Prospective Evaluation of FibroScan for the Diagnosis of Hepatic Fibrosis Compared with Liver Biopsy/AST Platelet Ratio Index and FIB-4 in Patients with Chronic HBV Infection (original) (raw)

Abstract

Background

The FibroScan (FS), the aspartate aminotransferase-to-platelet ratio index (APRI), and the FIB-4 index are simple and inexpensive methods to detect liver fibrosis.

Aims

The primary objective was to evaluate the performance of FS for the noninvasive diagnosis of hepatic fibrosis in Western Chinese patients with chronic hepatitis B virus (HBV) infection compared with APRI and FIB-4; the secondary objective was to determine liver stiffness measurement (LSM) cutoff values for the noninvasive diagnosis of significant fibrosis and liver cirrhosis.

Methods

Overall, 175 consecutive patients with chronic HBV infection, successful liver biopsy, and alanine aminotransferase levels ≤2× ULN were prospectively studied. Liver fibrosis was graded by an independent pathologist using the METAVIR (_F_0–_F_4) classification. APRI and FIB-4 were calculated from laboratory data.

Results

The area under receiver operating characteristics curves (AUROC) for LSM for significant fibrosis (METAVIR _F_2–3) and cirrhosis (_F_4) was 0.95 (95% confidence interval, 0.91–0.98) and 0.98 (0.96–0.99), respectively. For the detection of significant fibrosis and cirrhosis, the AUROC of APRI were 0.81 (0.74–0.87) and 0.83 (0.77–0.90); the AUROC of FIB-4 were 0.86 (0.80–0.91) and 0.77 (0.68–0.85). FS optimal cutoff values for the identification of significant fibrosis and cirrhosis were 7.9 and 13.8 kPa, respectively.

Conclusions

FS is a reliable predictor of significant fibrosis and cirrhosis in Western Chinese patients with chronic HBV infection, and is superior to APRI and FIB-4. FS cutoff values could be considered as clinical reference for detecting significant fibrosis and cirrhosis**.**

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Acknowledgments

We wish to thank all patients who participated in the study. We also thank Prof. Li-Chun Wang and Bing-Jun Lei (Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China) who agreed to have their patients participate in this study. This work was financially supported by the National Key Technologies Research and Development Program of China during the 11th Five-Year Plan Period (No.2008ZX10002-006), National S&T Major Project for Infections Diseases Control (No.2009ZX10004-905), and the National Basic Research Program of China (No.2007CB512902).

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Authors and Affiliations

  1. Center of Infectious Diseases, West China Hospital of Sichuan University, No.37 Guo Xue Xiang, 610041, Wu Hou District, Chengdu, China
    Xia Zhu, Li-Chun Wang, En-Qiang Chen, Xue-Bing Chen, Li-Yu Chen, Li Liu, Xue-Zhong Lei, Cong Liu & Hong Tang
  2. Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, 610041, Chengdu, China
    Xia Zhu, Li-Chun Wang, En-Qiang Chen, Xue-Bing Chen, Li-Yu Chen, Li Liu, Xue-Zhong Lei, Cong Liu & Hong Tang

Authors

  1. Xia Zhu
  2. Li-Chun Wang
  3. En-Qiang Chen
  4. Xue-Bing Chen
  5. Li-Yu Chen
  6. Li Liu
  7. Xue-Zhong Lei
  8. Cong Liu
  9. Hong Tang

Corresponding author

Correspondence toHong Tang.

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Zhu, X., Wang, LC., Chen, EQ. et al. Prospective Evaluation of FibroScan for the Diagnosis of Hepatic Fibrosis Compared with Liver Biopsy/AST Platelet Ratio Index and FIB-4 in Patients with Chronic HBV Infection.Dig Dis Sci 56, 2742–2749 (2011). https://doi.org/10.1007/s10620-011-1659-1

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