Multifaceted Roles of Integrins in Breast Cancer Metastasis (original) (raw)

• Guarneri V, Conte PF. The curability of breast cancer and the treatment of advanced disease. Eur J Nucl Med Mol Imaging 2004; 31(Suppl 1):S1 49–61.
  Article PubMed Google Scholar
• Demicheli R, Terenziani M, Valagussa P, Moliterni A, Zambetti M, Bonadonna G. Local recurrences following mastectomy: support for the concept of tumor dormancy. J Natl Cancer Inst 1994; 86(1): 45–8.
  Article PubMed CAS Google Scholar
• Karrison TG, Ferguson DJ, Meier P. Dormancy of mammary carcinoma after mastectomy. J Natl Cancer Inst 1999; 91(1): 80–5.
  Article PubMed CAS Google Scholar
• Fidler IJ. Critical determinants of metastasis. Semin Cancer Biol 2002; 12(2): 89–96.
  Article PubMed Google Scholar
• Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002; 2(8): 563–72.
  Article PubMed CAS Google Scholar
• Taddei I, Faraldo MM, Teuliere J, Deugnier MA, Thiery JP, Glukhova MA. Integrins in mammary gland development and differentiation of mammary epithelium. J Mammary Gland Biol Neoplasia 2003; 8(4): 383–94.
  Article PubMed Google Scholar
• Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, et al. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006; 126(3): 489–502.
  Article PubMed CAS Google Scholar
• White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, et al. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 2004; 6(2): 159–70.
  Article PubMed CAS Google Scholar
• Moro L, Venturino M, Bozzo C, Silengo L, Altruda F, Beguinot L, et al. Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J 1998; 17(22): 6622–32.
  Article PubMed CAS Google Scholar
• Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, et al. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci USA 1998; 95(25): 14821–6.
  Article CAS Google Scholar
• Miyamoto S, Teramoto H, Gutkind JS, Yamada KM. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol 1996; 135(6 Pt 1): 1633–42.
  Article PubMed CAS Google Scholar
• Gambaletta D, Marchetti A, Benedetti L, Mercurio AM, Sacchi A, Falcioni R. Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. J Biol Chem 2000; 275(14): 10604–10.
  Article PubMed CAS Google Scholar
• Yoon SO, Shin S, Lipscomb EA. A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling. Cancer Res 2006; 66(5): 2732–9.
  Article PubMed CAS Google Scholar
• Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, et al. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol 2004; 24(19): 8586–99.
  Article PubMed CAS Google Scholar
• Miranti CK, Brugge JS. Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 2002; 4(4): E83–90.
  Article PubMed CAS Google Scholar
• Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, et al. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 1997; 137(1): 231–45.
  Article PubMed CAS Google Scholar
• Guy CT, Muthuswamy SK, Cardiff RD, Soriano P, Muller WJ. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev 1994; 8(1): 23–32.
  Article PubMed CAS Google Scholar
• McLean GW, Brown K, Arbuckle MI, Wyke AW, Pikkarainen T, Ruoslahti E, et al. Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis. Cancer Res 2001; 61(23): 8385–9.
  PubMed CAS Google Scholar
• White DE, Cardiff RD, Dedhar S, Muller WJ. Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 2001; 20(48): 7064–72.
  Article PubMed CAS Google Scholar
• Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, et al. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 1996; 379(6560): 91–6.
  Article PubMed CAS Google Scholar
• Elliott BE, Ekblom P, Pross H, Niemann A, Rubin K. Anti-beta 1 integrin IgG inhibits pulmonary macrometastasis and the size of micrometastases from a murine mammary carcinoma. Cell Adhes Commun 1994; 1(4): 319–32.
  PubMed CAS Google Scholar
• Khalili P, Arakelian A, Chen G, Plunkett ML, Beck I, Parry GC, et al. A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol Cancer Ther 2006; 5(9): 2271–80.
  Article PubMed CAS Google Scholar
• Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, Deryugina EI, et al. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 2003; 160(2): 267–77.
  Article PubMed CAS Google Scholar
• Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, et al. Cell migration: integrating signals from front to back. Science 2003; 302(5651): 1704–9.
  Article PubMed CAS Google Scholar
• Ridley AJ. Rho GTPases and cell migration. J Cell Sci 2001; 114(Pt 15): 2713–22.
  PubMed CAS Google Scholar
• Giannone G, Dubin-Thaler BJ, Dobereiner HG, Kieffer N, Bresnick AR, Sheetz MP. Periodic lamellipodial contractions correlate with rearward actin waves. Cell 2004; 116(3): 431–43.
  Article PubMed CAS Google Scholar
• Adelsman MA, McCarthy JB, Shimizu Y. Stimulation of beta 1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase. Mol Biol Cell 1999; 10(9): 2861–78.
  PubMed CAS Google Scholar
• Trusolino L, Bertotti A, Comoglio PM. A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell 2001; 107(5): 643–54.
  Article PubMed CAS Google Scholar
• McCawley LJ, Matrisian LM. Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today 2000; 6(4): 149–56.
  Article PubMed CAS Google Scholar
• Brooks PC, Stromblad S, Sanders LC, von Schalscha TL, Aimes RT, Stetler-Stevenson WG, et al. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 1996; 85(5): 683–93.
  Article PubMed CAS Google Scholar
• Morini M, Mottolese M, Ferrari N, Ghiorzo F, Buglioni S, Mortarini R, et al. The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity. Int J Cancer 2000; 87(3): 336–42.
  Article PubMed CAS Google Scholar
• Brunhilde FH, Emilia F, Timothy EOT, Lisa M, Barbara F, Mary H. Involvement of tumor cell integrin αvβ3 in hematogenous metastasis of human melanoma cells. Clin Exp Metastasis 2002; 19(5): 427–36.
  Article Google Scholar
• Hofmann UB, Westphal JR, Waas ET, Becker JC, Ruiter DJ, van Muijen GN. Coexpression of integrin alpha(v)beta3 and matrix metalloproteinase-2 (MMP-2) coincides with MMP-2 activation: correlation with melanoma progression. J Invest Dermatol 2000; 115(4): 625–32.
  Article PubMed CAS Google Scholar
• Hofmann UB, Westphal JR, Van Kraats AA, Ruiter DJ, Van Muijen GN. Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo. Int J Cancer 2000; 87(1): 12–9.
  Article PubMed CAS Google Scholar
• Baum O, Hlushchuk R, Forster A, Greiner R, Clezardin P, Zhao Y, et al. Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the beta3 integrin subunit. Int J Oncol 2007; 30(2): 325–32.
  PubMed CAS Google Scholar
• Furger KA, Allan AL, Wilson SM, Hota C, Vantyghem SA, Postenka CO, et al. {beta}3 Integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin. Mol Cancer Res 2003; 1(11): 810–19.
  PubMed CAS Google Scholar
• Tuck AB, Elliott BE, Hota C, Tremblay E, Chambers AF. Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met). J Cell Biochem 2000; 78(3): 465–75.
  Article PubMed CAS Google Scholar
• Tuck AB, Arsenault DM, O’Malley FP, Hota C, Ling MC, Wilson SM, et al. Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells. Oncogene 1999; 18(29): 4237–46.
  Article PubMed CAS Google Scholar
• Ellis V, Pyke C, Eriksen J, Solberg H, Dano K. The urokinase receptor: involvement in cell surface proteolysis and cancer invasion. Ann N Y Acad Sci 1992; 667: 13–31.
  Article PubMed CAS Google Scholar
• Tarui T, Andronicos N, Czekay RP, Mazar AP, Bdeir K, Parry GC, et al. Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling. J Biol Chem 2003; 278(32): 29863–72.
  Article PubMed CAS Google Scholar
• Aguirre-Ghiso JA, Liu D, Mignatti A, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 2001; 12(4): 863–79.
  PubMed CAS Google Scholar
• Sturge J, Hamelin J, Jones GE. N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. J Cell Sci 2002; 115(Pt 4): 699–711.
  PubMed CAS Google Scholar
• Deryugina EI, Ratnikov B, Monosov E, Postnova TI, DiScipio R, Smith JW, et al. MT1-MMP initiates activation of pro-MMP-2 and integrin [alpha]v[beta]3 promotes maturation of MMP-2 in breast carcinoma cells. Exp Cell Res 2001; 263(2): 209–23.
  Article PubMed CAS Google Scholar
• Mueller SC, Ghersi G, Akiyama SK, Sang QX, Howard L, Pineiro-Sanchez M, et al. A novel protease-docking function of integrin at invadopodia. J Biol Chem 1999; 274(35): 24947–52.
  Article PubMed CAS Google Scholar
• Nakahara H, Otani T, Sasaki T, Miura Y, Takai Y, Kogo M. Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells. Genes Cells 2003; 8(12): 1019–27.
  Article PubMed CAS Google Scholar
• Hauck CR, Hsia DA, Ilic D, Schlaepfer DD. v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion. J Biol Chem 2002; 277(15): 12487–90.
  Article PubMed CAS Google Scholar
• Mi Z, Guo H, Wai PY, Gao C, Kuo PC. Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Carcinogenesis 2006; 27(6): 1134–45.
  Article PubMed CAS Google Scholar
• Aguirre-Ghiso JA. The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities. Cell Cycle 2006; 5(16): 1740–3.
  PubMed CAS Google Scholar
• Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86(3): 353–64.
  Article PubMed CAS Google Scholar
• Li CY, Shan S, Cao Y, Dewhirst MW. Role of incipient angiogenesis in cancer metastasis. Cancer Metastasis Rev 2000; 19(1–2): 7–11.
  Article PubMed CAS Google Scholar
• Indraccolo S, Favaro E, Amadori A. Dormant tumors awaken by a short-term angiogenic burst: the spike hypothesis. Cell Cycle 2006; 5(16): 1751–5.
  PubMed CAS Google Scholar
• Goodison S, Kawai K, Hihara J, Jiang P, Yang M, Urquidi V, et al. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein. Clin Cancer Res 2003; 9(10 Pt 1): 3808–14.
  PubMed CAS Google Scholar
• Naumov GN, MacDonald IC, Weinmeister PM, Kerkvliet N, Nadkarni KV, Wilson SM, et al. Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res 2002; 62(7): 2162–8.
  PubMed CAS Google Scholar
• Aguirre Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999; 147(1): 89–104.
  Article PubMed CAS Google Scholar
• Aguirre Ghiso JA. Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo. Oncogene 2002; 21(16): 2513–24.
  Article PubMed Google Scholar
• Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 2002; 1(5): 445–57.
  Article PubMed CAS Google Scholar
• Lahti JM, Teitz T, Stupack DG. Does integrin-mediated cell death confer tissue tropism in metastasis? Cancer Res 2006; 66(12): 5981–4.
  Article PubMed CAS Google Scholar
• Sloan EK, Pouliot N, Stanley KL, Chia J, Moseley JM, Hards DK, et al. Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res 2006; 8(2): R20.
  Article PubMed Google Scholar
• Liapis H, Flath A, Kitazawa S. Integrin alpha V beta 3 expression by bone-residing breast cancer metastases. Diagn Mol Pathol 1996; 5(2): 127–35.
  Article PubMed CAS Google Scholar
• Riisbro R, Christensen IJ, Piironen T, Greenall M, Larsen B, Stephens RW, et al. Prognostic significance of soluble urokinase plasminogen activator receptor in serum and cytosol of tumor tissue from patients with primary breast cancer. Clin Cancer Res 2002; 8(5): 1132–41.
  PubMed Google Scholar
• Sier CF, Sidenius N, Mariani A, Aletti G, Agape V, Ferrari A, et al. Presence of urokinase-type plasminogen activator receptor in urine of cancer patients and its possible clinical relevance. Lab Invest 1999; 79(6): 717–22.
  PubMed CAS Google Scholar
• Labat-Robert J. Cell-matrix interactions, alteration with aging and age associated diseases. A review. Pathol Biol 2001; 49(4): 349–52.
  Article PubMed CAS Google Scholar
• Labat-Robert J. Fibronectin in malignancy. Semin Cancer Biol 2002; 12(3): 187–95.
  Article PubMed CAS Google Scholar
• Weaver VM, Lelievre S, Lakins JN, Chrenek MA, Jones JCR, Giancotti F, et al. [beta]4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2002; 2(3): 205–16.
  Article PubMed CAS Google Scholar