Relationship of serum levels and dietary intake of isoflavone, and the novel bacterium Slackia sp. strain NATTS with the risk of prostate cancer: a case–control study among Japanese men (original) (raw)

Abstract

Purpose

Isoflavones may play a role in the prevention of hormone-related cancers. Equol is an isoflavone metabolized from daidzein in the presence of certain intestinal bacteria. Slackia sp. strain NATTS, a newly identified equol-producing bacterium, was recently isolated from human feces in Japan. We investigated the association of serum levels and dietary intake of isoflavones and Slackia sp. strain NATTS with the risk of prostate cancer in a case–control study among Japanese men.

Methods

Fifty-six patients with newly diagnosed prostate cancer and 56 hospital controls were enrolled in this study. Isoflavones were assessed by measurement of serum levels and administration of a food frequency questionnaire. Slackia sp. strain NATTS in feces was also measured. The odds ratios (ORs) and 95 % confidence intervals (CIs) for prostate cancer were then determined using a logistic regression model.

Results

The adjusted ORs for prostate cancer in comparison with the highest to lowest categories were 0.06 (95 % CI 0.02–0.24) for serum genistein, 0.18 (95 % CI 0.06–0.52) for daidzein, 0.16 (95 % CI 0.06–0.46) for glycitein, 0.52 (95 % CI 0.22–1.22) for equol, 0.86 (95 % CI 0.30–2.48) for dietary genistein, and 0.80 (95 % CI 0.28–2.28) for dietary daidzein. The adjusted OR for prostate cancer in comparison with values above versus below the median was 0.95 (95 % CI 0.42–2.16) for Slackia sp. strain NATTS.

Conclusion

Our study findings suggest that high serum levels of genistein, daidzein, and glycitein are significantly associated with a decreased risk of prostate cancer among Japanese men.

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Acknowledgments

This work was supported by the Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas, Ministry of Education, Culture, Sports, Science and Technology (Grant No. 221S0001).

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Authors and Affiliations

1. Department of Public Health, Sapporo Medical University School of Medicine, West-17, South-1, Chuo-ku, Sapporo, 060-8556, Japan
   Yoshie Nagata, Yukiko Sugiyama, Hirofumi Ohnishi & Mitsuru Mori
2. Department of Urology, Sapporo Medical University School of Medicine, West-17, South-1, Chuo-ku, Sapporo, 060-8556, Japan
   Fumimasa Fukuta, Akio Takayanagi, Naoya Masumori & Taiji Tsukamoto
3. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, West-17, South-1, Chuo-ku, Sapporo, 060-8556, Japan
   Hiroshi Akasaka, Hirofumi Ohnishi & Tetsuji Miura
4. Department of Nursing, Sapporo Medical University School of Health Sciences, West-17, South-1, Chuo-ku, Sapporo, 060-8556, Japan
   Shigeyuki Saitoh
5. Yakult Central Institute for Microbiological Research, Izumi 5-11, Kunitachi, Tokyo, 186-0012, Japan
   Kaoru Moriyama & Hirokazu Tsuji
6. Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo, 153-8904, Japan
   Hideyuki Akaza

Authors

1. Yoshie Nagata
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2. Yukiko Sugiyama
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3. Fumimasa Fukuta
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4. Akio Takayanagi
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5. Naoya Masumori
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6. Taiji Tsukamoto
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7. Hiroshi Akasaka
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8. Hirofumi Ohnishi
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9. Shigeyuki Saitoh
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10. Tetsuji Miura
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11. Kaoru Moriyama
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12. Hirokazu Tsuji
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13. Hideyuki Akaza
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14. Mitsuru Mori
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Corresponding author

Correspondence toYoshie Nagata.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Nagata, Y., Sugiyama, Y., Fukuta, F. et al. Relationship of serum levels and dietary intake of isoflavone, and the novel bacterium Slackia sp. strain NATTS with the risk of prostate cancer: a case–control study among Japanese men.Int Urol Nephrol 48, 1453–1460 (2016). https://doi.org/10.1007/s11255-016-1335-7

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• Received: 13 March 2016
• Accepted: 24 May 2016
• Published: 04 June 2016
• Issue Date: September 2016
• DOI: https://doi.org/10.1007/s11255-016-1335-7

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