Adeneye AA (2008) Hypoglycemic and hypolipidemic effects of methanol seed extract of Citrus paradisi Macfad (Rutaceae) in alloxan-induced diabetic Wistar rats. Nig Q J Hosp Med 18:211–215 CAS Google Scholar
Diaz-Juárez JA, Tenorio-López FA, Zarco-Olvera G, Valle-Mondragón LD, Torres-Narváez JC, Pastelín-Hernández G (2009) Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo. Phytother Res 23:948–954 Article Google Scholar
Devhim F, Mndadi K, Patil BS, Faraji B (2008) Grapefruit pulp increases antioxidant status and improves bone quality in orchidectomized rats. Nutrition 24:1039–1044 Article Google Scholar
Oyelami OA, Agbakwuru EA, Adeyemi LA, Adedeji GB (2005) The effectiveness of grapefruit (Citrus paradisi) seeds in treating urinary tract infections. J Altern Complement Med 11:369–371 ArticleCAS Google Scholar
Miyata M, Takano H, Guo LQ, Nagata K, Yamazoe Y (2004) Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A4 activity. Carcinogenesis 25:203–209 ArticleCAS Google Scholar
Miyata M, Takano H, Takahashi K, Sasaki YF, Yamazoe Y (2002) Suppression of 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine-induced DNA damage in rat colon after grapefruit intake. Cancer Lett 183:17–22 ArticleCAS Google Scholar
Alvarez-Gonzalez I, Madrigal-Bujaidar E, Martino-Roaro L, Espinosa-Aguirre JJ (2004) Antigenotoxic and antioxidant effect of grapefruit juice in mice treated with daunorubicin. Toxicol Lett 152:203–211 ArticleCAS Google Scholar
Bronzetti G, Cini M, Andreoli E, Caltavuturo L, Panunzio M, Croce CD (2001) Protective effects of vitamins and selenium compounds in yeast. Mutat Res 496:105–115 CAS Google Scholar
Record IR, Jannes M, Dreosti IE (1996) Protection by zinc against UVA -and UVB-induced cellular and genomic damage in vivo and in vitro. Biol Trace Elem Res 53:19–25 ArticleCAS Google Scholar
Alvarez-Gonzalez I, Madrigal-Bujaidar E, Dorado V, Espinosa-Aguirre JJ (2001) Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse and evaluation of its modulatory effect on the cyp3a subfamily. Mutat Res 480(481):171–178 Google Scholar
Dechant KL, Brogden RN, Pilkington T, Faulds D (1991) Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer. Drugs 42:428–467 ArticleCAS Google Scholar
Korkmaz A, Topal T, Oter S (2007) Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 23:303–312 ArticleCAS Google Scholar
Tucker JD, Auletta A, Cimino MC, Dearfield KL, Jacobson-Kram D, Tice RR, Carrano AV (1993) Sister-chromatid exchange: second report of the Gene-Tox program. Mutat Res 297:101–180 CAS Google Scholar
Li L, Jiang L, Geng C, Cao J, Zhong L (2008) The role of oxidative stress in acrolein induced DNA damage in HepG2 cells. Free Radic Res 42:354–361 ArticleCAS Google Scholar
Takabe W, Niki E, Uchida K, Yamada S, Satoh K, Noguchi N (2001) Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein. Carcinogenesis 22:935–941 ArticleCAS Google Scholar
Brüggemann SK, Radike K, Braasch K, Hinrichs J, Kisro J, Hagenah W, Peters SO, Wagner T (2006) Chloroacetaldehyde: mode of antitumor action of the ifosfamide metabolite. Cancer Chemother Pharmacol 57:349–356 Article Google Scholar
Kandala JC, Mrema JE, DeAngelo A, Daniel FB, Guntaka RV (1990) 2-chloroacetaldehyde and 2-choroacetal are potent inhibitors of DNA synthesis in animal cells. Biochem Biophys Res Commun 167:457–463 ArticleCAS Google Scholar
Chiang SY, Swenberg JA, Weisman WH, Skopek TR (1997) Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. Carcinogenesis 18:31–36 ArticleCAS Google Scholar
Crebelli R, Conti G, Conti L, Carere A (1990) Chloroacetaldehyde is a powerful inducer of mitotic aneuploidy in Aspergillus nidulans. Mutagenesis 5:165–168 ArticleCAS Google Scholar
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ (2005) Metabolism and transport of oxazaphosphorines and the clinical implications. Drug Metab Rev 37:611–703 ArticleCAS Google Scholar
Hanly L, Chen N, Rieder M, Koren G (2009) Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention. Expert Opin Drug Saf 6:155–168 Article Google Scholar
Batista CK, Mota JM, Souza ML, Leitão BT, Souza MH, Brito GA, Cunha FQ, Ribeiro RA (2007) Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis. Cancer Chemother Pharmacol 59:71–7 ArticleCAS Google Scholar
Sehirli O, Sakarcan A, Velioğlu-Oğünç A, Cetinel S, Gedik N, Yeğen BC, Sener G (2007) Resveratrol improves ifosfamide-induced Fanconi syndrome in rats. Toxicol Appl Pharmacol 222:33–41 ArticleCAS Google Scholar
Gupta S, Chaudhuri T, Ganguly DK, Giri AK (2001) Anticlastogenic effects of black tea (World blend) and its two active polyphenols theaflavins and thearubigins in vivo in Swiss albino mice. Life Sci 69:2735–2744 ArticleCAS Google Scholar
Rodríguez-Muñoz E, Herrera-Ruiz G, Pedraza-Aboytes G, Loarca-Piña G (2009) Antioxidant capacity and antimutagenic activity of natural oleoresin from greenhouse grown tomatoes (Lycospersicon esculentum). Plant Foods Hum Nutr 64:46–51 Article Google Scholar
Martino-Roaro L, Garcia-Aguirre KK, Alvarez-Gonzalez I, Madrigal-Bujaidar E (2009) Grapefruit juice reduce preneoplastic lesions induced by azoxymethane in mouse colon. II Congress on free radicals and oxidative stress. Taxco, Mexico