Phenotype of single hepatocytes expressing an activated version of β-catenin in liver of transgenic mice (original) (raw)

References

• Aydinlik H, Nguyen TD, Moennikes O, Buchmann A, Schwarz M (2001) Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene 20(53):7812–7816
  Article PubMed CAS Google Scholar
• Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C, Vasseur-Cognet M, Kuo CJ, Kahn A, Perret C, Colnot S (2006) Apc tumor suppressor gene is the “zonation-keeper” of mouse liver. Dev Cell 10(6):759–770
  Article PubMed CAS Google Scholar
• Borowiak M, Garratt AN, Wustefeld T, Strehle M, Trautwein C, Birchmeier C (2004) Met provides essential signals for liver regeneration. Proc Natl Acad Sci USA 101(29):10608–10613
  Article PubMed CAS Google Scholar
• Braeuning A (2009) Regulation of cytochrome p450 expression by ras- and Beta catenin-dependent signaling. Curr Drug Metab 10(2):138–158
  Article PubMed CAS Google Scholar
• Braeuning A, Schwarz M (2010) Beta-catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver. Biol Chem 391(2–3):139–148
  Article PubMed CAS Google Scholar
• Braeuning A, Sanna R, Huelsken J, Schwarz M (2009) Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. Drug Metab Dispos 37:1138–1145
  Article PubMed CAS Google Scholar
• Braeuning A, Singh Y, Rignall B, Buchmann A, Hammad S, Othman A, von Recklinghausen I, Godoy P, Hoehme S, Drasdo D, Hengstler JG, Schwarz M (2010) Phenotype and growth behavior of residual beta-catenin-positive hepatocytes in livers of beta-catenin-deficient mice. Histochem Cell Biol 134(5):469–481
  Article PubMed CAS Google Scholar
• Braeuning A, Kohle C, Buchmann A, Schwarz M (2011) Coordinate regulation of cytochrome P450 1A1 expression in mouse liver by the aryl hydrocarbon receptor and the {beta}-catenin pathway. Toxicol Sci 122(1):16–25
  Google Scholar
• Cadoret A, Ovejero C, Saadi-Kheddouci S, Souil E, Fabre M, Romagnolo B, Kahn A, Perret C (2001) Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin. Cancer Res 61(8):3245–3249
  PubMed CAS Google Scholar
• Cadoret A, Ovejero C, Terris B, Souil E, Levy L, Lamers WH, Kitajewski J, Kahn A, Perret C (2002) New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 21(54):8293–8301
  Article PubMed CAS Google Scholar
• Colnot S, Decaens T, Niwa-Kawakita M, Godard C, Hamard G, Kahn A, Giovannini M, Perret C (2004) Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci USA 101(49):17216–17221
  Article PubMed CAS Google Scholar
• Devereux TR, Anna CH, Foley JF, White CM, Sills RC, Barrett JC (1999) Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis. Oncogene 18(33):4726–4733
  Article PubMed CAS Google Scholar
• Gebhardt R (1988) Different proliferative activity in vitro of periportal and perivenous hepatocytes. Scand J Gastroenterol Suppl 151:8–18
  Article PubMed CAS Google Scholar
• Gebhardt R, Mecke D (1983) Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. EMBO J 2(4):567–570
  PubMed CAS Google Scholar
• Gebhardt R, Cruise J, Houck KA, Luetteke NC, Novotny A, Thaler F, Michalopoulos GK (1986) Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and—negative hepatocytes in primary culture. Differentiation 33(1):45–55
  Article PubMed CAS Google Scholar
• Giles RH, van Es JH, Clevers H (2003) Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653(1):1–24
  PubMed CAS Google Scholar
• Hailfinger S, Jaworski M, Braeuning A, Buchmann A, Schwarz M (2006) Zonal gene expression in murine liver: lessons from tumors. Hepatology 43(3):407–414
  Article PubMed CAS Google Scholar
• Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M, Taketo MM (2002) Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res 62(7):1971–1977
  PubMed CAS Google Scholar
• Hoehme S, Brulport M, Bauer A, Bedawy E, Schormann W, Hermes M, Puppe V, Gebhardt R, Zellmer S, Schwarz M, Bockamp E, Timmel T, Hengstler JG, Drasdo D (2010) Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration. Proc Natl Acad Sci USA 107(23):10371–10376
  Article PubMed CAS Google Scholar
• Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134(4):657–667
  Article PubMed CAS Google Scholar
• Loeppen S, Schneider D, Gaunitz F, Gebhardt R, Kurek R, Buchmann A, Schwarz M (2002) Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res 62(20):5685–5688
  PubMed CAS Google Scholar
• Loeppen S, Koehle C, Buchmann A, Schwarz M (2005) A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. Carcinogenesis 26:239–248
  Article PubMed CAS Google Scholar
• Marx-Stoelting P, Mahr J, Knorpp T, Schreiber S, Templin MF, Ott T, Buchmann A, Schwarz M (2008) Tumor promotion in liver of mice with a conditional Cx26 knockout. Toxicol Sci 103(2):260–267
  Article PubMed CAS Google Scholar
• Moennikes O, Buchmann A, Romualdi A, Ott T, Werringloer J, Willecke K, Schwarz M (2000) Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice. Cancer Res 60(18):5087–5091
  PubMed CAS Google Scholar
• Monga SP, Pediaditakis P, Mule K, Stolz DB, Michalopoulos GK (2001) Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology 33(5):1098–1109
  Article PubMed CAS Google Scholar
• Murata M, Miyoshi Y, Ohsawa M, Shibata K, Ohta T, Imai Y, Nishikawa M, Iwao K, Tateishi H, Shimano T, Kobayashi T, Nakamura Y (2001) Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis. Hepatol Res 21(2):126–135
  Article PubMed CAS Google Scholar
• Rignall B, Braeuning A, Buchmann A, Schwarz M (2011) Tumor formation in liver of conditional {beta}-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen. Carcinogenesis 32(1):52–57
  Article PubMed CAS Google Scholar
• Sekine S, Lan BYA, Bedolli M, Feng S, Hebrok M (2006) Liver-specific loss of ß-catenin blocks glutamine synthetis pathway activity and cytochrome P450 expression in mice. Hepatology 43:817–825
  Article PubMed CAS Google Scholar
• Sekine S, Gutierrez PJ, Lan BY, Feng S, Hebrok M (2007) Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. Hepatology 45(2):361–368
  Article PubMed CAS Google Scholar
• Tan X, Behari J, Cieply B, Michalopoulos GK, Monga SP (2006) Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 131(5):1561–1572
  Article PubMed CAS Google Scholar
• Ueberham E, Arendt E, Starke M, Bittner R, Gebhardt R (2004) Reduction and expansion of the glutamine synthetase expressing zone in livers from tetracycline controlled TGF-b1 transgenic mice and multiple starved mice. J Hepatol 41(1):75–81
  Article PubMed CAS Google Scholar
• Wachstein M, Meisel E (1957) Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. Am J Clin Pathol 27(1):13–23
  PubMed CAS Google Scholar
• Willert K, Nusse R (1998) Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 8(1):95–102
  Article PubMed CAS Google Scholar

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