Involvement of substance P and the NK-1 receptor in human pathology (original) (raw)

References

• Abidi MH, Tageja N, Ayash L, Abrams J, Ratanatharathorn V, Al-Kadhimi Z, Lum L, Cronin S, Ventimiglia M, Uberti J (2012) Aprepitant for prevention of nausea and vomiting secondary to high-dose cyclophosphamide administered to patients undergoing autologous peripheral blood stem cells mobilization: a phase II trial. Support Care Cancer 20:2363–2369
  PubMed Central PubMed Google Scholar
• Angulo JA, McEwen BS (1994) Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. Brain Res Brain Res Rev 19:1–28
  PubMed Google Scholar
• Annunziata P, Cioni C, Toneatto S, Paccagnini E (1998) HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P. AIDS 12:2377–2385
  CAS PubMed Google Scholar
• Arck PC, Merali FS, Stanisz AM, Stead RH, Chaouat G, Manuel J, Clark DA (1995) Stress-induced murine abortion associated with substance P-dependent alteration in cytokines in maternal uterine decidua. Biol Reprod 53:814–819
  CAS PubMed Google Scholar
• Armstrong DM, Pickel VM, Joh TH, Reis DJ, Miller RJ (1981) Immunocytochemical localization of catecholamine synthesizing enzymes and neuropeptides in the area postrema and medial nucleus tractus solitarius of rat brain. J Comp Neurol 196:505–517
  CAS PubMed Google Scholar
• Azzari C, Rossi ME, Resti M, Caldini AL, Lega L, Galli L, Fico E, Vierucci A (1992) Changed levels of substance P and somatostatin in HIV-positive children. Pediatr Med Chir 14:577–581
  CAS PubMed Google Scholar
• Baek MN, Jung KH, Halder D, Choi MR, Lee BH, Lee BC, Jung MH, Choi IG, Chung MK, Oh DY, Chai YG (2010) Artificial microRNA-based neurokinin-1 receptor gene silencing reduces alcohol consumption in mice. Neurosci Lett 475:124–128
  CAS PubMed Google Scholar
• Bang R, Sass G, Kiemer AK, Vollmar AM, Neuhuber WL, Tiegs G (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J Pharmacol Exp Ther 305:31–39
  CAS PubMed Google Scholar
• Bang R, Biburger M, Neuhuber WL, Tiegs G (2004) Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage. J Pharmacol Exp Ther 308:1174–1180
  CAS PubMed Google Scholar
• Bardelli C, Amoruso A, Manzetti E, Fresu LG, Valsesia R, Zeppegno P, Brunelleschi S (2013) Recurrent major depressive disorder: imbalance of neurokinin (NK)-1 and NK-2 receptor expression in monocytes. Pharmacol Res 68:24–30
  CAS PubMed Google Scholar
• Berger M, Neth O, Ilmer M, Garnier A, Salinas-Martín MV, de Agustín Asencio JC, von Schweinitz D, Kappler R, Muñoz M (2014) Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo. J Hepatol (in press)
• Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8:136–142
  CAS PubMed Google Scholar
• Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ (2012) Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discov Today 17:964–973
  CAS PubMed Google Scholar
• Bountra C, Bunce K, Dale K, Gardner C, Jordan C, Twissell D, Ward P (1993) Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. Eur J Pharmacol 249:R3–R4
  CAS PubMed Google Scholar
• Brener S, González-Moles MA, Tostes D, Esteban F, Gil-Montoya JA, Ruiz-Avila I, Bravo M, Muñoz M (2009) A role for the substance P/NK-1 receptor complex in cell proliferation in oral squamous cell carcinoma. Anticancer Res 29:2323–2329
  PubMed Google Scholar
• Carletti R, Corsi M, Melotto S, Caberlotto L (2005) Down-regulation of amygdala preprotachykinin A mRNA but not 3H-SP receptor binding sites in subjects affected by mood disorders and schizophrenia. Eur J Neurosci 21:1712–1718
  PubMed Google Scholar
• Castro-Obregón S, del Río G, Chen SF, Swanson RA, Frankowski H, Rao RV, Stoka V, Vesce S, Nicholls DG, Bredesen DE (2002) A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death Differ 9:807–817
  PubMed Google Scholar
• Chauhan VS, Sterka DG Jr, Gray DL, Bost KL, Marriott I (2008) Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi. J Immunol 180:8241–8249
  CAS PubMed Central PubMed Google Scholar
• Chauhan VS, Kluttz JM, Bost KL, Marriott I (2011) Prophylactic and therapeutic targeting of the neurokinin-1 receptor limits neuroinflammation in a murine model of pneumococcal meningitis. J Immunol 186:7255–7263
  CAS PubMed Central PubMed Google Scholar
• Connor HE (1998) Clinical evaluation of a novel, potent, CNS penetrating NK-1 receptor antagonist in the acute treatment of migraine. Cephalalgia 18:392
  Google Scholar
• Cuello AC, Kanazawa I (1978) The distribution of substance P immunoreactive fibres in the rat central nervous system. J Comp Neurol 178:129–156
  CAS PubMed Google Scholar
• de Lanerolle NC, Brines M, Williamson A, Kim JH, Spencer DD (1992) Neurotransmitters and their receptors in human temporal lobe epilepsy. Epilepsy Res 7:235–250
  Google Scholar
• Diener HC (2003) RPR100893 Study Group. RPR100893, a substance-P antagonist, is not effective in the treatment of migraine attacks. Cephalalgia 23:183–185
  PubMed Google Scholar
• Dionne RA, Max MB, Gordon SM, Parada S, Sang C, Gracely RH, Sethna NF, MacLean DB (1998) The substance P receptor antagonist CP-99,994 reduces acute postoperative pain. Clin Pharmacol Ther 64:562–568
  CAS PubMed Google Scholar
• Dunzendorfer S, Meierhofer C, Wiedermann CJ (1998) Signaling in neuropeptide-induced migration of human eosinophils. J Leukocyte Biol 64:828–834
  CAS PubMed Google Scholar
• Ebner K, Singewald N (2006) The role of substance P in stress and anxiety responses. Amino Acids 31:251–272
  CAS PubMed Google Scholar
• Ebner K, Rupniak NM, Saria A, Singewald N (2004) Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats. Proc Natl Acad Sci USA 101:4280–4285
  CAS PubMed Central PubMed Google Scholar
• Ebner K, Sartori SB, Singewald N (2009) Tachykinin receptors as therapeutic targets in stress-related disorders. Curr Pharm Des 15:1647–1674
  CAS PubMed Google Scholar
• Esteban F, González-Moles MA, Castro D, Martín-Jaén MM, Redondo M, Ruiz-Avila I, Rosso M, Muñoz M (2009) Expression of substance P and neurokinin-1-receptor in laryngeal cancer: linking chronic inflammation to cancer promotion and progression. Histopathology 54:258–260
  PubMed Google Scholar
• Fackler OT, Grosse R (2008) Cell motility through plasma membrane blebbing. J Cell Biol 181:879–884
  CAS PubMed Central PubMed Google Scholar
• Feistritzer C, Clausen J, Sturn DH, Djanani A, Gunsilius E, Wiedermann CJ, Kahler CM (2003) Natural killer cell functions mediated by the neuropeptide substance P. Regul Pept 116:119–126
  CAS PubMed Google Scholar
• Fong TM, Yu H, Strader CD (1992) Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP-67,580. J Biol Chem 267:25668–25671
  Google Scholar
• Friess H, Zhu Z, Liard V, Shi X, Shrikhande SV, Wang L, Lieb K, Korc M, Palma C, Zimmermann A, Reubi JC, Buchler MW (2003) Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer. Lab Invest 83:731–742
  CAS PubMed Google Scholar
• Furmark T, Appel L, Michelgard A, Wahlstedt K, Ahs F, Zancan S, Jacobsson E, Flyckt K, Grohp M, Bergström M, Pich EM, Nilsson LG, Bani M, Långström B, Fredrikson M (2005) Cerebral blood flow changes after treatment of social phobia with the eurokinin-1 antagonist GR-205,171, citalopram, or placebo. Biol Psychiatry 58:132–142
  CAS PubMed Google Scholar
• Fusayasu E, Kowa H, Takeshima T, Nakaso K, Nakashima K (2007) Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods. Pain 128:209–214
  CAS PubMed Google Scholar
• Gallai V, Sarchielli P, Flofidi A, Francceschini M, Codini M, Trequattrini A, Palumbo R (1995) Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally. Cephalalgia 15:384–390
  CAS PubMed Google Scholar
• Garant DS, Iadarola MJ, Gale K (1986) Substance P antagonists in substantia nigra are anticonvulsant. Brain Res 382:372–378
  CAS PubMed Google Scholar
• George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt JE, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M (2008) Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science 319:1536–1539
  CAS PubMed Google Scholar
• Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of human during migraine headache. Ann Neurol 28:183–187
  CAS PubMed Google Scholar
• Goldstein DJ, Wang O, Saper JR, Stoltz R, Silberstein SD, Mathew NT (1997) Ineffectiveness of neurokinin-1 antagonist in acute migraine: a crossover study. Cephalalgia 17:785–790
  CAS PubMed Google Scholar
• Goldstein DJ, Wang O, Gitter BD, Iyengar S (2001) Dose-response study of the analgesic effect of lanepitant in patients with painful diabetic neuropathy. Clin Neuropharmacol 24:16–22
  CAS PubMed Google Scholar
• González-Moles MA, Mosqueda-Taylor A, Esteban F, Gil-Montoya JA, Díaz-Franco MA, Delgado M, Muñoz M (2008) Cell proliferation associated with actions of the substance P/NK-1 receptor complex in keratocystic odontogenic tumours. Oral Oncol 44:1127–1133
  PubMed Google Scholar
• Graham GJ, Stevens JM, Page NM, Grant AD, Brain SD, Lowry PJ, Gibbins JM (2004) Tachykinins regulate the function of platelets. Blood 104:1058–1065
  CAS PubMed Google Scholar
• Green SA, Alon A, Ianus J, McNaughton KS, Tozzi CA, Reiss TF (2006) Efficacy and safety of a neurokinin-1 receptor antagonist in postmenopausal women with overactive bladder with urge urinary incontinence. J Urol 176:2535–2540
  CAS PubMed Google Scholar
• Guha S, Eibl G, Kisfalvi K, Fan RS, Burdick M, Reber H, Hines OJ, Strieter R, Rozengurt E (2005) Broad-spectrum G protein–coupled receptor antagonist, [D-Arg1, DTrp5,7,9, Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res 65:2738–2745
  CAS PubMed Google Scholar
• Harrison S, Geppetti P (2001) Substance P. Int J Biochem Cell Biol 33:555–576
  CAS PubMed Google Scholar
• Harrowe G, Mitsuhashi M, Payan DG (1990) Measles virus-substance P receptor interactions. Possible novel mechanism of viral fusion. J Clin Invest 85:1324–1327
  CAS PubMed Central PubMed Google Scholar
• Hegde A, Zhang H, Moochhala SM, Bhatia M (2007) Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. J Leukoc Biol 82:678–685
  CAS PubMed Google Scholar
• Hegde A, Tamizhselvi R, Manikandan J, Melendez AJ, Moochhala SM, Bhatia M (2010a) Substance P in polymicrobial sepsis: molecular fingerprint of lung injury in preprotachykinin-A −/− mice. Mol Med 16:188–198
  CAS PubMed Central PubMed Google Scholar
• Hegde A, Koh YH, Moochhala SM, Bhatia M (2010b) Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: molecular insights. Int J Inflam 2010:601098
  PubMed Central PubMed Google Scholar
• Herrstedt J, Apornwirat W, Shaharyar A, Aziz Z, Roila F, Van Belle S, Russo MW, Levin J, Ranganathan S, Guckert M, Gunberg SM (2009) Phase III trial of casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of nausea and vomiting in patients receiving moderately emetogenic chemotherapy. J Clin Oncol 27:5363–5369
  CAS PubMed Google Scholar
• Hesketh PJ, Gralla RJ, Webb RT, Ueno W, DelPrete S, Bachinsky ME, Dirlam NL, Stack CB, Silberman SL (1999) Randomized Phase II study of the neurokinin 1 receptor antagonist CJ-11,974 in the control of cisplatin-induced emesis. J Clin Oncol 17:338–343
  CAS PubMed Google Scholar
• Hill R (2000) NK1 (substance P) receptor antagonists: why are they not analgesic in humans? Trends Pharmacol Sci 21:244–246
  CAS PubMed Google Scholar
• Ho WZ, Cnaan A, Li YH, Zhao H, Lee HR, Song L, Douglas SD (1996) Substance P modulates human immunodeficiency virus replication in human peripheral blood monocyte-derived macrophages. AIDS Res Hum Retroviruses 12:195–198
  CAS PubMed Google Scholar
• Hökfelt T, Pernow B, Nilsson G, Wetterberg L, Goldstein M, Jeffcoate SL (1978) Dense plexus of substance P-immunoreactive nerve terminals in eminentia medialis of the primate hypothalamus. Proc Natl Acad Sci USA 74:1013–1015
  Google Scholar
• Hökfelt T, Broberger C, David Xu Z-Q, Sergeyev V, Ubink R, Diez M (2000) Neuropeptides: an overview. Neuropharmacology 39:1337–1356
  PubMed Google Scholar
• Hökfelt T, Pernow B, Wahren J (2001) Substance P: a pioneer amongst neuropeptides. J Intern Med 249:27–40
  PubMed Google Scholar
• Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24:739–768
  CAS PubMed Google Scholar
• Janelsins BM, Mathers AR, Tkacheva OA, Erdos G, Shufesky WJ, Morelli AE, Larregina AT (2009) Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood 113:3017–3026
  CAS PubMed Central PubMed Google Scholar
• Jang JH, Nam TS, Paik KS, Leem JW (2004) Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat. Neurosci Lett 360:129–132
  CAS PubMed Google Scholar
• Kalinichev M, Bradford A, Bison S, Lucas A, Sartori I, Garbati N, Andreetta F, Bate S, Austin NE, Jones DN, Read KD, Alvaro G, Large CH (2010) Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat. Epilepsia 51:1543–1551
  CAS PubMed Google Scholar
• Keller M, Montgomery S, Ball W, Morrison M, Snavely D, Liu G, Hargreaves R, Hietala J, Lines C, Beebe K, Reines S (2006) Lack of efficacy of the substance P (neurokinin-1 receptor) antagonist aprepitant in the treatment of major depressive disorder. Biol Psychiatry 59:216–223
  CAS PubMed Google Scholar
• King KA, Hu C, Rodriguez MM, Romaguera R, Jiang X, Piedimonte G (2001) Exaggerated neurogenic inflammation and substance P receptor upregulation in RSV-infected weanling rats. Am J Respir Cell Mol Biol 24:101–107
  CAS PubMed Google Scholar
• Ko FJ, Chiang CH, Liu WJ, Chiang W (1991) Somatostatin, substance P, prolactin and vasoactive intestinal peptide levels in serum and cerebrospinal fluid of children with seizure disorders. Gaoxiong Yi Xue Ke Xue Za Zhi 7:391–397
  CAS PubMed Google Scholar
• Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Halle JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlsson EJ, Hargreaves RJ, Rupniak NM (1998) Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281:1640–1645
  CAS PubMed Google Scholar
• Kramer MS, Winokur A, Kelsey J, Preskorn SH, Rothschild AJ, Snavely D, Ghosh K, Ball WA, Reines SA, Munjack D, Apter JT, Cunningham L, Kling M, Bari M, Getson A, Lee Y (2004) Demonstration of the efficacy and safety of a novel substance P (NK-1) receptor antagonist in major depression. Neuropsychopharmacology 29:385–392
  CAS PubMed Google Scholar
• Lai JP, Douglas SD, Rappaport E, Wu JM, Ho WZ (1998) Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes. J Neuroimmunol 91:121–128
  CAS PubMed Google Scholar
• Lambrecht BN, Germonpre PR, Everaert EG, Carro-Muino I, De Veerman M, de Felipe C, Hunt SP, Thielemans K, Joos GF, Pauwels RA (1999) Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation. Eur J Immunol 29:3815–3825
  CAS PubMed Google Scholar
• Lang K, Drell TL, Lindecke A, Niggemann B, Kaltschmidt C, Zaenker KS, Entschladen F (2004) Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 112:231–238
  CAS PubMed Google Scholar
• Lembeck F, Donnerer J, Tsuchiya M, Nagahisa A (1992) The non-peptide tachykinin antagonist, CP-96.345, is a potent inhibitor of neurogenic inflammation. Br J Pharmacol 105:527–530
  CAS PubMed Central PubMed Google Scholar
• Lieb K, Fiebich BL, Berger M, Bauer J, Schulze-Osthoff K (1997) The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J Immunol 159:4952–4958
  CAS PubMed Google Scholar
• Lieb KL, Treffurth Y, Hamke M, Akundi RS, von Kleinsorgen M, Fiebich BL (2003) Valproic acid inhibits substance P-induced activation of protein kinase C epsilon and expression of the substance P receptor. J Neurochem 86:69–76
  CAS PubMed Google Scholar
• Liu H, Cao Y, Basbaum AI, Mazarati AM, Sankar R, Wasterlain CG (1999) Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Proc Natl Acad Sci USA 96:12096–12101
  CAS PubMed Central PubMed Google Scholar
• Lotz M, Vaughan JH, Carson DA (1988) Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 241:1218–1221
  CAS PubMed Google Scholar
• Maeno H, Kiyama H, Tohyama M (1993) Distribution of the substance P (NK1) receptor in the central nervous system. Mol Brain Res 18:43–58
  CAS PubMed Google Scholar
• Mai JK, Stephens PH, Hopf A, Cuello AC (1986) Substance P in the human brain. Neuroscience 17:709–739
  CAS PubMed Google Scholar
• Makhortova NR, Askovich P, Patterson CE, Gechman LA, Gerard NP, Rall GF (2007) Neurokinin-1 enables measles virus trans-synaptic spread in neurons. Virology 362:235–244
  CAS PubMed Central PubMed Google Scholar
• Manak MM, Moshkoff DA, Nguyen LT, Meshki J, Tebas P, Tuluc F, Douglas SD (2010) Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals. AIDS 24:2789–2796
  CAS PubMed Central PubMed Google Scholar
• Marriott I, Mason MJ, Elhofy A, Bost KL (2000) Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells. J Neuroimmunol 102:163–171
  CAS PubMed Google Scholar
• Meshki J, Douglas SD, Lai JP, Schwartz L, Kilpatrick LE, Tuluc F (2009) Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism. J Biol Chem 284:9280–9289
  CAS PubMed Central PubMed Google Scholar
• Muñoz M, Coveñas R (2010) A new frontier in the treatment of cancer: NK-1 receptor antagonists. Curr Med Chem 17:504–516
  PubMed Google Scholar
• Muñoz M, Coveñas R (2011) NK-1 receptor antagonists: a new paradigm in pharmacological therapy. Curr Med Chem 18:1820–1831
  PubMed Google Scholar
• Muñoz M, Coveñas R (2013a) Involvement of substance P and the NK-1 receptor in cancer. Peptides 48:1–9
  PubMed Google Scholar
• Muñoz M, Coveñas R (2013b) Safety of neurokinin-1 receptor antagonists. Expert Opin Drug Saf 12:673–685
  PubMed Google Scholar
• Muñoz M, Rosso M, Coveñas R, Montero I, González-Moles MA, Robles MJ (2007) Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonist, L-732,138. Invest Ophthalmol Vis Sci 48:2775–2781
  PubMed Google Scholar
• Muñoz M, Rosso M, Robles-Frías MJ, Salinas-Martín MV, Coveñas R (2010) The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines. Lab Invest 90:1259–1269
  PubMed Google Scholar
• Muñoz M, González-Ortega A, Rosso M, Robles-Frías MJ, Carranza A, Salinas-Martín MV, Coveñas R (2012) The substance P/Neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists. Peptides 38:318–325
  PubMed Google Scholar
• Muñoz M, Berger M, Rosso M, González-Ortega A, Carranza A, Coveñas R (2014) Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts. Int J Oncol 44:137–146
  PubMed Google Scholar
• Murtra P, Sheasby AM, Hunt SP, de Felipe C (2000) Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature 405:180–183
  CAS PubMed Google Scholar
• Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N (1994) Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol 347:249–274
  CAS PubMed Google Scholar
• Nikolaus S, Huston JP, Hasenohrl RU (1999a) The neurokinin-1 receptor antagonist WIN51,708 attenuates the anxiolytic-like effects of ventralpallidal substance P injection. NeuroReport 10:2293–2296
  CAS PubMed Google Scholar
• Nikolaus S, Huston JP, Hasenohrl RU (1999b) Reinforcing effects of neurokinin substance P in the ventral pallidum: mediation by the tachykinin NK1 receptor. Eur J Pharmacol 370:93–99
  CAS PubMed Google Scholar
• Nikolaus S, Huston JP, Hasenohrl RU (2000) Anxiolytic-like effects in rats produced by ventral pallidal injection of both N- and C-terminal fragments of substance P. Neurosci Lett 283:37–40
  CAS PubMed Google Scholar
• Nio DA, Moylan RN, Roche JK (1993) Modulation of T lymphocyte function by neuropeptides. Evidence for their role as local immunoregulatory elements. J Immunol 150:5281–5288
  CAS PubMed Google Scholar
• Norman B (1998) A placebo-controlled, in-clinic study to explore the preliminary safety and efficacy of intravenous L-758,298 (a prodrug of the NK-1 receptor antagonist L-754,030) in the acute treatment of migraine. Cephalalgia 18:407
  Google Scholar
• O’Connor TM, O’Connell J, O’Brien DI, Goode T, Bredin CP, Shanahan F (2004) The role of substance P in inflammatory disease. J Cell Physiol 201:167–180
  PubMed Google Scholar
• Olver IN, Grimison P, Chatfield M, Stockler MR, Toner GC, Gebski V, Harrup R, Underhill C, Kichenadasse G, Singhal N, Davis ID, Boland A, McDonald A, Thomson D, Australian and New Zealand Urogenital and Prostate Cancer Trials Group (2013) Results of a 7-day aprepitant schedule for the prevention of nausea and vomiting in 5-day cisplatin-based germ cell tumor chemotherapy. Suport Care Cancer 21:1561–1568
  CAS Google Scholar
• Pascual DW, Bost KL (1990) Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide. Immunology 71:52–56
  CAS PubMed Central PubMed Google Scholar
• Pfister HW, Kümpfel T, Koedel U (1995) Involvement of substance P in pial arteriolar vasodilatation during pneumococcal meningitis in the rat. NeuroReport 6:1301–1305
  CAS PubMed Google Scholar
• Piedimonte G, Rodriguez MM, King KA, McLean S, Jiang X (1999) Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Am J Physiol 277:L831–L840
  CAS PubMed Google Scholar
• Puneet P, Hegde A, Ng SW, Lau HY, Lu J, Moochhala SM, Bhatia M (2006) Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis. J Immunol 176:3813–3820
  CAS PubMed Google Scholar
• Quartara L, Maggi CA (1998) The tachykinin NK1 receptor part II: distribution and pathophysiological roles. Neuropeptides 32:1–49
  CAS PubMed Google Scholar
• Ramalho R, Almeida J, Beltrão M, Pirraco A, Costa R, Sokhatska O, Guardão L, Palmares C, Guimarães JT, Delgado L, Moreira A, Soares R (2013) Substance P antagonist improves both obesity and asthma in a mouse model. Allergy 68:48–54
  CAS PubMed Google Scholar
• Reid MS, Herrera-Marschitz M, Hökfelt T, Ohlin M, Valentino KL, Ungerstedt U (1990a) Effects of intranigral substance P and neurokinin A on striatal dopamine release-I. Interactions with substance P antagonists. Neuroscience 36:643–658
  CAS PubMed Google Scholar
• Reid MS, Herrera-Marschitz M, Kehr J, Ungerstedt U (1990b) Striatal dopamine and glutamate release: effects of intranigral injections of substance P. Acta Physiol Scand 140:527–537
  CAS PubMed Google Scholar
• Reinhardt R (1998) Comparison of neurokinin-1 antagonist, L-745,030, to placebo, acetaminophen and ibuprofen in the dental pain model. Clin Pharmacol Ther 63:168
  Google Scholar
• Ripley TL, Gadd CA, De Felipe C, Hunt SP, Stephens DN (2002) Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptors. Neuropharmacology 43:1258–1268
  CAS PubMed Google Scholar
• Rittner HL, Lux C, Labuz D, Mousa SA, Achäfer M, Stein C, Brack A (2007) Neurokinin-1 receptor antagonists inhibit the recruitment of opioid-containing leukocytes and impair peripheral antinociception. Anesthesiology 107:1009–1017
  CAS PubMed Google Scholar
• Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ (2009) Substance P is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med 2:76–86
  CAS PubMed Central PubMed Google Scholar
• Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B, Tweardy DJ (2012) Substance P causes seizures in neurocysticercosis. PLoS Pathog 8:e1002489
  CAS PubMed Central PubMed Google Scholar
• Rodríguez FD, Coveñas R (2011) Targeting opioid and neurokinin-1 receptors to treat alcoholism. Curr Med Chem 18:4321–4334
  PubMed Google Scholar
• Rosenberg ZF, Fauci AS (1990) Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression. Immunol Today 11:176–180
  CAS PubMed Google Scholar
• Rosenberg ZF, Fauci AS (1991) Immunopathogenesis of HIV infection. FASEB J 5:2382–2390
  CAS PubMed Google Scholar
• Ruff MR, Wahl SM, Pert CB (1985) Substance P receptor-mediated chemotaxis of human monocytes. Peptides 6:107–111
  CAS PubMed Google Scholar
• Rupniak NM, Carlson EC, Boyce S, Webb JK, Hill RG (1996) Enantioselective inhibition of the formalin paw late phase by the NK-1 receptor antagonist L-733,060 in gerbils. Pain 67:189–195
  CAS PubMed Google Scholar
• Rupniak NM, Carlson EC, Harrison T, Oates B, Seward E, Owen S, de Felipe C, Hunt S, Wheeldon A (2000) Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice. Neuropharmacology 39:1413–1421
  CAS PubMed Google Scholar
• Rupniak NM, Calrson EJ, Webb JK, Harrison T, Porsolt RD, Roux S, de Felipe C, Hunt SP, Oates B, Wheeldon A (2001) Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1) receptor in assays for antidepressant and anxiolytic drugs. Behav Pharmacol 12:497–508
  CAS PubMed Google Scholar
• Sachais BS, Snider RM, Lowe JA 3rd, Krause JE (1993) Molecular basis for the species selectivity of the substance P antagonist CP-96,345. J Biol Chem 268:2319–2323
  Google Scholar
• Saffroy M, Beaujouan JC, Torrens Y, Besseyre J, Bergstrom L, Glowinski J (1988) Localization of tachykinin binding sites (NK1, NK2, NK3 ligands) in the rat brain. Peptides 9:227–241
  CAS PubMed Google Scholar
• Saito H, Yoshizawa H, Yoshimori K, Katakami N, Katsumata N, Kawahara M, Eguchi K (2013) Efficacy and safety of single-dose fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving high-dose cisplatin: a multicentre, randomised, double-bind, placebo-controlled phase 3 trial. Ann Oncol 24:1067–1073
  CAS PubMed Central PubMed Google Scholar
• Samsam M, Coveñas R, Ahangari R, Yajeya J, Narváez JA, Tramu G (2000) Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. Pain 84:389–395
  CAS PubMed Google Scholar
• Samsam M, Coveñas R, Csillik B, Ahangari R, Yajeya J, Riquelme R, Narváez JA, Tramu G (2001) Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; A possible neurophysiological and neuroanatomical link to generalized head pain. J Chem Neuroanat 21:161–169
  CAS PubMed Google Scholar
• Santini D, Vincenzi B, Guida FM, Imperatori M, Schiavon G, Venditti O, Frezza AM, Berti P, Tonini G (2012) Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study. Lancet Oncol 13:1020–1024
  CAS PubMed Google Scholar
• Sartori SB, Burnet PWJ, Sharp T, Singewald N (2004) Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain. Neuropharmacology 46:1177–1183
  CAS PubMed Google Scholar
• Schratzberger P, Reinisch N, Prodinger WM, Kahler CM, Sitte BA, Bellmann R, Fischer-Colbrie R, Winkler H, Wiedermann CJ (1997) Differential chemotactic activities of sensory neuropeptides for human peripheral blood mononuclear cells. J Immunol 158:3895–3901
  CAS PubMed Google Scholar
• Scicchinato R, Biennenstock J, Stanisz AM (1988) In vivo immunomodulation by the neuropeptide substance P. Immunology 63:733–735
  Google Scholar
• Shibata H, Mio M, Tasaka K (1985) Analysis of the mechanism of histamine release induced by substance P. Biochem Biophys Acta 846:1–7
  CAS PubMed Google Scholar
• Shirayama Y, Mitsushio H, Takashima M, Ichinawa H, Takahashi K (1996) Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat. Brain Res 739:70–78
  PubMed Google Scholar
• Singh D, Joshi DD, Hameed M, Qian J, Gascón P, Maloof PB, Mosenthal A, Rameshwar P (2000) Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis. Proc Natl Acad Sci USA 97:388–393
  CAS PubMed Central PubMed Google Scholar
• Sperk G, Wieser R, Widmann R, Singer EA (1986) Kainic acid induced seizures: changes in somatostatin, substance P and neurotensin. Neuroscience 17:1117–1126
  CAS PubMed Google Scholar
• Sporn MB (1996) The war on cancer. Lancet 347:1377–1381
  CAS PubMed Google Scholar
• Ständer S, Siepmann D, Herrgott I, Sunderkötter C, Luger TA (2010) Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy. PLoS One 5:e10968
  PubMed Central PubMed Google Scholar
• Tebas P, Tuluc F, Barret JS, Wagner W, Kim D, Zhao H, Gonin R, Korelitz J, Douglas SD (2011) A randomized, placebo controlled, double masked phase Ib study evaluating the safety and antiviral activity of aprepitant, a neurokinin-1 receptor antagonist in HIV-1 infected adults. PLoS One 6:e24180
  CAS PubMed Central PubMed Google Scholar
• Teodoro FC, Tronco Júnior MF, Zampronio AR, Martini AC, Rae GA, Chichorro JG (2013) Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models. Neuropeptides 47:199–206
  CAS PubMed Google Scholar
• Thornton E, Vink R (2012) Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson’s disease. PLoS One 7:e34138
  CAS PubMed Central PubMed Google Scholar
• Thorsell A, Schank JR, Singley E, Hunt SP, Heilig M (2010) Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice. Psychopharmacology 209:103–111
  CAS PubMed Google Scholar
• Trivedi M, Bergasa NV (2010) Serum concentrations of substance P in cholestasis. Ann Hepatol 9:177–180
  CAS PubMed Google Scholar
• Twardy BS, Channappanavar R, Suvas S (2011) Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions. Invest Ophthalmol Vis Sci 52:8604–8613
  CAS PubMed Central PubMed Google Scholar
• Unger T, Rascher W, Schuster C, Pavlovitch R, Schömig A, Dietz R, Ganten D (1981) Central blood pressure effects of substance P and angiotensin II: role of the sympathetic nervous system and vasopressin. Eur J Pharmacol 71:33–42
  CAS PubMed Google Scholar
• Wallace-Boone TL, Newton AE, Wright RN, Lodge NJ, McElroy JF (2008) Behavioral and pharmacological validation of the gerbil forced-swim test: effects of neurokinin-1 receptor antagonists. Neuropsychopharmacology 33:1919–1928
  CAS PubMed Google Scholar
• Wolf SS, Moody TW, Quirion R, O’Donohue TL (1985) Biochemical characterization and autoradiographic localization of central SP receptor using [125I] physalaemin. Brain Res 332:299–307
  CAS PubMed Google Scholar
• Yu J, Cadet JL, Angulo JA (2002) Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. J Neurochem 83:613–622
  CAS PubMed Google Scholar
• Zachrisson O, Lindefors N, Brené S (1998) A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity. Brain Res Mol Brain Res 60:291–295
  CAS PubMed Google Scholar
• Ziche M, Morbidelli L, Pacini M, Gepetti P, Alessandri G, Maggi CA (1990) Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc Res 40:264–278
  CAS PubMed Google Scholar

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