Serum total cholesterol and the risk of breast cancer in postmenopausal Korean women (original) (raw)

Abstract

Objective

To evaluate an association between serum total cholesterol level and breast cancer risk, for which inconsistent findings have been reported in spite of the role of serum cholesterol as a precursor to a breast cancer-related sex steroid hormone.

Methods

Postmenopausal Korean women (n = 170,374), categorized into four groups by quartiles of cholesterol level, were followed up for occurrence of breast cancer from 1993 to 2003. Relative risks were assessed by Cox proportional hazard analysis.

Results

A positive association between cholesterol level and breast cancer risk was found with 31% greater age-adjusted risk of breast cancer in the highest cholesterol group (≥5.95 mmol/l) than that in the lowest cholesterol group (<4.63 mmol/l). The strength of association was reduced slightly but persisted after the adjustment for reproductive and behavioral covariates. However, the association further attenuated and the positive trend was no longer significant when BMI was additionally adjusted (_p_-trend, 0.0684). Stratified analysis by BMI showed that the risk of breast cancer increased with increasing cholesterol level only in normal BMI (<25 kg/m2) group, but the interaction term was not significant.

Conclusion

Serum total cholesterol level is not associated with the risk of breast cancer in postmenopausal Korean women.

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References

  1. Eliassen AH, Missmer SA, Tworoger SS et al (2006) Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst 98:1406–1415
    PubMed CAS Google Scholar
  2. Missmer SA, Eliassen AH, Barbieri RL, Hankinson SE (2004) Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women. J Natl Cancer Inst 96:1856–1865
    PubMed CAS Google Scholar
  3. Hiatt RA, Friedman GD, Bawol RD, Ury HK (1982) Breast cancer and serum cholesterol. J Natl Cancer Inst 68:885–889
    PubMed CAS Google Scholar
  4. Hoyer AP, Engholm G (1992) Serum lipids and breast cancer risk: a cohort study of 5,207 Danish women. Cancer Causes Control 3:403–408. doi:10.1007/BF00051352
    Article PubMed CAS Google Scholar
  5. Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE (2005) Serum lipids, lipid-lowering drugs, and the risk of breast cancer. Arch Intern Med 165:2264–2271. doi:10.1001/archinte.165.19.2264
    Article PubMed CAS Google Scholar
  6. Gaard M, Tretli S, Urdal P (1994) Risk of breast cancer in relation to blood lipids: a prospective study of 31,209 Norwegian women. Cancer Causes Control 5:501–509. doi:10.1007/BF01831377
    Article PubMed CAS Google Scholar
  7. Kaye JA, Meier CR, Walker AM, Jick H (2002) Statin use, hyperlipidaemia, and the risk of breast cancer. Br J Cancer 86:1436–1439. doi:10.1038/sj.bjc.6600267
    Article PubMed CAS Google Scholar
  8. Vatten LJ, Foss OP (1990) Total serum cholesterol and triglycerides and risk of breast cancer: a prospective study of 24,329 Norwegian women. Cancer Res 50:2341–2346
    PubMed CAS Google Scholar
  9. Tornberg SA, Holm LE, Carstensen JM (1988) Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure. Acta Oncol 27:31–37. doi:10.3109/02841868809090315
    Article PubMed CAS Google Scholar
  10. Li YH, Li Y, Davis CE et al (2002) Serum cholesterol changes from 1983–1984 to 1993–1994 in the People’s Republic of China. Nutr Metab Cardiovasc Dis 12:118–126
    PubMed CAS Google Scholar
  11. Sekikawa A, Kuller LH, Ueshima H et al (1999) Coronary heart disease mortality trends in men in the post World War II birth cohorts aged 35–44 in Japan, South Korea and Taiwan compared with the United States. Int J Epidemiol 28:1044–1049. doi:10.1093/ije/28.6.1044
    Article PubMed CAS Google Scholar
  12. Okayama A, Ueshima H, Marmot MG, Nakamura M, Kita Y, Yamakawa M (1993) Changes in total serum cholesterol and other risk factors for cardiovascular disease in Japan 1980–1989. Int J Epidemiol 22:1038–1047. doi:10.1093/ije/22.6.1038
    Article PubMed CAS Google Scholar
  13. Tominaga S, Kuroishi T (1999) Epidemiology and prevention of breast cancer in the 21st century. Breast Cancer 6:283–288. doi:10.1007/BF02966440
    Article PubMed Google Scholar
  14. Yoo KY, Kim Y, Park SK, Kang D (2006) Lifestyle, genetic susceptibility and future trends of breast cancer in Korea. Asian Pac J Cancer Prev 7:679–682
    PubMed Google Scholar
  15. Seow A, Duffy SW, McGee MA, Lee J, Lee HP (1996) Breast cancer in Singapore: trends in incidence 1968–1992. Int J Epidemiol 25:40–45. doi:10.1093/ije/25.1.40
    Article PubMed CAS Google Scholar
  16. Brown MS, Kovanen PT, Goldstein JL (1981) Regulation of plasma cholesterol by lipoprotein receptors. Science 212:628–635. doi:10.1126/science.6261329
    Article PubMed CAS Google Scholar
  17. Kovanen PT (1987) Regulation of plasma cholesterol by hepatic low-density lipoprotein receptors. Am Heart J 113:464–469. doi:10.1016/0002-8703(87)90615-6
    Article PubMed CAS Google Scholar
  18. Friedenreich CM (2001) Review of anthropometric factors and breast cancer risk. Eur J Cancer Prev 10:15–32. doi:10.1097/00008469-200102000-00003
    Article PubMed CAS Google Scholar
  19. Hulka BS, Moorman PG (2001) Breast cancer: hormones and other risk factors. Maturitas 38:103–113. doi:10.1016/S0378-5122(00)00196-1
    Article PubMed CAS Google Scholar
  20. Park YJ, Koo BS, Kang HC, Chun SH, Yoon JW (2001) The menopausal age and climacteric symptoms, and the related factors of Korean women. Korean J Women Health Nurs 7:473–485
    Google Scholar
  21. Song YM, Sung J, Kim JS (2000) Which cholesterol level is related to the lowest mortality in a population with low mean cholesterol level: a 6.4-year follow-up study of 482,472 Korean men. Am J Epidemiol 151:739–747
    PubMed CAS Google Scholar
  22. National Cancer Center (2007) Number of hospitals participating in Korea Central Cancer Registry
  23. Wallace RB, Rost C, Burmeister LF, Pomrehn PR (1982) Cancer incidence in humans: relationship to plasma lipids and relative weight. J Natl Cancer Inst 68:915–918
    PubMed CAS Google Scholar
  24. Beck P, Wysowski DK, Downey W, Butler-Jones D (2003) Statin use and the risk of breast cancer. J Clin Epidemiol 56:280–285. doi:10.1016/S0895-4356(02)00614-5
    Article PubMed Google Scholar
  25. Bonovas S, Filioussi K, Tsavaris N, Sitaras NM (2005) Use of statins and breast cancer: a meta-analysis of seven randomized clinical trials and nine observational studies. J Clin Oncol 23:8606–8612. doi:10.1200/JCO.2005.02.7045
    Article PubMed Google Scholar
  26. Boudreau DM, Yu O, Miglioretti DL, Buist DS, Heckbert SR, Daling JR (2007) Statin use and breast cancer risk in a large population-based setting. Cancer Epidemiol Biomarkers Prev 16:416–421. doi:10.1158/1055-9965.EPI-06-0737
    Article PubMed CAS Google Scholar
  27. Pocobelli G, Newcomb PA, Trentham-Dietz A, Titus-Ernstoff L, Hampton JM, Egan KM (2008) Statin use and risk of breast cancer. Cancer 112:27–33. doi:10.1002/cncr.23129
    Article PubMed Google Scholar
  28. Ferraroni M, Gerber M, Decarli A et al (1993) HDL-cholesterol and breast cancer: a joint study in northern Italy and southern France. Int J Epidemiol 22:772–780. doi:10.1093/ije/22.5.772
    Article PubMed CAS Google Scholar
  29. Furberg AS, Veierod MB, Wilsgaard T, Bernstein L, Thune I (2004) Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk. J Natl Cancer Inst 96:1152–1160
    Article PubMed CAS Google Scholar

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Acknowledgments

This study was supported by grants from the Samsung Biomedical Research Institute (#SBRI C-A7-416-1), National Cancer Center (# 0610552-2), Ministry of Science and Technology, Korea (National R&D project grant M1-0306-03-0000), and Ministry of Health and Welfare, Korea (#01-PJ1-PG1-01CH10-0007).

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Authors and Affiliations

  1. Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, South Korea
    Mina Ha
  2. Department of Epidemiology, The Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea
    Joohon Sung
  3. Department of Epidemiology and Cancer Prevention, National Cancer Center, Goyang, Gyeonggi-do, South Korea
    Joohon Sung
  4. Department of Family Medicine, Samsung Medical Center, and Center for Clinical Research, Samsung Biomedical Research Institute, SungKyunKwan University School of Medicine, 50 Irwondong, Gangnamgu, Seoul, 135-710, South Korea
    Yun-Mi Song

Authors

  1. Mina Ha
  2. Joohon Sung
  3. Yun-Mi Song

Corresponding author

Correspondence toYun-Mi Song.

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Ha, M., Sung, J. & Song, YM. Serum total cholesterol and the risk of breast cancer in postmenopausal Korean women.Cancer Causes Control 20, 1055–1060 (2009). https://doi.org/10.1007/s10552-009-9301-7

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