The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats (original) (raw)
Buendia I, Michalska P, Navarro E, Gameiro I, Egea J, Leon R (2016) Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157:84–104 ArticleCASPubMed Google Scholar
Bundy JD, He J (2016) Hypertension and related cardiovascular disease burden in China. Ann Glob Health 82:227–233 ArticlePubMed Google Scholar
Butler RN, Miller RA, Perry D, Carnes BA, Williams TF, Cassel C, Brody J, Bernard MA, Partridge L, Kirkwood T, Martin GM, Olshansky SJ (2008) New model of health promotion and disease prevention for the 21st century. BMJ 337:a399 ArticlePubMed Google Scholar
Chetelat G, Ossenkoppele R, Villemagne VL, Perrotin A, Landeau B, Mezenge F, Jagust WJ, Dore V, Miller BL, Egret S, Seeley WW, van der Flier WM, La Joie R, Ames D, van Berckel BN, Scheltens P, Barkhof F, Rowe CC, Masters CL, de La Sayette V, Bouwman F, Rabinovici GD (2016) Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer’s disease. Brain 139:2528–2539 ArticlePubMed Google Scholar
Costa LG, Garrick JM, Roque PJ, Pellacani C (2016) Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxidative Med Cell Longev 2016:2986796 Google Scholar
Digicaylioglu M, Lipton SA (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412:641–647 ArticleCASPubMed Google Scholar
Engel PA (2016) Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson’s disease? Implications for treatment and inverse cancer risk. Med Hypotheses 93:154–160 ArticleCASPubMed Google Scholar
Gassen NC, Chrousos GP, Binder EB, Zannas AS (2016) Life stress, glucocorticoid signaling, and the aging epigenome: implications for aging-related diseases. Neurosci Biobehav Rev
Genc K, Egrilmez MY, Genc S (2010) Erythropoietin induces nuclear translocation of Nrf2 and heme oxygenase-1 expression in SH-SY5Y cells. Cell Biochem Funct 28:197–201 ArticleCASPubMed Google Scholar
Herrera-Arozamena C, Marti-Mari O, Estrada M, de la Fuente Revenga M, Rodriguez-Franco MI (2016) Recent advances in neurogenic small molecules as innovative treatments for neurodegenerative diseases. Molecules 21
Jin W, Kong J, Lu T, Wang H, Ni H, Wu J, Dai Y, Jiang J, Liang W (2011) Erythropoietin prevents secondary brain injury induced by cortical lesion in mice: possible involvement of Nrf2 signaling pathway. Ann Clin Lab Sci 41:25–32 CASPubMed Google Scholar
Juul S (2012) Neuroprotective role of erythropoietin in neonates. J Matern Fetal Neonatal Med 25(Suppl 4):105–107 PubMed Google Scholar
Katsuoka F, Yamamoto M (2016) Small Maf proteins (MafF, MafG, MafK): history, structure and function. Gene 586:197–205 ArticleCASPubMed Google Scholar
Katsuoka F, Motohashi H, Engel JD, Yamamoto M (2005) Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. J Biol Chem 280:4483–4490 ArticleCASPubMed Google Scholar
Khalil SK, Amer HA, El Behairy AM, Warda M (2016) Oxidative stress during erythropoietin hyporesponsiveness anemia at end stage renal disease: molecular and biochemical studies. J Adv Res 7:348–358 ArticleCASPubMedPubMed Central Google Scholar
Kilic E, Kilic U, Soliz J, Bassetti CL, Gassmann M, Hermann DM (2005) Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways. FASEB J 19:2026–2028 CASPubMed Google Scholar
Koltover VK (2016) Free radical timer of aging: from chemistry of free radicals to systems theory of reliability. Curr Aging Sci
Koskenkorva-Frank TS, Weiss G, Koppenol WH, Burckhardt S (2013) The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress. Free Radic Biol Med 65:1174–1194 ArticleCASPubMed Google Scholar
Kume T, Suenaga A, Izumi Y, Akaike A (2016) Protective effect of dimethyl fumarate on an oxidative stress model induced by sodium nitroprusside in mice. Biol Pharm Bull 39:1055–1059 ArticleCASPubMed Google Scholar
Li YP, Yang GJ, Jin L, Yang HM, Chen J, Chai GS, Wang L (2015) Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid beta42 in mice. Brain Res 1618:159–167 ArticleCASPubMed Google Scholar
Liochev SI (2015) Which is the most significant cause of aging? Antioxidants (Basel) 4:793–810 ArticleCAS Google Scholar
Lu MC, Ji JA, Jiang ZY, You QD (2016) The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target: an update. Med Res Rev 36:924–963 ArticleCASPubMed Google Scholar
Merelli A, Czornyj L, Lazarowski A (2013) Erythropoietin: a neuroprotective agent in cerebral hypoxia, neurodegeneration, and epilepsy. Curr Pharm Des 19:6791–6801 ArticleCASPubMed Google Scholar
Merelli A, Czornyj L, Lazarowski A (2015) Erythropoietin as a new therapeutic opportunity in brain inflammation and neurodegenerative diseases. Int J Neurosci 125:793–797 ArticleCASPubMed Google Scholar
Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R (1997) Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76:105–116 ArticleCASPubMed Google Scholar
Sanz A (2016) Mitochondrial reactive oxygen species: do they extend or shorten animal lifespan? Biochim Biophys Acta 1857:1116–1126 ArticleCASPubMed Google Scholar
Sargin D, Friedrichs H, El-Kordi A, Ehrenreich H (2010) Erythropoietin as neuroprotective and neuroregenerative treatment strategy: comprehensive overview of 12 years of preclinical and clinical research. Best Pract Res Clin Anaesthesiol 24:573–594 ArticleCASPubMed Google Scholar
Wu H, Wang H, Zhang W, Wei X, Zhao J, Yan P, Liu C (2015) rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. Int J Clin Exp Pathol 8:6870–6880 PubMedPubMed Central Google Scholar
Zhang DD (2006) Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38:769–789 ArticleCASPubMed Google Scholar