Low level of circulating basophil counts in biopsy-proven active lupus nephritis (original) (raw)

Abstract

Basophils have been shown to be important players in promoting lupus nephritis (LN). However, the relationship between circulating basophil counts and renal pathology activity of LN remains unclear. In this retrospective study, 159 clinical and pathology samples from patients with biopsy-proven LN were analyzed. The renal activity and classification were evaluated according to renal pathology. The correlations between circulating basophil counts and renal pathology activity index were assessed. Overall, circulating basophil counts correlated with total systemic lupus erythematosus disease activity index (SLEDAI) score (r = − 0.31), renal SLEDAI score (r = − 0.35), activity index (AI) score(r = − 0.40), and renal histologic activity parameters (p < 0.05, respectively). Compared with systemic lupus erythematosus (SLE) non-LN patients, the LN group had lower basophil counts (0.007 ± 0.007 vs. 0.011 ± 0.010 × 109/L, _p_ = 0.04). Subgroup analyses revealed that the circulating basophil counts in group B (AI > 8) were significantly lower than that in group A (AI ≤ 8) (0.004 ± 0.006 vs. 0.009 ± 0.009 × 109/L, p < 0.001). The difference was still significant when eliminating the influence of SLEDAI. Significant differences were found in circulating basophil counts among LN pathology classification groups (p < 0.01). Groups of classes III, IV, and V were more likely to have lower circulating basophil counts when compared with group of class I/II (p < 0.05). These findings suggest a potential role of circulating basophil counts as a convenient and helpful marker for renal activity of LN.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Fiehn C (2006) Early diagnosis and treatment in lupus nephritis: how we can influence the risk for terminal renal failure. J Rheumatol 33:1464–1466
    PubMed Google Scholar
  2. Illei GG, Tackey E, Lapteva L, Lipsky PE (2004) Biomarkers in systemic lupus erythematosus: II. Markers of disease activity. Arthritis Rheum 50:2048–2065
    Article CAS PubMed Google Scholar
  3. Madureira Silva MV, Moscoso-Solorzano GT, Nishida SK, Mastroianni-Kirsztajn G (2012) Serum beta 2-microglobulin/cystatin C index: a useful biomarker in lupus nephritis? Nephron Extra 2:169–176
    Article PubMed PubMed Central Google Scholar
  4. Tan Y, Song D, Wu LH, Yu F, Zhao MH (2013) Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis. BMC Nephrol 14:63
    Article CAS PubMed PubMed Central Google Scholar
  5. Marks SD, Shah V, Pilkington C, Tullus K (2010) Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis. Pediatr Nephrol 25:2283–2288
    Article PubMed Google Scholar
  6. Abd-Elkareem MI, Al Tamimy HM, Khamis OA, Abdellatif SS, Hussein MR (2010) Increased urinary levels of the leukocyte adhesion molecules ICAM-1 and VCAM-1 in human lupus nephritis with advanced renal histological changes: preliminary findings. Clin Exp Nephrol 14:548–557
    Article CAS PubMed Google Scholar
  7. Rubinstein T, Pitashny M, Levine B et al (2010) Urinaryneutrophil gelatinase-associated lipocalin as a novel biomarker for disease activity in lupus nephritis. Rheumatology (Oxford) 49:960–971
    Article CAS Google Scholar
  8. Karasuyama H, Mukai K, Obata K, Tsujimura Y, Wada T (2011) Nonredundant roles of basophils in immunity. Annu Rev Immunol 29:45–69
    Article CAS PubMed Google Scholar
  9. Charles N, Hardwick D, Daugas E, Illei GG, Rivera J (2010) Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 16:701–707
    Article CAS PubMed PubMed Central Google Scholar
  10. Liang P, Tang Y, Fu S et al (2015) Basophil count, a marker for disease activity in systemic lupus erythematosus. Clin Rheumatol 34:891–896
    Article PubMed Google Scholar
  11. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725–1732
    Article CAS PubMed Google Scholar
  12. Gladman DD, Ibanez D, Urowitz MB (2002) Systemic lupus erythematosus disease activity index 2000. J Rheumatol 29:288–291
    PubMed Google Scholar
  13. Pitashny M, Schwartz N, Qing X et al (2007) Urinary lipocalin-2 isassociated with renal disease activity in human lupus nephritis. Arthritis Rheum 56:1894–18903
    Article CAS PubMed Google Scholar
  14. Weening JJ, D’ Agati VD, Schwartz MM (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 65:521–530
    Article PubMed Google Scholar
  15. Austin HA 3rd, Muenz LR, Joyce KM, Antonovych TT, Balow JE (1984) Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney Int 25:689–695
    Article PubMed Google Scholar
  16. Egido J, Sánchez Crespo M, Lahoz C, García R, López-Trascasa M, Hernando L (1980) Evidence of an immediate hypersensitivity mechanism in systemic lupus erythematosus. Ann Rheum Dis 39:312–317
    Article CAS PubMed PubMed Central Google Scholar
  17. Yoshimura C, Miyamasu M, Nagase H et al (2001) Glucocorticoids induce basophil apoptosis. J Allergy Clin Immunol 108:215–220
    Article CAS PubMed Google Scholar
  18. Saavedra-Delgado AM, Mathews KP, Pan PM, Kay DR, Muilenberg ML (1980) Dose-response studies of the suppression of whole blood histamine and basophil counts by prednisone. J Allergy Clin Immunol 66:464–471
    Article CAS PubMed Google Scholar
  19. Kallel-Sellami M, Baili-Klila L, Zerzeri Y et al (2007) Pediatric systemic lupus erythematosus with C1q deficiency. Ann N Y Acad Sci 1108:193–196
    Article CAS PubMed Google Scholar
  20. Charles N, Rivera J (2011) Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus. Curr Allergy Asthma Rep 11:378–387
    Article CAS PubMed PubMed Central Google Scholar
  21. Amundsen EK, Henriksson CE, Holthe MR, Urdal P (2012) Is theblood count sufficiently precise, accurate, and specific?: three automated hematology instruments and flow cytometry compared. Am J Clin Pathol 137:86–92
    Article PubMed Google Scholar

Download references

Acknowledgements

We thank Professor Lie Dai et al. of the Department of Rheumatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, and Professor Lianghong Yin of Jinan University for the help with sample collection.

Funding

This work was supported by grant from public welfare research and capacity building special fund project (social development field) of Guangdong province 2014A020212062 and grant [2013]163 from Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology.

Author information

Author notes

  1. Peifen Liang and Ying Tang contributed equally to this work.

Authors and Affiliations

  1. Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China
    Peifen Liang, Ying Tang, Haowen Zhong, Hui Yang, Yuchun Zeng, Jun Lv, Xiaomei Li, Yanying Lu & Anping Xu
  2. Guangdong Provincial Key Laboratory of Maligant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China
    Peifen Liang, Ying Tang, Haowen Zhong, Hui Yang, Yuchun Zeng, Jun Lv, Xiaomei Li, Yanying Lu & Anping Xu
  3. Department of Internal Medicine, The Eighth People’s Hospital, Guangzhou, 510220, China
    Liu Lin

Authors

  1. Peifen Liang
  2. Ying Tang
  3. Liu Lin
  4. Haowen Zhong
  5. Hui Yang
  6. Yuchun Zeng
  7. Jun Lv
  8. Xiaomei Li
  9. Yanying Lu
  10. Anping Xu

Corresponding author

Correspondence toAnping Xu.

Ethics declarations

This study was approved by the ethics committee of the Sun Yat-sen Memorial Hospital, Sun Yat-sen University (2016-20).

Disclosures

None.

Rights and permissions

About this article

Cite this article

Liang, P., Tang, Y., Lin, L. et al. Low level of circulating basophil counts in biopsy-proven active lupus nephritis.Clin Rheumatol 37, 459–465 (2018). https://doi.org/10.1007/s10067-017-3858-4

Download citation

Keywords