Association of a DASH diet and magnetoencephalography in dementia-free adults with different risk levels of Alzheimer’s disease (original) (raw)

Abstract

This study explored how adherence to the DASH diet relates to electrophysiological measures in individuals at varying Alzheimer’s disease (AD) risk due to family history (FH). There were 179 dementia-free subjects. DASH index was calculated, and participants were classified into different DASH adherence groups. Tertiles of relative alpha power in default mode network (DMN) regions were calculated. Multivariate logistic regression models were used to examine the association. Lower DASH adherence was associated with decreased odds of higher relative alpha power in the DMN, observed across the entire sample and specifically among those without a FH of AD. Logistic regression models indicated that participants with poorer DASH adherence had a reduced likelihood of elevated DMN alpha power, potentially influenced by vascular and amyloid-beta mechanisms. These findings underscore the dietary pattern’s potential role in neural activity modulation, particularly in individuals not genetically predisposed to AD.

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

We would like to thank the Spanish Ministry of Economy and Competitiveness, the Spanish Ministry of Universities for the fundings, and all the participants who have selflessly given us their time and made this study possible.

Funding

This work was supported by the Spanish Ministry of Economy and Competitiveness (PSI2015-68793-C3-1-R). Complimentary, it was supported by predoctoral grants by the Spanish Ministry of Universities (PRE2019-087612) to AGC, European Union-Next Generation EU (CT19/23-INVM-74) to ATF, and Margarita Salas postdoctoral contract of the Ministry of Universities funded by the European Union-Next Generation EU (CT18/22) to APS. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.

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Author notes

  1. Alfredo Trabado-Fernández and Alejandra García-Colomo contributed equally to this work.

Authors and Affiliations

  1. Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Pl. de Ramón y Cajal S/N, 28040, Madrid, Spain
    Alfredo Trabado-Fernández, Esther Cuadrado-Soto, África Peral-Suárez, María Dolores Salas-González, Ana María Lorenzo-Mora, Aránzazu Aparicio & Ana M. López-Sobaler
  2. Department of Experimental Psychology, Cognitive Processes and Speech Therapy, Faculty of Psychology, Complutense University of Madrid, 28223, Madrid, Spain
    Alejandra García-Colomo, María Luisa Delgado-Losada & Fernando Maestú-Unturbe
  3. Center for Cognitive and Computational Neuroscience, Complutense University of Madrid, 28223, Madrid, Spain
    Alejandra García-Colomo & Fernando Maestú-Unturbe
  4. VALORNUT Research Group, Department of Nutrition and Food Science, Complutense University of Madrid, 28040, Madrid, Spain
    Esther Cuadrado-Soto, África Peral-Suárez, María Dolores Salas-González, Aránzazu Aparicio, María Luisa Delgado-Losada & Ana M. López-Sobaler
  5. Department of Nursing and Nutrition, Faculty of Biomedical Sciences, Universidad Europea de Madrid, 28670, Villaviciosa de Odón, Madrid, Spain
    Ana María Lorenzo-Mora
  6. Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040, Madrid, Spain
    Aránzazu Aparicio, María Luisa Delgado-Losada, Fernando Maestú-Unturbe & Ana M. López-Sobaler

Authors

  1. Alfredo Trabado-Fernández
  2. Alejandra García-Colomo
  3. Esther Cuadrado-Soto
  4. África Peral-Suárez
  5. María Dolores Salas-González
  6. Ana María Lorenzo-Mora
  7. Aránzazu Aparicio
  8. María Luisa Delgado-Losada
  9. Fernando Maestú-Unturbe
  10. Ana M. López-Sobaler

Contributions

Conception and design of the study: ATF, AGC, FM, AMLS. Acquisition and data analysis: ATF, AGC, AA, ECS, APS, MDSG, AMLM, MLDL. Drafting a significant portion of the manuscript: AGC, ATF, FM, AMLS.

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Correspondence toEsther Cuadrado-Soto.

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Trabado-Fernández, A., García-Colomo, A., Cuadrado-Soto, E. et al. Association of a DASH diet and magnetoencephalography in dementia-free adults with different risk levels of Alzheimer’s disease.GeroScience 47, 1747–1759 (2025). https://doi.org/10.1007/s11357-024-01361-3

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