Effects of Cannabis on Neurocognitive Functioning: Recent Advances, Neurodevelopmental Influences, and Sex Differences (original) (raw)

References

• Abdullaev, Y., Posner, M. I., Nunnally, R., & Dishion, T. J. (2010). Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. Behavioural Brain Research, 215(1), 45–57.
  Article PubMed Google Scholar
• Abush, H., & Akirav, I. (2012). Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats. PLoS One, 7(2), e31731.
  Article PubMed CAS Google Scholar
• Aharonovich, E., Brooks, A. C., Nunes, E. V., & Hasin, D. S. (2008). Cognitive deficits in marijuana users: effects on motivational enhancement therapy plus cognitive behavioral therapy treatment outcome. Drug and Alcohol Dependence, 95(3), 279–283.
  Article PubMed Google Scholar
• Anderson, B. M., Rizzo, M., Block, R. I., Pearlson, G. D., & O’Leary, D. S. (2010). Sex, drugs, and cognition: effects of marijuana. Journal of Psychoactive Drugs, 42(4), 413–424.
  Article PubMed Google Scholar
• Asbridge, M., Hayden, J. A., & Cartwright, J. L. (2012). Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis. BMJ, 344, e536.
  Article PubMed Google Scholar
• Ballard, M. E., Gallo, D. A., & de Wit, H. (2012). Psychoactive drugs and false memory: comparison of dextroamphetamine and delta-9-tetrahydrocannabinol on false recognition. Psychopharmacology, 219(1), 15–24.
  Article PubMed CAS Google Scholar
• Battisti, R. A., Roodenrys, S., Johnstone, S. J., Pesa, N., Hermens, D. F., & Solowij, N. (2010). Chronic cannabis users show altered neurophysiological functioning on Stroop task conflict resolution. Psychopharmacology, 212(4), 613–624.
  Article PubMed CAS Google Scholar
• Battisti, R. A., Roodenrys, S., Johnstone, S. J., Respondek, C., Hermens, D. F., & Solowij, N. (2010). Chronic use of cannabis and poor neural efficiency in verbal memory ability. Psychopharmacology, 209(4), 319–330.
  Article PubMed CAS Google Scholar
• Bava, S., & Tapert, S. F. (2010). Adolescent brain development and the risk for alcohol and other drug problems. Neuropsychology Review, 20(4), 398–413.
  Article PubMed Google Scholar
• Bechara, A. (2005). Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nature Neuroscience, 8(11), 1458–1463.
  Article PubMed CAS Google Scholar
• Becker, B., Wagner, D., Gouzoulis-Mayfrank, E., Spuentrup, E., & Daumann, J. (2010). The impact of early-onset cannabis use on functional brain correlates of working memory. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(6), 837–845.
  Article CAS Google Scholar
• Bhattacharyya, S., Fusar-Poli, P., Borgwardt, S., Martin-Santos, R., Nosarti, C., O’Carroll, C., et al. (2009). Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. Archives of General Psychiatry, 66(4), 442–451.
  Article PubMed CAS Google Scholar
• Bhattacharyya, S., Morrison, P. D., Fusar-Poli, P., Martin-Santos, R., Borgwardt, S., Winton-Brown, T., et al. (2010). Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology, 35(3), 764–774.
  Article PubMed CAS Google Scholar
• Bhattacharyya, S., Crippa, J. A., Allen, P., Martin-Santos, R., Borgwardt, S., Fusar-Poli, P., et al. (2012). Induction of psychosis by Delta9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing. Archives of General Psychiatry, 69(1), 27–36.
  Article PubMed CAS Google Scholar
• Boggio, P. S., Zaghi, S., Villani, A. B., Fecteau, S., Pascual-Leone, A., & Fregni, F. (2010). Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC). Drug and Alcohol Dependence, 112(3), 220–225.
  Article PubMed Google Scholar
• Bolla, K. I., Eldreth, D. A., Matochik, J. A., & Cadet, J. L. (2004). Sex-related differences in a gambling task and its neurological correlates. Cerebral Cortex, 14(11), 1226–1232.
  Article PubMed CAS Google Scholar
• Bolla, K. I., Eldreth, D. A., Matochik, J. A., & Cadet, J. L. (2005). Neural substrates of faulty decision-making in abstinent marijuana users. NeuroImage, 26(2), 480–492.
  Article PubMed Google Scholar
• Borgwardt, S. J., Allen, P., Bhattacharyya, S., Fusar-Poli, P., Crippa, J. A., Seal, M. L., et al. (2008). Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition. Biological Psychiatry, 64(11), 966–973.
  Article PubMed CAS Google Scholar
• Bossong, M. G., Jager, G., van Hell, H. H., Zuurman, L., Jansma, J. M., Mehta, M. A., et al. (2012). Effects of Delta9-tetrahydrocannabinol administration on human encoding and recall memory function: a pharmacological FMRI study. Journal of Cognitive Neuroscience, 24(3), 588–599.
  Article PubMed Google Scholar
• Bossong, M. G., Jansma, J. M., van Hell, H. H., Jager, G., Oudman, E., Saliasi, E., et al. (2012). Effects of delta9-tetrahydrocannabinol on human working memory function. Biological Psychiatry, 71(8), 693–699.
  Google Scholar
• Bradshaw, H. B., Rimmerman, N., Krey, J. F., & Walker, J. M. (2006). Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 291(2), R349–R358.
  Article PubMed CAS Google Scholar
• Burgdorf, J. R., Kilmer, B., & Pacula, R. L. (2011). Heterogeneity in the composition of marijuana seized in California. Drug and Alcohol Dependence, 117(1), 59–61.
  Article PubMed CAS Google Scholar
• Burston, J. J., Wiley, J. L., Craig, A. A., Selley, D. E., & Sim-Selley, L. J. (2010). Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure. British Journal of Pharmacology, 161(1), 103–112.
  Article PubMed CAS Google Scholar
• Busemeyer, J. R., & Stout, J. C. (2002). A contribution of cognitive decision models to clinical assessment: decomposing performance on the Bechara gambling task. Psychological Assessment, 14(3), 253–262.
  Article PubMed Google Scholar
• Cane, J. E., Sharma, D., & Albery, I. P. (2009). The addiction Stroop task: examining the fast and slow effects of smoking and marijuana-related cues. Journal of Psychopharmacology, 23(5), 510–519.
  Article PubMed CAS Google Scholar
• Cha, Y. M., Jones, K. H., Kuhn, C. M., Wilson, W. A., & Swartzwelder, H. S. (2007). Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats. Behavioural Pharmacology, 18(5–6), 563–569.
  Article PubMed CAS Google Scholar
• Chang, L., Yakupov, R., Cloak, C., & Ernst, T. (2006). Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain, 129(Pt 5), 1096–1112.
  Article PubMed CAS Google Scholar
• Clark, L., Cools, R., & Robbins, T. W. (2004). The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning. Brain and Cognition, 55(1), 41–53.
  Article PubMed CAS Google Scholar
• Clark, L., Roiser, J. P., Robbins, T. W., & Sahakian, B. J. (2009). Disrupted ‘reflection’ impulsivity in cannabis users but not current or former ecstasy users. Journal of Psychopharmacology, 23(1), 14–22.
  Article PubMed CAS Google Scholar
• Cocchetto, D. M., Owens, S. M., Perez-Reyes, M., DiGuiseppi, S., & Miller, L. L. (1981). Relationship between plasma delta-9-tetrahydrocannabinol concentration and pharmacologic effects in man. Psychopharmacology, 75(2), 158–164.
  Article PubMed CAS Google Scholar
• Cohen, P. J. (2010). Medical marijuana 2010: it’s time to fix the regulatory vacuum. The Journal of Law, Medicine & Ethics, 38(3), 654–666.
  Article Google Scholar
• Compton, W. M., Grant, B. F., Colliver, J. D., Glantz, M. D., & Stinson, F. S. (2004). Prevalence of marijuana use disorders in the United States: 1991–1992 and 2001–2002. Journal of the American Medical Association, 291(17), 2114–2121.
  Article PubMed CAS Google Scholar
• Crean, R. D., Crane, N. A., & Mason, B. J. (2011). An evidence based review of acute and long-term effects of cannabis Use on executive cognitive functions. Journal of Addiction Medicine, 5(1), 1–8.
  Article PubMed Google Scholar
• Crippa, J. A., Zuardi, A. W., Martin-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., et al. (2009). Cannabis and anxiety: a critical review of the evidence. Human Psychopharmacology, 24(7), 515–523.
  Article PubMed CAS Google Scholar
• Crippa, J. A., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., et al. (2011). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology, 25(1), 121–130.
  Article PubMed CAS Google Scholar
• Cunha, P. J., Nicastri, S., de Andrade, A. G., & Bolla, K. I. (2010). The frontal assessment battery (FAB) reveals neurocognitive dysfunction in substance-dependent individuals in distinct executive domains: abstract reasoning, motor programming, and cognitive flexibility. Addictive Behaviors, 35(10), 875–881.
  Article PubMed Google Scholar
• de Wit, H. (2009). Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addiction Biology, 14(1), 22–31.
  Article PubMed Google Scholar
• Drummer, O. H., Gerostamoulos, J., Batziris, H., Chu, M., Caplehorn, J. R., Robertson, M. D., et al. (2003). The incidence of drugs in drivers killed in Australian road traffic crashes. Forensic Science International, 134(2–3), 154–162.
  Article PubMed Google Scholar
• D’Souza, D. C., Braley, G., Blaise, R., Vendetti, M., Oliver, S., Pittman, B., et al. (2008). Effects of haloperidol on the behavioral, subjective, cognitive, motor, and neuroendocrine effects of Delta-9-tetrahydrocannabinol in humans. Psychopharmacology, 198(4), 587–603.
  Article PubMed CAS Google Scholar
• D’Souza, D. C., Ranganathan, M., Braley, G., Gueorguieva, R., Zimolo, Z., Cooper, T., et al. (2008). Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis. Neuropsychopharmacology, 33(10), 2505–2516.
  Article PubMed CAS Google Scholar
• Dumont, G. J., van Hasselt, J. G., de Kam, M., van Gerven, J. M., Touw, D. J., Buitelaar, J. K., et al. (2011). Acute psychomotor, memory and subjective effects of MDMA and THC co-administration over time in healthy volunteers. Journal of Psychopharmacology, 25(4), 478–489.
  Article PubMed CAS Google Scholar
• Durston, S., Hulshoff Pol, H. E., Casey, B. J., Giedd, J. N., Buitelaar, J. K., & van Engeland, H. (2001). Anatomical MRI of the developing human brain: what have we learned? Journal of the American Academy of Child and Adolescent Psychiatry, 40(9), 1012–1020.
  Article PubMed CAS Google Scholar
• Ehrenreich, H., Rinn, T., Kunert, H. J., Moeller, M. R., Poser, W., Schilling, L., et al. (1999). Specific attentional dysfunction in adults following early start of cannabis use. Psychopharmacology, 142(3), 295–301.
  Article PubMed CAS Google Scholar
• Elikkottil, J., Gupta, P., & Gupta, K. (2009). The analgesic potential of cannabinoids. Journal of Opioid Management, 5(6), 341–357.
  PubMed Google Scholar
• Ellis, R. J., Toperoff, W., Vaida, F., van den Brande, G., Gonzales, J., Gouaux, B., et al. (2009). Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology, 34(3), 672–680.
  Article PubMed CAS Google Scholar
• Elsohly, M. A., & Slade, D. (2005). Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sciences, 78(5), 539–548.
  Article PubMed CAS Google Scholar
• Fairfield, K. M., Eisenberg, D. M., Davis, R. B., Libman, H., & Phillips, R. S. (1998). Patterns of use, expenditures, and perceived efficacy of complementary and alternative therapies in HIV-infected patients. Archives of Internal Medicine, 158(20), 2257–2264.
  Article PubMed CAS Google Scholar
• Fattore, L., Spano, M. S., Altea, S., Angius, F., Fadda, P., & Fratta, W. (2007). Cannabinoid self-administration in rats: sex differences and the influence of ovarian function. British Journal of Pharmacology, 152(5), 795–804.
  Article PubMed CAS Google Scholar
• Fernandez-Serrano, M. J., Perez-Garcia, M., Schmidt Rio-Valle, J., & Verdejo-Garcia, A. (2010). Neuropsychological consequences of alcohol and drug abuse on different components of executive functions. Journal of Psychopharmacology, 24(9), 1317–1332.
  Article PubMed Google Scholar
• Fernandez-Serrano, M. J., Perez-Garcia, M., & Verdejo-Garcia, A. (2011). What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance? Neuroscience and Biobehavioral Reviews, 35(3), 377–406.
  Article PubMed CAS Google Scholar
• Ferraro, D. P. (1980). Acute effects of marijuana on human memory and cognition. NIDA Research Monograph, 31, 98–119.
  PubMed CAS Google Scholar
• Fisk, J. E., & Montgomery, C. (2008). Real-world memory and executive processes in cannabis users and non-users. Journal of Psychopharmacology, 22(7), 727–736.
  Article PubMed CAS Google Scholar
• Fontes, M. A., Bolla, K. I., Cunha, P. J., Almeida, P. P., Jungerman, F., Laranjeira, R. R., et al. (2011a). Cannabis use before age 15 and subsequent executive functioning. The British Journal of Psychiatry, 198(6), 442–447.
  Article PubMed Google Scholar
• Fontes, M. A., Bolla, K. I., Cunha, P. J., Almeida, P. P., Jungerman, F., Laranjeira, R. R., et al. (2011b). Frontal Assessment Battery (FAB) is a simple tool for detecting executive deficits in chronic cannabis users. Journal of Clinical and Experimental Neuropsychology, 33(5), 523–531.
  Article PubMed Google Scholar
• Fridberg, D. J., Queller, S., Ahn, W. Y., Kim, W., Bishara, A. J., Busemeyer, J. R., et al. (2010). Cognitive mechanisms underlying risky decision-making in chronic cannabis users. Journal of Mathematical Psychology, 54(1), 28–38.
  Article PubMed Google Scholar
• Fusar-Poli, P., & Meyer-Lindenberg, A. (2012a). Striatal presynaptic dopamine in schizophrenia, Part I: meta-analysis of dopamine active transporter (DAT) density. Schizophrenia Bulletin. doi:10.1093/schbul/sbr111.
• Fusar-Poli, P., & Meyer-Lindenberg, A. (2012b). Striatal presynaptic dopamine in schizophrenia, Part II: meta-analysis of [18F/11C]-DOPA PET studies. Schizophrenia Bulletin. doi:10.1093/schbul/sbr180.
• Fusar-Poli, P., Crippa, J. A., Bhattacharyya, S., Borgwardt, S. J., Allen, P., Martin-Santos, R., et al. (2009). Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Archives of General Psychiatry, 66(1), 95–105.
  Article PubMed CAS Google Scholar
• Fusar-Poli, P., Allen, P., Bhattacharyya, S., Crippa, J. A., Mechelli, A., Borgwardt, S., et al. (2010a). Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. The International Journal of Neuropsychopharmacology, 13(4), 421–432.
  Article PubMed CAS Google Scholar
• Fusar-Poli, P., Howes, O. D., Allen, P., Broome, M., Valli, I., Asselin, M. C., et al. (2010b). Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Archives of General Psychiatry, 67(7), 683–691.
  Article PubMed Google Scholar
• Fusar-Poli, P., Borgwardt, S., Crescini, A., Deste, G., Kempton, M. J., Lawrie, S., et al. (2011a). Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis. Neuroscience and Biobehavioral Reviews, 35(5), 1175–1185.
  Article PubMed CAS Google Scholar
• Fusar-Poli, P., Howes, O. D., Allen, P., Broome, M., Valli, I., Asselin, M. C., et al. (2011b). Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis. Molecular Psychiatry, 16(1), 67–75.
  Article PubMed CAS Google Scholar
• Fusar-Poli, P., Radua, J., McGuire, P., & Borgwardt, S. (2011c). Neuroanatomical maps of psychosis onset: voxel-wise meta-analysis of antipsychotic-naive VBM studies. Schizophrenia Bulletin. doi:10.1093/schbul/sbr134.
• Fusar-Poli, P., Stone, J. M., Broome, M. R., Valli, I., Mechelli, A., McLean, M. A., et al. (2011d). Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis. Archives of General Psychiatry, 68(9), 881–890.
  Article PubMed CAS Google Scholar
• Fusar-Poli, P., Bechdolf, A., Taylor, M. J., Bonoldi, I., Carpenter, W. T., Yung, A. R., et al. (2012). At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk. Schizophrenia Bulletin. doi:10.1093/schbul/sbs060.
• Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A., Schultze-Lutter, F., et al. (in press). The psychosis high risk state: a comprehensive state of the art review. Archives of General Psychiatry.
• Gfroerer, J. C., & Epstein, J. F. (1999). Marijuana initiates and their impact on future drug abuse treatment need. Drug and Alcohol Dependence, 54(3), 229–237.
  Article PubMed CAS Google Scholar
• Giedd, J. N. (2004). Structural magnetic resonance imaging of the adolescent brain. Annals of the New York Academy of Sciences, 1021, 77–85.
  Article PubMed Google Scholar
• Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., et al. (1999). Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience, 2(10), 861–863.
  Article PubMed CAS Google Scholar
• Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., et al. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America, 101(21), 8174–8179.
  Article PubMed CAS Google Scholar
• Goldstein, R. Z., & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. The American Journal of Psychiatry, 159(10), 1642–1652.
  Article PubMed Google Scholar
• Gonzalez, R. (2007). Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance. Neuropsychology Review, 17(3), 347–361.
  Article PubMed Google Scholar
• Gonzalez, S., Mauriello-Romanazzi, G., Berrendero, F., Ramos, J. A., Franzoni, M. F., & Fernandez-Ruiz, J. (2000). Decreased cannabinoid CB1 receptor mRNA levels and immunoreactivity in pituitary hyperplasia induced by prolonged exposure to estrogens. Pituitary, 3(4), 221–226.
  Article PubMed CAS Google Scholar
• Gonzalez, R., Carey, C., & Grant, I. (2002). Nonacute (residual) neuropsychological effects of cannabis use: a qualitative analysis and systematic review. Journal of Clinical Pharmacology, 42(11 Suppl), 48S–57S.
  PubMed CAS Google Scholar
• Gonzalez, R., Rippeth, J. D., Carey, C. L., Heaton, R. K., Moore, D. J., Schweinsburg, B. C., et al. (2004). Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure. Drug and Alcohol Dependence, 76(2), 181–190.
  Article PubMed CAS Google Scholar
• Gonzalez, R., Bechara, A., & Martin, E. M. (2007). Executive functions among individuals with methamphetamine or alcohol as drugs of choice: preliminary observations. Journal of Clinical and Experimental Neuropsychology, 29(2), 155–159.
  Article PubMed Google Scholar
• Gonzalez, R., Vassileva, J., & Scott, J. C. (2009). Neuropsychological consequences of drug abuse. In I. Grant & K. M. Adams (Eds.), Neuropsychological Assessment of Neuropsychiatric Disorders (3rd ed., pp. 455–479). New York: Oxford University Press.
  Google Scholar
• Gonzalez, R., Schuster, R. M., Vassileva, J., & Martin, E. M. (2011). Impact of HIV and a history of marijuana dependence on procedural learning among individuals with a history of substance dependence. Journal of Clinical and Experimental Neuropsychology, 33(7), 735–752.
  Article PubMed Google Scholar
• Gonzalez, R., Schuster, R.M., Crane, N.A., Martin, E.M., Vassileva, J. (2012). Decision-Making Performance Influences the Relationship between Amount of Cannabis use and its Negative Consequences. Journal of the International Neuropsychological Society, 18. doi:10.1017/S1355617712000549.
• Gonzalez, R., Schuster, R. M., Mermelstein, R. J., Vassileva, J., Martin, E. M., & Diviak, K. R. (2012). Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationships to symptoms of cannabis use disorders. Journal of Clinical and Experimental Neuropsychology. doi:10.1080/13803395.2012.703642
• Gorzalka, B. B., Hill, M. N., & Hillard, C. J. (2008). Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders. Neuroscience and Biobehavioral Reviews, 32(6), 1152–1160.
  Article PubMed CAS Google Scholar
• Grant, I., Gonzalez, R., Carey, C. L., Natarajan, L., & Wolfson, T. (2003). Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study. Journal of the International Neuropsychological Society, 9(5), 679–689.
  Article PubMed CAS Google Scholar
• Grant, J. E., Chamberlain, S. R., Schreiber, L., & Odlaug, B. L. (2011). Neuropsychological deficits associated with cannabis use in young adults. Drug and Alcohol Dependence, 121(1-2), 159–162.
  Google Scholar
• Gruber, S. A., Sagar, K. A., Dahlgren, M. K., Racine, M., & Lukas, S. E. (2012). Age of onset of marijuana use and executive function. Psychology of Addictive Behaviors, 26(3), 496–506.
  Google Scholar
• Gruber, S. A., Dahlgren, M. K., Sagar, K. A., Gonenc, A., & Killgore, W. D. (2012). Age of onset of marijuana use impacts inhibitory processing. Neuroscience Letters, 511(2), 89–94.
  Article PubMed CAS Google Scholar
• Gur, R. C., Richard, J., Calkins, M. E., Chiavacci, R., Hansen, J. A., Bilker, W. B., et al. (2012). Age group and sex differences in performance on a computerized neurocognitive battery in children age 8–21. Neuropsychology, 26(2), 251–265.
  Article PubMed Google Scholar
• Hadjiefthyvoulou, F., Fisk, J. E., Montgomery, C., & Bridges, N. (2011). Prospective memory functioning among ecstasy/polydrug users: evidence from the Cambridge Prospective Memory Test (CAMPROMPT). Psychopharmacology, 215(4), 761–774.
  Article PubMed CAS Google Scholar
• Hampson, A. J., Grimaldi, M., Axelrod, J., & Wink, D. (1998). Cannabidiol and (−)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America, 95(14), 8268–8273.
  Article PubMed CAS Google Scholar
• Hanson, K. L., Winward, J. L., Schweinsburg, A. D., Medina, K. L., Brown, S. A., & Tapert, S. F. (2010). Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addictive Behaviors, 35(11), 970–976.
  Article PubMed Google Scholar
• Hart, C. L., Ilan, A. B., Gevins, A., Gunderson, E. W., Role, K., Colley, J., et al. (2010). Neurophysiological and cognitive effects of smoked marijuana in frequent users. Pharmacology, Biochemistry, and Behavior, 96(3), 333–341.
  Article PubMed CAS Google Scholar
• Harte, L. C., & Dow-Edwards, D. (2010). Sexually dimorphic alterations in locomotion and reversal learning after adolescent tetrahydrocannabinol exposure in the rat. Neurotoxicology and Teratology, 32(5), 515–524.
  Article PubMed CAS Google Scholar
• Harvey, M. A., Sellman, J. D., Porter, R. J., & Frampton, C. M. (2007). The relationship between non-acute adolescent cannabis use and cognition. Drug and Alcohol Review, 26(3), 309–319.
  Article PubMed Google Scholar
• Hermann, D., Sartorius, A., Welzel, H., Walter, S., Skopp, G., Ende, G., et al. (2007). Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users. Biological Psychiatry, 61(11), 1281–1289.
  Article PubMed CAS Google Scholar
• Hermann, D., Lemenager, T., Gelbke, J., Welzel, H., Skopp, G., & Mann, K. (2009). Decision making of heavy cannabis users on the Iowa Gambling Task: stronger association with THC of hair analysis than with personality traits of the Tridimensional Personality Questionnaire. European Addiction Research, 15(2), 94–98.
  Article PubMed Google Scholar
• Hernandez-Avila, C. A., Rounsaville, B. J., & Kranzler, H. R. (2004). Opioid-, cannabis- and alcohol-dependent women show more rapid progression to substance abuse treatment. Drug and Alcohol Dependence, 74(3), 265–272.
  Article PubMed CAS Google Scholar
• Hester, R., Nestor, L., & Garavan, H. (2009). Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users. Neuropsychopharmacology, 34(11), 2450–2458.
  Article PubMed Google Scholar
• Huestegge, L., Kunert, H. J., & Radach, R. (2010). Long-term effects of cannabis on eye movement control in reading. Psychopharmacology, 209(1), 77–84.
  Article PubMed CAS Google Scholar
• Hunault, C. C., Mensinga, T. T., Bocker, K. B., Schipper, C. M., Kruidenier, M., Leenders, M. E., et al. (2009). Cognitive and psychomotor effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg delta-9-tetrahydrocannabinol (THC). Psychopharmacology, 204(1), 85–94.
  Article PubMed CAS Google Scholar
• Indlekofer, F., Piechatzek, M., Daamen, M., Glasmacher, C., Lieb, R., Pfister, H., et al. (2009). Reduced memory and attention performance in a population-based sample of young adults with a moderate lifetime use of cannabis, ecstasy and alcohol. Journal of Psychopharmacology, 23(5), 495–509.
  Article PubMed CAS Google Scholar
• Iversen, L. (2003). Cannabis and the brain. Brain, 126(6), 1252–1270.
  Article PubMed Google Scholar
• Jacobsen, L. K., Mencl, W. E., Westerveld, M., & Pugh, K. R. (2004). Impact of cannabis use on brain function in adolescents. Annals of the New York Academy of Sciences, 1021, 384–390.
  Article PubMed Google Scholar
• Jacobsen, L. K., Pugh, K. R., Constable, R. T., Westerveld, M., & Mencl, W. E. (2007). Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. Biological Psychiatry, 61(1), 31–40.
  Article PubMed CAS Google Scholar
• Jacobus, J., McQueeny, T., Bava, S., Schweinsburg, B. C., Frank, L. R., Yang, T. T., et al. (2009). White matter integrity in adolescents with histories of marijuana use and binge drinking. Neurotoxicology and Teratology, 31(6), 349–355.
  Article PubMed CAS Google Scholar
• Jager, G., & Ramsey, N. F. (2008). Long-term consequences of adolescent cannabis exposure on the development of cognition, brain structure and function: an overview of animal and human research. Current Drug Abuse Reviews, 1(2), 114–123.
  Article PubMed CAS Google Scholar
• Jager, G., Kahn, R. S., Van Den Brink, W., Van Ree, J. M., & Ramsey, N. F. (2006). Long-term effects of frequent cannabis use on working memory and attention: an fMRI study. Psychopharmacology, 185(3), 358–368.
  Article PubMed CAS Google Scholar
• Jager, G., Van Hell, H. H., De Win, M. M., Kahn, R. S., Van Den Brink, W., Van Ree, J. M., et al. (2007). Effects of frequent cannabis use on hippocampal activity during an associative memory task. European Neuropsychopharmacology, 17(4), 289–297.
  Article PubMed CAS Google Scholar
• Jager, G., Block, R. I., Luijten, M., & Ramsey, N. F. (2010). Cannabis use and memory brain function in adolescent boys: a cross-sectional multicenter functional magnetic resonance imaging study. Journal of the American Academy of Child and Adolescent Psychiatry, 49(6), 561–572, 572 e561-563.
  Google Scholar
• Johnston, L. D., O’Malley, P. M., Bachman, J. G., & Schulenberg, J. E. (2012). Monitoring the Future national results on adolescent drug use: Overview of key findings, 2011. Ann Arbor: Institute for Social Research, The University of Michigan.
  Google Scholar
• Kalant, H. (2004). Adverse effects of cannabis on health: an update of the literature since 1996. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 28(5), 849–863.
  Article CAS Google Scholar
• King, G. R., Ernst, T., Deng, W., Stenger, A., Gonzales, R. M., Nakama, H., et al. (2011). Altered brain activation during visuomotor integration in chronic active cannabis users: relationship to cortisol levels. Journal of Neuroscience, 31(49), 17923–17931.
  Article PubMed CAS Google Scholar
• Korver, N., Nieman, D. H., Becker, H. E., van de Fliert, J. R., Dingemans, P. H., de Haan, L., et al. (2010). Symptomatology and neuropsychological functioning in cannabis using subjects at ultra-high risk for developing psychosis and healthy controls. The Australian and New Zealand Journal of Psychiatry, 44(3), 230–236.
  Article PubMed Google Scholar
• Kramer, J. H., Delis, D. C., & Daniel, M. (1988). Sex-differences in verbal-learning. Journal of Clinical Psychology, 44(6), 907–915.
  Article Google Scholar
• Lane, S. D., Cherek, D. R., Tcheremissine, O. V., Lieving, L. M., & Pietras, C. J. (2005). Acute marijuana effects on human risk taking. Neuropsychopharmacology, 30(4), 800–809.
  Article PubMed CAS Google Scholar
• Lane, S. D., Cherek, D. R., Tcheremissine, O. V., Steinberg, J. L., & Sharon, J. L. (2007). Response perseveration and adaptation in heavy marijuana-smoking adolescents. Addictive Behaviors, 32(5), 977–990.
  Article PubMed Google Scholar
• Lastres-Becker, I., Molina-Holgado, F., Ramos, J. A., Mechoulam, R., & Fernandez-Ruiz, J. (2005). Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease. Neurobiology of Disease, 19(1–2), 96–107.
  Article PubMed CAS Google Scholar
• Lenroot, R. K., Gogtay, N., Greenstein, D. K., Wells, E. M., Wallace, G. L., Clasen, L. S., et al. (2007). Sexual dimorphism of brain developmental trajectories during childhood and adolescence. NeuroImage, 36(4), 1065–1073.
  Article PubMed Google Scholar
• Li, M. C., Brady, J. E., DiMaggio, C. J., Lusardi, A. R., Tzong, K. Y., & Li, G. (2012). Marijuana use and motor vehicle crashes. Epidemiologic Reviews, 34(1), 65–72.
  Article PubMed CAS Google Scholar
• Looby, A., & Earleywine, M. (2010). Gender moderates the impact of stereotype threat on cognitive function in cannabis users. Addictive Behaviors, 35(9), 834–839.
  Article PubMed Google Scholar
• Lopez, H. H. (2010). Cannabinoid-hormone interactions in the regulation of motivational processes. Hormones and Behavior, 58(1), 100–110.
  Article PubMed CAS Google Scholar
• Mackie, K. (2005). Distribution of cannabinoid receptors in the central and peripheral nervous system. Handbook of Experimental Pharmacology, 168, 299–325.
  Article PubMed CAS Google Scholar
• Mahmood, O. M., Jacobus, J., Bava, S., Scarlett, A., & Tapert, S. F. (2010). Learning and memory performances in adolescent users of alcohol and marijuana: interactive effects. Journal of Studies on Alcohol and Drugs, 71(6), 885–894.
  PubMed Google Scholar
• Makela, P., Wakeley, J., Gijsman, H., Robson, P. J., Bhagwagar, Z., & Rogers, R. D. (2006). Low doses of delta-9 tetrahydrocannabinol (THC) have divergent effects on short-term spatial memory in young, healthy adults. Neuropsychopharmacology, 31(2), 462–470.
  Article PubMed CAS Google Scholar
• Malone, D. T., Hill, M. N., & Rubino, T. (2010). Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models. British Journal of Pharmacology, 160(3), 511–522.
  Article PubMed CAS Google Scholar
• Martin-Santos, R., Fagundo, A. B., Crippa, J. A., Atakan, Z., Bhattacharyya, S., Allen, P., Fusar-Poli, P., Borgwardt, S., Seal, M., Busatto, G. F., & McGuire, P. (2010). Neuroimaging in cannabis use: a systematic review of the literature. Psychological Medicine, 40(3), 383–398.
  Article PubMed CAS Google Scholar
• Martin-Soelch, C., Kobel, M., Stoecklin, M., Michael, T., Weber, S., Krebs, B., et al. (2009). Reduced response to reward in smokers and cannabis users. Neuropsychobiology, 60(2), 94–103.
  Article PubMed Google Scholar
• Mason, B. J., Crean, R., Goodell, V., Light, J. M., Quello, S., Shadan, F., et al. (2012). A proof-of-concept randomized controlled study of gabapentin: effects on cannabis use, withdrawal and executive function deficits in cannabis-dependent adults. Neuropsychopharmacology, 37(7), 1689–1698.
  Article PubMed CAS Google Scholar
• Mateos, B., Borcel, E., Loriga, R., Luesu, W., Bini, V., Llorente, R., et al. (2011). Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors. Journal of Psychopharmacology, 25(12), 1676–1690.
  Article PubMed CAS Google Scholar
• McDonald, J., Schleifer, L., Richards, J. B., & de Wit, H. (2003). Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology, 28(7), 1356–1365.
  Article PubMed CAS Google Scholar
• McHale, S., & Hunt, N. (2008). Executive function deficits in short-term abstinent cannabis users. Human Psychopharmacology, 23(5), 409–415.
  Article PubMed Google Scholar
• McQueeny, T., Padula, C. B., Price, J., Medina, K. L., Logan, P., & Tapert, S. F. (2011). Gender effects on amygdala morphometry in adolescent marijuana users. Behavioural Brain Research, 224(1), 128–134.
  Article PubMed Google Scholar
• Mechoulam, R., Spatz, M., & Shohami, E. (2002). Endocannabinoids and neuroprotection. Science Signaling, 2002(129), re5.
  Article CAS Google Scholar
• Mechoulam, R., Peters, M., Murillo-Rodriguez, E., & Hanus, L. O. (2007). Cannabidiol–recent advances. Chemistry & Biodiversity, 4(8), 1678–1692.
  Article CAS Google Scholar
• Medina, K. L., Hanson, K. L., Schweinsburg, A. D., Cohen-Zion, M., Nagel, B. J., & Tapert, S. F. (2007). Neuropsychological functioning in adolescent marijuana users: subtle deficits detectable after a month of abstinence. Journal of the International Neuropsychological Society, 13(5), 807–820.
  Article PubMed Google Scholar
• Medina, K. L., Schweinsburg, A. D., Cohen-Zion, M., Nagel, B. J., & Tapert, S. F. (2007). Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry. Neurotoxicology and Teratology, 29(1), 141–152.
  Article PubMed CAS Google Scholar
• Medina, K. L., McQueeny, T., Nagel, B. J., Hanson, K. L., Yang, T. T., & Tapert, S. F. (2009). Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects. Addiction Biology, 14(4), 457–468.
  Article PubMed Google Scholar
• Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M., & Swann, A. C. (2001). Psychiatric aspects of impulsivity. The American Journal of Psychiatry, 158(11), 1783–1793.
  Article PubMed CAS Google Scholar
• Montgomery, C., Seddon, A. L., Fisk, J. E., Murphy, P. N., & Jansari, A. (2012). Cannabis-related deficits in real-world memory. Human Psychopharmacology, 27(2), 217–225.
  Article PubMed CAS Google Scholar
• Morgan, C. J., Gardener, C., Schafer, G., Swan, S., Demarchi, C., Freeman, T. P., et al. (2012). Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being. Psychological Medicine, 42(2), 391–400.
  Google Scholar
• Morgan, C. J., Schafer, G., Freeman, T. P., & Curran, H. V. (2010). Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected]. The British Journal of Psychiatry, 197(4), 285–290.
  Article PubMed Google Scholar
• Morrison, P. D., Zois, V., McKeown, D. A., Lee, T. D., Holt, D. W., Powell, J. F., et al. (2009). The acute effects of synthetic intravenous Delta9-tetrahydrocannabinol on psychosis, mood and cognitive functioning. Psychological Medicine, 39(10), 1607–1616.
  Article PubMed CAS Google Scholar
• Mura, P., Kintz, P., Ludes, B., Gaulier, J. M., Marquet, P., Martin-Dupont, S., et al. (2003). Comparison of the prevalence of alcohol, cannabis and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. Forensic Science International, 133(1–2), 79–85.
  Article PubMed CAS Google Scholar
• Murphy, L. L., Steger, R. W., Smith, M. S., & Bartke, A. (1990). Effects of delta-9-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combinations, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat. Neuroendocrinology, 52(4), 316–321.
  Article PubMed CAS Google Scholar
• Murphy, L. L., Newton, S. C., Dhali, J., & Chavez, D. (1991). Evidence for a direct anterior pituitary site of delta-9-tetrahydrocannabinol action. Pharmacology Biochemistry and Behavior, 40(3), 603–607.
  Article CAS Google Scholar
• Murphy, L. L., Rodriguez de Fonseca, F., & Steger, R. W. (1991). delta 9-Tetrahydrocannabinol antagonism of the anterior pituitary response to estradiol in immature female rats. Steroids, 56(2), 97–102.
  Article PubMed CAS Google Scholar
• Murphy, L. L., Gher, J., Steger, R. W., & Bartke, A. (1994). Effects of delta 9-tetrahydrocannabinol on copulatory behavior and neuroendocrine responses of male rats to female conspecifics. Pharmacology Biochemistry and Behavior, 48(4), 1011–1017.
  Article CAS Google Scholar
• Murphy, L. L., Adrian, B. A., & Kohli, M. (1999). Inhibition of luteinizing hormone secretion by delta9-tetrahydrocannabinol in the ovariectomized rat: effect of pretreatment with neurotransmitter or neuropeptide receptor antagonists. Steroids, 64(9), 664–671.
  Article PubMed CAS Google Scholar
• Murphy, P. N., Erwin, P. G., Maciver, L., Fisk, J. E., Larkin, D., Wareing, M., et al. (2011). The relationships of ‘ecstasy’ (MDMA) and cannabis use to impaired executive inhibition and access to semantic long-term memory. Human Psychopharmacology, 26(7), 460–469.
  Article PubMed CAS Google Scholar
• Narimatsu, S., Watanabe, K., Yamamoto, I., & Yoshimura, H. (1991). Sex difference in the oxidative metabolism of delta 9-tetrahydrocannabinol in the rat. Biochemical Pharmacology, 41(8), 1187–1194.
  Article PubMed CAS Google Scholar
• Nestor, L., Roberts, G., Garavan, H., & Hester, R. (2008). Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users. NeuroImage, 40(3), 1328–1339.
  Article PubMed Google Scholar
• Newman, J. L., & Mello, N. K. (2009). Neuroactive gonadal steroid hormones and drug addiction in women. In K. T. Brady, S. E. Back, & S. F. Greenfield (Eds.), Women and Addiction: A Comprehensive Textbook (pp. 35–64). New York: Guildford Press.
  Google Scholar
• Nixon, S. J., Paul, R., & Phillips, M. (1998). Cognitive efficiency in alcoholics and polysubstance abusers. Alcoholism, Clinical and Experimental Research, 22(7), 1414–1420.
  Article PubMed CAS Google Scholar
• O’Connell, T. J., & Bou-Matar, C. B. (2007). Long term marijuana users seeking medical cannabis in California (2001–2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants. Harm Reduction Journal, 4, 16.
  Article PubMed Google Scholar
• O’Leary, D. S., Block, R. I., Koeppel, J. A., Schultz, S. K., Magnotta, V. A., Ponto, L. B., et al. (2007). Effects of smoking marijuana on focal attention and brain blood flow. Human Psychopharmacology, 22(3), 135–148.
  Article PubMed Google Scholar
• O’Shea, M., Singh, M. E., McGregor, I. S., & Mallet, P. E. (2004). Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats. Journal of Psychopharmacology, 18(4), 502–508.
  Article PubMed Google Scholar
• O’Shea, M., McGregor, I. S., & Mallet, P. E. (2006). Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats. Journal of Psychopharmacology, 20(5), 611–621.
  Article PubMed Google Scholar
• Overman, W. H., Frassrand, K., Ansel, S., Trawalter, S., Bies, B., & Redmond, A. (2004). Performance on the IOWA card task by adolescents and adults. Neuropsychologia, 42(13), 1838–1851.
  Article PubMed Google Scholar
• Padula, C. B., Schweinsburg, A. D., & Tapert, S. F. (2007). Spatial working memory performance and fMRI activation interaction in abstinent adolescent marijuana users. Psychology of Addictive Behaviors, 21(4), 478–487.
  Article PubMed Google Scholar
• Perkins, K. A., Levine, M., Marcus, M., Shiffman, S., D’Amico, D., Miller, A., et al. (2000). Tobacco withdrawal in women and menstrual cycle phase. Journal of Consulting and Clinical Psychology, 68(1), 176–180.
  Article PubMed CAS Google Scholar
• Pertwee, R. G. (2008). Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addiction Biology, 13(2), 147–159.
  Article PubMed CAS Google Scholar
• Piechatzek, M., Indlekofer, F., Daamen, M., Glasmacher, C., Lieb, R., Pfister, H., et al. (2009). Is moderate substance use associated with altered executive functioning in a population-based sample of young adults? Human Psychopharmacology, 24(8), 650–665.
  Article PubMed Google Scholar
• Pillay, S. S., Rogowska, J., Kanayama, G., Gruber, S., Simpson, N., Pope, H. G., et al. (2008). Cannabis and motor function: fMRI changes following 28 days of discontinuation. Experimental and Clinical Psychopharmacology, 16(1), 22–32.
  Article PubMed Google Scholar
• Piomelli, D. (2003). The molecular logic of endocannabinoid signalling. Nature Reviews Neuroscience, 4(11), 873–884.
  Article PubMed CAS Google Scholar
• Pope, H. G., Jr., Gruber, A. J., & Yurgelun-Todd, D. (1995). The residual neuropsychological effects of cannabis: the current status of research. Drug and Alcohol Dependence, 38(1), 25–34.
  Article PubMed Google Scholar
• Pope, H. G., Jr., Jacobs, A., Mialet, J. P., Yurgelun-Todd, D., & Gruber, S. (1997). Evidence for a sex-specific residual effect of cannabis on visuospatial memory. Psychotherapy and Psychosomatics, 66(4), 179–184.
  Article PubMed Google Scholar
• Pope, H. G., Jr., Gruber, A. J., Hudson, J. I., Cohane, G., Huestis, M. A., & Yurgelun-Todd, D. (2003). Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug and Alcohol Dependence, 69(3), 303–310.
  Article PubMed Google Scholar
• Quinn, H. R., Matsumoto, I., Callaghan, P. D., Long, L. E., Arnold, J. C., Gunasekaran, N., et al. (2008). Adolescent rats find repeated Delta(9)-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology, 33(5), 1113–1126.
  Article PubMed Google Scholar
• Ramaekers, J. G., Berghaus, G., van Laar, M., & Drummer, O. H. (2004). Dose related risk of motor vehicle crashes after cannabis use. Drug and Alcohol Dependence, 73(2), 109–119.
  Article PubMed CAS Google Scholar
• Ramaekers, J. G., Kauert, G., Theunissen, E. L., Toennes, S. W., & Moeller, M. R. (2009). Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. Journal of Psychopharmacology, 23(3), 266–277.
  Article PubMed CAS Google Scholar
• Ramaekers, J. G., Theunissen, E. L., de Brouwer, M., Toennes, S. W., Moeller, M. R., & Kauert, G. (2011). Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users. Psychopharmacology, 214(2), 391–401.
  Article PubMed CAS Google Scholar
• Ranganathan, M., & D’Souza, D. C. (2006). The acute effects of cannabinoids on memory in humans: a review. Psychopharmacology, 188(4), 425–444.
  Article PubMed CAS Google Scholar
• Realini, N., Rubino, T., & Parolaro, D. (2009). Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids. Pharmacological Research, 60(2), 132–138.
  Article PubMed CAS Google Scholar
• Reavis, R., & Overman, W. H. (2001). Adult sex differences on a decision-making task previously shown to depend on the orbital prefrontal cortex. Behavioral Neuroscience, 115(1), 196–206.
  Article PubMed CAS Google Scholar
• Reich, C. G., Taylor, M. E., & McCarthy, M. M. (2009). Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats. Behavioural Brain Research, 203(2), 264–269.
  Article PubMed CAS Google Scholar
• Roberts, G. M., & Garavan, H. (2010). Evidence of increased activation underlying cognitive control in ecstasy and cannabis users. NeuroImage, 52(2), 429–435.
  Article PubMed Google Scholar
• Rodriguez de Fonseca, F., Cebeira, M., Ramos, J. A., Martin, M., & Fernandez-Ruiz, J. J. (1994). Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sciences, 54(3), 159–170.
  Article PubMed CAS Google Scholar
• Rogers, R. D., Wakeley, J., Robson, P. J., Bhagwagar, Z., & Makela, P. (2007). The effects of low doses of delta-9 tetrahydrocannabinol on reinforcement processing in the risky decision-making of young healthy adults. Neuropsychopharmacology, 32(2), 417–428.
  Article PubMed CAS Google Scholar
• Roser, P., Gallinat, J., Weinberg, G., Juckel, G., Gorynia, I., & Stadelmann, A. M. (2009). Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects. European Archives of Psychiatry and Clinical Neuroscience, 259(5), 284–292.
  Article PubMed Google Scholar
• Rubino, T., Vigano, D., Realini, N., Guidali, C., Braida, D., Capurro, V., et al. (2008). Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates. Neuropsychopharmacology, 33(11), 2760–2771.
  Article PubMed CAS Google Scholar
• Rubino, T., Realini, N., Braida, D., Alberio, T., Capurro, V., Vigano, D., et al. (2009). The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex. Neurotoxicity Research, 15(4), 291–302.
  Article PubMed CAS Google Scholar
• Rubino, T., Realini, N., Braida, D., Guidi, S., Capurro, V., Vigano, D., et al. (2009). Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. Hippocampus, 19(8), 763–772.
  Article PubMed CAS Google Scholar
• SAMSHA. (2011). Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings, NSDUH. Rockville: Substance Abuse and Mental Health Services Administration.
  Google Scholar
• Schepis, T. S., Desai, R. A., Smith, A. E., Cavallo, D. A., Liss, T. B., McFetridge, A., et al. (2008). Impulsive sensation seeking, parental history of alcohol problems, and current alcohol and tobacco use in adolescents. Journal of Addiction Medicine, 2(4), 185–193.
  Article PubMed Google Scholar
• Scholes, K. E., & Martin-Iverson, M. T. (2009). Alterations to pre-pulse inhibition (PPI) in chronic cannabis users are secondary to sustained attention deficits. Psychopharmacology, 207(3), 469–484.
  Article PubMed CAS Google Scholar
• Scholes, K. E., & Martin-Iverson, M. T. (2010). Cannabis use and neuropsychological performance in healthy individuals and patients with schizophrenia. Psychological Medicine, 40(10), 1635–1646.
  Article PubMed CAS Google Scholar
• Scholes-Balog, K. E., & Martin-Iverson, M. T. (2011). Cannabis use and sensorimotor gating in patients with schizophrenia and healthy controls. Human Psychopharmacology, 26(3), 373–385.
  Google Scholar
• Schuster, R. M., Crane, N. A., Mermelstein, R., & Gonzalez, R. (2012). The influence of inhibitory control and episodic memory on the risky sexual behavior of young adult cannabis users. Journal of the International Neuropsychological Society, 18(5), 827–833.
  Article PubMed Google Scholar
• Schweinsburg, A. D., Brown, S. A., & Tapert, S. F. (2008). The influence of marijuana use on neurocognitive functioning in adolescents. Current Drug Abuse Reviews, 1(1), 99–111.
  Article PubMed Google Scholar
• Schweinsburg, A. D., Schweinsburg, B. C., Medina, K. L., McQueeny, T., Brown, S. A., & Tapert, S. F. (2010). The influence of recency of use on fMRI response during spatial working memory in adolescent marijuana users. Journal of Psychoactive Drugs, 42(3), 401–412.
  Article PubMed Google Scholar
• Schweinsburg, A. D., Schweinsburg, B. C., Nagel, B. J., Eyler, L. T., & Tapert, S. F. (2011). Neural correlates of verbal learning in adolescent alcohol and marijuana users. Addiction, 106(3), 564–573.
  Article PubMed Google Scholar
• Scorticati, C., Mohn, C., De Laurentiis, A., Vissio, P., Fernandez Solari, J., Seilicovich, A., et al. (2003). The effect of anandamide on prolactin secretion is modulated by estrogen. Proceedings of the National Academy of Sciences of the United States of America, 100(4), 2134–2139.
  Article PubMed CAS Google Scholar
• Scorticati, C., Fernandez-Solari, J., De Laurentiis, A., Mohn, C., Prestifilippo, J. P., Lasaga, M., et al. (2004). The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen. Proceedings of the National Academy of Sciences of the United States of America, 101(32), 11891–11896.
  Article PubMed CAS Google Scholar
• Sofuoglu, M., Dudish-Poulsen, S., Nelson, D., Pentel, P. R., & Hatsukami, D. K. (1999). Sex and menstrual cycle differences in the subjective effects from smoked cocaine in humans. Experimental and Clinical Psychopharmacology, 7(3), 274–283.
  Article PubMed CAS Google Scholar
• Solowij, N., & Battisti, R. (2008). The chronic effects of cannabis on memory in humans: a review. Current Drug Abuse Reviews, 1(1), 81–98.
  Article PubMed Google Scholar
• Solowij, N., & Pesa, N. (2010). Cognitive abnormalities and cannabis use. Revista Brasileira de Psiquiatria, 32(Suppl 1), S31–S40.
  PubMed Google Scholar
• Solowij, N., Jones, K. A., Rozman, M. E., Davis, S. M., Ciarrochi, J., Heaven, P. C., et al. (2011). Verbal learning and memory in adolescent cannabis users, alcohol users and non-users. Psychopharmacology, 216(1), 131–144.
  Article PubMed CAS Google Scholar
• Solowij, N., Jones, K. A., Rozman, M. E., Davis, S. M., Ciarrochi, J., Heaven, P. C., et al. (2012). Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents. Psychopharmacology, 219(2), 575–586.
  Article PubMed CAS Google Scholar
• Steger, R. W., Silverman, A. Y., Siler-Khodr, T. M., & Asch, R. H. (1980). The effects of delta 9-tetrahydrocannabinol on the positive and negative feedback control of luteinizing hormone release. Life Sciences, 27(20), 1911–1916.
  Article PubMed CAS Google Scholar
• Steger, R. W., DePaolo, L., Asch, R. H., & Silverman, A. Y. (1983). Interactions of delta 9-tetrahydrocannabinol (THC) with hypothalamic neurotransmitters controlling luteinizing hormone and prolactin release. Neuroendocrinology, 37(5), 361–370.
  Article PubMed CAS Google Scholar
• Sugarman, D. E., Poling, J., & Sofuoglu, M. (2011). The safety of modafinil in combination with oral 9-tetrahydrocannabinol in humans. Pharmacology, Biochemistry, and Behavior, 98(1), 94–100.
  Article PubMed CAS Google Scholar
• Tait, R. J., Mackinnon, A., & Christensen, H. (2011). Cannabis use and cognitive function: 8-year trajectory in a young adult cohort. Addiction, 106(12), 2195–2203.
  Article PubMed Google Scholar
• Tapert, S. F., Schweinsburg, A. D., Drummond, S. P., Paulus, M. P., Brown, S. A., Yang, T. T., et al. (2007). Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology, 194(2), 173–183.
  Article PubMed CAS Google Scholar
• Theunissen, E. L., Kauert, G. F., Toennes, S. W., Moeller, M. R., Sambeth, A., Blanchard, M. M., et al. (2011). Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication. Psychopharmacology, 220(2), 341–350.
  Article CAS Google Scholar
• Tulving, E. (2001). Episodic memory and common sense: how far apart? Philosophical Transactions of the Royal Society of London, 356(1413), 1505–1515.
  Article PubMed CAS Google Scholar
• United Nations Office on Drugs and Crimes. (2011). World Drug Report, United Nations Publications, Sales No. E.11.XI.10.
• Vadhan, N. P., Hart, C. L., van Gorp, W. G., Gunderson, E. W., Haney, M., & Foltin, R. W. (2007). Acute effects of smoked marijuana on decision making, as assessed by a modified gambling task, in experienced marijuana users. Journal of Clinical and Experimental Neuropsychology, 29(4), 357–364.
  Article PubMed Google Scholar
• Vaidya, J. G., Block, R. I., O’Leary, D. S., Ponto, L. B., Ghoneim, M. M., & Bechara, A. (2012). Effects of chronic marijuana use on brain activity during monetary decision-making. Neuropsychopharmacology, 37(3), 618–629.
  Article PubMed Google Scholar
• Van Laere, K., Goffin, K., Casteels, C., Dupont, P., Mortelmans, L., de Hoon, J., et al. (2008). Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET. NeuroImage, 39(4), 1533–1541.
  Article PubMed Google Scholar
• Viveros, M. P., Llorente, R., Suarez, J., Llorente-Berzal, A., Lopez-Gallardo, M., & Rodriguez de Fonseca, F. (2012). The endocannabinoid system in critical neurodevelopmental periods: sex differences and neuropsychiatric implications. Journal of Psychopharmacology, 26(1), 164–176.
  Article PubMed CAS Google Scholar
• Wadsworth, E. J., Moss, S. C., Simpson, S. A., & Smith, A. P. (2006). Cannabis use, cognitive performance and mood in a sample of workers. Journal of Psychopharmacology, 20(1), 14–23.
  Article PubMed CAS Google Scholar
• Wagner, D., Becker, B., Gouzoulis-Mayfrank, E., & Daumann, J. (2010). Interactions between specific parameters of cannabis use and verbal memory. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(6), 871–876.
  Article Google Scholar
• Ware, M. A., Adams, H., & Guy, G. W. (2005). The medicinal use of cannabis in the UK: results of a nationwide survey. International Journal of Clinical Practice, 59(3), 291–295.
  Article PubMed CAS Google Scholar
• Watson, S. J., Benson, J. A., Jr., & Joy, J. E. (2000). Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report. Archives of General Psychiatry, 57(6), 547–552.
  Article PubMed CAS Google Scholar
• Weinstein, A., Brickner, O., Lerman, H., Greemland, M., Bloch, M., Lester, H., et al. (2008a). Brain imaging study of the acute effects of Delta9-tetrahydrocannabinol (THC) on attention and motor coordination in regular users of marijuana. Psychopharmacology, 196(1), 119–131.
  Article PubMed CAS Google Scholar
• Weinstein, A., Brickner, O., Lerman, H., Greemland, M., Bloch, M., Lester, H., et al. (2008b). A study investigating the acute dose–response effects of 13 mg and 17 mg Delta 9- tetrahydrocannabinol on cognitive-motor skills, subjective and autonomic measures in regular users of marijuana. Journal of Psychopharmacology, 22(4), 441–451.
  Article PubMed CAS Google Scholar
• Weller, J. A., Levin, I. P., & Bechara, A. (2010). Do individual differences in Iowa Gambling Task performance predict adaptive decision making for risky gains and losses? Journal of Clinical and Experimental Neuropsychology, 32(2), 141–150.
  Article PubMed Google Scholar
• Wenger, T., Fernandez-Ruiz, J. J., & Ramos, J. A. (1999). Immunocytochemical demonstration of CB1 cannabinoid receptors in the anterior lobe of the pituitary gland. Journal of Neuroendocrinology, 11(11), 873–878.
  Article PubMed CAS Google Scholar
• Wert, R. C., & Raulin, M. L. (1986). The chronic cerebral effects of cannabis use. II. Psychological findings and conclusions. The International Journal of the Addictions, 21(6), 629–642.
  PubMed CAS Google Scholar
• Wesley, M. J., Hanlon, C. A., & Porrino, L. J. (2011). Poor decision-making by chronic marijuana users is associated with decreased functional responsiveness to negative consequences. Psychiatry Research, 191(1), 51–59.
  Article PubMed Google Scholar
• Winton-Brown, T. T., Allen, P., Bhattacharyya, S., Borgwardt, S. J., Fusar-Poli, P., Crippa, J. A., et al. (2011). Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study. Neuropsychopharmacology, 36(7), 1340–1348.
  Article PubMed CAS Google Scholar
• Yucel, M., Solowij, N., Respondek, C., Whittle, S., Fornito, A., Pantelis, C., et al. (2008). Regional brain abnormalities associated with long-term heavy cannabis use. Archives of General Psychiatry, 65(6), 694–701.
  Article PubMed Google Scholar

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