Dimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis (original) (raw)

References

  1. Pinsky, M.R. 2004. Dysregulation of the immune response in severe sepsis. The American Journal of the Medical Sciences 328: 220–229.
    Article Google Scholar
  2. Fleischmann, C., A. Scherag, N.K. Adhikari, C.S. Hartog, T. Tsaganos, P. Schlattmann, D.C. Angus, K. Reinhart, and International Forum of Acute Care Trialists. 2016. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. American Journal of Respiratory and Critical Care Medicine 193: 259–272.
    Article CAS Google Scholar
  3. Qiu, P., Y. Liu, and J. Zhang. 2019. Review: The role and mechanisms of macrophage autophagy in sepsis. Inflammation 42: 6–19.
    Article CAS Google Scholar
  4. Evans, T.J. 1996. The role of macrophages in septic shock. Immunobiology 195: 655–659.
    Article CAS Google Scholar
  5. Kumar, V. 2018. Targeting macrophage immunometabolism: dawn in the darkness of sepsis. International Immunopharmacology 58: 173–185.
    Article CAS Google Scholar
  6. van der Poll, T., F.L. van de Veerdonk, B.P. Scicluna, and M.G. Netea. 2017. The immunopathology of sepsis and potential therapeutic targets. Nature Reviews. Immunology 17: 407–420.
    Article CAS Google Scholar
  7. Hooftman, A., and L.A.J. O’Neill. 2019. The immunomodulatory potential of the metabolite itaconate. Trends in Immunology 40: 687–698.
    Article CAS Google Scholar
  8. Mills, E.L., D.G. Ryan, H.A. Prag, D. Dikovskaya, D. Menon, Z. Zaslona, M.P. Jedrychowski, A.S.H. Costa, M. Higgins, E. Hams, J. Szpyt, M.C. Runtsch, M.S. King, J.F. McGouran, R. Fischer, B.M. Kessler, A.F. McGettrick, M.M. Hughes, R.G. Carroll, L.M. Booty, E.V. Knatko, P.J. Meakin, M.L.J. Ashford, L.K. Modis, G. Brunori, D.C. Sévin, P.G. Fallon, S.T. Caldwell, E.R.S. Kunji, E.T. Chouchani, C. Frezza, A.T. Dinkova-Kostova, R.C. Hartley, M.P. Murphy, and L.A. O’Neill. 2018. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556: 113–117.
    Article CAS Google Scholar
  9. Weischenfeldt J., Porse B. 2008. Bone marrow-derived macrophages (BMM): isolation and applications. CSH Protoc 2008:pdb prot5080.
  10. Zhao, Y.F., Y.M. Luo, W. Xiong, W. Ding, Y.R. Li, W. Zhao, H.Z. Zeng, H.C. Gao, and X.L. Wu. 2015. Mesenchymal stem cell-based FGF2 gene therapy for acute lung injury induced by lipopolysaccharide in mice. European Review for Medical and Pharmacological Sciences 19: 857–865.
    PubMed Google Scholar
  11. Lampropoulou, V., A. Sergushichev, M. Bambouskova, S. Nair, E.E. Vincent, E. Loginicheva, L. Cervantes-Barragan, X. Ma, S.C.C. Huang, T. Griss, C.J. Weinheimer, S. Khader, G.J. Randolph, E.J. Pearce, R.G. Jones, A. Diwan, M.S. Diamond, and M.N. Artyomov. 2016. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation. Cell Metabolism 24: 158–166.
    Article CAS Google Scholar
  12. O’Neill, L.A.J., and M.N. Artyomov. 2019. Itaconate: the poster child of metabolic reprogramming in macrophage function. Nature Reviews. Immunology 19: 273–281.
    Article CAS Google Scholar
  13. Iskander, K.N., M.F. Osuchowski, D.J. Stearns-Kurosawa, S. Kurosawa, D. Stepien, C. Valentine, and D.G. Remick. 2013. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiological Reviews 93: 1247–1288.
    Article CAS Google Scholar
  14. Huang, X., F. Venet, Y.L. Wang, A. Lepape, Z. Yuan, Y. Chen, R. Swan, H. Kherouf, G. Monneret, C.S. Chung, and A. Ayala. 2009. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proceedings of the National Academy of Sciences of the United States of America 106: 6303–6308.
    Article Google Scholar
  15. Banyer, J.L., N.H. Hamilton, I.A. Ramshaw, and A.J. Ramsay. 2000. Cytokines in innate and adaptive immunity. Reviews in Immunogenetics 2: 359–373.
    PubMed CAS Google Scholar
  16. Thimmulappa, R.K., H. Lee, T. Rangasamy, S.P. Reddy, M. Yamamoto, T.W. Kensler, and S. Biswal. 2006. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. The Journal of Clinical Investigation 116: 984–995.
    Article CAS Google Scholar
  17. McFadden, B.A., and S. Purohit. 1977. Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera. Journal of Bacteriology 131: 136–144.
    Article CAS Google Scholar
  18. Rittenhouse, J.W., and B.A. McFadden. 1974. Inhibition of isocitrate lyase from Pseudomonas indigofera by itaconate. Archives of Biochemistry and Biophysics 163: 79–86.
    Article CAS Google Scholar
  19. Bambouskova, M., L. Gorvel, V. Lampropoulou, A. Sergushichev, E. Loginicheva, K. Johnson, D. Korenfeld, M.E. Mathyer, H. Kim, L.H. Huang, D. Duncan, H. Bregman, A. Keskin, A. Santeford, R.S. Apte, R. Sehgal, B. Johnson, G.K. Amarasinghe, M.P. Soares, T. Satoh, S. Akira, T. Hai, C. de Guzman Strong, K. Auclair, T.P. Roddy, S.A. Biller, M. Jovanovic, E. Klechevsky, K.M. Stewart, G.J. Randolph, and M.N. Artyomov. 2018. Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis. Nature 556: 501–504.
    Article CAS Google Scholar
  20. Thimmulappa, R.K., K.H. Mai, S. Srisuma, T.W. Kensler, M. Yamamoto, and S. Biswal. 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Research 62: 5196–5203.
    PubMed CAS Google Scholar

Download references