From bench to bedside and back: the SENIEUR Protocol and the efficacy of influenza vaccination in the elderly (original) (raw)
Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Würzner R et al (2005) Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol 79(6):3675–3683. doi:10.1128/JVI.79.6.3675-3683.2005 ArticlePubMedCAS Google Scholar
Appels A, Bär FW, Bär J, Bruggeman C, de Baets M (2000) Inflammation, depressive symptomtology, and coronary artery disease. Psychosom Med 62(5):601–605 PubMedCAS Google Scholar
Boring L, Gosling J, Cleary M, Charo IF (1998) Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394(6696):894–897. doi:10.1038/29788 ArticlePubMedCAS Google Scholar
Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jørgensen T, Pedersen BK (2003) Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol 132(1):24–31. doi:10.1046/j.1365-2249.2003.02137.x ArticlePubMedCAS Google Scholar
Castle SC, Uyemura K, Rafi A, Akande O, Makinodan T (2005) Comorbidity is a better predictor of impaired immunity than chronological age in older adults. J Am Geriatr Soc 53(9):1565–1569. doi:10.1111/j.1532-5415.2005.53512.x ArticlePubMed Google Scholar
Centres for Disease Control and Prevention (2006) Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 55:1–41 Google Scholar
Coory M, Scott I (2007) Analysing low-risk patient populations allows better discrimination between high-performing and low-performing hospitals: a case study using inhospital mortality from acute myocardial infarction. Qual Saf Health Care 16(5):324–328. doi:10.1136/qshc.2006.018457 ArticlePubMed Google Scholar
Deuschle M, Weber B, Colla M, Depner M, Heuser I (1998) Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation study. Stress 2:281–287 ArticlePubMedCAS Google Scholar
Di Iorio A, Ferrucci L, Sparvieri E, Cherubini A, Volpato S, Corsi A et al (2003) Serum IL-1beta levels in health and disease: a population-based study. ‘The InCHIANTI study’. Cytokine 22(6):198–205. doi:10.1016/S1043-4666(03)00152-2 ArticlePubMedCAS Google Scholar
Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B (1995) Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci 50:B378–B382 PubMedCAS Google Scholar
Franceschi C, Bonafe M, Valensin S (2000) Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18(16):1717–1720. doi:10.1016/S0264-410X(99)00513-7 ArticlePubMedCAS Google Scholar
Frasure-Smith N, Lespérance F, Irwin MR, Sauvé C, Lespérance J, Théroux P (2007) Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biol Psychiatry 62(4):302–308. doi:10.1016/j.biopsych.2006.09.029 ArticlePubMedCAS Google Scholar
Gartside SE, Leitch MM, McQuade R, Swarbrick DJ (2003) Flattening the glucocorticoid rhythm causes changes in hippocampal expression of messenger RNAs coding structural and functional proteins: implications for aging and depression. Neuropsychopharmacology 28(5):821–829 PubMedCAS Google Scholar
Gravenstein S, Drinka P, Duthie EH, Miller BA, Brown CS, Hensley M et al (1994) Efficacy of an influenza hemagglutinin-diphtheria toxoid conjugate vaccine in elderly nursing home subjects during an influenza outbreak. J Am Geriatr Soc 42:245–251 PubMedCAS Google Scholar
Gross PA, Weksler ME, Quinnan GV (1987) Immunization of elderly people with two doses of influenza vaccine. J Clin Microbiol 25:1763–1765 PubMedCAS Google Scholar
Hadrup SR, Strindhall J, Kollgaard T, Seremet T, Johansson B, Pawelec G, thor Straten P, Wikby A (2006) Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol 176(4):2645–2653 PubMedCAS Google Scholar
Hak Ł, Myśliwska J, Wieckiewicz J, Szyndler K, Trzonkowski P, Siebert J et al (2007) NK cell compartment in patients with coronary heart disease. Immun Ageing 4:3. doi:10.1186/1742-4933-4-3 ArticlePubMedCAS Google Scholar
Hickman SP, Turka LA (2006) Homeostatic T cell proliferation as a barrier to T cell tolerance. Philos Trans R Soc Lond B Biol Sci 360(1461):1713–1721. doi:10.1098/rstb.2005.1699 Google Scholar
Humphries SE, Luong LA, Ogg MS, Hawe E, Miller GJ (2001) The interleukin-6-174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 22(24):2243–2252. doi:10.1053/euhj.2001.2678 ArticlePubMedCAS Google Scholar
Jackson LA, Campbell LA, Schmidt RA, Kuo CC, Cappuccio AL, Lee MJ et al (1997) Specificity of detection of Chlamydia pneumoniae in cardiovascular atheroma: evaluation of the innocent bystander hypothesis. Am J Pathol 150(5):1785–1790 PubMedCAS Google Scholar
Jenny NS, Tracy RP, Ogg MS, Luong le A, Kuller LH, Arnold AM, Sharrett AR, Humphries SE (2002) In the elderly, interleukin-6 plasma levels and the -174G > C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol 22(12):2066–2071. doi:10.1161/01.ATV.0000040224.49362.60 ArticlePubMedCAS Google Scholar
Keitel WA, Cate TR, Couch RB, Huggins LL, Hess KR (1997) Efficacy of repeated annual immunization with inactivated influenza virus vaccines over a five year period. Vaccine 15:1114–1122. doi:10.1016/S0264-410X(97)00003-0 ArticlePubMedCAS Google Scholar
Khaiboullina SF, Maciejewski JP, Crapnell K, Spallone PA, Dean Stock A, Pari GS et al (2004) Human cytomegalovirus persists in myeloid progenitors and is passed to the myeloid progeny in a latent form. Br J Haematol 126(3):410–417. doi:10.1111/j.1365-2141.2004.05056.x ArticlePubMed Google Scholar
Levine M, Beattie BL, McLean DM (1987) Comparison of one- and two-dose regimens of influenza vaccine for elderly men. CMAJ 137:722–726 PubMedCAS Google Scholar
Levy SM, Herberman RB, Lee J, Whiteside T, Beadle M, Heiden L et al (1991) Persistently low natural killer cell activity, age, and environmental stress as predictors of infectious morbidity. Nat Immun Cell Growth Regul 10:289–307 PubMedCAS Google Scholar
Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B et al (1984) Admission criteria for immunogerontological studies in man: the SENIEUR Protocol. Mech Ageing Dev 28:47–55. doi:10.1016/0047-6374(84)90152-0 ArticlePubMedCAS Google Scholar
Ligthart GJ, Corberand JX, Geertzen HGM, Meinders AE, Knook DL, Hijmans W (1994) Necessity of the assessment of health status in human immunogerontological studies: evaluation of the Senieur Protocol. Mech Ageing Dev 55:89–105. doi:10.1016/0047-6374(90)90108-R Article Google Scholar
Linn BS, Lin MS, Gurel L (1968) Cumulative illness rating scale. J Am Geriatr Soc 16:622–626 PubMedCAS Google Scholar
Lupien SJ, Nair NP, Brière S, Maheu F, Tu MT, Lemay M et al (1999) Increased cortisol levels and impaired cognition in human aging: implication for depression and dementia in later life. Rev Neurosci 10(2):117–139 PubMedCAS Google Scholar
Madjid M, Aboshady I, Awan I, Litovsky S, Casscells SW (2004) Influenza and cardiovascular disease: is there a causal relationship? Tex Heart Inst J 31(1):4–13 PubMed Google Scholar
McDougall FA, Matthews FE, Kvaal K, Dewey ME, Brayne C (2007) Prevalence and symptomatology of depression in older people living in institutions in England and Wales. Age Ageing 36(5):562–568. doi:10.1093/ageing/afm111 ArticlePubMedCAS Google Scholar
McElhaney JE, Xie D, Hager WD, Barry MB, Wang Y, Kleppinger A et al (2006) T cell responses are better correlates of vaccine protection in the elderly. J Immunol 176(10):6333–6339 PubMedCAS Google Scholar
Meda L, Cassatella MA, Szendrei GI, Otvos L, Baron P, Villalba M et al (1995) Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374(6523):647–650. doi:10.1038/374647a0 ArticlePubMedCAS Google Scholar
Miller GE, Freedland KE, Duntley S, Carney RM (2005) Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein–Barr virus) in patients with earlier acute coronary syndromes. Am J Cardiol 95(3):317–321. doi:10.1016/j.amjcard.2004.09.026 ArticlePubMedCAS Google Scholar
Mysliwska J, Trzonkowski P, Szmit E, Brydak LB, Machala M, Mysliwski A (2004) Immunomodulating effect of influenza vaccination in the elderly differing in health status. Exp Gerontol 39(10):1447–1458. doi:10.1016/j.exger.2004.08.005 ArticlePubMedCAS Google Scholar
Myśliwska J, Bryl E, Chodnik T, Foerster J, Myśliwski A (1992) Level of NK cytotoxic activity in the elderly aged more than 80 years. Arch Gerontol Geriatr 15:21–28. doi:10.1016/0167-4943(92)90036-4 ArticlePubMed Google Scholar
Myśliwska J, Bryl E, Foerster J, Myśliwski A (1999) The upregulation of TNFalpha production is not a generalised phenomenon in the elderly between their sixth and seventh decades of life. Mech Ageing Dev 107:1–14. doi:10.1016/S0047-6374(98)00111-0 ArticlePubMed Google Scholar
Myśliwska J, Wieckiewicz J, Hak L, Siebert J, Rogowski J, Szyndler K et al (2006) Interleukin 6 polymorphism corresponds to the number of severely stenosed coronary arteries. Eur Cytokine Netw 17(3):181–188 PubMed Google Scholar
Myśliwska J, Wieckiewicz J, Hak L, Siebert J, Rogowski J, Szyndler K et al (2007a) Long-term prognosis after coronary bypass surgery depends on interleukin 6 polymorphism and past acute infections. Int J Cardiol 118(3):421–422. doi:10.1016/j.ijcard.2006.07.092 ArticlePubMed Google Scholar
Myśliwski A, Kaszubowska L, Detlaff-Pokora A, Szaryńska M, Myśliwska J (2007b) Telomere length, telomerase activity and biological activity of NK cells of the elderly are indicators of longevity. In: 10th Meeting of the society of natural immunity, Cambridge
Nabipour I, Vahdat K, Jafari SM, Pazoki R, Sanjdideh Z (2006) The association of metabolic syndrome and Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus type 1: the Persian Gulf Healthy Heart Study. Cardiovasc Diabetol 5:25. doi:10.1186/1475-2840-5-25 ArticlePubMedCAS Google Scholar
Nakhin AN, Rudenko LG, Arden N, Katz J, Grigoreva EP, Rekstin AR et al (1998) Formation of humoral and secretory immunity in elderly persons with different schemes of immunization with flu vaccines. Vopr Virusol 43:20–24 (in Russian) Google Scholar
Noisakran S, Halford WP, Veress L, Carr DJ (1998) Role of the hypothalamic pituitary adrenal axis and IL-6 in stress-induced reactivation of latent herpes simplex virus type 1. J Immunol 160(11):5441–5447 PubMedCAS Google Scholar
Odelin MF, Pozzetto B, Aymard M, Defayolle M, Jolly-Million J (1993) Role of influenza vaccination in the elderly during an epidemic of A/H1N1 virus in 1988–1989: clinical and serological data. Gerontology 39:109–116 ArticlePubMedCAS Google Scholar
Ouyang Q, Wagner WM, Voehringer D, Wikby A, Klatt T, Walter S et al (2003) Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp Gerontol 38(4):911–920. doi:10.1016/S0531-5565(03)00134-7 ArticlePubMedCAS Google Scholar
Paganelli R, Quinti I, Fagiolo U, Cossarizza A, Ortolani C, Guerra E et al (1992) Changes in circulating B cells and immunoglobulin classes and subclasses in healthy aged population. Clin Exp Immunol 90:351–354 PubMedCAS Google Scholar
Palache AM, Beyer WE, Sprenger MJ, Masurel N, de Jonge S, Vardy A et al (1993) Antibody response after influenza immunization with various vaccine doses: a double-blind, placebo-controlled, multi-centre, dose-response study in elderly nursing-home residents and young volunteers. Vaccine 11(1):3–9. doi:10.1016/0264-410X(93)90333-S ArticlePubMedCAS Google Scholar
Parmelee PA, Thuras PD, Katz IR, Lawton MP (1995) Validation of the cumulative illness rating scale in a geriatric residential population. J Am Geriatr Soc 43:130–137 PubMedCAS Google Scholar
Pawelec G, Ouyang Q, Colonna-Roman G, Candore G, Lio D, Caruso C (2002) Is human immunosenescence clinically relevant? Looking for “immunological risk phenotypes”. Trends Immunol 23:330. doi:10.1016/S1471-4906(02)02255-X ArticlePubMedCAS Google Scholar
Posnett DN, Edinger JW, Manavalan JS, Irwin C, Marodon G (1999) Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones. Int Immunol 11(2):229–241. doi:10.1093/intimm/11.2.229 ArticlePubMedCAS Google Scholar
Pussinen PJ, Tuomisto K, Jousilahti P, Havulinna AS, Sundvall J, Salomaa V (2007) Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol 27(6):1433–1439. doi:10.1161/ATVBAHA.106.138743 ArticlePubMedCAS Google Scholar
Ravaglia G, Forti P, Maioli F, Chiappelli M, Montesi F, Tumini E et al (2007) Blood inflammatory markers and risk of dementia: the Conselice Study of brain aging. Neurobiol Aging 28(12):1810–1820. doi:10.1016/j.neurobiolaging.2006.08.012 ArticlePubMedCAS Google Scholar
Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1998) Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation 97(5):425–428 PubMedCAS Google Scholar
Song C, Lin A, Bonaccorso S, Heide C, Verkerk R, Kenis G et al (1998) The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression. J Affect Disord 49(3):211–219. doi:10.1016/S0165-0327(98)00025-1 ArticlePubMedCAS Google Scholar
Speir E, Modali R, Huang ES, Leon MB, Shawl F, Finkel T et al (1994) Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 265(5170):391–394. doi:10.1126/science.8023160 ArticlePubMedCAS Google Scholar
Staras SA, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ (2006) Seroprevalence of cytomegalovirus infection in the United States, 1988–1994. Clin Infect Dis 9(9):1143–1151. doi:10.1086/508173 Article Google Scholar
Strindhall J, Nilsson BO, Lofgren S, Ernerudh J, Pawelec G, Johansson B et al (2007) No immune risk profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp Gerontol 42:753–761. doi:10.1016/j.exger.2007.05.001 ArticlePubMedCAS Google Scholar
Trzonkowski P, Myśliwski A (2003) Vaccination against influenza in the elderly (in Polish). Medical University of Gdańsk Press
Trzonkowski P, Mysliwska J, Szmit E, Wieckiewicz J, Lukaszuk K, Brydak LB et al (2003) Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence. Vaccine 21(25–26):3826–3836. doi:10.1016/S0264-410X(03)00309-8 ArticlePubMedCAS Google Scholar
Trzonkowski P, Myśliwska J, Godlewska B, Szmit E, Łukaszuk K, Więckiewicz J et al (2004) Immune consequences of the spontaneous pro-inflammatory status in depressed elderly patients. Brain Behav Immun 18(2):135–148. doi:10.1016/S0889-1591(03)00111-9 ArticlePubMedCAS Google Scholar
Trzonkowski P, Szmit E, Myśliwska J, Myśliwski A (2006) CD4+ CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence. Clin Immunol 19(3):307–316 ArticleCAS Google Scholar
Trzonkowski P, Zilvetti M, Chapman S, Więckiewicz J, Sutherland A, Friend P et al (2008) Homeostatic repopulation by CD28-CD8+ T-cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression. Am J Transplant 8(2):338–347 PubMedCAS Google Scholar
Vu T, Farish S, Jenkins M, Kelly H (2002) A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community. Vaccine 20:1831–1836. doi:10.1016/S0264-410X(02)00041-5 ArticlePubMed Google Scholar
Wikby A, Ferguson F, Forsey R, Thompson J, Strindhall J, Lofgren S et al (2005) An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci 60(5):556–565 PubMed Google Scholar
Wikby A, Nilsson BO, Forsey R, Thompson J, Strindhall J, Lofgren S et al (2006) The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech Ageing Dev 127:695–704. doi:10.1016/j.mad.2006.04.003 ArticlePubMedCAS Google Scholar
Wreghitt TG, Teare EL, Sule O, Devi R, Rice P (2003) Cytomegalovirus infection in immunocompetent patients. Clin Infect Dis 37:1603–1606. doi:10.1086/379711 ArticlePubMedCAS Google Scholar
Yamamoto H, Watanabe T, Miyazaki A, Katagiri T, Idei T, Iguchi T et al (2005) High prevalence of Chlamydia pneumoniae antibodies and increased high-sensitive C-reactive protein in patients with vascular dementia. J Am Geriatr Soc 53(4):583–589. doi:10.1111/j.1532-5415.2005.53204.x ArticlePubMed Google Scholar
Yan ZQ, Hansson GK (2007) Innate immunity, macrophage activation, and atherosclerosis. Immunol Rev 219:187–203 ArticlePubMedCAS Google Scholar
Zanni F, Vescovini R, Biasini C, Fagnoni F, Zanlari L, Telera A et al (2003) Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol 38(9):981–987. doi:10.1016/S0531-5565(03)00160-8 ArticlePubMedCAS Google Scholar
Zorrilla EP, Luborsky L, McKay JR, Rosenthal R, Houldin A, Tax A et al (2000) The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain Behav Immun 15:199–226. doi:10.1006/brbi.2000.0597 ArticleCAS Google Scholar