Progression of O6-methylguanine-DNA methyltransferase and temozolomide resistance in cancer research (original) (raw)
Guo J, Cui Q, Jiang W et al (2013) Research on DNA methylation of human osteosarcoma cell MGMT and its relationship with cell resistance to alkylating agents. Biochem Cell Biol 91:209–213 ArticleCASPubMed Google Scholar
Rhee DJ, Kong DS, Kim WS et al (2005) Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomas. Clin Neurol Neurosurg 111:748–751 Article Google Scholar
Kaina B, Margison GP, Christmann M (2010) Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy. Cell Mol Life Sci 67:3663–3681 ArticleCASPubMed Google Scholar
Hegi ME, Diserens A-C, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997–1003 ArticleCASPubMed Google Scholar
Zhang J, Stevens MF, Bradshaw TD (2012) Temozolomide: mechanisms of action, repair and resistance. Curr Mol Pharmacol 5:102–114 ArticleCASPubMed Google Scholar
Turriziani M, Caporaso P, Bonmassar L et al (2006) O6-(4-bromothenyl) guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro. Pharmacol Res 53:317–323 ArticleCASPubMed Google Scholar
Kreinecker SS, Pirker C, Filipits M et al (2010) O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients. Neuro Oncol 12:28–36 Article Google Scholar
Buttarelli FR, Massimino M, Antonelli M et al (2010) Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas. Childs Nerv Syst 26:1051–1056 ArticlePubMed Google Scholar
Middleton MR, Grob JJ, Aaronson N et al (2000) Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol 18:158–166 CASPubMed Google Scholar
Gerson SL (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Nat Rev Cancer 4:296–307 ArticleCASPubMed Google Scholar
Harris LC, Potter PM, Tono K et al (1991) Characterization of the promoter region of the human O6-methylguanine-DNA mehthyltransferase gene. Nucleic Acids Res 19:6163 ArticlePubMed CentralCASPubMed Google Scholar
Chen FY, Harris LC, Remack JS et al (1997) Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells. Proc Natl Acad Sci USA 94:4348–4353 ArticlePubMed CentralCASPubMed Google Scholar
Fritz G, Tano K, Mitra S et al (1991) Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments. Mol Cell Biol 11:4660–4668 PubMed CentralCASPubMed Google Scholar
Karran P (2001) Mechanisms of tolerance to DNA damaging therapeutic drugs. Carcinogenesis 22:1931–1937 ArticleCASPubMed Google Scholar
Middleton MR, Margison GP (2003) Improvement of chemotherapy efficiency by inactivation of a DNA repair pathway. Lancet Oncol 4:37–44 ArticleCASPubMed Google Scholar
Quillien V, Vauléon E, Saikali S et al (2011) MGMT analysis in gliomas. Bull Cancer 98:291–303 CASPubMed Google Scholar
Matsukura S, Miyazaki K, Yakushiji H et al (2003) Combined loss of O6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma. J Surg Oncol 82:194–200 ArticleCASPubMed Google Scholar
Watanabe R, Nakasu Y, Tashiro H et al (2011) O6-methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma. Brain Tumor Pathol 28:127–135 ArticleCASPubMed Google Scholar
Kuo LT, Kuo KT, Lee MJ et al (2009) Correlation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors. Int J Cancer 124:2872–2879 ArticleCASPubMed Google Scholar
Challouf S, Ziadi S, Zaghdoudi R et al (2012) Patterns of aberrant DNA hypermethylation in nasopharyngeal carcinoma in Tunisian patients. Clin Chim Acta 413:795–802 ArticleCASPubMed Google Scholar
Tuononen K, Tynninen O, Sarhadi VK et al (2012) The hypermethylation of the O6-methylguanine-DNA methyltransferase gene promoter in gliomas–correlation with array comparative genome hybridization results and IDH1 mutation. Genes Chromosom Cancer 51:20–29 ArticleCASPubMed Google Scholar
Huang SH, Lee HS, Mar K et al (2010) Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:883–889 ArticlePubMed Google Scholar
Kuester D, El-Rifai W, Peng D et al (2009) Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barrett’s esophagus. Cancer Lett 275:117–126 ArticlePubMed CentralCASPubMed Google Scholar
Chan AO, Broaddus RR, Houlihan PS et al (2002) CpG island methylation in aberrant crypt foci of the colorectum. Am J Pathol 160:1823–1830 ArticlePubMed CentralCASPubMed Google Scholar
van Nifterik KA, van den Berg J, van der Meide WF et al (2010) Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide. Br J Cancer 103:29–35 ArticlePubMed CentralPubMed Google Scholar
Amatu A, Sartore-Bianchi A, Moutinho C et al (2013) Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer. Clin Cancer Res 19:2265–2272 ArticleCASPubMed Google Scholar
Newlands ES, Stevens MF, Wedge SR et al (1997) Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treat Rev 23:35–61 ArticleCASPubMed Google Scholar
Liu L, Markowitz S, Gerson SL (1996) Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res 56:5375–5379 CASPubMed Google Scholar
Alvino E, Castiglia D, Caporali S et al (2006) A single cycle of treatment with temozolomide, alone or combined with O6-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro:role of O6-methylguanine-DNA methyltransferase and the mismatch repair system. Int J Oncol 29:785–797 CASPubMed Google Scholar
Pagani E, Falcinelli S, Pepponi R et al (2007) Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O6-methylguanine-DNA methyltransferase activity. Int J Oncol 30:443–451 CASPubMed Google Scholar
Hansen WK, Kelley MR (2000) Review of mammalian DNA repair and translational implications. J Pharmacol Exp Ther 295:1–9 CASPubMed Google Scholar
Augustine CK, Yoo JS, Potti A, Yoshimoto Y et al (2009) Genomic and molecular profiling predicts response to temozolomide in melanoma. Clin Cancer Res 15:502–510 ArticleCASPubMed Google Scholar
Sasai K, Akagi T, Aoyanagi E et al (2007) O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells:implications for anti-glioma therapies. Mol Cancer 6:36 ArticlePubMed CentralPubMed Google Scholar
Malley DS, Hamoudi RA, Ko cialkowski S et al (2011) A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts. Acta Neuropathol 121:651–661 ArticleCASPubMed Google Scholar
Ramakrishnan V, Kushwaha D, Koay DC et al (2011) Post-transcriptional regulation of O6-methylguanine-DNA methyltransferase MGMT in glioblastomas. Cancer Biomark 10:185–193 CASPubMed Google Scholar
Taspinar M, Ilgaz S, Ozdemir M et al (2013) Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells. Tumour Biol 34:1935–1947 ArticleCASPubMed Google Scholar
Watson AJ, Middleton MR, McGown G et al (2009) O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib. Br J Cancer 100:1250–1256 ArticlePubMed CentralCASPubMed Google Scholar
Watson AJ, Sabharwal A, Thorncroft M et al (2010) Tumor O6-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. Clin Cancer Res 16:743–749 ArticlePubMed CentralCASPubMed Google Scholar
Quinn JA, Desjardins A, Weingart J et al (2005) Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol 23:7178–7187 ArticleCASPubMed Google Scholar
Osanai T, Takagi Y, Toriya Y et al (2005) Inverse correlation between the expression of O6-methylguanine-DNA methyltransferase (MGMT) and p53 in breast cancer. Jpn J Clin Oncol 35:121–125 ArticlePubMed Google Scholar
Liu Y, Wang J, Zhang H et al (2010) The expression of O6-methylguanine DNA methyltransferase and p53 in non-small cell lung cancer and the association with the prognosis. Zhonghua Jie He He Hu Xi Za Zhi 33:427–431 PubMed Google Scholar
Lotfi M, Afsharnezhad S, Raziee HR et al (2011) Immunohistochemical assessment of MGMT expression and p53 mutation in glioblastoma multiforme. Tumori 97:104–108 PubMed Google Scholar
Blough MD, Zlatescu MC, Cairncross JG (2007) O6-methylguanine-DNA methyltransferase regulation by p53 in Astrocytic Cells. Cancer Res 67:580–584 ArticleCASPubMed Google Scholar
Srivenugopal KS, Shou J, Mullapudi SR et al (2001) Enforced expression of wild-type p53 curtails the transcription of the O6-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. Clin Cancer Res 7:1398–1409 CASPubMed Google Scholar
Bobustuc GC, Baker CH, Limaye A et al (2010) Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide. Neuro Oncol 12:917–927 ArticlePubMed CentralCASPubMed Google Scholar
Vannucchi S, Chiantore MV, Mangino G et al (2007) Perspectives in biomolecular therapeutic intervention in cancer: from the early to the new strategies with type I interferons. Curr Med Chem 14:667–679 ArticleCASPubMed Google Scholar
Rosati SF, Williams RF, Nunnally LC et al (2008) IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression. Mol Cancer Ther 7:3852–3858 ArticlePubMed CentralCASPubMed Google Scholar
Motomura K, Natsume A, Kishida Y et al (2011) Benefits of interferon-beta and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: a multicenter study. Cancer 17:1721–1730 Article Google Scholar
Jiang G, Liu YQ, Wei ZP et al (2010) Enhanced anti-tumor activity by the combination of a conditionally replicating adenovirus mediated interleukin-24 and dacarbazine against melanoma cells via induction of apoptosis. Cancer Lett 294:220–228 ArticleCASPubMed Google Scholar
Kaliberova LN, Krendelchtchikova V, Harmon DK et al (2009) CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma. Cancer Gene Ther 16:794–805 ArticlePubMed CentralCASPubMed Google Scholar
Alonso MM, Gomez-Manzano C, Bekele BN et al (2007) Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter. Cancer Res 67:11499–11504 ArticleCASPubMed Google Scholar
Jiang G, Xin Y, Zheng JN et al (2011) Combining conditionally replicating adenovirus-mediated gene therapy with chemotherapy: a novel antitumor approach. Int J Cancer 129:263–274 ArticleCASPubMed Google Scholar
Yang WQ, Zhang Y (2012) RNAi- mediated gene silencing in cancer therapy. Expert Opin Biol Ther 12:1495–1504 ArticleCASPubMed Google Scholar
Kuo CC, Liu JF, Chang JY (2006) DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors. J Pharmacol Exp Ther 316:946–954 ArticleCASPubMed Google Scholar
Kato T, Natsume A, Toda H et al (2010) Efficient delivery of liposome-mediated _MGMT_-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells. Gene Ther 17:1363–1371 ArticleCASPubMed Google Scholar
Zheng JN, Pei DS, Mao LJ et al (2009) Inhibition of renal cancer cell growth in vitro and in vivo with oncolytic adenovirus armed short hairpin RNA targeting Ki-67 encoding mRNA. Cancer Gene Ther 16:20–32 ArticleCASPubMed Google Scholar
Zheng JN, Pei DS, Sun FH et al (2009) Inhibition of renal cancer cell growth by oncolytic adenovirus armed short hairpin RNA targeting hTERT gene. Cancer Biol Ther 8:84–91 ArticleCASPubMed Google Scholar
Bobola MS, Kolstoe DD, Blank A et al (2010) Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression. Mol Cancer Ther 9:1208–1218 ArticlePubMed CentralCASPubMed Google Scholar
Jiang G, Li LT, Xin Y et al (2012) Strategy for reversing resistance to temozolomide in malignant melanoma. Curr Med Chem 19:3886–3892 ArticleCASPubMed Google Scholar
Ranson M, Middleton MR, Bridgewater J et al (2006) Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 12:1577–1584 ArticleCASPubMed Google Scholar
Friedman HS, Pluda J, Quinn JA et al (2000) Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol 18:3522–3528 CASPubMed Google Scholar
Jiang G, Wei ZP, Pei DS et al (2011) A novel approach to overcome temozolomide resistance in glioma and melanoma: inactivation of MGMT by gene therapy. Biochem Biophys Res Commun 406:311–314 ArticleCASPubMed Google Scholar