Association of CTLA4 gene A-G polymorphism with rheumatoid arthritis in Chinese (original) (raw)

Abstract

The aim of this study was to investigate the allelic association of a single nucleotide polymorphism in exon 1 of the cytotoxic T-lymphocyte antigen-4 (CTLA4) gene with rheumatoid arthritis (RA) in Chinese people. One hundred and eighty-six unrelated adults with RA and 203 randomly selected normal adults were studied. All were ethnic Chinese living in Taiwan. The CTLA4 A-G polymorphism was genotyped with a polymerase chain reaction (PCR) and digestion with the restriction enzyme _BstE_II. The genotype and allele frequencies of CTLA4 in patients with rheumatoid arthritis differed significantly from those of adult controls (#E5/E5#=0.022 and #E5/E5#=0.037, respectively). Genotype CTLA4 49 G/G and allele G were associated with an increased risk of RA (RR=1.72, 95% CI=1.15–2.57, #E5/E5#=0.008; RR=1.39, 95% CI=1.02–1.89, #E5/E5#=0.037, respectively), whereas genotype A/G and allele A were associated with protection against RA (RR=0.58, 95% CI=0.39–0.87, #E5/E5#=0.008 and RR=0.72, 95% CI=0.53–0.98, #E5/E5#=0.037, respectively). We concluded that, the CTLA4 49 A-G polymorphism is associated with RA in Chinese patients from Taiwan.

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Acknowledgments.

This research was supported by grants NSC-88-2314-B-195-012 from the National Science Council, Executive Yuan and MMH-8952 from Mackay Memorial Hospital, Taiwan.

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Authors and Affiliations

  1. Departments of Rheumatology, Pediatrics and Medical Research, Mackay Memorial Hospital, Taipei, 10449, Taiwan
    C.-S. Lee, Y.-J. Lee, H.-F. Liu, C.-H. Su, S.-C. Chang, B.-R. Wang, T.-L. Chen & T.-L. Liu
  2. Head, Division of Pediatric Endocrinology, Departments of Pediatrics and Medical Research, Mackay Memorial Hospital 92 Section 2, Chung-San N Rd, Taipei, 10049, Taiwan
    Y.-J. Lee

Authors

  1. C.-S. Lee
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  2. Y.-J. Lee
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  3. H.-F. Liu
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  4. C.-H. Su
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  5. S.-C. Chang
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  6. B.-R. Wang
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  7. T.-L. Chen
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  8. T.-L. Liu
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Corresponding author

Correspondence toY.-J. Lee.

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Lee, CS., Lee, YJ., Liu, HF. et al. Association of CTLA4 gene A-G polymorphism with rheumatoid arthritis in Chinese.Clin Rheumatol 22, 221–224 (2003). https://doi.org/10.1007/s10067-003-0720-7

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