Human Alzheimer’s disease synaptic O-GlcNAc site mapping and iTRAQ expression proteomics with ion trap mass spectrometry (original) (raw)

• Abel T, Nguyen PV (2008) Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase. Prog Brain Res 169:97–115
  Article PubMed CAS Google Scholar
• Akimoto Y, Comer FI, Cole RN, Kudo A, Kawakami H, Hirano H, Hart GW (2003) Localization of the _O_-GlcNAc transferase and _O_-GlcNAc-modified proteins in rat cerebellar cortex. Brain Res 966:194–205
  Article PubMed CAS Google Scholar
• Arnold CS, Johnson GV, Cole RN, Dong DL, Lee M, Hart GW (1996) The microtubule-associated protein tau is extensively modified with _O_-linked _N_-acetylglucosamine. J Biol Chem 271:28741–28744
  Article PubMed CAS Google Scholar
• Bantscheff M, Boesche M, Eberhard D, Matthieson T, Sweetman G, Kuster B (2008) Robust and sensitive iTRAQ quantification on an LTQ Orbitrap mass spectrometer. Mol Cell Proteomics 7:1702–1713
  Article PubMed CAS Google Scholar
• Brackley KI, Grantham J (2009) Activities of the chaperonin containing TCP-1 (CCT): implications for cell cycle progression and cytoskeletal organisation. Cell Stress Chaperones 14:23–31
  Article PubMed CAS Google Scholar
• Brunet A, Pages G, Pouyssegur J (1994) Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1). FEBS Lett 346:299–303
  Article PubMed CAS Google Scholar
• Carlin RK, Grab DJ, Cohen RS, Siekevitz P (1980) Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities. J Cell Biol 86:831–845
  Article PubMed CAS Google Scholar
• Castegna A, Aksenov M, Aksenova M, Thongboonkerd V, Klein JB, Pierce WM, Booze R, Markesbery WR, Butterfield DA (2002) Proteomic identification of oxidatively modified proteins in Alzheimer’s disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic Biol Med 33:562–571
  Article PubMed CAS Google Scholar
• Chalkley RJ, Thalhammer A, Schoepfer R, Burlingame AL (2009) Identification of protein _O_-GlcNAcylation sites using electron transfer dissociation mass spectrometry on native peptides. Proc Natl Acad Sci USA 106:8894–8899
  Article PubMed CAS Google Scholar
• Choi J, Levey AI, Weintraub ST, Rees HD, Gearing M, Chin LS, Li L (2004) Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson’s and Alzheimer’s diseases. J Biol Chem 279:13256–13264
  Article PubMed CAS Google Scholar
• Cole RN, Hart GW (2001) Cytosolic _O_-glycosylation is abundant in nerve terminals. J Neurochem 79:1080–1089
  Article PubMed CAS Google Scholar
• Collins MO, Yu L, Coba MP, Husi H, Campuzano I, Blackstock WP, Choudhary JS, Grant SG (2005) Proteomic analysis of in vivo phosphorylated synaptic proteins. J Biol Chem 280:5972–5982
  Article PubMed CAS Google Scholar
• Comer FI, Hart GW (2001) Reciprocity between _O_-GlcNAc and _O_-phosphate on the carboxyl terminal domain of RNA polymerase II. Biochemistry 40:7845–7852
  Article PubMed CAS Google Scholar
• Corradi A, Zanardi A, Giacomini C, Onofri F, Valtorta F, Zoli M, Benfenati F (2008) Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment. J Cell Sci 121:3042–3051
  Article PubMed CAS Google Scholar
• Cox J, Jackson AP, Bond J, Woods CG (2006) What primary microcephaly can tell us about brain growth. Trends Mol Med 12:358–366
  Article PubMed CAS Google Scholar
• Cumming RC, Schubert D (2005) Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer’s disease. Faseb J 19:2060–2062
  PubMed CAS Google Scholar
• Cunningham C Jr, Glish GL, Burinsky DJ (2006) High amplitude short time excitation: a method to form and detect low mass product ions in a quadrupole ion trap mass spectrometer. J Am Soc Mass Spectrom 17:81–84
  Article PubMed CAS Google Scholar
• Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci USA 105:10762–10767
  Article PubMed CAS Google Scholar
• Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H (2003) Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci USA 100:721–726
  Article PubMed CAS Google Scholar
• Evans CG, Wisen S, Gestwicki JE (2006) Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1–42) aggregation in vitro. J Biol Chem 281:33182–33191
  Article PubMed CAS Google Scholar
• Fdez E, Hilfiker S (2006) Vesicle pools and synapsins: new insights into old enigmas. Brain Cell Biol 35:107–115
  Article PubMed Google Scholar
• Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (2000) Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Neuron 25:203–214
  Article PubMed CAS Google Scholar
• Fifre A, Sponne I, Koziel V, Kriem B, Yen Potin FT, Bihain BE, Olivier JL, Oster T, Pillot T (2006) Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid beta-peptide-induced neuronal apoptosis. Synergistic involvement of calpain and caspase-3. J Biol Chem 281:229–240
  Article PubMed CAS Google Scholar
• Gao Y, Wells L, Comer FI, Parker GJ, Hart GW (2001) Dynamic _O_-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-_N_-acetylglucosaminidase from human brain. J Biol Chem 276:9838–9845
  Article PubMed CAS Google Scholar
• Gong B, Cao Z, Zheng P, Vitolo OV, Liu S, Staniszewski A, Moolman D, Zhang H, Shelanski M, Arancio O (2006) Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell 126:775–788
  Article PubMed CAS Google Scholar
• Gong Y, Lippa CF, Zhu J, Lin Q, Rosso AL (2009) Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer’s disease. Brain Res 1292:191–198
  Article PubMed CAS Google Scholar
• Greber S, Lubec G, Cairns N, Fountoulakis M (1999) Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer’s disease. Electrophoresis 20:928–934
  Article PubMed CAS Google Scholar
• Griffin TJ, Xie H, Bandhakavi S, Popko J, Mohan A, Carlis JV, Higgins L (2007) iTRAQ reagent-based quantitative proteomic analysis on a linear ion trap mass spectrometer. J Proteome Res 6:4200–4209
  Article PubMed CAS Google Scholar
• Guo T, Gan CS, Zhang H, Zhu Y, Kon OL, Sze SK (2008) Hybridization of pulsed-Q dissociation and collision-activated dissociation in linear ion trap mass spectrometer for iTRAQ quantitation. J Proteome Res 7:4831–4840
  Article PubMed CAS Google Scholar
• Gygi SP, Rist B, Gerber SA, Turecek F, Gelb MH, Aebersold R (1999) Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol 17:994–999
  Article PubMed CAS Google Scholar
• Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM (2004) Synaptic changes in Alzheimer’s disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol 165:1809–1817
  Article PubMed CAS Google Scholar
• Hlavanda E, Klement E, Kokai E, Kovacs J, Vincze O, Tokesi N, Orosz F, Medzihradszky KF, Dombradi V, Ovadi J (2007) Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. J Biol Chem 282:29531–29539
  Article PubMed CAS Google Scholar
• Hol EM, Roelofs RF, Moraal E, Sonnemans MA, Sluijs JA, Proper EA, de Graan PN, Fischer DF, van Leeuwen FW (2003) Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms. Mol Psychiatry 8:786–796
  Article PubMed CAS Google Scholar
• Hornbeck PV, Chabra I, Kornhauser JM, Skrzypek E, Zhang B (2004) PhosphoSite: a bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics 4:1551–1561
  Article PubMed CAS Google Scholar
• Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I (2008) Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453:481–488
  Article PubMed CAS Google Scholar
• Ii K, Ito H, Tanaka K, Hirano A (1997) Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly. J Neuropathol Exp Neurol 56:125–131
  Article PubMed CAS Google Scholar
• Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC (2004) Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 62:925–931
  PubMed CAS Google Scholar
• Inoue E, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Kitajima I, Ohtsuka T, Takai Y (2006) ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. Genes Cells 11:659–672
  Article PubMed CAS Google Scholar
• Jose M, Nair DK, Altrock WD, Dresbach T, Gundelfinger ED, Zuschratter W (2008) Investigating interactions mediated by the presynaptic protein bassoon in living cells by Foerster’s resonance energy transfer and fluorescence lifetime imaging microscopy. Biophys J 94:1483–1496
  Article PubMed CAS Google Scholar
• Kamino K, Nagasaka K, Imagawa M, Yamamoto H, Yoneda H, Ueki A, Kitamura S, Namekata K, Miki T, Ohta S (2000) Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer’s disease in the Japanese population. Biochem Biophys Res Commun 273:192–196
  Article PubMed CAS Google Scholar
• Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J (2004) Glycosylation changes in Alzheimer’s disease as revealed by a proteomic approach. Neurosci Lett 367:235–240
  Article PubMed CAS Google Scholar
• Keller JN, Hanni KB, Markesbery WR (2000) Impaired proteasome function in Alzheimer’s disease. J Neurochem 75:436–439
  Article PubMed CAS Google Scholar
• Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (1998) Identification of septins in neurofibrillary tangles in Alzheimer’s disease. Am J Pathol 153:1551–1560
  Article PubMed CAS Google Scholar
• Klement E, Lipinszki Z, Kupihar Z, Udvardy A, Medzihradszky KF (2010) Enrichment of _O_-GlcNAc modified proteins by the periodate oxidation—hydrazide resin capture approach. J Proteome Res 9(5):2200–2206
  Article PubMed CAS Google Scholar
• Kneass ZT, Marchase RB (2005) Protein _O_-GlcNAc modulates motility-associated signaling intermediates in neutrophils. J Biol Chem 280:14579–14585
  Article PubMed CAS Google Scholar
• Kovacs GG, Gelpi E, Lehotzky A, Hoftberger R, Erdei A, Budka H, Ovadi J (2007) The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases. Acta Neuropathol 113:153–161
  Article PubMed CAS Google Scholar
• Kreppel LK, Blomberg MA, Hart GW (1997) Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique _O_-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem 272:9308–9315
  Article PubMed CAS Google Scholar
• Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL (2004) Synaptic targeting by Alzheimer’s-related amyloid beta oligomers. J Neurosci 24:10191–10200
  Article PubMed CAS Google Scholar
• LaFerla FM, Oddo S (2005) Alzheimer’s disease: Abeta, tau and synaptic dysfunction. Trends Mol Med 11:170–176
  Article PubMed CAS Google Scholar
• Leal-Ortiz S, Waites CL, Terry-Lorenzo R, Zamorano P, Gundelfinger ED, Garner CC (2008) Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis. J Cell Biol 181:831–846
  Article PubMed CAS Google Scholar
• Li X, Lu F, Wang JZ, Gong CX (2006) Concurrent alterations of _O_-GlcNAcylation and phosphorylation of tau in mouse brains during fasting. Eur J Neurosci 23:2078–2086
  Article PubMed Google Scholar
• Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (2005) p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. J Biol Chem 280:5703–5715
  Article PubMed CAS Google Scholar
• Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX (2004) _O_-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer’s disease. Proc Natl Acad Sci USA 101:10804–10809
  Article PubMed CAS Google Scholar
• Liu F, Shi J, Tanimukai H, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX (2009) Reduced _O_-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer’s disease. Brain 132:1820–1832
  Article PubMed Google Scholar
• Magrane J, Smith RC, Walsh K, Querfurth HW (2004) Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons. J Neurosci 24:1700–1706
  Article PubMed CAS Google Scholar
• Markesbery WR (1999) The role of oxidative stress in Alzheimer disease. Arch Neurol 56:1449–1452
  Article PubMed CAS Google Scholar
• Meany DL, Xie H, Thompson LV, Arriaga EA, Griffin TJ (2007) Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry. Proteomics 7:1150–1163
  Article PubMed CAS Google Scholar
• Oddo S (2008) The ubiquitin-proteasome system in Alzheimer’s disease. J Cell Mol Med 12:363–373
  Article PubMed CAS Google Scholar
• Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409–421
  Article PubMed CAS Google Scholar
• Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S (2008) Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci 28:6239–6249
  Article PubMed CAS Google Scholar
• Ohta S, Ohsawa I (2006) Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer’s disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. J Alzheimers Dis 9:155–166
  PubMed Google Scholar
• Ohta S, Ohsawa I, Kamino K, Ando F, Shimokata H (2004) Mitochondrial ALDH2 deficiency as an oxidative stress. Ann N Y Acad Sci 1011:36–44
  Article PubMed CAS Google Scholar
• Ong SE, Mann M (2005) Mass spectrometry-based proteomics turns quantitative. Nat Chem Biol 1:252–262
  Article PubMed CAS Google Scholar
• Ovadi J, Orosz F (2009) An unstructured protein with destructive potential: TPPP/p25 in neurodegeneration. Bioessays 31:676–686
  Article PubMed CAS Google Scholar
• Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M (2004) CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet 13:703–714
  Article PubMed CAS Google Scholar
• Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, Khainovski N, Pillai S, Dey S, Daniels S, Purkayastha S, Juhasz P, Martin S, Bartlet-Jones M, He F, Jacobson A, Pappin DJ (2004) Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics 3:1154–1169
  Article PubMed CAS Google Scholar
• Rowan MJ, Klyubin I, Cullen WK, Anwyl R (2003) Synaptic plasticity in animal models of early Alzheimer’s disease. Philos Trans R Soc Lond B Biol Sci 358:821–828
  Article PubMed CAS Google Scholar
• Schubert D (2005) Glucose metabolism and Alzheimer’s disease. Ageing Res Rev 4:240–257
  Article PubMed CAS Google Scholar
• Schwartz JC, Syka JP, Quarmby ST (2005) In: Presented at the 53rd ASMS conference on mass spectrometry, San Antonio, TX, June 5–9
• Selkoe DJ (2002) Alzheimer’s disease is a synaptic failure. Science 298:789–791
  Article PubMed CAS Google Scholar
• Shadforth IP, Dunkley TP, Lilley KS, Bessant C (2005) i-Tracker: for quantitative proteomics using iTRAQ. BMC Genomics 6:145
  Article PubMed Google Scholar
• Shalova IN, Cechalova K, Rehakova Z, Dimitrova P, Ognibene E, Caprioli A, Schmalhausen EV, Muronetz VI, Saso L (2007) Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer’s disease. Biochim Biophys Acta 1770:826–832
  PubMed CAS Google Scholar
• Sharma P, Veeranna, Sharma M, Amin ND, Sihag RK, Grant P, Ahn N, Kulkarni AB, Pant HC (2002) Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol Chem 277:528–534
• Sitz JH, Baumgartel K, Hammerle B, Papadopoulos C, Hekerman P, Tejedor FJ, Becker W, Lutz B (2008) The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4. Neuroscience 157:596–605
  Article PubMed CAS Google Scholar
• Sumegi M, Hunyadi-Gulyas E, Medzihradszky KF, Udvardy A (2003) 26S proteasome subunits are _O_-linked _N_-acetylglucosamine-modified in Drosophila melanogaster. Biochem Biophys Res Commun 312:1284–1289
  Article PubMed CAS Google Scholar
• Sweatt JD (2004) Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol 14:311–317
  Article PubMed CAS Google Scholar
• Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (2004) Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. J Cell Biol 164:301–311
  Article PubMed CAS Google Scholar
• Tallent MK, Varghis N, Skorobogatko Y, Hernandez-Cuebas L, Whelan K, Vocadlo DJ, Vosseller K (2009) In vivo modulation of _O_-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem 284:174–181
  Article PubMed CAS Google Scholar
• tom Dieck S, Altrock WD, Kessels MM, Qualmann B, Regus H, Brauner D, Fejtova A, Bracko O, Gundelfinger ED, Brandstatter JH (2005) Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex. J Cell Biol 168:825–836
  Article PubMed Google Scholar
• Veereshwarayya V, Kumar P, Rosen KM, Mestril R, Querfurth HW (2006) Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis. J Biol Chem 281:29468–29478
  Article PubMed CAS Google Scholar
• Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JH, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL (2006a) _O_-GlcNAc proteomics of postsynaptic density preparations using lectin weak affinity chromatography (LWAC) and mass spectrometry. Mol Cell Proteomics 5(5):923–934
  Article PubMed CAS Google Scholar
• Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JO, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL (2006b) _O_-linked _N_-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Mol Cell Proteomics 5:923–934
  Article PubMed CAS Google Scholar
• Wells L, Vosseller K, Hart GW (2003) A role for _N_-acetylglucosamine as a nutrient sensor and mediator of insulin resistance. Cell Mol Life Sci 60:222–228
  Article PubMed CAS Google Scholar
• Xu B, Wilsbacher JL, Collisson T, Cobb MH (1999) The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J Biol Chem 274:34029–34035
  Article PubMed CAS Google Scholar
• Yao PJ, Coleman PD (1998) Reduced _O_-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer’s disease. Neurosci Lett 252:33–36
  Article PubMed CAS Google Scholar
• Yao T, Song L, Xu W, DeMartino GN, Florens L, Swanson SK, Washburn MP, Conaway RC, Conaway JW, Cohen RE (2006) Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol 8:994–1002
  Article PubMed CAS Google Scholar
• Yates JR 3rd, Eng JK, McCormack AL, Schieltz D (1995) Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database. Anal Chem 67:1426–1436
  Article PubMed CAS Google Scholar
• Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ (2008) A potent mechanism-inspired _O_-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4:483–490
  Article PubMed CAS Google Scholar
• Zhang F, Su K, Yang X, Bowe DB, Paterson AJ, Kudlow JE (2003) _O_-GlcNAc modification is an endogenous inhibitor of the proteasome. Cell 115:715–725
  Article PubMed CAS Google Scholar