Human Antimicrobial Peptides: Defensins, Cathelicidins and Histatins (original) (raw)
B Agerberth J Charo J Werr B Olsson F Idali L Lindbom R Kiessling H Jornvall H Wigzell GH Gudmundsson (2000)ArticleTitleThe human antimicrobial and chemotactic peptides LL−37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations_Blood_ 96 3086–3093Occurrence Handle11049988 PubMed Google Scholar
M Ahmad M Piludu FG Oppenheim EJ Helmerhorst AR Hand (2004)ArticleTitleImmunocytochemical localization of histatins in human salivary glands_J. Histochem. Cytochem._ 52 361–370Occurrence Handle14966203 PubMed Google Scholar
A Axen A Carlsson A Engstrom H Bennich (1997)ArticleTitleGloverin, an antibacterial protein from the immune hemolymph of Hyalophora pupae_Eur. J. Biochem._ 247 614–619Occurrence Handle10.1111/j.1432-1033.1997.00614.xOccurrence Handle9266704 ArticlePubMed Google Scholar
D Baev XS Li J Dong P Keng M Edgerton (2002)ArticleTitleHuman salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicansInfect. Immun.70 4777–4784Occurrence Handle10.1128/IAI.70.9.4777-4784.2002Occurrence Handle12183519 ArticlePubMed Google Scholar
D Baev A Rivetta XS Li S Vylkova E Bashi CL Slayman M Edgerton (2003)ArticleTitleKilling of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1_Infect. Immun._ 71 3251–3260Occurrence Handle10.1128/IAI.71.6.3251-3260.2003Occurrence Handle12761106 ArticlePubMed Google Scholar
D Baev A Rivetta S Vylkova JN Sun GF Zeng CL Slayman M Edgerton (2004)ArticleTitleThe TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5_J. Biol. Chem._ 279 55060–55072Occurrence Handle10.1074/jbc.M411031200Occurrence Handle15485849 ArticlePubMed Google Scholar
R Bals (2000)ArticleTitleEpithelial antimicrobial peptides in host defense against infection_Resp. Res._ 1 141–150Occurrence Handle10.1186/rr25 Article Google Scholar
R Bals X Wang M Zasloff JM Wilson (1998)ArticleTitleThe peptide antibiotic LL−37/hCAP−18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface_Proc. Natl. Acad. Sci. USA_ 95 9541–9546Occurrence Handle10.1073/pnas.95.16.9541Occurrence Handle9689116 ArticlePubMed Google Scholar
R Bals DJ Weiner AD Moscioni RL Meegalla JM Wilson (1999)ArticleTitleAugmentation of innate host defense by expression of a cathelicidin antimicrobial peptide_Infect. Immun._ 67 6084–6089Occurrence Handle10531270 PubMed Google Scholar
A Bateman A Singh LF Congote S Solomon (1991)ArticleTitleThe effect of HP−1 and related neutrophil granule peptides on DNA synthesis in HL60 cells_Regul. Pept._ 35 135–143Occurrence Handle10.1016/0167-0115(91)90476-WOccurrence Handle1758971 ArticlePubMed Google Scholar
KW Bensch M Raida HJ Magert P Schulz-Knappe WG Forssmann (1995)ArticleTitlehBD-1: a novel beta-defensin from human plasma_FEBS Lett._ 368 331–335Occurrence Handle10.1016/0014-5793(95)00687-5Occurrence Handle7628632 ArticlePubMed Google Scholar
HG Boman B Agerberth A Boman (1993)ArticleTitleMechanisms of action on Escherichia coli of cecropin P1 and PR−39, two antibacterial peptides from pig intestine_Infect. Immun._ 61 2978–2984Occurrence Handle8514403 PubMed Google Scholar
M Brahmachary SP Krishnan JL Koh AM Khan SH Seah TW Tan V Brusic VB Bajic (2004)ArticleTitleANTIMIC: a database of antimicrobial sequences_Nucleic Acids Res._ 32 IssueIDDatabase issue D586–D589Occurrence Handle10.1093/nar/gkh032Occurrence Handle14681487 ArticlePubMed Google Scholar
M Castagnola R Inzitari DV Rossetti C Olmi T Cabras V Piras P Nicolussi MT Sanna M Pellegrini B Giardina I Messana (2004)ArticleTitleA cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway_J. Biol. Chem._ 279 41436–41443Occurrence Handle10.1074/jbc.M404322200Occurrence Handle15272024 ArticlePubMed Google Scholar
YV Chaly EM Paleolog TS Kolesnikova II Tikhonov EV Petratchenko NN Voitenok (2000)ArticleTitleNeutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells_Eur. Cytokine Netw._ 11 257–266Occurrence Handle10903805 PubMed Google Scholar
PA Charp WG Rice RL Raynor E Reimund JM Kinkade T Ganz ME Selsted RI Lehrer JF Kuo (1988)ArticleTitleInhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils_Biochem. Pharmacol._ 37 951–956Occurrence Handle10.1016/0006-2952(88)90187-6Occurrence Handle3345204 ArticlePubMed Google Scholar
SN Chitnis DB Kameswari KS Prasad (1993)ArticleTitleInduction of autolysis in starved Escherichia coli cells by seminalplasmin, an antimicrobial protein from bovine seminal plasma_FEMS Microbiol. Lett._ 112 147–150Occurrence Handle10.1016/0378-1097(93)90156-VOccurrence Handle8405956 ArticlePubMed Google Scholar
JB Cowland AH Johnsen N Borregaard (1995)ArticleTitlehCAP−18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules_FEBS Lett._ 368 173–176Occurrence Handle10.1016/0014-5793(95)00634-LOccurrence Handle7615076 ArticlePubMed Google Scholar
R Fernandez CaleyaParticlede B Gonzalez-Pascual F Garcia-Olmedo P Carbonero (1972)ArticleTitleSusceptibility of phytopathogenic bacteria to wheat purothionins in vitroAppl. Microbiol.23 998–1000Occurrence Handle5031563 PubMed Google Scholar
K SmetParticleDe R Reekmans R Contreras (2004)ArticleTitleRole of oxidative phosphorylation in histatin 5-induced cell death in Saccharomyces cerevisiae_Biotechnol. Lett._ 26 1781–1785Occurrence Handle10.1007/s10529-004-4608-7Occurrence Handle15672214 ArticlePubMed Google Scholar
M Edgerton SE Koshlukova TE Lo BG Chrzan RM Straubinger PA Raj (1998)ArticleTitleCandidacidal activity of salivary histatins. Identification of a histatin 5-binding protein on Candida albicansJ. Biol. Chem.273 20438–20447Occurrence Handle10.1074/jbc.273.32.20438Occurrence Handle9685398 ArticlePubMed Google Scholar
P Engstrom A Carlsson A Engstrom ZJ Tao H Bennich (1984)ArticleTitleThe antibacterial effect of attacins from the silk moth Hyalophora cecropia is directed against the outer membrane of Escherichia coliEmbo J.3 3347–3351Occurrence Handle6396089 PubMed Google Scholar
M Frohm B Agerberth G Ahangari M Stahle-Backdahl S Liden H Wigzell GH Gudmundsson (1997)ArticleTitleThe expression of the gene coding for the antibacterial peptide LL−37 is induced in human keratinocytes during inflammatory disorders_J. Biol. Chem._ 272 15258–15263Occurrence Handle10.1074/jbc.272.24.15258Occurrence Handle9182550 ArticlePubMed Google Scholar
T Ganz ME Selsted RI Lehrer (1990)ArticleTitleDefensins_Eur. J. Haematol._ 44 1–8Occurrence Handle2407547 PubMed Google Scholar
T Ganz (2005)ArticleTitleDefensins and other antimicrobial peptides: a historical perspective and an update_Comb. Chem. High Throughput Screen._ 8 209–217Occurrence Handle10.2174/1386207053764594Occurrence Handle15892623 ArticlePubMed Google Scholar
JR Garcia A Krause S Schulz FJ Rodriguez-Jimenez E Kluver K Adermann U Forssmann A Frimpong-Boateng R Bals WG Forssmann (2001)ArticleTitleHuman beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity_FASEB J._ 15 1819–1821Occurrence Handle11481241 PubMed Google Scholar
EA Groisman (1996)ArticleTitleBacterial responses to host-defense peptides_Trends Microbiol_ 4 127–128.Occurrence Handle10.1016/0966-842X(96)30013-9Occurrence Handle8728603 ArticlePubMed Google Scholar
GH Gudmundsson B Agerberth J Odeberg T Bergman B Olsson R Salcedo (1996)ArticleTitleThe human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL−37 in␣granulocytes_Eur. J. Biochem._ 238 325–332Occurrence Handle10.1111/j.1432-1033.1996.0325z.xOccurrence Handle8681941 ArticlePubMed Google Scholar
N Guex MC Peitsch (1997)ArticleTitleSWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling_Electrophoresis_ 18 2714–2723Occurrence Handle10.1002/elps.1150181505Occurrence Handle9504803 ArticlePubMed Google Scholar
H Gusman J Travis EJ Helmerhorst J Potempa RF Troxler FG Oppenheim (2001a)ArticleTitleSalivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease_Infect. Immun._ 69 1402–1408Occurrence Handle10.1128/IAI.69.3.1402-1408.2001 Article Google Scholar
H Gusman U Lendenmann J Grogan RF Troxler FG Oppenheim (2001b)ArticleTitleIs salivary histatin 5 a metallopeptide?Biochim. Biophys. Acta1545 86–95 Google Scholar
C Gyurko U Lendenmann RF Troxler FG Oppenheim (2000)ArticleTitle_Candida albicans_ mutants deficient in respiration are resistant to the small cationic salivary antimicrobial peptide histatin 5_Antimicrob. Agents Chemother_ 44 348–354Occurrence Handle10.1128/AAC.44.2.348-354.2000Occurrence Handle10639361 ArticlePubMed Google Scholar
KG Hamil P Sivashanmugam RT Richardson G Grossman SM Ruben JL Mohler P Petrusz MG O’Rand FS French SH Hall (2000)ArticleTitleHE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human_Endocrinology_ 141 1245–1253Occurrence Handle10.1210/en.141.3.1245Occurrence Handle10698202 ArticlePubMed Google Scholar
RE Hancock G Diamond (2000)ArticleTitleThe role of cationic antimicrobial peptides in innate host defences_Trends Microbiol._ 8 402–410Occurrence Handle10.1016/S0966-842X(00)01823-0Occurrence Handle10989307 ArticlePubMed Google Scholar
J Harder J Bartels E Christophers JM Schroder (1997)ArticleTitleA peptide antibiotic from human skin_Nature_ 387 861Occurrence Handle10.1038/43088Occurrence Handle9202117 ArticlePubMed Google Scholar
J Harder J Bartels E Christophers JM Schroder (2001)ArticleTitleIsolation and characterization of human beta-defensin−3, a novel human inducible peptide antibiotic_J. Biol. Chem._ 276 5707–5713Occurrence Handle10.1074/jbc.M008557200Occurrence Handle11085990 ArticlePubMed Google Scholar
EJ Helmerhorst IM Reijnders W van’t Hof I Simoons-Smit EC Veerman AV Amerongen (1999a)ArticleTitleAmphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides_Antimicrob. Agents Chemother_ 43 702–704 Google Scholar
EJ Helmerhorst P Breeuwer W van’t Hof E Walgreen-Weterings LC Oomen EC Veerman AV Amerongen T Abee (1999b)ArticleTitleThe cellular target of histatin 5 on Candida albicans is the energized mitochondrion_J. Biol. Chem._ 274 7286–7291Occurrence Handle10.1074/jbc.274.11.7286 Article Google Scholar
EJ Helmerhorst RF Troxler FG Oppenheim (2001)ArticleTitleThe human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species_Proc. Natl. Acad. Sci. USA_ 98 14637–14642Occurrence Handle10.1073/pnas.141366998Occurrence Handle11717389 ArticlePubMed Google Scholar
IB Holbrook PC Molan (1973)ArticleTitleA further study of the factors enhancing glycolysis in human saliva_Arch. Oral Biol._ 18 1275–1282Occurrence Handle10.1016/0003-9969(73)90040-XOccurrence Handle4518747 ArticlePubMed Google Scholar
T Imatani T Kato K Minaguchi K Okuda (2000)ArticleTitleHistatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalisOral Microbiol. Immunol.15 378–382Occurrence Handle10.1034/j.1399-302x.2000.150607.xOccurrence Handle11154435 ArticlePubMed Google Scholar
I Iontcheva FG Oppenheim RF Troxler (1997)ArticleTitleHuman salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins_J. Dent. Res._ 76 734–743Occurrence Handle9109822 PubMed Google Scholar
JL Jensen MS Lamkin FG Oppenheim (1992)ArticleTitleAdsorption of human salivary proteins to hydroxyapatite: a comparison between whole saliva and glandular salivary secretions_J. Dent. Res._ 71 1569–1576Occurrence Handle1381733 PubMed Google Scholar
S Joly C Maze PB McCray JM Guthmiller (2004)ArticleTitleHuman beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms_J. Clin. Microbiol._ 42 1024–1029Occurrence Handle10.1128/JCM.42.3.1024-1029.2004Occurrence Handle15004048 ArticlePubMed Google Scholar
DE Jones CL Bevins (1992)ArticleTitlePaneth cells of the human small intestine express an antimicrobial peptide gene_J. Biol. Chem._ 267 23216–23225Occurrence Handle1429669 PubMed Google Scholar
DE Jones CL Bevins (1993)ArticleTitleDefensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel_FEBS Lett._ 315 187–192Occurrence Handle10.1016/0014-5793(93)81160-2Occurrence Handle8417977 ArticlePubMed Google Scholar
W Kamysz M Okroj J Lukasiak (2003)ArticleTitleNovel properties of antimicrobial peptides_Acta Biochim. Pol._ 50 461–469Occurrence Handle12833170 PubMed Google Scholar
K Kavanagh S Dowd (2004)ArticleTitleHistatins: antimicrobial peptides with therapeutic potential_J. Pharm. Pharmacol._ 56 285–289Occurrence Handle10.1211/0022357022971Occurrence Handle15025852 ArticlePubMed Google Scholar
SE Koshlukova MW Araujo D Baev M Edgerton (2000)ArticleTitleReleased ATP is an extracellular cytotoxic mediator in salivary histatin 5-induced killing of Candida albicansInfect. Immun.68 6848–6856Occurrence Handle10.1128/IAI.68.12.6848-6856.2000Occurrence Handle11083804 ArticlePubMed Google Scholar
SE Koshlukova TL Lloyd MW Araujo M Edgerton (1999)ArticleTitleSalivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death_J. Biol. Chem._ 274 18872–18879Occurrence Handle10.1074/jbc.274.27.18872Occurrence Handle10383383 ArticlePubMed Google Scholar
JY Leem C Nishimura S Kurata I Shimada A Kobayashi S Natori (1996)ArticleTitlePurification and characterization of N-beta-alanyl−5-S-glutathionyl−3,4-dihydroxyphenylalanine, a novel antibacterial substance of Sarcophaga peregrina (flesh fly)J. Biol. Chem.271 13573–13577Occurrence Handle10.1074/jbc.271.23.13573Occurrence Handle8662858 ArticlePubMed Google Scholar
RI Lehrer (2004)ArticleTitlePrimate defensins_Nat. Rev. Microbiol._ 2 727–738Occurrence Handle10.1038/nrmicro976Occurrence Handle15372083 ArticlePubMed Google Scholar
XS Li MS Reddy D Baev M Edgerton (2003)ArticleTitleCandida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5_J. Biol. Chem._ 278 28553–28561Occurrence Handle10.1074/jbc.M300680200Occurrence Handle12761219 ArticlePubMed Google Scholar
A Lichtenstein T Ganz ME Selsted RI Lehrer (1986)ArticleTitle_In vitro_ tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes_Blood_ 68 1407–1410Occurrence Handle3779104 PubMed Google Scholar
BJ MacKay JJ Pollock VJ Iacono BJ Baum (1984a)ArticleTitleIsolation of milligram quantities of a group of histidine-rich polypeptides from human parotid saliva_Infect. Immun._ 44 688–694 Google Scholar
BJ MacKay L Denepitiya VJ Iacono SB Krost JJ Pollock (1984b)ArticleTitleGrowth-inhibitory and bactericidal effects of human parotid salivary histidine-rich polypeptides on Streptococcus mutansInfect. Immun.44 695–701 Google Scholar
Y Murakami T Xu EJ Helmerhorst G Ori RF Troxler ET Lally FG Oppenheim (2002)ArticleTitleInhibitory effect of synthetic histatin 5 on leukotoxin from Actinobacillus actinomycetemcomitansOral Microbiol. Immunol.17 143–149Occurrence Handle10.1034/j.1399-302X.2002.170302.xOccurrence Handle12030965 ArticlePubMed Google Scholar
CJ Murphy BA Foster MJ Mannis ME Selsted TW Reid (1993)ArticleTitleDefensins are mitogenic for epithelial cells and fibroblasts_J. Cell. Physiol._ 155 408–413Occurrence Handle10.1002/jcp.1041550223Occurrence Handle8482733 ArticlePubMed Google Scholar
K Okumura A Itoh E Isogai K Hirose Y Hosokawa Y Abiko T Shibata M Hirata H Isogai (2004)ArticleTitleC-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells_Cancer Lett._ 212 185–194Occurrence Handle10.1016/j.canlet.2004.04.006Occurrence Handle15279899 ArticlePubMed Google Scholar
FG Oppenheim T Xu FM McMillian SM Levitz RD Diamond GD Offner RF Troxler (1988)ArticleTitleHistatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicansJ. Biol. Chem.263 7472–7477Occurrence Handle3286634 PubMed Google Scholar
JJ Oppenheim A Biragyn LW Kwak D Yang (2003)ArticleTitleRoles of antimicrobial peptides such as defensins in innate and adaptive immunity_Ann. Rheum. Dis._ 62 IssueIDSuppl 2 ii17–ii21Occurrence Handle10.1136/ard.62.suppl_2.ii17Occurrence Handle14532141 ArticlePubMed Google Scholar
C Osterhoff C Kirchhoff N Krull R Ivell (1994)ArticleTitleMolecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis_Biol. Reprod._ 50 516–525Occurrence Handle8167223 PubMed Google Scholar
DW Paquette DM Simpson P Friden V Braman RC Williams (2002)ArticleTitleSafety and clinical effects of topical histatin gels in humans with experimental gingivitis_J. Clin. Periodontol._ 29 1051–1058Occurrence Handle10.1034/j.1600-051X.2002.291201.xOccurrence Handle12492903 ArticlePubMed Google Scholar
CB Park HS Kim SC Kim (1998)ArticleTitleMechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions_Biochem. Biophys. Res. Commun._ 244 253–257Occurrence Handle10.1006/bbrc.1998.8159Occurrence Handle9514864 ArticlePubMed Google Scholar
JJ Pollock L Denepitiya BJ MacKay VJ Iacono (1984)ArticleTitleFungistatic and fungicidal activity of human parotid salivary histidine-rich polypeptides on Candida albicansInfect. Immun.44 702–707Occurrence Handle6373615 PubMed Google Scholar
PA Raj E Marcus DK Sukumaran (1998)ArticleTitleStructure of human salivary histatin 5 in aqueous and nonaqueous solutions_Biopolymers_ 45 51–67Occurrence Handle10.1002/(SICI)1097-0282(199801)45:1<51::AID-BIP5>3.0.CO;2-YOccurrence Handle9433185 ArticlePubMed Google Scholar
KV Reddy RD Yedery C Aranha (2004)ArticleTitleAntimicrobial peptides: premises and promises_Int. J. Antimicrob. Agents_ 24 536–547Occurrence Handle10.1016/j.ijantimicag.2004.09.005Occurrence Handle15555874 ArticlePubMed Google Scholar
DM Rothstein P Spacciapoli LT Tran T Xu FD Roberts M Dalla Serra DK Buxton FG Oppenheim P Friden (2001)ArticleTitleAnticandida activity is retained in P−113, a 12-amino-acid fragment of histatin 5_Antimicrob. Agents Chemother_ 45 1367–1373Occurrence Handle10.1128/AAC.45.5.1367-1373.2001Occurrence Handle11302797 ArticlePubMed Google Scholar
LM Sabatini EA Azen (1989)ArticleTitleHistatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2)Biochem. Biophys. Res. Commun.160 495–502Occurrence Handle10.1016/0006-291X(89)92460-1Occurrence Handle2719677 ArticlePubMed Google Scholar
US Sajjan LT Tran N Sole C Rovaldi A Akiyama PM Friden JF Forstner DM Rothstein (2001)ArticleTitleP−113D, an antimicrobial peptide active against Pseudomonas aeruginosa, retains activity in the presence of sputum from cystic fibrosis patients_Antimicrob. Agents Chemother._ 45 3437–3444Occurrence Handle10.1128/AAC.45.12.3437-3444.2001Occurrence Handle11709321 ArticlePubMed Google Scholar
BC Schutte JP Mitros JA Bartlett JD Walters HP Jia MJ Welsh TL Casavant PB McCray (2002)ArticleTitleDiscovery of five conserved beta-defensin gene clusters using a computational search strategy_Proc. Natl. Acad. Sci. USA_ 99 2129–2133Occurrence Handle10.1073/pnas.042692699Occurrence Handle11854508 ArticlePubMed Google Scholar
OE Sorensen N Borregaard (2005)ArticleTitleCathelicidins–nature’s attempt at combinatorial chemistry_Comb. Chem. High Throughput Screen_ 8 273–280Occurrence Handle10.2174/1386207053764602Occurrence Handle15892628 ArticlePubMed Google Scholar
MC Territo T Ganz ME Selsted R Lehrer (1989)ArticleTitleMonocyte-chemotactic activity of defensins from human neutrophils_J. Clin. Invest._ 84 2017–2020Occurrence Handle2592571 PubMed Google Scholar
H Tsai LA Bobek (1997)ArticleTitleHuman salivary histatin−5 exerts potent fungicidal activity against Cryptococcus neoformansBiochim. Biophys. Acta1336 367–369Occurrence Handle9367163 PubMed Google Scholar
J Turner Y Cho NN Dinh AJ Waring RI Lehrer (1998)ArticleTitleActivities of LL−37, a cathelin-associated antimicrobial peptide of human neutrophils_Antimicrob. Agents Chemother._ 42 2206–2214Occurrence Handle9736536 PubMed Google Scholar
T DykeParticleVan D Paquette S Grossi V Braman J Massaro R D’Agostino S Dibart P Friden (2002)ArticleTitleClinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase−2 multi-center study_J. Clin. Periodontol._ 29 168–176Occurrence Handle10.1034/j.1600-051x.2002.290212.xOccurrence Handle11895545 ArticlePubMed Google Scholar
JC vanderSpek HE Wyandt JC Skare A Milunsky FG Oppenheim RF Troxler (1989)ArticleTitleLocalization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs_Am. J. Hum. Genet._ 45 381–387Occurrence Handle2773933 PubMed Google Scholar
EC Veerman K Nazmi W Van’t Hof JG Bolscher AL HertogParticleDen AV Nieuw Amerongen (2004)ArticleTitleReactive oxygen species play no role in the candidacidal activity of the salivary antimicrobial peptide histatin 5_Biochem. J._ 381 447–452Occurrence Handle10.1042/BJ20040208Occurrence Handle15109304 ArticlePubMed Google Scholar
M Velasco MJ Diaz-Guerra P Diaz-Achirica D Andreu L Rivas L Bosca (1997)ArticleTitleMacrophage triggering with cecropin A and melittin-derived peptides induces type II nitric oxide synthase expression_J. Immunol._ 158 4437–4443Occurrence Handle9127009 PubMed Google Scholar
HH HorstenParticlevon P Derr C Kirchhoff (2002)ArticleTitleNovel antimicrobial peptide of human epididymal duct origin_Biol. Reprod_ 67 804–813Occurrence Handle10.1095/biolreprod.102.004564Occurrence Handle12193388 ArticlePubMed Google Scholar
Z Wang G Wang (2004)ArticleTitleAPD: the Antimicrobial Peptide Database_Nucleic Acids Res._ 32 IssueIDDatabase issue D590– D592Occurrence Handle10.1093/nar/gkh025Occurrence Handle14681488 ArticlePubMed Google Scholar
SH White WC Wimley ME Selsted (1995)ArticleTitleStructure, function, and membrane integration of defensins_Curr. Opin. Struct. Biol._ 5 521–527Occurrence Handle10.1016/0959-440X(95)80038-7Occurrence Handle8528769 ArticlePubMed Google Scholar
D Wunder J Dong D Baev M Edgerton (2004)ArticleTitleHuman salivary histatin 5 fungicidal action does not induce programmed cell death pathways in Candida albicansAntimicrob. Agents Chemother.48 110–115Occurrence Handle10.1128/AAC.48.1.110-115.2004Occurrence Handle14693527 ArticlePubMed Google Scholar
Y Yamaguchi T Nagase R Makita S Fukuhara T Tomita T Tominaga H Kurihara Y Ouchi (2002)ArticleTitleIdentification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice_J. Immunol._ 169 2516–2523Occurrence Handle12193721 PubMed Google Scholar
Q Yan A Bennick (1995)ArticleTitleIdentification of histatins as tannin-binding proteins in human saliva_Biochem. J._ 311 341–347Occurrence Handle7575474 PubMed Google Scholar
S Yenugu KG Hamil Y Radhakrishnan FS French SH Hall (2004a)ArticleTitleThe androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin_Endocrinology_ 145 3165–3173Occurrence Handle10.1210/en.2003-1698 Article Google Scholar
S Yenugu KG Hamil FS French SH Hall (2004b)ArticleTitleAntimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2alpha, HE2beta1 and HE2beta2_Reprod. Biol. Endocrinol._ 2 61Occurrence Handle10.1186/1477-7827-2-61 Article Google Scholar
YC Yoo R Watanabe Y Koike M Mitobe K Shimazaki S Watanabe I Azuma (1997)ArticleTitleApoptosis in human leukemic cells induced by lactoferricin, a bovine milk protein-derived peptide: involvement of reactive oxygen species_Biochem. Biophys. Res. Commun._ 237 624–628Occurrence Handle10.1006/bbrc.1997.7199Occurrence Handle9299415 ArticlePubMed Google Scholar
M Zanetti (2004)ArticleTitleCathelicidins, multifunctional peptides of the innate immunity_J. Leukoc. Biol._ 75 39–48Occurrence Handle10.1189/jlb.0403147Occurrence Handle12960280 ArticlePubMed Google Scholar