Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier (original) (raw)

References

  1. Krimbou L, Denis M, Haidar B, Carrier M, Marcil M, Genest J Jr (2004) Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J Lipid Res 45(5):839–848
    Article PubMed CAS Google Scholar
  2. Klaassen CD, Aleksunes LM (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev 62(1):1–96
    Article PubMed CAS Google Scholar
  3. Wellington CL, Walker EK, Suarez A, Kwok A, Bissada N, Singaraja R, Yang YZ, Zhang LH, James E, Wilson JE, Francone O, McManus BM, Hayden MR (2002) ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation. Lab Invest 82(3):273–283
    Article PubMed CAS Google Scholar
  4. Karasinska JM, Rinninger F, Lutjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR (2009) Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci 29(11):3579–3589
    Article PubMed CAS Google Scholar
  5. Ohtsuki S, Watanabe Y, Hori S, Suzuki H, Bhongsatiern J, Fujiyoshi M, Kamoi M, Kamiya N, Takanaga H, Terasaki T (2004) mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells. Biol Pharm Bull 27(9):1437–1440
    Article PubMed CAS Google Scholar
  6. Dutheil F, Jacob A, Dauchy S, Beaune P, Scherrmann JM, Decleves X, Loriot MA (2010) ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders. Expert Opin Drug Metab Toxicol 6(10):1161–1174
    Article PubMed CAS Google Scholar
  7. Nicolazzo JA, Katneni K (2009) Drug transport across the blood–brain barrier and the impact of breast cancer resistance protein (ABCG2). Curr Top Med Chem 9(2):130–147
    Article PubMed CAS Google Scholar
  8. Ueno M, Nakagawa T, Wu B, Onodera M, Huang CL, Kusaka T, Araki N, Sakamoto H (2010) Transporters in the brain endothelial barrier. Curr Med Chem 17(12):1125–1138
    Article PubMed CAS Google Scholar
  9. Urquhart BL, Kim RB (2009) Blood–brain barrier transporters and response to CNS-active drugs. Eur J Clin Pharmacol 65(11):1063–1070
    Article PubMed CAS Google Scholar
  10. Burns MP, Vardanian L, Pajoohesh-Ganji A, Wang L, Cooper M, Harris DC, Duff K, Rebeck GW (2006) The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem 98(3):792–800
    Article PubMed CAS Google Scholar
  11. Koldamova R, Fitz NF, Lefterov I (2010) The role of ATP-binding cassette transporter A1 in Alzheimer’s disease and neurodegeneration. Biochim Biophys Acta 1801(8):824–830
    PubMed CAS Google Scholar
  12. Kim WS, Bhatia S, Elliott DA, Agholme L, Kagedal K, McCann H, Halliday GM, Barnham KJ, Garner B (2010) Increased ATP-binding cassette transporter A1 expression in Alzheimer’s disease hippocampal neurons. J Alzheimers Dis 21(1):193–205
    PubMed CAS Google Scholar
  13. Xiong H, Callaghan D, Jones A, Walker DG, Lue LF, Beach TG, Sue LI, Woulfe J, Xu H, Stanimirovic DB, Zhang W (2008) Cholesterol retention in Alzheimer’s brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol Dis 29(3):422–437
    Article PubMed CAS Google Scholar
  14. Grimm MO, Grimm HS, Tomic I, Beyreuther K, Hartmann T, Bergmann C (2008) Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels. J Biol Chem 283(17):11302–11311
    Article PubMed CAS Google Scholar
  15. Favari E, Zanotti I, Zimetti F, Ronda N, Bernini F, Rothblat GH (2004) Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol 24(12):2345–2350
    Article PubMed CAS Google Scholar
  16. McNeish J, Aiello RJ, Guyot D, Turi T, Gabel C, Aldinger C, Hoppe KL, Roach ML, Royer LJ, de Wet J, Broccardo C, Chimini G, Francone OL (2000) High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc Natl Acad Sci U S A 97(8):4245–4250
    Article PubMed CAS Google Scholar
  17. Triguero D, Buciak J, Pardridge WM (1990) Capillary depletion method for quantification of blood–brain barrier transport of circulating peptides and plasma proteins. J Neurochem 54(6):1882–1888
    Article PubMed CAS Google Scholar
  18. Rousselle C, Clair P, Lefauconnier JM, Kaczorek M, Scherrmann JM, Temsamani J (2000) New advances in the transport of doxorubicin through the blood–brain barrier by a peptide vector-mediated strategy. Mol Pharmacol 57(4):679–686
    PubMed CAS Google Scholar
  19. Dallaire L, Tremblay L, Beliveau R (1991) Purification and characterization of metabolically active capillaries of the blood–brain barrier. Biochem J 276(Pt 3):745–752
    PubMed Google Scholar
  20. Gebhardt FM, Scott HA, Dodd PR (2010) Housekeepers for accurate transcript expression analysis in Alzheimer’s disease autopsy brain tissue. Alzheimers Dement 6(6):465–474
    Article PubMed CAS Google Scholar
  21. Weickert CS, Sheedy D, Rothmond DA, Dedova I, Fung S, Garrick T, Wong J, Harding AJ, Sivagnanansundaram S, Hunt C, Duncan C, Sundqvist N, Tsai SY, Anand J, Draganic D, Harper C (2010) Selection of reference gene expression in a schizophrenia brain cohort. Aust N Z J Psychiatry 44(1):59–70
    Article PubMed Google Scholar
  22. Kim WS, Guillemin GJ, Glaros EN, Lim CK, Garner B (2006) Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Neuroreport 17(9):891–896
    Article PubMed CAS Google Scholar
  23. Su YR, Linton MF, Fazio S (2002) Rapid quantification of murine ABC mRNAs by real time reverse transcriptase-polymerase chain reaction. J Lipid Res 43(12):2180–2187
    Article PubMed CAS Google Scholar
  24. Milane A, Fernandez C, Vautier S, Bensimon G, Meininger V, Farinotti R (2007) Minocycline and riluzole brain disposition: interactions with p-glycoprotein at the blood–brain barrier. J Neurochem 103(1):164–173
    PubMed CAS Google Scholar
  25. Dagenais C, Rousselle C, Pollack GM, Scherrmann JM (2000) Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice. J Cereb Blood Flow Metab 20(2):381–386
    Article PubMed CAS Google Scholar
  26. Zhao R, Kalvass JC, Pollack GM (2009) Assessment of blood–brain barrier permeability using the in situ mouse brain perfusion technique. Pharm Res 26(7):1657–1664
    Article PubMed CAS Google Scholar
  27. Takasato Y, Rapoport SI, Smith QR (1984) An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 247(3 Pt 2):H484–H493
    PubMed CAS Google Scholar
  28. Janvilisri T, Venter H, Shahi S, Reuter G, Balakrishnan L, van Veen HW (2003) Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem 278(23):20645–20651
    Article PubMed CAS Google Scholar
  29. Koshiba S, An R, Saito H, Wakabayashi K, Tamura A, Ishikawa T (2008) Human ABC transporters ABCG2 (BCRP) and ABCG4. Xenobiotica 38(7–8):863–888
    Article PubMed CAS Google Scholar
  30. Le Goff W, Settle M, Greene DJ, Morton RE, Smith JD (2006) Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis. J Lipid Res 47(1):51–58
    Article PubMed CAS Google Scholar
  31. Gosselet F, Candela P, Sevin E, Berezowski V, Cecchelli R, Fenart L (2009) Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: use of an in vitro model. Brain Res 1249:34–42
    Article PubMed CAS Google Scholar
  32. Panzenboeck U, Balazs Z, Sovic A, Hrzenjak A, Levak-Frank S, Wintersperger A, Malle E, Sattler W (2002) ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood–brain barrier constituted of porcine brain capillary endothelial cells. J Biol Chem 277(45):42781–42789
    Article PubMed CAS Google Scholar
  33. Cisternino S, Mercier C, Bourasset F, Roux F, Scherrmann JM (2004) Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood–brain barrier. Cancer Res 64(9):3296–3301
    Article PubMed CAS Google Scholar
  34. Warren MS, Zerangue N, Woodford K, Roberts LM, Tate EH, Feng B, Li C, Feuerstein TJ, Gibbs J, Smith B, de Morais SM, Dower WJ, Koller KJ (2009) Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacol Res 59(6):404–413
    Article PubMed CAS Google Scholar
  35. Pardridge WM, Mietus LJ (1980) Palmitate and cholesterol transport through the blood–brain barrier. J Neurochem 34(2):463–466
    Article PubMed CAS Google Scholar
  36. Jurevics H, Morell P (1995) Cholesterol for synthesis of myelin is made locally, not imported into brain. J Neurochem 64(2):895–901
    Article PubMed CAS Google Scholar
  37. Lutjohann D, Breuer O, Ahlborg G, Nennesmo I, Siden A, Diczfalusy U, Bjorkhem I (1996) Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci USA 93(18):9799–9804
    Article PubMed CAS Google Scholar
  38. Ohtsuki S, Ito S, Matsuda A, Hori S, Abe T, Terasaki T (2007) Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood–brain barrier. J Neurochem 103(4):1430–1438
    Article PubMed CAS Google Scholar
  39. Xie C, Lund EG, Turley SD, Russell DW, Dietschy JM (2003) Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J Lipid Res 44(9):1780–1789
    Article PubMed CAS Google Scholar
  40. Cisternino S, Rousselle C, Lorico A, Rappa G, Scherrmann JM (2003) Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood–brain barrier endothelial cells. Pharm Res 20(6):904–909
    Article PubMed CAS Google Scholar
  41. Cattelotte J, Andre P, Ouellet M, Bourasset F, Scherrmann JM, Cisternino S (2008) In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain. J Cereb Blood Flow Metab 28(8):1449–1459
    Article PubMed Google Scholar
  42. Taylor JM, Borthwick F, Bartholomew C, Graham A (2010) Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. Cardiovasc Res 86(3):526–534
    Article PubMed CAS Google Scholar

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