Wnt Pathway-Related Gene Expression in Inflammatory Bowel Disease (original) (raw)
References
de Lau W, Barker N, Clevers H (2007) WNT signaling in the normal intestine and colorectal cancer. Front Biosci 12:471–491 ArticlePubMed Google Scholar
Pinto D, Clevers H (2005) Wnt control of stem cells and differentiation in the intestinal epithelium. Exp Cell Res 306:357–363 ArticlePubMedCAS Google Scholar
Miyoshi Y, Nagase H, Ando H, Ichii S, Nakatsura S, Aoki T, Miki Y, Mori T, Nakamura Y (1992) Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1:229–233 ArticlePubMedCAS Google Scholar
Potter JD (1999) Colorectal cancer: molecules and populations. J Nat’l Cancer Inst 91:916–932 ArticleCAS Google Scholar
Hovanes K, Li TW, Munguia JE, Truong T, Milovanovic T, Lawrence Marsh J, Holcombe RF, Waterman ML (2001) Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat Genet 28:53–57 ArticlePubMedCAS Google Scholar
Holcombe RF, Marsh JL, Waterman ML, Lin F, Milovanovic T, Truong T (2002) Expression of Wnt ligands and frizzled receptors in colonic mucosa and in colon carcinoma. Mol Pathol 55:220–226 ArticlePubMedCAS Google Scholar
Cadigan KM, Nusse R (1997) Wnt signaling: a common theme in animal development. Genes Dev 11:3286–3305 ArticlePubMedCAS Google Scholar
Klingensmith J, Nusse R, Perrimon N (1994) The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev 8:118–130 ArticlePubMedCAS Google Scholar
Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W (1996) Functional interaction of β-catenin with the transcription factor LEF1. Nature 382:638–642 ArticlePubMedCAS Google Scholar
He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281:1509–1512 ArticlePubMedCAS Google Scholar
Howe LR, Subbaramaiah K, Chung WJ, Dannenberg AJ, Brown AM (1999) Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer Res 59:1572–1577 PubMedCAS Google Scholar
Stutman M, Zhurinsky J, Simcha I, Albanese C, D’Amico M, Pestall R, Ben-Ze’ev A (1999) The cyclin D1 gene is a target of the beta-catenin/LEF1 pathway. PNAS 96:5522–5527 Article Google Scholar
Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (1999) Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem 274:16180–16187 ArticlePubMedCAS Google Scholar
Aust DE, Terdiman JP, Willenbucher RF, Chang CG, Molinaro-Clark A, Baretton GB, Loehrs U, Waldman FM (2002) The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis. Cancer 94:1421–1427 ArticlePubMedCAS Google Scholar
Umetani N, Sasaki S, Watanabe T, Shinozaki M, Matsuda K, Ishigami H, Ueda E, Muto T (1999) Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability. Jpn J Cancer Res 90:1081–1087 PubMedCAS Google Scholar
Tarmin L, Yin J, Harpaz N, Kozam M, Noordzij J, Antonio LB, Jiang HY, Chan O, Cymes K, Meltzer SJ (1995) Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms. Cancer Res 55:2035–2038 PubMedCAS Google Scholar
Tamura K (2003) Alterations of CDKNZA and mismatch repair deficiency may be important as early events of colorectal tumors associated with ulcerative colitis. Proc AACR 44:1477 Google Scholar
Tanaka T, Kohno H, Murakami M, Shimada R, Kagami S (2000) Colitis-related rat colon carcinogenesis induced by 1-hydrozy-antraquinone and methylazoxymethanol acetate. Oncol Rep 7:501–508 PubMedCAS Google Scholar
Suzui M, Ushijima T, Yoshimi N, Nakagama H, Hara A, Sugimura T, Nagao M, Mori H (1997) No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydrozyanthraquinone and methylazixymethanol acetate. Mol Carcinog 20:389–393 ArticlePubMedCAS Google Scholar
Suzui M, Ushijima T, Dashwood RH, Yoshimi N, Sugimura T, Mori H, Nagao M (1999) Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydrozyanthraquinone. Mol Carcinog 24:232–237 ArticlePubMedCAS Google Scholar
Uthoff SM, Eichenberger MR, Lewis RK, Fox MP, Hamilton CJ, McAuliffe TL, Grimes HL, Falandiuk S (2001) Identification of candidate genes in ulcerative colitis and Crohn’s disease using cDNA array technology. Int J Oncolo 19:803–810 CAS Google Scholar
You J, Bryant PJ, Jurnak F, Holcombe RF (2007) Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease. Oncol Rep 18(3):691–694 Google Scholar
Kollios G, Valatas V, Ward SG (2004) Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology 113:427–437 Article Google Scholar
Du Q, Park KS, Guo Z, He P, Nagashima M, Shao L, Sahai R, Geller DA, Hussain SP (2006) Regulation of human nitric oxide synthase 2 expression by Wnt β-catenin signaling. Cancer Res 66:7024–7031 ArticlePubMedCAS Google Scholar
Kullmann F, Fadaie M, Gross V, Knuchel R, Bocker T, Steinbach P, Scholmerich J, Ruschoff J (1996) Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. Eur J Gastroenterol Hepatol 8:371–379 ArticlePubMedCAS Google Scholar
Mikami T, Mitomi H, Hara A, Yanagisawa N, Yoshida T, Tsuruta O, Okayasu I (2000) Decreased expression of CD44, alpha-catenin, and deleted colon carcinoma and altered expression of beta-catenin in unlcerative colitis-associated dysplasia and carcinoma, as compared with sporadic colon neoplasms. Cancer 89:733–740 ArticlePubMedCAS Google Scholar
Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116:883–895 ArticlePubMedCAS Google Scholar
Wong NA, Mayer NJ, Anderson CE, McKenzie HC, Morris RG, Diebold J, Mayr D, Brock IW, Royds JA, Gilmour HM, Harrison DJ (2003) CyclinD1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms. Hum Pathol 34:580–588 ArticlePubMedCAS Google Scholar
Zorn AM, Barish GD, Williams BO, Lavender P, Klymkowdky MW, Varmus HE (1999) Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Mol Cell 4:487–498 ArticlePubMedCAS Google Scholar
Sinner D, Rankin S, Lee M, Zorn AM (2004) Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development 131:3069–3080 ArticlePubMedCAS Google Scholar
Park KS, Wells JM, Zorn AM, Wert SE, Whitsett JA (2006) Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol 294:192–202 ArticlePubMedCAS Google Scholar
Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, Kurohmaru M, Sanai Y, Uonekawa H, Yazaki K, Tam PP, Hayashi Y (2002) Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 129:2367–2379 PubMedCAS Google Scholar
Lundberg S, Holst M, Hellstrom PM (2006) Expression of iNOS mRNA associated with suppression of colonic contraction in rat colitis. Acta Physiol 187:489–494 ArticleCAS Google Scholar
Ljung T, Lundberg S, Varsanyi M, Johansson C, Schmidt PT, Herulf M, Lundberg JO, Hellstrom PM (2006) Rectal nitric oxide as a biomarker in the treatment of inflammatory bowel disease: responders versus nonresponders. World J Gastroenterol 12:3386–3392 PubMedCAS Google Scholar
Porras M, Martin MT, Torres R, Vergara P (2006) Cyclical upregulated iNOS and long-term downregulated nNOS are the bases for relapse and quiescent phases in a rat model of IBD. Am J Physiol Gastrointest Liver Physiol 290:G423–G430 ArticlePubMedCAS Google Scholar
Zhang R, Ma A, Urbanski SJ, McCafferty DM (2006) Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma. Carcinogenesis 28(5):1122–1130 Google Scholar