hao S, Rudell JB, Gietzen DW (2006) Co-localization of phosphorylated extracellular signal-regulated protein kinases 1/2 (ERK1/2) and phosphorylated eukaryotic initiation factor 2alpha (eIF2alpha) in response to a threonine-devoid diet. J Comp Neurol 494:485–494
  Article PubMed CAS Google Scholar
• Suryawan A, O’Connor PMJ, Bush JA, Nguyen HV, Davis TA (2008) Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs. Amino Acids. doi:10.1007/s00726-008-0149-z
• Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS (2008) MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem 283:10848–10857
  Article PubMed CAS Google Scholar
• Vattem KM, Wek RC (2004) Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci USA 101:11269–11274
  Article PubMed CAS Google Scholar
• Wang X, Proud CG (2008) A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. Mol Cell Biol 28:1429–1442
  Article PubMed CAS Google Scholar
• Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR (2002) The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 22:6681–6688
  Article PubMed CAS Google Scholar