Statin therapy for Alzheimer’s disease (original) (raw)

• Akiyama H., Barger S., Barnum S., et al. (2000) Inflammation and Alzheimer’s disease. Neurobiol. Aging 21, 383–421.
  Article PubMed CAS Google Scholar
• Bodovitz S. and Klein W. L. (1996) Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J. Biol. Chem. 271, 4436–4440.
  Article PubMed CAS Google Scholar
• Blumenthal R. S. (2000) Statins: effective antiatherosclerotic therapy. Am. Heart 4, 577–583.
  Article Google Scholar
• Cucchiara B. and Kasner S. E. (2001) Use of statins in CNS disorders. J. Neurol. Sci. 187, 81–89.
  Article PubMed CAS Google Scholar
• Evans R. M., Emsley C. L., Gao S., Sahota A., Hall K. S., Farlow M. R., and Hendrie H. (2000) Serum cholesterol, APOE genotype, and the risk of Alzheimer’s disease: a population-based study of African Americans. Neurology 54, 240–242.
  PubMed CAS Google Scholar
• Fassbender K., Simons M., Bergmann C., et al. (2001) Simvastatin strongly reduces levels of Alzheimer’s disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98, 5856–5861.
  Article PubMed CAS Google Scholar
• Frears E. R., Stephens D. J., Walters C. E., Davies H., and Austen B. M. (1999) The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 10, 1699–1705.
  Article PubMed CAS Google Scholar
• Friedhoff L. T., Cullen E. I., Geoghagen N. S., et al. (2001) Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide. Int. J. Neuropsychopharmacol. 4, 127–130.
  Article PubMed CAS Google Scholar
• Hamelin B. A. and Turgeon J. (1998) Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol. Sci. 19, 26–37.
  Article PubMed CAS Google Scholar
• Howland D. S., Trusko S. P., Savage M. J., et al. (1998) Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. J. Biol. Chem. 273, 16576–16582.
  Article PubMed CAS Google Scholar
• Holcomb L., Gordon M. N., McGowan E., et al. (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4, 97–100.
  Article PubMed CAS Google Scholar
• Hutton M., Perez-Tur J., and Hardy J. (1998) Genetics of Alzheimer’s disease. Essays Biochem. 33, 117–131.
  PubMed CAS Google Scholar
• Jarvik G. P., Austin M. A., Fabsitz R. R., et al. (1994) Genetic influences on age-related change in total cholesterol, low-density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects. Genet. Epidemiol. 11, 375–384.
  Article PubMed CAS Google Scholar
• Jarvik G. P., Wijsman E. M., Kukull W. A., et al. (1995) Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer’s disease: a case-control study. Neurology 45, 1092–1096.
  PubMed CAS Google Scholar
• Jick H., Zornberg G. L., Jick S. S., Seshadri S., and Drachman D. A. (2000) Statins and the risk of dementia. Lancet 356, 1627–1631.
  Article PubMed CAS Google Scholar
• Kalmijn S., Launer L. J., Ott A., et al. (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann. Neurol. 42, 776–782.
  Article PubMed CAS Google Scholar
• Maron D. J., Fazio S., and Linton M. F. (2000) Current perspectives on statins. Circulation 101, 207–213.
  PubMed CAS Google Scholar
• Mizuno T., Haass C., Michikawa M., et al. (1998) Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells. Biochim. Biophys. Acta 1373, 119–130.
  Article PubMed CAS Google Scholar
• Moghadasian M. H. (1999) Clinical pharmacology of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Life Sci. 13, 1329–1337.
  Article Google Scholar
• Notkola I. L., Sulkava R., Pekkanen J., et al. (1998) Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer’s disease. Neuroepidemiology 17, 14–20.
  Article PubMed CAS Google Scholar
• Puglielli L., Konopka G., Pack-Chung E., et al. (2001) Acylcoenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat. Cell Biol. 905–912.
• Refolo L. M., Pappolla M. A., Malester B., et al. (2000) Hypercholesterolemia accelerates the Alzheimer’s amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7, 321–331.
  Article PubMed CAS Google Scholar
• Refolo L. M., Pappolla M. A., LaFrancois J., et al. (2001) A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer’s disease. Neurobiol. Dis. 5, 890–899.
  Article Google Scholar
• Roher A. E., Kuo Y. M., Kokjohn K. M., et al. (1999) Amyloid and lipids in the pathology of Alzheimer disease. Amyloid 6, 136–145.
  PubMed CAS Google Scholar
• Simons M., Keller P., De Strooper B., et al. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA 95, 6460–6464.
  Article PubMed CAS Google Scholar
• Sparks D. L., Scheff S. W., Hunsaker J. C., et al. (1994) Induction of Alzheimer’s-like beta-amyloid immunore-activity in brains of rabbits with dietary cholesterol. Exp. Neurol. 126, 88–94.
  Article PubMed CAS Google Scholar
• Sparks D. L. (1997) Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer’s disease? Ann. NY Acad. Sci. 826, 128–146.
  Article PubMed CAS Google Scholar
• Sparks D. L., Martin T. A., Gross D. G., and Hunsaker J. C. III (2000) Link between heart disease, cholesterol, and alzheimer’s disease: a review. Microscopy Res. Technique 50, 287–290.
  Article CAS Google Scholar
• Tokuda T., Tamaoka A., Matsuno S., et al. (2001) Plasma levels of amyloid beta proteins did not differ between subjects taking statins and those not taking statins. Ann. Neurol. 49, 546–547.
  Article PubMed CAS Google Scholar
• Wolozin B., Kellman W., Ruosseau P., et al. (2000) Decreased prevalence of Alzheimer’s disease associated with 3-hydroxy3-methylglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57, 1439–1443.
  Article PubMed CAS Google Scholar
• Wolozin B. (2001) A fluid connection: cholesterol and Abeta. Proc. Natl. Acad. Sci. USA 98, 5371–5373.
  Article PubMed CAS Google Scholar