The therapeutic potential of TRAIL receptor signalling in cancer cells (original) (raw)
Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257 ArticlePubMedCAS Google Scholar
O’Reilly L, Tai L, Lee L et al (2009) Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature 461:659–663 ArticleCAS Google Scholar
Bodmer JL, Schneider P, Tschopp J (2002) The molecular architecture of the TNF superfamily. Trends Biochem Sci 27:19–26 ArticlePubMedCAS Google Scholar
Nikolaev A, McLaughlin T, O’Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981–989 ArticlePubMedCAS Google Scholar
Wu GS, Burns TF, Zhan Y et al (1999) Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res 59:2770–2775 PubMedCAS Google Scholar
Wilson NS, Dixit V, Ashkenazi A (2009) Death receptor signal transducers: nodes of coordination in immune signaling networks. Nature Immunol 10:348–355 ArticleCAS Google Scholar
Wiley SR, Schooley K, Smolak PJ et al (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3:673–682 ArticlePubMedCAS Google Scholar
Pitti RM, Marsters SA, Ruppert S et al (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271:12687–12690 ArticlePubMedCAS Google Scholar
Ashkenazi A, Pai RC, Fong S et al (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104:155–162 ArticlePubMedCAS Google Scholar
Walczak H, Miller RE, Ariail K et al (1999) Tumoricidal activity of tumor necrosis factorrelated apoptosis-inducing ligand in vivo. Nat Med 5:157–163 ArticlePubMedCAS Google Scholar
Duiker EW, Mom CH, de Jong S et al (2006) The clinical trial of TRAIL. Eur J Cancer 42:2233–2240 ArticlePubMedCAS Google Scholar
Pan G, O’Rourke K, Chinnaiyan AM et al (1997) The receptor for the cytotoxic ligand TRAIL. Science 276:111–113 ArticlePubMedCAS Google Scholar
Schneider P, Bodmer JL, Thome M et al (1997) Characterization of two receptors for TRAIL. FEBS Lett 416:329–334 ArticlePubMedCAS Google Scholar
MacFarlane M, Ahmad M, Srinivasula SM et al (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem 272:25417–25420 ArticlePubMedCAS Google Scholar
Sheridan JP, Marsters SA, Pitti RM et al (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277:818–821 ArticlePubMedCAS Google Scholar
Walczak H, Degli-Esposti MA, Johnson RS et al (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J 16:5386–5397 ArticlePubMedCAS Google Scholar
Degli-Esposti MA, Smolak PJ, Walczak H et al (1997) Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J Exp Med 186:1165–1170 ArticlePubMedCAS Google Scholar
Emery JG, McDonnell P, Burke MB et al (1998) Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 273:14363–14367 ArticlePubMedCAS Google Scholar
Chan FK, Chun HJ, Zheng L et al (2000) A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288:2351–2354 ArticlePubMedCAS Google Scholar
Wang TT, Jeng J (2000) Coordinated regulation of two TRAIL-R2/KILLER/DR5 mRNA isoforms by DNA damaging agents, serum and 17beta-estradiol in human breast cancer cells. Breast Cancer Res Treat 61:87–96 ArticlePubMedCAS Google Scholar
Merino D, Lalaoui N, Morizot A et al (2006) Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol 26:7046–7055 ArticlePubMedCAS Google Scholar
Lacey DL, Timms E, Tan HL et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165–176 ArticlePubMedCAS Google Scholar
Cretney E, Takeda K, Yagita H et al (2002) Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 168:1356–1361 PubMedCAS Google Scholar
Ichikawa K, Liu W, Zhao L et al (2001) Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 7:954–960 ArticlePubMedCAS Google Scholar
Rossin A, Derouet M, Abdel-Sater F, Hueber AO (2009) Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling. Biochem J 419:185–192, 2 p following 192 ArticlePubMedCAS Google Scholar
Tang Z, Bauer JA, Morrison B, Lindner DJ (2006) Nitrosylcobalamin promotes cell death via S nitrosylation of Apo2L/TRAIL receptor DR4. Mol Cell Biol 26:5588–5594 ArticlePubMedCAS Google Scholar
Wagner KW, Punnoose EA, Januario T et al (2007) Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 13:1070–1077 ArticlePubMedCAS Google Scholar
Diehl GE, Yue HH, Hsieh K et al (2004) TRAIL-R as a negative regulator of innate immune cell responses. Immunity 21:877–889 ArticlePubMedCAS Google Scholar
Lamhamedi-Cherradi SE, Zheng SJ, Maguschak KA et al (2003) Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/-mice. Nat Immunol 4:255–260 ArticlePubMedCAS Google Scholar
Grosse-Wilde A, Voloshanenko O, Bailey SL et al (2008) TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest 118:100–110 ArticlePubMedCAS Google Scholar
Takeda K, Hayakawa Y, Smyth MJ et al (2001) Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 7:94–100 ArticlePubMedCAS Google Scholar
Sprick MR, Weigand MA, Rieser E et al (2000) FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12:599–609 ArticlePubMedCAS Google Scholar
Gonzalvez F, Ashkenazi A (2010) New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29:4752–4765 ArticlePubMedCAS Google Scholar
Yamada H, Tada-Oikawa S, Uchida A, Kawanishi S (1999) TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells. Biochem Biophys Res Commun 265:130–133 ArticlePubMedCAS Google Scholar
LeBlanc H, Lawrence D, Varfolomeev E et al (2002) Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. Nat Med 8:274–281 ArticlePubMedCAS Google Scholar
Luo X, Budihardjo I, Zou H et al (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481–490 ArticlePubMedCAS Google Scholar
Irmler M, Thome M, Hahne M et al (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388:190–195 ArticlePubMedCAS Google Scholar
MacFarlane M, Harper N, Snowden RT et al (2002) Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene 21:6809–6818 ArticlePubMedCAS Google Scholar
Djerbi M, Darreh-Shori T, Zhivotovsky B, Grandien A (2001) Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms. Scan J Immunol 54:180–189 ArticleCAS Google Scholar
Golks A, Brenner D, Fritsch C et al (2005) c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem 280:14507–14513 ArticlePubMedCAS Google Scholar
Micheau O, Thome M, Schneider P et al (2002) The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem 277:45162–45171 ArticlePubMedCAS Google Scholar
Xiao C, Yang BF, Asadi N et al (2002) Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. J Biol Chem 277:25020–25025 ArticlePubMedCAS Google Scholar
Palacios C, Yerbes R, Lopez-Rivas A (2006) Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells. Cancer Res 66:8858–8869 ArticlePubMedCAS Google Scholar
Sharp DA, Lawrence DA, Ashkenazi A (2005) Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis. J Biol Chem 280:19401–19409 ArticlePubMedCAS Google Scholar
Yerbes R, Palacios C, Reginato MJ, Lopez-Rivas A (2011) Cellular FLIP(L) plays a survival role and regulates morphogenesis in breast epithelial cells. Biochim Biophys Acta 1813:168–178 ArticlePubMedCAS Google Scholar
Jin Z, Li Y, Pitti R et al (2009) Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137:721–735 ArticlePubMedCAS Google Scholar
Song JH, Tse MC, Bellail A et al (2007) Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Cancer Res 67:6946–6955 ArticlePubMedCAS Google Scholar
Kohlhaas SL, Craxton A, Sun XM et al (2007) Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. J Biol Chem 282:12831–12841 ArticlePubMedCAS Google Scholar
Zhao X, Liu Y, Ma Q et al (2009) Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells. Biochem Biophys Res Commun 378:21–26 ArticlePubMedCAS Google Scholar
Jin Z, El-Deiry WS (2006) Distinct signaling pathways in TRAIL-versus tumor necrosis factor-induced apoptosis. Mol Cell Biol 26:8136–8148 ArticlePubMedCAS Google Scholar
Varfolomeev E, Maecker H, Sharp D et al (2005) Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.J Biol Chem 280:40599–40608 ArticleCAS Google Scholar
Secchiero P, Melloni E, Corallini F et al (2008) Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Stem Cells 26:2955–2963 ArticlePubMedCAS Google Scholar
Ehrhardt H, Fulda S, Schmid I et al (2003) TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene 22:3842–3852 ArticlePubMedCAS Google Scholar
Ishimura N, Isomoto H, Bronk SF, Gores GJ (2006) Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells. Am J Physiol Gastrointest Liver Physiol 290:G129–136 ArticlePubMedCAS Google Scholar
Meurette O, Rebillard A, Huc L et al (2007) TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions. Cancer Res 67:218–226 ArticlePubMedCAS Google Scholar
Smyth MJ, Cretney E, Takeda K et al (2001) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J Exp Med 193:661–670 ArticlePubMedCAS Google Scholar
Zerafa N, Westwood JA, Cretney E et al (2005) Cutting edge: TRAIL deficiency accelerates hematological malignancies. J Immunol 175:5586–5590 PubMedCAS Google Scholar
Yue HH, Diehl GE, Winoto A (2005) Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ 12:94–97 ArticlePubMedCAS Google Scholar
Bos PD, Zhang XH, Nadal C et al (2009) Genes that mediate breast cancer metastasis to the brain. Nature 459:1005–1009 ArticlePubMedCAS Google Scholar
Johnstone RW, Frew AJ, Smyth MJ (2008) The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer 8:782–798 ArticlePubMedCAS Google Scholar
Lee SH, Shin MS, Kim HS et al (1999) Alterations of the DR5/TRAIL receptor 2 gene in nonsmall cell lung cancers. Cancer Res 59:5683–5686 PubMedCAS Google Scholar
Shin MS, Kim HS, Lee SH et al (2001) Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers. Cancer Res 61:4942–4946 PubMedCAS Google Scholar
Sanlioglu AD, Korcum AF, Pestereli E et al (2007) TRAIL death receptor-4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma. Int J Radiat Oncol Biol Phys 69:716–723 ArticlePubMedCAS Google Scholar
Lawrence D, Shahrokh Z, Marsters S et al (2001) Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 7:383–385 ArticlePubMedCAS Google Scholar
Ashkenazi A (2008) Directing cancer cells to self-destruct with pro-apoptotic receptor agonists. Nat Rev Drug Discov 7:1001–1012 ArticlePubMedCAS Google Scholar
Herbst RS, Eckhardt SG, Kurzrock R et al (2010) Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol 28:2839–2846 ArticlePubMedCAS Google Scholar
Takeda K, Yamaguchi N, Akiba H et al (2004) Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med 199:437–448 ArticlePubMedCAS Google Scholar
Wilson NS, Yang B, Yang A et al (2011) An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell 19:101–113 ArticlePubMedCAS Google Scholar
Eramo A, Pallini R, Lotti F et al (2005) Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. Cancer Res 65:11469–11477 ArticlePubMedCAS Google Scholar
Koschny R, Ganten TM, Sykora J et al (2007) TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology 45:649–658 ArticlePubMedCAS Google Scholar
Nguyen T, Zhang XD, Hersey P (2001) Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Clin Cancer Res 7:966s–973s PubMedCAS Google Scholar
Wu GS, Burns TF, McDonald ER 3rd et al (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 17:141–143 ArticlePubMedCAS Google Scholar
Wen J, Ramadevi N, Nguyen D et al (2000) Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. Blood 96:3900–3906 PubMedCAS Google Scholar
Greco FA, Bonomi P, Crawford J et al (2008) Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 61:82–90 ArticlePubMed Google Scholar
Holoch PA, Griffith TS (2009) TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies. Eur J Pharmacol 625:63–72 ArticlePubMedCAS Google Scholar
Yee L, Fanale M, Dimick K et al (2007) A phase 1b safety and pharmacokinetic (PK) study of recombinant human APO2L/TRAIL in combination with rituximab in patients with low-grade non-Hodgkin lymphoma. J Clin Oncol 25:8078 Google Scholar
Soria JC, Smit E, Khayat D et al (2010) Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer. J Clin Oncol 28:1527–1533 ArticlePubMedCAS Google Scholar
Ling J, Herbst RS, Mendelson DS et al (2006) APO2L/TRAIL pharmacokinetics in a phase 1a trial in advanced cancer and lymphoma. J Clin Oncol 24:3047 Google Scholar
Pan Y, Xu R, Peach M et al (2007) Application of phamacodynamic assays in a phase 1a trial of APO2L/TRAIL in patients with advanced tumors. J Clin Oncol 25:3535 Google Scholar
Tolcher AW, Mita M, Meropol NJ et al (2007) Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 25:1390–1395 ArticlePubMedCAS Google Scholar
Younes A, Vose J, Zelenetz AD et al (2005) Results of a phase 2 trial of HGS-ETR1 in subjects with relapsed/refractory non-Hodgkin’s lymphoma (NHL). 47th Annual Meeting of the American Society of Hematology Abstracts 106:489 Google Scholar
Kanzler S, Trarbach T, Heinemann V et al (2005) Results of a phase 2 trial of HGS-ETR1 in subjects with relapsed or refractory colorectal cancer (CRC). ECCO 13: The European Cancer Conference Abstract #630
Wakelee HA, Patnaik A, Sikic BI et al (2010) Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors. Ann Oncol 21:376–381 ArticlePubMedCAS Google Scholar
LoRusso P, Hong D, Heath E et al (2007) First-inhuman study of AMG655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors. J Clin Oncol 25:3534 Article Google Scholar
Camidge DR (2008) Apomab: an agonist monoclonal antibody directed against death receptor 5/TRAIL-receptor 2 for use in the treatment of solid tumors. Exp Opin Biol Ther 8:1167–1176 ArticleCAS Google Scholar
Saleh MN, Percent I, Wood TE et al (2008) A phase 1 study of CS-1008 administered weekly to patients with advanced solid tumors or lymphomas. J Clin Oncol 26:3537 Google Scholar
Yee L, Burris HA, Kozloff M et al (2009) Phase 1b study of recombinant human APO2L/TRAIL plus irinotecan and cetuximab or FOLFIRI in metastatic colorectal cancer (mCRC) patients: preliminary results. J Clin Oncol 27: 4129 Google Scholar
Mom CH, Verweij J, Oldenhuis CN et al (2009) Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: a phase I study. Clin Cancer Res 15:5584–5590 ArticlePubMedCAS Google Scholar
Leong S, Cohen RB, Gustafson DL et al (2009) Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study. J Clin Oncol 27:4413–4421 ArticlePubMedCAS Google Scholar
Sikic BI, Wakelee HA, von Mehren M et al (2007) A phase 1b study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine, pemetrexed, doxorubicin or FOLFIRI. J Clin Oncol 25:14006 Google Scholar
Paz-Ares L, Sánchez Torres JM, Diaz-Padilla I et al (2009) Safety and efficacy of AMG 655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 27:19048 Google Scholar
Blay J-Y, Chawla S, Demetri GD et al (2008) 2 open-label study of AMG 655 in combination with doxorubicin for the first-line treatment of patients with locally advanced or metastatic, unresectable soft tissue sarcoma. CTOS 14th Annual Meeting, London, p 34845
Saltz L, Infante J, Schwartzberg L et al (2009) Safety and efficacy of AMG 655 plus modified FOLFOX6 and bevacizumab for the first-line treatment of patients with metastatic colorectal cancer. J Clin Oncol 27:4079 Google Scholar
Kindler HL, Garbo L, Stephenson J et al (2009) A phase 1b study to evaluate the safety and efficacy of AMG 655 in combination with gemcitabine in patients with metastatic pancreatic cancer. J Clin Oncol 27:4501 Google Scholar
Rougier P, Infante J, Van Laethem J et al (2009) A phase 1b/2 trial of AMG 655 and panitumumab for the treatment of metastatic colorectal cancer: safety results. J Clin Oncol 27:4130 Article Google Scholar