Al-Moslih MI, Abuodeh RO, Hu YW (2004) Detection and genotyping of TT virus in healthy and subjects with HBV or HCV in different populations in the United Arab Emirates. J Med Virol 72(3):502–508. doi:10.1002/jmv.20017 ArticlePubMedCAS Google Scholar
Ansar Ahmed S, Karpuzoglu E, Khan D (2010) Effects of sex steroids on innate and adaptive immunity. In: Klein SL, Roberts C (eds) Sex hormones and immunity to infection. Springer, Berlin, pp 19–51. doi:10.1007/978-3-642-02155-8_2 Chapter Google Scholar
Beland K, Dore-Nguyen M, Gagne MJ, Patey N, Brassard J, Alvarez F, Halac U (2013) Torque teno virus in children with orthotopic liver transplantation: new insights about a common pathogen. J Infect Dis. doi:10.1093/infdis/jit423 PubMed Google Scholar
Biagini P, de Micco P (2008) Anellovirus. In: Mahy BWJ, Regenmortel MHVV (eds) Encyclopedia of virology, Thirdth edn. Academic, Oxford, pp 104–110 Chapter Google Scholar
Burra P, Masier A, Boldrin C, Calistri A, Andreoli E, Senzolo M, Zorzi M, Sgarabotto D, Guido M, Cillo U, Canova D, Bendinelli M, Pistello M, Maggi F, Palu G (2008) Torque teno virus: any pathological role in liver transplanted patients? Transpl Int 21(10):972–979. doi:10.1111/j.1432-2277.2008.00714.x ArticlePubMed Google Scholar
Chen T, Vaisanen E, Mattila PS, Hedman K, Soderlund-Venermo M (2013) Antigenic diversity and seroprevalences of Torque teno viruses in children and adults by ORF2-based immunoassays. J Gen Virol 94(Pt 2):409–417. doi:10.1099/vir.0.046862-0 ArticlePubMedCAS Google Scholar
Colonna-Romano G, Akbar AN, Aquino A, Bulati M, Candore G, Lio D, Ammatuna P, Fletcher JM, Caruso C, Pawelec G (2007) Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily. Exp Gerontol 42(10):995–1002. doi:10.1016/j.exger.2007.05.006 ArticlePubMedCAS Google Scholar
Focosi D, Maggi F, Albani M, Macera L, Ricci V, Gragnani S, Di Beo S, Ghimenti M, Antonelli G, Bendinelli M, Pistello M, Ceccherini-Nelli L, Petrini M (2010) Torquetenovirus viremia kinetics after autologous stem cell transplantation are predictable and may serve as a surrogate marker of functional immune reconstitution. J Clin Virol 47(2):189–192 ArticlePubMedCAS Google Scholar
Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128(1):92–105. doi:10.1016/j.mad.2006.11.016 ArticlePubMedCAS Google Scholar
Furman D, Hejblum BP, Simon N, Jojic V, Dekker CL, Thiébaut R, Tibshirani RJ, Davis MM (2014) Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc Natl Acad Sci 111(2):869–874. doi:10.1073/pnas.1321060111 ArticlePubMedCASPubMed Central Google Scholar
Görzer I, Haloschan M, Jaksch P, Klepetko W, Puchhammer-Stöckl E (2014) Plasma DNA levels of Torque teno virus and immunosuppression after lung transplantation. J Heart Lung Transpl 33(3):320–323. doi:10.1016/j.healun.2013.12.007 Article Google Scholar
Hadrup SR, Strindhall J, Køllgaard T, Seremet T, Johansson B, Pawelec G, Thor Straten P, Wikby A (2006) Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol 176(4):2645–2653 ArticlePubMedCAS Google Scholar
Kim OY, Chae JS, Paik JK, Seo HS, Jang Y, Cavaillon JM, Lee JH (2012) Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women. Age 34(2):415–425. doi:10.1007/s11357-011-9244-2 ArticlePubMedCASPubMed Central Google Scholar
Klein S, Huber S (2010) Sex differences in susceptibility to viral infection. In: Klein SL, Roberts C (eds) Sex hormones and immunity to infection. Springer, Berlin, pp 93–122. doi:10.1007/978-3-642-02155-8_4 Chapter Google Scholar
Klein SL, Roberts C (eds) (2010) Sex hormones and immunity to infection. Springer, Berlin Heidelberg Google Scholar
Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G (2008) Aging of the immune system as a prognostic factor for human longevity. Physiology 23(2):64–74. doi:10.1152/physiol.00040.2007 ArticlePubMedCAS Google Scholar
Maggi F, Pistello M, Vatteroni M, Presciuttini S, Marchi S, Isola P, Fornai C, Fagnani S, Andreoli E, Antonelli G, Bendinelli M (2001) Dynamics of persistent TT virus infection, as determined in patients treated with alpha interferon for concomitant hepatitis C virus infection. J Virol 75(24):11999–12004. doi:10.1128/JVI.75.24.11999-12004.2001 ArticlePubMedCASPubMed Central Google Scholar
Maggi F, Pifferi M, Fornai C, Andreoli E, Tempestini E, Vatteroni M, Presciuttini S, Marchi S, Pietrobelli A, Boner A, Pistello M, Bendinelli M (2003) TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity. J Virol 77(4):2418–2425 ArticlePubMedCASPubMed Central Google Scholar
Maggi F, Andreoli E, Lanini L, Fornai C, Vatteroni M, Pistello M, Presciuttini S, Bendinelli M (2005a) Relationships between total plasma load of torquetenovirus (TTV) and TTV genogroups carried. J Clin Microbiol 43(9):4807–4810. doi:10.1128/JCM.43.9.4807-4810.2005 ArticlePubMedPubMed Central Google Scholar
Maggi F, Tempestini E, Lanini L, Andreoli E, Fornai C, Giannecchini S, Vatteroni M, Pistello M, Marchi S, Ciccorossi P, Specter S, Bendinelli M (2005b) Blood levels of TT virus following immune stimulation with influenza or hepatitis B vaccine. J Med Virol 75(2):358–365. doi:10.1002/jmv.20278 ArticlePubMed Google Scholar
Moen EM, Sagedal S, Bjoro K, Degre M, Opstad PK, Grinde B (2003) Effect of immune modulation on TT virus (TTV) and TTV-like-mini-virus (TLMV) viremia. J Med Virol 70(1):177–182. doi:10.1002/jmv.10356 ArticlePubMed Google Scholar
Moro-Garcia MA, Alonso-Arias R, Lopez-Vazquez A, Suarez-Garcia FM, Solano-Jaurrieta JJ, Baltar J, Lopez-Larrea C (2012) Relationship between functional ability in older people, immune system status, and intensity of response to CMV. Age 34(2):479–495. doi:10.1007/s11357-011-9240-6 ArticlePubMedCASPubMed Central Google Scholar
Naganuma M, Tominaga N, Miyamura T, Soda A, Moriuchi M, Moriuchi H (2008) TT virus prevalence, viral loads and genotypic variability in saliva from healthy Japanese children. Acta Paediatr 97(12):1686–1690. doi:10.1111/j.1651-2227.2008.00962.x ArticlePubMed Google Scholar
Naylor K, Li G, Vallejo AN, Lee W-W, Koetz K, Bryl E, Witkowski J, Fulbright J, Weyand CM, Goronzy JJ (2005) The influence of age on T cell generation and TCR diversity. J Immunol 174(11):7446–7452 ArticlePubMedCAS Google Scholar
Niel C, Saback FL, Lampe E (2000) Coinfection with multiple TT virus strains belonging to different genotypes is a common event in healthy Brazilian adults. J Clin Microbiol 38(5):1926–1930 PubMedCASPubMed Central Google Scholar
O’Connor D, Trück J, Lazarus R, Clutterbuck EA, Voysey M, Jeffery K, Pollard AJ (2013) The effect of chronic cytomegalovirus infection on pneumococcal vaccine responses. J Infect Dis. doi:10.1093/infdis/jit673 Google Scholar
Okamoto H (2009) History of discoveries and pathogenicity of TT viruses. Curr Top Microbiol Immunol 331:1–20 PubMedCAS Google Scholar
Pinho-Nascimento CA, Leite JP, Niel C, Diniz-Mendes L (2011) Torque teno virus in fecal samples of patients with gastroenteritis: prevalence, genogroups distribution, and viral load. J Med Virol 83(6):1107–1111. doi:10.1002/jmv.22024 ArticlePubMed Google Scholar
Puchhammer-Stöckl E, Aberle SW, Heinzl H (2012) Association of age and gender with alphaherpesvirus infections of the central nervous system in the immunocompetent host. J Clin Virol 53(4):356–359. doi:10.1016/j.jcv.2011.12.015 ArticlePubMed Google Scholar
Roberts ET, Haan MN, Dowd JB, Aiello AE (2010) Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up. Am J Epidemiol 172(4):363–371. doi:10.1093/aje/kwq177 ArticlePubMedPubMed Central Google Scholar
Rocchi J, Ricci V, Albani M, Lanini L, Andreoli E, Macera L, Pistello M, Ceccherini-Nelli L, Bendinelli M, Maggi F (2009) Torquetenovirus DNA drives proinflammatory cytokines production and secretion by immune cells via toll-like receptor 9. Virology 394(2):235–242. doi:10.1016/j.virol.2009.08.036 ArticlePubMedCAS Google Scholar
Sakiani S, Olsen NJ, Kovacs WJ (2013) Gonadal steroids and humoral immunity. Nat Rev Endocrinol 9(1):56–62 ArticlePubMedCAS Google Scholar
Savva GM, Pachnio A, Kaul B, Morgan K, Huppert FA, Brayne C, Moss PAH, The Medical Research Council Cognitive F, Ageing S (2013) Cytomegalovirus infection is associated with increased mortality in the older population. Aging Cell 12(3):381–387. doi:10.1111/acel.12059 ArticlePubMedCAS Google Scholar
Turner JE, Campbell JP, Edwards KM, Howarth LJ, Pawelec G, Aldred S, Moss P, Drayson MT, Burns VE, Bosch JA (2013) Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age. doi:10.1007/s11357-013-9557-4 PubMed Central Google Scholar
Wang GC, Kao WHL, Murakami P, Xue Q-L, Chiou RB, Detrick B, McDyer JF, Semba RD, Casolaro V, Walston JD, Fried LP (2010) Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study. Am J Epidemiol 171(10):1144–1152. doi:10.1093/aje/kwq062 ArticlePubMedPubMed Central Google Scholar
Zheng H, Ye L, Fang X, Li B, Wang Y, Xiang X, Kong L, Wang W, Zeng Y, Wu Z, She Y, Zhou X (2007) Torque teno virus (SANBAN isolate) ORF2 protein suppresses NF-kappaB pathways via interaction with IkappaB kinases. J Virol 81(21):11917–11924. doi:10.1128/JVI.01101-07 ArticlePubMedCASPubMed Central Google Scholar