Bone Tumors in Adolescents and Young Adults (original) (raw)

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This is the largest series of patients with primary metastatic osteosarcoma.

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Other than commonly assumed, patients with skip-metastases were found to have relatively good outcomes if treated with multidrug chemotherapy and surgery of all affected sites.

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Adding ifosfamide did not improve EFS or overall survival, while the immune modulator MTP was associated with significantly improved survival in this largest published randomized osteosarcoma trial.

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This is the key reference supplying randomized evidence from a large trial that adding ifosfamide plus etoposide to the former standard of vincristine, doxorubicin, and cyclophosphamide improves outcome in ESFT.

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In this publication a new (biological) growing prosthesis was introduced, which did not lengthen the prosthesis but the adjacent bone.

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This and reference [54] are the largest analyses concerning the merits of different local therapy approaches in ESFT.

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This and reference [53] are the largest analyses concerning the merits of different local therapy approaches in ESFT.

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Number of lesions and recurrence free-interval correlated with postrecurrence outcomes in this large series of 576 patients. Complete surgery was a prerequisite for cure, and second-line chemotherapy seemed to improve outcomes.

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This report proves that the molecular rearrangement in ESFT is the ultimate cause for the manifestation of the malignant phenotype, and that it can be reversed in principal.

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