Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis (original) (raw)
Abstract
Purpose
Polycystic ovary syndrome (PCOS) is a common disorder affecting up to 15% of women in the reproductive age. Prior studies suggest that PCOS can be associated with mood and psychiatric disorders. The purpose of this study is to examine the prevalence of any psychiatric disorder in women with PCOS.
Methods
We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through February 08, 2017 for studies that examined the prevalence of any psychiatric disorder in adolescents or adults with a clinical or biochemical diagnosis of PCOS. We used a random-effects model to generate pooled estimates and 95% confidence intervals (CI).
Results
We included 57 studies reporting on 172,040 patients. The majority of studies addressed depression and anxiety. Studies had fair methodological quality although most estimates were unadjusted. Women with PCOS were more likely to have a clinical diagnosis of depression (odds ratio (OR), 2.79; 95% CI, 2.23–3.50), anxiety (OR, 2.75; 95% CI, 2.10–3.60), bipolar disorder (OR, 1.78; 95% CI, 1.43–2.23) and obsessive compulsive disorder (OCD) (OR, 1.37; 95% CI 1.22–1.55), but not social phobia or panic disorder. Using various scales, the severity of symptoms of depression, anxiety, obsessive compulsive disorder, and somatization disorders were higher compared to women without PCOS.
Conclusions
PCOS is associated with an increased risk of diagnosis of depression, anxiety, bipolar disorder, and obsessive compulsive disorder. It is associated with worse symptoms of depression, anxiety, OCD, and somatization. Screening for these disorders to allow early intervention may be warranted.
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Abbreviations
Polycystic ovary syndrome:
PCOS
Confidence interval:
CI
Obsessive-compulsive disorder:
OCD
Odds ratio:
OR
Preferred Reporting Items for Systematic Reviews and Meta-Analyses:
PRISMA
Institutional Review Board:
IRB
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Authors and Affiliations
- Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN, USA
Claire Brutocao - Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
Feras Zaiem - Evidence-Based Practice Center, Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA
Mouaz Alsawas, Allison S. Morrow & M. Hassan Murad - Division of Pediatric and Adolescent Gynecology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA
Asma Javed
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- Claire Brutocao
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Correspondence toClaire Brutocao.
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Brutocao, C., Zaiem, F., Alsawas, M. et al. Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis.Endocrine 62, 318–325 (2018). https://doi.org/10.1007/s12020-018-1692-3
- Received: 30 March 2018
- Accepted: 21 July 2018
- Published: 31 July 2018
- Issue Date: November 2018
- DOI: https://doi.org/10.1007/s12020-018-1692-3