Evidence of Clinically Relevant Efficacy for Dietary Supplements and Nutraceuticals (original) (raw)

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1. Gaziano TA. Cardiovascular disease in the developing world and its cost-effective management. Circulation. 2005;112:3547–53.
   Article PubMed Google Scholar
2. Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–23.
   PubMed Google Scholar
3. Lawes CM, Vanders HS, Rodgers A. Global burden of blood-pressure related disease, 2001. Lancet. 2008;371:1513–8.
   Article PubMed Google Scholar
4. McInnes GT. Lowering blood pressure for cardiovascular risk reduction. J Hypertens Suppl. 2005;23:S3–8.
   Article PubMed CAS Google Scholar
5. Mancia G, De Backer G, Dominiczak A, et al. Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25(6):1105–87.
   Article PubMed CAS Google Scholar
6. Appel LJ, Giles TD, Black HR, et al. American society of hypertension writing group: ASH position paper: dietary approaches to lower blood pressure. J Clin Hypertens. 2009;11(7):358–68.
   Article CAS Google Scholar
7. Miller 3rd ER, Erlinger TP, Appel LJ. The effects of macronutrients on blood pressure and lipids: an overview of the DASH and OmniHeart trials. Curr Atheroscler Rep. 2006;8(6):460–5.
   Article PubMed CAS Google Scholar
8. Pérez-López FR, Chedraui P, et al. Effects of the Mediterranean diet on longevity and age-related morbid conditions. Maturitas. 2009;64(2):67–79.
   Article PubMed Google Scholar
9. Hall WL. Dietary saturated and unsaturated fats as determinants of blood pressure and vascular function. Nutr Res Rev. 2009;22(1):18–38.
   Article PubMed CAS Google Scholar
10. Cicero AF, Ertek S, Borghi C. Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management. Curr Vasc Pharmacol. 2009;7(3):330–7.
    Article PubMed CAS Google Scholar
11. • Pase MP, Grima NA, Sarris J. Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials. Br J Nutr. 2011;106(7):974–80. _A comprehensive recent meta_-analysis of randomized controlled trials on the effect of PUFAs on arterial stiffness.
    Article PubMed CAS Google Scholar
12. Balakumar P, Taneja G. Fish oil and vascular endothelial protection: bench to bedside. Free Radic Biol Med. 2012;53(2):271–9.
    Article PubMed CAS Google Scholar
13. Altorf-van der Kuil W, Engberink MF, Brink EJ, et al. Dietary protein and blood pressure: a systematic review. PLoS One. 2010;5(8):e12102.
    Article Google Scholar
14. •• Cicero AF, Gerocarni B, Laghi L, Borghi C. Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials. J Hum Hypertens. 2011;25(7):425–36. _A comprehensive recent meta_-analysis of randomized controlled trials on the effect of lactotripeptides on human BP, with a particular focus on effect of ethnicity on the BP lowering efficacy.
    Article PubMed CAS Google Scholar
15. Cicero AF, Rosticci M, Gerocarni B, et al. Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or first-degree hypertension: a randomized double-blind clinical trial. Hypertens Res. 2011;34(9):1035–40.
    Article PubMed CAS Google Scholar
16. Lordan S, Ross P, Stanton C. Marine Bioactives as functional food ingredients: potential to reduce the incidence of chronic disease. Mar Drugs. 2011;9(6):1056–100.
    Article PubMed CAS Google Scholar
17. Rajapakse NW, Mattson DL. Role of L-arginine in nitric oxide production in health and hypertension. Clin Exp Pharmacol Physiol. 2009;36(3):249–55.
    Article PubMed CAS Google Scholar
18. • Dong JY, Qin JQ, Zhang ZL, et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011;162:959–65. _A comprehensive recent meta_-_analysis of randomized controlled trials on the effect of L_-Arginine BP lowering effect.
    Article PubMed CAS Google Scholar
19. Martina V, Masha A, Gigliardi VR, et al. Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes. Diabetes Care. 2008;31(5):940–4.
    Article PubMed CAS Google Scholar
20. Zulli A. Taurine in cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2011;14(1):57–60.
    Article PubMed CAS Google Scholar
21. Moloney MA, Casey RG, O'Donnell DH, et al. Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res. 2010;7(4):300–10.
    Article PubMed Google Scholar
22. Whelton PK, He J. Potassium in preventing and treating high blood pressure. Semin Nephrol. 1999;19:494–9.
    PubMed CAS Google Scholar
23. Gu D, He J, Xigui W, Duan X, Whelton PK. Effect of potassium supplementation on blood pressure in Chinese: a randomized, placebo controlled trial. J Hypertens. 2001;19:1325–31.
    Article PubMed CAS Google Scholar
24. D'Elia L, Barba G, Cappuccio FP, Strazzullo P. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies. J Am Coll Cardiol. 2011;57(10):1210–9.
    Article PubMed Google Scholar
25. Yang Q, Liu T, Kuklina EV, et al. Sodium and potassium intake and mortality among US adults: prospective data from the third national health and nutrition examination survey. Arch Int Med. 2011;171(13):1183–91.
    Article Google Scholar
26. Houston MC. The importance of potassium in managing hypertension. Curr Hypertens Rep. 2011;13(4):309–17.
    Article PubMed CAS Google Scholar
27. Houston MC, Harper KJ. Potassium, Magnesium, and Calcium: their role in both the cause and treatment of hypertension. J Clin Hypertens. 2008;10(7S2):3–11.
    CAS Google Scholar
28. • Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr. 2012;66(4):411–8. _A comprehensive recent meta_-analysis of randomized controlled trials on the effect of oral magnesium supplementation BP lowering effect.
    Article PubMed CAS Google Scholar
29. Laurant P, Touyz RM. Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. J Hypertens. 2000;18:1177–91.
    Article PubMed CAS Google Scholar
30. Widman L, Wester PO, Stegmayr BG, Wirell MP. The dose dependent reduction in blood pressure through administration of magnesium: a double-blind placebo-controlled cross-over trial. Am J Hypertens. 1993;6:41–5.
    PubMed CAS Google Scholar
31. Houston MC. The role of magnesium in hypertension and cardiovascular disease. J Clin Hyperten. 2011;13(11):843–7.
    Article CAS Google Scholar
32. • Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2010;8:CD001059. _A comprehensive recent meta_-_analysis of randomized controlled trials on the effect of calcium supplementation on prevention of pre_-eclampsia in pregnants.
    PubMed Google Scholar
33. Garcia Zozaya JL, Padilla VM. Alterations of calcium, magnesium, and zinc in essential hypertension: their relation to the renin-angiotensin aldosterone system. Invest Clin. 1997;38:27–40.
    PubMed Google Scholar
34. Bergomi M, Rovesti S, Vinceti M, et al. Zinc and copper status and blood pressure. J Trace Elem Med Biol. 1997;11:166–9.
    Article PubMed CAS Google Scholar
35. Ness AR, Khaw K-T, Bingham S, Day NE. Vitamin C status and blood pressure. J Hypertens. 1996;14:503–8.
    Article PubMed CAS Google Scholar
36. Enstrom JE, Kanim LE, Klein M. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992;3:194–202.
    Article PubMed CAS Google Scholar
37. Block G, Jensen CD, Norkus EP, et al. Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young black and white women. Nut J. 2008;17(7):35–46.
    Article Google Scholar
38. Ness AR, Chee D, Elliott P. Vitamin C and blood pressure—an overview. J Hum Hypertens. 1997;11(6):343–50.
    Article PubMed CAS Google Scholar
39. Block G, Mangels AR, Norkus EP, et al. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension. 2001;37:261–7.
    Article PubMed CAS Google Scholar
40. Sherman DL, Keaney JF, Biegelsen ES, et al. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension. 2000;35:936–41.
    Article PubMed CAS Google Scholar
41. • Juraschek SP, Guallar E, Appel LJ, Miller 3rd ER. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012;95(5):1079–88. _A comprehensive recent meta_-analysis of randomized controlled trials on the effect of supplemented vitamin C BP lowering effect.
    Article PubMed CAS Google Scholar
42. Mahajan AS, Babbar R, Kansai N, et al. Antihypertensive and antioxidant action of amlodipine and Vitamin C in patients of essential hypertension. J Clin Biochem Nutr. 2007;402:141–7.
    Article Google Scholar
43. Sato K, Dohi Y, Kojima M, Miyagawa K. Effects of ascorbic acid on ambulatory blood pressure in elderly patients with refractory hypertension. Arzneimittelforschung. 2006;6(7):535–40.
    Google Scholar
44. Plantinga Y, Ghiadoni L, Magagna A, Biannarelli C. Supplementation with Vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens. 2007;20(4):392–7.
    Article PubMed CAS Google Scholar
45. Simon JA. Vitamin C, and cardiovascular disease: a review. J Am Coll Nutr. 1992;11(2):107–25.
    PubMed CAS Google Scholar
46. Hatzitolios A, Iliadis F, Katsiki N, Baltatzi M. Is the antihypertensive effect of dietary supplements via aldehydes reduction evidence based: A systemic review. Clin Exp Hypertens. 2008;30(7):628–39.
    Article PubMed CAS Google Scholar
47. Ledlerc PC, Proulx CD, Arquin G, Belanger S. Ascorbic acid decreases the binding affinity of the AT1 Receptor for angiotensin II. Am J Hypertens. 2008;21(1):67–71.
    Article Google Scholar
48. Keniston R, Enriquez Sr JI. Relationship between blood pressure and plasma vitamin B6 levels in healthy middle-aged adults. Ann N Y Acad Sci. 1990;585:499–501.
    Article Google Scholar
49. Aybak M, Sermet A, Ayyildiz MO, Karakilcik AZ. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45:1271–3.
    PubMed CAS Google Scholar
50. van Dijk RA, Rauwerda JA, Steyn M, et al. Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol. 2001;21(12):2072–9.
    Article PubMed Google Scholar
51. Kim DH, Sabour S, Sagar UN, et al. Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). Am J Cardiol. 2008;102:1540–4.
    Article PubMed CAS Google Scholar
52. •• Vaidya A, Forman JP. Vitamin D and Vascular Disease: The Current and Future Status of Vitamin D Therapy in Hypertension and Kidney Disease. Curr Hypertens Rep. 2012;14:111–9. A very interesting and complete update on epidemiological, physiopathological and interventional evidence on the role of vitamin D supplementation in hypertension and its main organ target.
    Article PubMed CAS Google Scholar
53. Habauzit V, Morand C. Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians. Ther Adv Chronic Dis. 2012;3(2):87–106.
    Article PubMed CAS Google Scholar
54. • Ried K, Sullivan TR, Fakler P, et al. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. 2012;8:CD008893. _A large comprehensive recent meta_-analysis of randomized controlled trials on the effect of cocoa BP lowering effect, with particular attention to the content of flavanols.
    PubMed Google Scholar
55. Steffen M, Kuhle C, Hensrud D, et al. The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis. J Hypertens. 2012;30(12):2245–54.
    Article PubMed CAS Google Scholar
56. Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens. 2006;28(5):439–49.
    Article PubMed CAS Google Scholar
57. Yamaguchi T, Chikama A, Mori K, et al. Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure. Nutr Metab Cardiovasc Dis. 2008;18(6):408–14.
    Article PubMed CAS Google Scholar
58. Bogdanski P, Suliburska J, Szulinska M, et al. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res. 2012;32(6):421–7.
    Article PubMed CAS Google Scholar
59. Hodgson JM, Puddey IB, Woodman RJ, et al. Effects of black tea on blood pressure: a randomized controlled trial. Arch Intern Med. 2012;172(2):186–8.
    Article PubMed Google Scholar
60. Wahabi HA, Alansary LA, Al-Sabban AH, Glasziuo P. The effectiveness of Hibiscus sabdariffa in the treatment of hypertension: a systematic review. Phytomedicine. 2010;17(2):83–6.
    Article PubMed CAS Google Scholar
61. Li H, Xia N, Förstermann U. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide. 2012;26(2):102–10.
    Article PubMed Google Scholar
62. Poulsen MM, Vestergaard PF, Clasen BF, et al. High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition. Diabetes. 2012 Nov 28. [Epub ahead of print]
63. Feringa HH, Laskey DA, Dickson JE, Coleman CI. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet Assoc. 2011;111(8):1173–81.
    Article PubMed CAS Google Scholar
64. Cicero AFG, Derosa G, Manca M, et al. Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a 6-month, randomized clinical trial. Clin Exp Hypert. 2007;29:1–12.
    Article Google Scholar
65. Pal S, Khoussousi A, Binns C, et al. The effects of 12 week psyllium fibre supplementation or healthy diet on blood pressure and arterial stiffness in overweight and obese individuals. Brit J Nutr. 2012;107(5):725–34.
    Article PubMed CAS Google Scholar
66. Wichitsranoi J, Weerapreeyakul N, Boonsiri P, et al. Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans. Nutr J. 2011;10:82.
    Article PubMed CAS Google Scholar
67. Wu JH, Hodgson JM, Puddey IB, et al. Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women. Nutr Metab Cardiovasc Dis. 2009;19(11):774–80.
    Article PubMed CAS Google Scholar
68. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001;158(1):195–8.
    Article PubMed CAS Google Scholar
69. Lynn A, Hamadeh H, Leung WC, Russell JM, Barker ME. Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women. Plant Foods Hum Nutr. 2012;67(3):309–14.
    Article PubMed CAS Google Scholar
70. Langsjoen PH, Langsjoen AM. Overview of the use of Co Q 10 in cardiovascular disease. Biofactors. 1999;9:273–84.
    Article PubMed CAS Google Scholar
71. Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2009;4:CD007435.
    PubMed Google Scholar
72. Ankola DD, Viswanas B, Bhardqaj V, et al. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplement be used as first line therapeutic agents for prophylaxis/therapy? Eur J Pharm Biopharm. 2007;67(2):361–9.
    Article PubMed CAS Google Scholar
73. Ried K, Fakler P. Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials. Maturitas. 2011;68(4):299–310.
    Article PubMed CAS Google Scholar
74. Paran E, Novac C, Engelhard YN, Hazan-Halevy I. The effects of natural antioxidants form tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc Durgs Ther. 2009;23(2):145–51.
    Article CAS Google Scholar
75. Maimoona A, Naeem I, Saddiqe Z, Jameel K. A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract. J Ethnopharmacol. 2011;133(2):261–77.
    Article PubMed Google Scholar
76. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008;28(5):315–20.
    Article PubMed CAS Google Scholar
77. Liu X, Wei J, Tan F, et al. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004;74(7):855–62.
    Article PubMed CAS Google Scholar
78. Brzezinski A. Melatonin in humans. N Engl J Med. 1997;336(3):186–95.
    Article PubMed CAS Google Scholar
79. Rodella LF, Favero G, Foglio E, et al. Vascular endothelial cells and dysfunctions: role of melatonin. Front Biosci. 2013;5:119–29.
    Google Scholar
80. • Grossman E, Laudon M, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc Health Risk Manag. 2011;7:577–84. _A comprehensive recent meta_-analysis of randomized controlled trials on the effect melatonin BP lowering effect, _with a particular attention to the different effect of slow_-release and immediate release formulation.
    PubMed CAS Google Scholar
81. Scheer FA, Morris CJ, Garcia JI, et al. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012;35(10):1395–402.
    PubMed Google Scholar
82. Butt MS, Sultan MT, Butt MS, Iqbal J. Garlic: nature's protection against physiological threats. Crit Rev Food Sci Nutr. 2009;49(6):538–51.
    Article PubMed CAS Google Scholar
83. Ried K, Frank OR, Stocks NP, et al. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2008;8:13.
    Article PubMed Google Scholar
84. Reid K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomized controlled trial. Maturitas. 2010;67(2):144–50.
    Article Google Scholar
85. Wray DW, Nishiyama SK, Harris RA, et al. Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension. 2012;59(4):818–24.
    Article PubMed CAS Google Scholar
86. Rahman ST, Merchant N, Haque T, et al. The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study. J Cardiovasc Pharmacol Ther. 2012;17(2):139–45.
    Article PubMed CAS Google Scholar
87. Mate A, Miguel-Carrasco JL, Vázquez CM. The therapeutic prospects of using L-carnitine to manage hypertension-related organ damage. Drug Discov Today. 2010;15(11–12):484–92.
    Article PubMed CAS Google Scholar
88. Walker AF, Marakis G, Simpson E, et al. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen Pract. 2006;56(527):437–43.
    PubMed Google Scholar

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