Celastrol from ‘Thunder God Vine’ Protects SH-SY5Y Cells Through the Preservation of Mitochondrial Function and Inhibition of p38 MAPK in a Rotenone Model of Parkinson’s Disease (original) (raw)
Ahn DK (1998) Illustrated book of Korean medicinal herbs. Kyo-Hak Publishing, Seoul Google Scholar
Brinker AM, Ma J, Lipsky PE, Raskin I (2007) Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 68:732–766 ArticleCASPubMed Google Scholar
Salminen A, Lehtonen M, Paimela T, Kaarniranta K (2010) Celastrol: molecular targets of Thunder God Vine. Biochem Biophys Res Commun 394:439–442 ArticleCASPubMed Google Scholar
Celastrol MoritaT (2010) a new therapeutic potential of traditional chinese medicine. Am J Hypertens 23:821 Article Google Scholar
Lee JH, Koo TH, Yoon H, Jung HS, Jin HZ, Lee K et al (2006) Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem Pharmacol 72:1311–1321 ArticleCASPubMed Google Scholar
Sassa H, Takaishi Y, Terada H (1990) The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172:890–897 ArticleCASPubMed Google Scholar
Kannaiyan R, Shanmugam MK, Sethi G (2011) Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. Cancer Lett 303:9–20 ArticleCASPubMed Google Scholar
Allison AC, Cacabelos R, Lombardi VR, Alvarez XA, Vigo C (2001) Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatr 25:1341–1357 ArticleCAS Google Scholar
Kim DH, Shin EK, Kim YH, Lee BW, Jun JG, Park JH et al (2009) Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii. Eur J Clin Invest 39:819–827 ArticleCASPubMed Google Scholar
Heemskerk J, Tobin AJ, Bain LJ (2002) Teaching old drugs new tricks. Meeting of the neurodegeneration drug screening consortium, 7–8 April 2002, Washington, DC, USA. Trends Neurosci 25:494–506 ArticlePubMed Google Scholar
Paris D, Ganey NJ, Laporte V, Patel NS, Beaulieu-Abdelahad D, Bachmeier C et al (2010) Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer’s disease. J Neuroinflammation 7:17 ArticlePubMed CentralPubMed Google Scholar
Cleren C, Calingasan NY, Chen J, Beal MF (2005) Celastrol protects against MPTP- and 3-nitropropionic acid–induced neurotoxicity. J Neurochem 94:995–1004 ArticleCASPubMed Google Scholar
Chow AM, Brown IR (2007) Induction of heat shock proteins in differentiated human and rodent neurons by celastrol. Cell Stress Chaperones 12:237–244 ArticleCASPubMed CentralPubMed Google Scholar
Faust K, Gehrke S, Yang Y, Yang L, Beal MF, Lu B (2009) Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson’s disease. BMC Neurosci. doi:10.1186/1471-2202-10-109 PubMed CentralPubMed Google Scholar
Thomas B, Beal MF (2007) Parkinson’s disease. Hum Mol Genet 16(2):183–194 Article Google Scholar
Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nat Neurosci 3:1301–1306 ArticleCASPubMed Google Scholar
Alam M, Schmidt WJ (2002) Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav Brain Res 136:317–324 ArticleCASPubMed Google Scholar
Greenamyre JT, Betarbet R, Sherer TB (2003) The rotenone model of Parkinson’s disease: genes, environment and mitochondria. Parkinsonism Relat Disord Suppl 2:S59–S64 Article Google Scholar
Sherer TB, Richardson JR, Testa CM, Seo BB, Panov AV, Yagi T et al (2007) Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease. J Neurochem 100:1469–1479 CASPubMed Google Scholar
Sherer TB, Betarbet R, Testa CM, Seo BB, Richardson JR, Kim JH et al (2003) Mechanism of toxicity in rotenone models of Parkinson’s disease. J Neurosci 23:10756–10764 CASPubMed Google Scholar
Cannon JR, Tapias V, Na HM, Honick AS, Drolet RE, Greenamyre JT (2009) A highly reproducible rotenone model of Parkinson’s disease. Neurobiol Dis 34:279–290 ArticleCASPubMed CentralPubMed Google Scholar
Deng YN, Shi J, Liu J, Qu QM (2013) Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. Neurochem Int pii:S0197-0186(13)00128-9. doi:10.1016/j.neuint.2013.04.005 [Epub ahead of print]
Newhouse K, Hsuan SL, Chang SH, Cai B, Wang Y, Xia Z (2004) Rotenone induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells. Toxicol Sci 79:137–146 ArticleCASPubMed Google Scholar
Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787–795 ArticleCASPubMed Google Scholar
Cavalli A, Bolognesi ML, Minarini A, Rosini M, Tumiatti V, Recanatini M et al (2008) Multi-target-directed ligands to combat neurodegenerative diseases. J Med Chem 51:347–372 ArticleCASPubMed Google Scholar
Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH et al (2006) Intersecting pathways to neurodegeneration in Parkinson’s disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. Neurobiol Dis 22:404–420 ArticleCASPubMed Google Scholar
Kim SJ, Kim JS, Cho HS, Lee HJ, Kim SY, Kim S et al (2006) Carnosol a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells. NeuroReport 17:1729–1733 ArticleCASPubMed Google Scholar
Sapkota K, Kim S, Park SE, Kim SJ (2011) Detoxified extract of Rhus verniciflua stokes inhibits rotenone-induced apoptosis in human dopaminergic cells, SH-SY5Y. Cell Mol Neurobiol 31:213–223 ArticlePubMed Google Scholar
Jenner P, Olanow CW (1996) Oxidative stress and the pathogenesis of Parkinson’s disease. Neurology 47:161–170 Article Google Scholar
Perier C, Vila M (2012) Mitochondrial biology and Parkinson’s disease. Cold Spring Harb Perspect Med 2(2):a009332 ArticlePubMed Google Scholar
Testa CM, Sherer TB, Greenamyre JT (2005) Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res Mol Brain Res 134:109–118 ArticleCASPubMed Google Scholar
Vila M, Przedborski S (2003) Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci 4:365–375 ArticleCASPubMed Google Scholar
Borner C (2003) The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 39:615–647 ArticleCASPubMed Google Scholar
Chinnaiyan AM, Orth K, O’Rourke K, Duan H, Poirier GG, Dixit VM (1996) Molecular ordering of the cell death pathway-Bcl-2 and Bcl-x (L) function upstream of ced-3-like apoptotic proteases. J Biol Chem 271:4573–4576 ArticleCASPubMed Google Scholar
Mielke K, Herdegen T (2000) JNK and p38 stresskinases–degenerative effectors of signal-transduction-cascades in the nervous system. Prog Neurobiol 61:45–60 ArticleCASPubMed Google Scholar
Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 1802:396–405 ArticleCASPubMed Google Scholar
Choi WS, Eom DS, Han BS, Kim WK, Han BH, Choi EJ et al (2004) Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. J Biol Chem 279:20451–20460 ArticleCASPubMed Google Scholar
Pinna GF, Fiorucci M, Reimund JM, Taquet N, Arondel Y, Muller CD (2004) Celastrol inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies. Biochem Biophys Res Commun 322:778–786 ArticleCASPubMed Google Scholar
Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, Kim S et al (2004) Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem 279:56053–56060 ArticleCASPubMed Google Scholar