- Younossi ZM, Loomba R, Rinella ME, et al. Current and future therapeutic regimens for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Hepatology (Baltimore, Md). 2018;68:361–371.
Article Google Scholar
- Musso G, Cassader M, Gambino R. Nonalcoholic steatohepatitis: emerging molecular targets and therapeutic strategies. Nat Rev Drug Discov. 2016;15:249–274.
Article CAS PubMed Google Scholar
- Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md). 2018;67:328–357.
Article Google Scholar
- Lavine JE, Schwimmer JB, Van Natta ML, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA. 2011;305:1659–1668.
Article CAS PubMed PubMed Central Google Scholar
- Lavine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr. 2000;136:734–738.
Article CAS PubMed Google Scholar
- Zingg JM. Vitamin E: a role in signal transduction. Annu Rev Nutr. 2015;35:135–173.
Article CAS PubMed Google Scholar
- Xu JS, Li YY, Chen WD, et al. Hepatic carboxylesterase 1 is essential for both normal and farnesoid x receptor-controlled lipid homeostasis. Hepatology (Baltimore, Md). 2014;59:1761–1771.
Article CAS Google Scholar
- Maruichi T, Fukami T, Nakajima M, Yokoi T. Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2). Biochem Pharmacol. 2010;79:288–295.
Article CAS PubMed Google Scholar
- Yilmaz Y. Review article: fructose in nonalcoholic fatty liver disease. Aliment Pharmacol Ther. 2012;35:1135–1144.
Article CAS PubMed Google Scholar
- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419.
Article CAS PubMed Google Scholar
- DeFilippis AP, Blaha MJ, Martin, et al. Nonalcoholic fatty liver disease and serum lipoproteins: the multi-ethnic study of atherosclerosis. Atherosclerosis. 2013;227:429–436.
Article CAS PubMed PubMed Central Google Scholar
- McCarty MF. High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes. Med Hypotheses. 1999;52:401–406.
Article CAS PubMed Google Scholar
- Alwahsh SM, Gebhardt R. Dietary fructose as a risk factor for nonalcoholic fatty liver disease (NAFLD). Archiv Toxicol. 2017;91:1545–1563.
Article CAS Google Scholar
- Ouyang X, Cirillo P, Sautin Y, et al. Fructose consumption as a risk factor for nonalcoholic fatty liver disease. J Hepatol. 2008;48:993–999.
Article CAS PubMed PubMed Central Google Scholar
- Lim JS, Mietus-Snyder M, Valente A, Schwarz JM, Lustig RH. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol. 2010;7:251–264.
Article CAS PubMed Google Scholar
- Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 2012;142:1592–1609.
Article PubMed Google Scholar
- Sato K, Gosho M, Yamamoto T, et al. Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Nutrition. 2015;31:923–930.
Article CAS PubMed Google Scholar
- Quiroga AD, Li LN, Trotzmuller M, et al. Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. Hepatology (Baltimore, Md). 2012;56:2188–2198.
Article CAS Google Scholar
- Xu J, Yin L, Xu Y, et al. Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. PLoS ONE. 2014;9:e109663.
Article CAS PubMed PubMed Central Google Scholar
- Zhao B, Song J, St Clair RW, Ghosh S. Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages. Am J Physiol Cell Physiol. 2007;292:C405–C412.
Article CAS PubMed Google Scholar
- Ghosh S, St Clair RW, Rudel LL. Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase. J Lipid Res. 2003;44:1833–1840.
Article CAS PubMed Google Scholar
- Li J, Wang Y, Matye DJ, et al. Sortilin 1 modulates hepatic cholesterol lipotoxicity in mice via functional interaction with liver carboxylesterase 1. J Biol Chem. 2017;292:146–160.
Article CAS PubMed Google Scholar
- Sapiro JM, Mashek MT, Greenberg AS, Mashek DG. Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity. J Lipid Res. 2009;50:1621–1629.
Article CAS PubMed PubMed Central Google Scholar
- Gonzalez FJ, Shah YM. PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology. 2008;246:2–8.
Article CAS PubMed Google Scholar
- Ip E, Farrell GC, Robertson G, Hall P, Kirsch R, Leclercq I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology (Baltimore, Md). 2003;38:123–132.
Article CAS Google Scholar
- Brown MS, Goldstein JL. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA. 1999;96:11041–11048.
Article CAS PubMed PubMed Central Google Scholar
- Foufelle F, Ferre P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J. 2002;366:377–391.
Article CAS PubMed PubMed Central Google Scholar
- Aldridge WN. The esterases: perspectives and problems. Chem Biol Interact. 1993;87:5–13.
Article CAS PubMed Google Scholar
- Brigelius-Flohe R. Vitamin E and drug metabolism. Biochem Biophys Res Commun. 2003;305:737–740.
Article CAS PubMed Google Scholar
- Shi D, Yang J, Yang D, Yan B. Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: evidence for an involvement of the glucocorticoid receptor. Toxicology. 2008;254:97–105.
Article CAS PubMed Google Scholar
- Xu JS, Xu Y, Li YY, et al. Carboxylesterase 1 is regulated by hepatocyte nuclear factor 4 alpha and protects against alcohol- and MCD diet-induced liver injury. Sci Rep. 2016;6:24277.
Article CAS PubMed PubMed Central Google Scholar
- Zhang Y, Cheng X, Aleksunes L, Klaassen CD. Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice. Drug Metab Dispos. 2012;40:1191–1197.
Article CAS PubMed PubMed Central Google Scholar
- Chen Y-T, Shi D, Yang D, Yan B. Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2. Biochem Pharmacol. 2012;84:864–871.
Article CAS PubMed PubMed Central Google Scholar