Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5′-flanking region (−5229G/A) with bone mineral density (original) (raw)

Abstract

The 12/15-lipoxygenase gene Alox15 has been identified as a susceptibility gene for bone mineral density (BMD) in mice through combined genetic and genomic analyses. Here we studied the association between bone mineral density and an ALOX15 gene single nucleotide polymorphism to assess the potential involvement of the human ALOX15 gene in postmenopausal osteoporosis. Specifically, we examined the association between a single nucleotide polymorphism at −5299G/A in the ALOX15 5′-flanking region with BMD in 319 postmenopausal Japanese women (66.7 ± 8.9 years, mean ± SD). We found that subjects bearing at least one variant A allele (GA + AA; n = 273) had significantly lower Z scores for lumbar spine and total body bone mineral density than did subjects with no A allele (GG; n = 46) (lumbar spine, −0.25 ± 1.34 versus 0.48 ± 1.70; P = 0.0014; total body, 0.25 ± 1.01 vs 0.62 ± 1.11; P = 0.048). These findings suggest that the ALOX15 gene is one of the genetic determinants of BMD in postmenopausal women. Accordingly, this polymorphism could be useful as a genetic marker for predicting the risk of osteoporosis.

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Authors and Affiliations

1. Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
   Tomohiko Urano, Masayo Fujita, Yasuyoshi Ouchi & Satoshi Inoue
2. Research Institute and Practice for Involutional Diseases, Nagano, Japan
   Masataka Shiraki
3. Research Center for Genomic Medicine, Saitama Medical School, Saitama, Japan
   Masayo Fujita & Satoshi Inoue
4. Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
   Takayuki Hosoi
5. Health Science University, Yamanashi, Japan
   Hajime Orimo

Authors

1. Tomohiko Urano
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2. Masataka Shiraki
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3. Masayo Fujita
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4. Takayuki Hosoi
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5. Hajime Orimo
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6. Yasuyoshi Ouchi
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7. Satoshi Inoue
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Correspondence toSatoshi Inoue.

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Urano, T., Shiraki, M., Fujita, M. et al. Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5′-flanking region (−5229G/A) with bone mineral density.J Bone Miner Metab 23, 226–230 (2005). https://doi.org/10.1007/s00774-004-0588-x

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• Received: 22 October 2004
• Accepted: 16 November 2004
• Issue Date: May 2005
• DOI: https://doi.org/10.1007/s00774-004-0588-x

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