The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events (original) (raw)

Abstract

Background: Aspirin resistance may increase up to more then threefold the risk of major cardiovascular events (MACE) in patients with stable coronary artery disease.

_Aim:_The aim of our study was to determine; the prevalence of aspirin resistance in patients with acute coronary syndromes, the role of aspirin resistance on outcome in the follow-up and the effect of clopidogrel therapy in the prevention of MACE in aspirin resistant subjects.

Material and methods: We detected the prevelance of aspirin resistance in 105 patients with acute coronary syndrome. Platelet functions were analyzed in Platelet Function Analyzer (PFA)-100 (Dade Behring, Germany) with collagen and/or epinephrine (Col/Epi) and collagen and/or ADP (Col/ADP) cartridges. Primary end points of the study were myocardial infarction, unstable angina, cardiac death.

Results: 19% (n = 20) of patients were aspirin resistant by PFA-100. In the follow-up, MACE occured in 9 patients (45%) with aspirin resistance and in 10 patients (11.7%) with aspirin sensitive platelet aggregation (p = 0.001). Multivariate analysis showed that aspirin resistance was an independant predictor of MACE. The prevalence of MACE in patients who were on clopidogrel treatment for 12 months were lower compared to those who were on a clopidogrel treatment for the first six months (p = 0.040).

Conclusions: We determined that the MACE risk in patients with acute coronary syndromes having detected aspirin resistance, was higher at statistically significant levels compared to patients having aspirin sensitive platelet aggregation. Our results showed that aspirin resistance, was an independant predictor of MACE in patients with acute coronary syndrome.

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Authors and Affiliations

  1. Istanbul Faculty of Medicine, Department of Cardiology, Istanbul University, Hasan Halife Mahallesi Oksuzler Sokak No: 9 K:2 D: 4 Fatih, Istanbul, Turkey, 34080
    Burak Pamukcu
  2. Istanbul Faculty of Medicine, Department of Cardiology, Istanbul University, Istanbul
    Huseyin Oflaz (Associate Professor of Cardiology)
  3. Istanbul Faculty of Medicine, Department of Cardiology, Istanbul University, Istanbul
    Aytac Oncul (Professor of Medicine), Berrin Umman (Professor of Medicine), Fehmi Mercanoglu (Professor of Medicine), Mustafa Ozcan (Professor of Medicine), Mehmet Meric (Professor of Medicine) & Yilmaz Nisanci (Professor of Medicine)

Authors

  1. Burak Pamukcu
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  2. Huseyin Oflaz
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  3. Aytac Oncul
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  4. Berrin Umman
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  5. Fehmi Mercanoglu
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  6. Mustafa Ozcan
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  7. Mehmet Meric
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  8. Yilmaz Nisanci
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Correspondence toBurak Pamukcu.

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Pamukcu, B., Oflaz, H., Oncul, A. et al. The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events.J Thromb Thrombolysis 22, 103–110 (2006). https://doi.org/10.1007/s11239-006-8952-4

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