Cadaver skin allograft may improve mortality rate for burns involving over 30% of total body surface area: a propensity score analysis of data from four burn centers (original) (raw)

Abstract

Cadaver skin is used for temporary wound covering, but there is insufficient evidence regarding its clinical usefulness in patients with major burns. We aimed to analyze the effect of cadaveric skin allograft on mortality rates in patients with burns involving > 30% of total body surface area (TBSA). Our study included 1282 patients with > 30% of TBSA burned admitted to four hospitals in Korea between June 1, 2008 and December 31, 2016. Of these, 698 patients underwent cadaver skin allograft (cadaver group), and 584 were treated with conventional treatment (non-cadaver group). We corrected the differences between the two groups using propensity score matching, and generated 474 propensity score-matched pairs. Overall 90-day in-hospital mortality rate among all patients was 35.3% (453/1282). There was a significant difference in 90-day in-hospital mortality between the two groups for both unmatched [cadaver vs. conventional, 31.7 vs. 39.7%; difference, 8.0; 95% confidence interval (CI) 2.8–13.3] and propensity-matched groups (37.8 vs. 47.3%; difference, 9.5; 95% CI 3.2–15.8). Logistic regression analyses showed a significant association between cadaver skin allograft and lower 90-day in-hospital mortality in the propensity-matched groups (odds ratio, 0.42; 95% CI 0.29–0.62). Patients with major burns who underwent cadaver skin allograft had a lower mortality rate compared to those who did not. Cadaver skin allograft may improve the survival of patients with major burns, especially in the early phase of injury.

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Acknowledgements

This work was supported by the Soonchunhyang University Research Fund.

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Authors and Affiliations

1. Department of Emergency Medicine, Bestian Hospital, Seoul, Korea
   Young Hwan Choi, Jong Ho Lee, Yanghwan Choi & Changmin Sung
2. Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, 1174, Jung-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-020, Korea
   Young Soon Cho
3. Department of General Surgery, Bestian Hospital, Seoul, Korea
   Soo Young Noh, Seungchoon Park, Jin Kyu Lim, Jongdae Kim, Jae Jun Shin, Banseok Yang, Jiyun Jeong, Huan Chun & Kwang Jo Kim

Authors

1. Young Hwan Choi
2. Young Soon Cho
3. Jong Ho Lee
4. Yanghwan Choi
5. Soo Young Noh
6. Seungchoon Park
7. Changmin Sung
8. Jin Kyu Lim
9. Jongdae Kim
10. Jae Jun Shin
11. Banseok Yang
12. Jiyun Jeong
13. Huan Chun
14. Kwang Jo Kim

Corresponding author

Correspondence toYoung Soon Cho.

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The authors declare that there are no conflict of interest.

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Choi, Y.H., Cho, Y.S., Lee, J.H. et al. Cadaver skin allograft may improve mortality rate for burns involving over 30% of total body surface area: a propensity score analysis of data from four burn centers.Cell Tissue Bank 19, 645–651 (2018). https://doi.org/10.1007/s10561-018-9715-0

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• Received: 02 April 2018
• Accepted: 25 July 2018
• Published: 31 July 2018
• Version of record: 31 July 2018
• Issue date: December 2018
• DOI: https://doi.org/10.1007/s10561-018-9715-0

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