Interleukin-10-Secreting regulatory T cells in allergy and asthma (original) (raw)

• Robinson DS, Hamid Q, Ying S, et al.: Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992, 326:298–304.
  Article PubMed CAS Google Scholar
• Romagnani S: Regulation of the development of type 2 T-helper cells in allergy. Curr Opin Immunol 1994, 6:838–846.
  Article PubMed CAS Google Scholar
• Gershon RK, Kondo K: Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 1970, 18:723–737.
  PubMed CAS Google Scholar
• Schmidt-Weber CB, Kunzmann S, Blaser K: TGF-betamediated control of allergen-specific T-cell responses. Curr Allergy Asthma Rep 2002, 2:259–262.
  Article PubMed Google Scholar
• Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA: Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 2006, 24:99–146.
  Article PubMed CAS Google Scholar
• Shevach E: CD4+CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2004, 2:389–400.
  Google Scholar
• Sakaguchi S: Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004, 22:531–562.
  Article PubMed CAS Google Scholar
• Fontenot JD, Gavin MA, Rudensky AY: Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4:330–336.
  Article PubMed CAS Google Scholar
• Khattri R, Cox T, Yasayko SA, Ramsdell F: An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003, 4:337–342.
  Article PubMed CAS Google Scholar
• Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057–1061.
  Article PubMed CAS Google Scholar
• Fontenot JD, Rasmussen JP, Williams LM, et al.: Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005, 22:329–341.
  Article PubMed CAS Google Scholar
• O’Garra A, Vieira P: Regulatory T cells and mechanisms of immune system control. Nat Med 2004, 10:801–805.
  Article PubMed CAS Google Scholar
• Hawrylowicz CM, O’Garra A: Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 2005, 5:271–283.
  Article PubMed CAS Google Scholar
• Hawrylowicz CM: Regulatory T cells and IL-10 in allergic inflammation. J Exp Med 2005, 202:1459–1463.
  Article PubMed CAS Google Scholar
• Robinson DS: The role of regulatory T lymphocytes in asthma pathogenesis. Curr Allergy Asthma Rep 2005, 5:136–141.
  Article PubMed CAS Google Scholar
• Chatila TA, Blaeser F, Ho N, et al.: JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunityallergic dysregulation syndrome. J Clin Invest 2000, 106:R75-R81.
  PubMed CAS Google Scholar
• Ling EM, Smith T, Nguyen XD, et al.: Relation of CD4+CD25+ regulatory T-cell suppression of allergendriven T-cell activation to atopic status and expression of allergic disease. Lancet 2004, 363:608–615. Evidence that the naturally occurring CD4+CD25+ Treg compartment inhibits and prevents Th2 responses to ubiquitous allergens in healthy individuals
  Article PubMed CAS Google Scholar
• Pasare C, Medzhitov R: Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003, 299:1033–1036.
  Article PubMed CAS Google Scholar
• Ruprecht CR, Gattorno M, Ferlito F, et al.: Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med 2005, 201:1793–1803.
  Article PubMed CAS Google Scholar
• Doganci A, Eigenbrod T, Krug N, et al.: The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest 2005, 115:313–325.
  Article PubMed CAS Google Scholar
• Grindebacke H, Wing K, Andersson AC, et al.: Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy 2004, 34:1364–1372.
  Article PubMed CAS Google Scholar
• Bellinghausen I, Klostermann B, Knop J, Saloga J: Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J Allergy Clin Immunol 2003, 111:862–868.
  Article PubMed CAS Google Scholar
• Moore KW, de Waal Malefyt R, Coffman RL, O’Garra A: Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001, 19:683–765.
  Article PubMed CAS Google Scholar
• Asadullah K, Sterry W, Volk HD: Interleukin-10 therapy—review of a new approach. Pharmacol Rev 2003, 55:241–269. A comprehensive review and bibliography relating to the biology of and clinical studies with IL-10.
  Article PubMed CAS Google Scholar
• Grunig G, Corry DB, Leach MW, et al.: Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 1997, 185:1089–1099.
  Article PubMed CAS Google Scholar
• Tournoy KG, Kips JC, Pauwels RA: Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin Exp Allergy 2000, 30:775–783.
  Article PubMed CAS Google Scholar
• Akdis M, Verhagen J, Taylor A, et al.: Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004, 199:1567–1575. A study suggesting a high IL-10 to IL-4 ratio of allergen responsive T cells in the peripheral blood of healthy donors, as compared to allergic patients, may be important in the maintenance of immune homeostasis and prevention of inappropriate response to allergen.
  Article PubMed CAS Google Scholar
• John M, Lim S, Seybold J, et al.: Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med 1998, 157:256–262.
  PubMed CAS Google Scholar
• Borish L, Aarons A, Rumbyrt J, et al.: Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol 1996, 97:1288–1296.
  Article PubMed CAS Google Scholar
• Heaton T, Rowe J, Turner S, et al.: An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet 2005, 365:142–149. A study, together with John et al. [28], Borish et al. [29], and Lim et al. [31], suggesting an inverse correlation between IL-10 levels and the incidence and/or severity of allergic and asthmatic disease.
  Article PubMed CAS Google Scholar
• Lim S, Crawley E, Woo P, Barnes PJ: Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998, 352:113.
  Article PubMed CAS Google Scholar
• Bacchetta R, Bigler M, Touraine JL, et al.: High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 1994, 179:493–502.
  Article PubMed CAS Google Scholar
• Groux H, O’Garra A, Bigler M, et al.: Generation of a novel regulatory CD4+ T-cell population, which inhibits antigenspecific T-cell responses. Nature 1997, 389:737–742.
  Article PubMed CAS Google Scholar
• Levings MK, Sangregorio R, Galbiati F, et al.: IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 2001, 166:5530–5539.
  PubMed CAS Google Scholar
• McGuirk P, McCann C, Mills KH: Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 2002, 195:221–231.
  Article PubMed CAS Google Scholar
• Sundstedt A, O’Neill EJ, Nicolson KS, Wraith DC: Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J Immunol 2003, 170:1240–1248.
  PubMed CAS Google Scholar
• Jonuleit H, Schmitt E, Schuler G, et al.: Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000, 192:1213–1222.
  Article PubMed CAS Google Scholar
• Brinkmann V, Kristofic C: Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets. J Immunol 1995, 155:3322–3328.
  PubMed CAS Google Scholar
• Richards DF, Fernandez M, Caulfield J, Hawrylowicz CM: Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production. Eur J Immunol 2000, 30:2344–2354.
  Article PubMed CAS Google Scholar
• Barrat FJ, Cua DJ, Boonstra A, et al.: In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002, 195:603–616.
  Article PubMed CAS Google Scholar
• Xystrakis E, Kusumakar S, Boswell S, et al.: Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 2006, 116:146–155. This study, together with Hawrylowicz et al. [60], demonstrates that a poor clinical response to glucocorticoids correlates with poor in vitro glucocorticoid induction of IL-10 synthesis.
  Article PubMed CAS Google Scholar
• Peek EJ, Richards DF, Faith A, et al.: Interleukin-10 secreting ‘regulatory’ T cells induced by glucocorticoids and beta2-agonists. Am J Respir Cell Mol Biol 2005, 33:105–111.
  Article PubMed CAS Google Scholar
• Lloyd CM, Gonzalo JA, Coyle AJ, Gutierrez-Ramos JC: Mouse models of allergic airway disease. Adv Immunol 2001, 77:263–295.
  Article PubMed CAS Google Scholar
• Cottrez F, Hurst SD, Coffman RL, Groux H: T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 2000, 165:4848–4853.
  PubMed CAS Google Scholar
• Oh JW, Seroogy CM, Meyer EH, et al.: CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol 2002, 110:460–468.
  Article PubMed CAS Google Scholar
• Akbari O, Freeman GJ, Meyer EH, et al.: Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002, 8:1024–1032.
  Article PubMed CAS Google Scholar
• Stampfli MR, Cwiartka M, Gajewska BU, et al.: Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Am J Respir Cell Mol Biol 1999, 21:586–596.
  PubMed CAS Google Scholar
• Kearley J, Barker JE, Robinson DS, Lloyd CM: Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 2005, 202:1539–1547.
  Article PubMed CAS Google Scholar
• Dieckmann D, Bruett CH, Ploettner H, et al.: Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J Exp Med 2002, 196:247–253.
  Article PubMed CAS Google Scholar
• Bellinghausen I, Metz G, Enk AH, et al.: Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects. Eur J Immunol 1997, 27:1131–1139.
  Article PubMed CAS Google Scholar
• Akdis CA, Blesken, Akdis, M., Wuthrich, B., and Blaser, K.: Role of interleukin 10 in specific immunotherapy. J. Clin. Invest. 1998, 102:98–106.
  PubMed CAS Google Scholar
• Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R: Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based crosssectional study. Lancet 2001, 357:752–756.
  Article PubMed CAS Google Scholar
• Jeannin P, Lecoanet S, Delneste Y, et al.: IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol 1998, 160:3555–3561.
  PubMed CAS Google Scholar
• Strait RT, Morris SC, Finkelman FD: IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest 2006, 116:833–841.
  Article PubMed CAS Google Scholar
• Till SJ, Francis JN, Nouri-Aria K, Durham SR: Mechanisms of immunotherapy. J Allergy Clin Immunol 2004, 113:1025–1034; quiz 1035.
  Article PubMed CAS Google Scholar
• Kuehr J, Brauburger J, Zielen S, et al.: Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis. J Allergy Clin Immunol 2002, 109:274–280.
  Article PubMed CAS Google Scholar
• Novak N, Bieber T, Katoh N: Engagement of Fc epsilon RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells. J Immunol 2001, 167:797–804.
  PubMed CAS Google Scholar
• Larche M, Wraith DC: Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 2005, 11:S69–76.
  Article PubMed CAS Google Scholar
• Verhoef A, Alexander C, Kay AB, Larche M: T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. PLoS Med 2005, 2:e78.
  Article PubMed CAS Google Scholar
• Hawrylowicz C, Richards D, Loke TK, et al.: A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients. J Allergy Clin Immunol 2002, 109:369–370.
  Article PubMed CAS Google Scholar