Infrequent genetic alterations of the PTEN gene in Japanese patients with sporadic prostate cancer (original) (raw)

Journal of Human Genetics volume 43, pages 228–230 (1998)Cite this article

Abstract

Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers. These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.

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Authors and Affiliations

  1. Department of Molecular Pathology Tohoku University School of Medicine Sendai 980-8575, Japan Tel. +81-22-717-8042; Fax +81-22-717-8047 e-mail: horii@mail.cc.tohoku.ac.jp, Japan
    Kazuhiko Orikasa, Shin-ichi Fukushige & A. Horii
  2. Department of Urology Tohoku University School of Medicine Sendai, Japan, Japan
    Senji Hoshi & Seiichi Orikasa
  3. Department of Urology Yokohama City University School of Medicine Yokohama, Japan, Japan
    Keiichi Kondo, Yasuhide Miyoshi & Yoshinobu Kubota

Authors

  1. Kazuhiko Orikasa
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  2. Shin-ichi Fukushige
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  3. Senji Hoshi
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  4. Seiichi Orikasa
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  5. Keiichi Kondo
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  6. Yasuhide Miyoshi
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  7. Yoshinobu Kubota
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  8. A. Horii
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Received: February 6, 1998 / Accepted: July, 3, 1998

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Orikasa, K., Fukushige, Si., Hoshi, S. et al. Infrequent genetic alterations of the PTEN gene in Japanese patients with sporadic prostate cancer.J Hum Genet 43, 228–230 (1998). https://doi.org/10.1007/s100380050078

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