Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways (original) (raw)

• Aubert, J., S. Dessolin, N. Belmonte, M. Li, F.R. McKenzie, L. Staccini, P. Villageois, B. Barhanin, A. Vernallis, A.G. Smith, G. Ailhaud, and C. Dani. 1999. Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade. Journal of Biological Chemistry 274: 24965–24972.
  Article CAS PubMed Google Scholar
• Bae, S., and Y. Yoon. 2013. Anti-adipogenic activity of berberine is not mediated by the WNT/β-catenin pathway. Phytotherapy Research 27: 937–943.
  Article CAS PubMed Google Scholar
• Baudry, A., Z.Z. Yang, and B.A. Hemmings. 2006. PKBα is required for adipose differentiation of mouse embryonic fibroblasts. Journal of Cell Science 119: 889–897.
  Article CAS PubMed Google Scholar
• Baulande, S., and B. Fève. 2005. Identification of new genes involved in adipogenesis. Medical Science (Paris). 21: 26–28.
  Google Scholar
• Bennett, C.N., S.E. Ross, K.A. Longo, L. Bajnok, N. Hemati, K.W. Johnson, S.D. Harrison, and O.A. MacDougald. 2002. Regulation of Wnt signaling during adipogenesis. Journal of Biological Chemistry 277: 30998–31004.
  Article CAS PubMed Google Scholar
• Choi, J.S., J.H. Kim, M.Y. Ali, B.S. Min, G.D. Kim, and H.A. Jung. 2014. Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ. Fitoterapia 98: 199–208.
  Article CAS PubMed Google Scholar
• Claycombe, K.J., B.H. Jones, M.K. Standridge, Y. Guo, J.T. Chun, J.W. Taylor, and N. Moustaïd-Moussa. 1998. Insulin increases fatty acid synthase gene transcription in human adipocytes. American Journal of Physiology 274: R1253–R1259.
  CAS PubMed Google Scholar
• Cornelius, P., O.A. MacDougald, and M.D. Lane. 1994. Regulation of adipocyte development. Annual Review of Nutrition 14: 99–129.
  Article CAS PubMed Google Scholar
• Cristancho, A.G., and M.A. Lazar. 2011. Forming functional fat: a growing understanding of adipocyte differentiation. Nature Reviews Molecular Cell Biology 12: 722–734.
  Article CAS PubMed Google Scholar
• Doggrell, S.A. 2005. Berberine-a novel approach to cholesterol lowering. Expert Opinion on Investigational Drugs 14: 683–685.
  Article CAS PubMed Google Scholar
• Green, H., and M. Meuth. 1974. An established pre-adipose cell line and its differentiation in culture. Cell 3: 127–133.
  Article CAS PubMed Google Scholar
• Grundy, S.M. 2004. Obesity, metabolic syndrome, and cardiovascular disease. Journal of Clinical Endocrinology and Metabolism 89: 2595–2600.
  Article CAS PubMed Google Scholar
• Han, Y.L., H.L. Yu, D. Li, X.L. Meng, Z.Y. Zhou, Q. Yu, X.Y. Zhang, F.J. Wang, and C. Guo. 2011. In vitro inhibition of Huanglian [Rhizoma coptidis (L.)] and its six active alkaloids on six cytochrome P450 isoforms in human liver microsomes. Phytotherapy Research 25: 1660–1665.
  Article CAS PubMed Google Scholar
• Hsieh, Y.S., W.H. Kuo, T.W. Lin, H.R. Chang, T.H. Lin, P.N. Chen, and S.C. Chu. 2007. Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells. Journal of Agriculture and Food Chemistry 55: 10437–10445.
  Article CAS Google Scholar
• Huang, C., Y. Zhang, Z. Gong, X. Sheng, Z. Li, W. Zhang, and Y. Qin. 2006. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARγ pathway. Biochemical Biophysical Research Communications 348: 571–578.
  Article CAS PubMed Google Scholar
• Ikuta, A., and H. Itokawa. 1988. Alkaloids of tissue cultures of Nandina domestica. Phytochemistry 27: 2143–2145.
  Article CAS Google Scholar
• Jiang, X.F., L.J. Wang, X.G. Li, Z.Q. Zhao, and J.Y. Zhu. 2011. Isolation of jatrorrhizine and epiberberine in Coptis chinensis and their in vitro hypoglycemic effect. Guizhou Agricultural Sciences 9: 44–49.
  Google Scholar
• Jo, J., O. Gavrilova, S. Pack, W. Jou, S. Mullen, A.E. Sumner, S.W. Cushman, and V. Periwal. 2009. Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Computational Biology 5: e1000324.
  Article PubMed Central PubMed Google Scholar
• Jung, H.A., B.S. Min, T. Yokozawa, J.H. Lee, Y.S. Kim, and J.S. Choi. 2009. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biological and Pharmaceutical Bulletin 32: 1433–1438.
  Article CAS PubMed Google Scholar
• Jung, H.A., N.Y. Yoon, H.J. Bae, B.S. Min, and J.S. Choi. 2008. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Archives of Pharmaceutical Research 31: 1405–1412.
  Article CAS Google Scholar
• Kawai, M., S. Mushiake, K. Bessho, M. Murakami, N. Namba, C. Kokubu, T. Michigami, and K. Ozono. 2007. Wnt/Lrp/β-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARγ and C/EBPα. Biochemical Biophysical Research Communications 363: 276–282.
  Article CAS PubMed Google Scholar
• Khandekar, M.J., P. Cohen, and B.M. Spiegelman. 2011. Molecular mechanisms of cancer development in obesity. Nature Reviews Cancer 11: 886–895.
  Article CAS PubMed Google Scholar
• Kim, J.B., and B.M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes & Development 10: 1096–1107.
  Article CAS Google Scholar
• Kim, S.W., A.M. Muise, P.J. Lyons, and H.S. Ro. 2001. Regulation of adipogenesis by a transcriptional repressor that modulates MAPK activation. Journal of Biological Chemistry 276: 10199–10206.
  Article CAS PubMed Google Scholar
• Ko, W.H., X.Q. Yao, C.W. Lau, W.I. Law, Z.Y. Chen, W. Kwok, K. Ho, and Y. Huang. 2000. Vasorelaxant and antiproliferative effects of berberine. European Journal of Pharmacology 399: 187–196.
  Article CAS PubMed Google Scholar
• Kohn, A.D., S.A. Summers, M.J. Birnbaum, and R.A. Roth. 1996. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. Journal of Biological Chemistry 271: 31372–31378.
  Article CAS PubMed Google Scholar
• Kuo, C.L., C.W. Chi, and T.Y. Liu. 2004. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Letters 203: 127–137.
  Article CAS PubMed Google Scholar
• Kwak, D.H., J.H. Lee, D.G. Kim, T. Kim, K.J. Lee, and J.Y. Ma. 2013. Inhibitory effects of hwangryunhaedok-tang in 3T3-L1 adipogenesis by regulation of Raf/MEK1/ERK1/2 pathway and PDK1/Akt phosphorylation. Evidence Based Complementary and Alternative Medicine 2013: 413906.
  PubMed Central PubMed Google Scholar
• Lee, H.Y., and C.W. Kim. 1997. Studies on the constituents of Berberis amurensis Ruprecht. Korean Journal of Pharmacognosy 28: 257–263.
  Google Scholar
• Logan, C.Y., and R. Nusse. 2004. The Wnt signaling pathway in development and disease. Annual Review of Cell and Developmental Biology 20: 781–810.
  Article CAS PubMed Google Scholar
• Lowe, C.E., S. O’Rahilly, and J.J. Rochford. 2011. Adipogenesis at a glance. Journal of Cell Science 124: 2681–2686.
  Article CAS PubMed Google Scholar
• Magun, R., B.M. Burgering, P.J. Coffer, D. Pardasani, Y. Lin, J. Chabot, and A. Sorisky. 1996. Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137: 3590–3593.
  CAS PubMed Google Scholar
• Manning, B.D., and L.C. Cantley. 2007. AKT/PKB signaling: navigating downstream. Cell 129: 1261–1274.
  Article PubMed Central CAS PubMed Google Scholar
• Park, M.Y., D.W. Seo, J.Y. Lee, M.K. Sung, Y.M. Lee, H.H. Jang, H.Y. Choi, J.H. Kim, and D.S. Park. 2011. Effects of Panicum miliaceum L. extract on adipogenic transcription factors and fatty acid accumulation in 3T3-L1 adipocytes. Nutrition Research and Practice 5: 192–197.
  Article PubMed Central PubMed Google Scholar
• Pilch, P.F., and N. Bergenhem. 2006. Pharmacological targeting of adipocytes/fat metabolism for treatment of obesity and diabetes. Molecular Pharmacology 70: 779–785.
  Article CAS PubMed Google Scholar
• Prestwich, T.C., and O.A. Macdougald. 2007. Wnt/β-catenin signaling in adipogenesis and metabolism. Current Opinion in Cell Biology 19: 612–617.
  Article PubMed Central CAS PubMed Google Scholar
• Prusty, D., B.H. Park, K.E. Davis, and S.R. Farmer. 2002. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptorγ (PPARγ) and C/EBPα gene expression during the differentiation of 3T3-L1 preadipocytes. Journal of Biological Chemistry 277: 46226–46232.
  Article CAS PubMed Google Scholar
• Rayalam, S., M.A. Della-Fera, and C.A. Baile. 2008. Phytochemicals and regulation of the adipocyte life cycle. Journal of Nutritional Biochemistry 19: 717–726.
  Article CAS PubMed Google Scholar
• Rosen, E.D., and O.A. MacDougald. 2006. Adipocyte differentiation from the inside out. Nature Reviews Molecular Cell Biology 7: 885–896.
  Article CAS PubMed Google Scholar
• Seger, R., and E.G. Krebs. 1995. The MAPK signaling cascade. FASEB Journal 9: 726–735.
  CAS PubMed Google Scholar
• Smith, P.J., L.S. Wise, R. Berkowitz, C. Wan, and C.S. Rubin. 1988. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. Journal of Biological Chemistry 263: 9402–9408.
  CAS PubMed Google Scholar
• Tang, J.J., J.G. Li, W. Qi, W.W. Qiu, P.S. Li, B.L. Li, and B.L. Song. 2011. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metabolism 13: 44–56.
  Article CAS PubMed Google Scholar
• Tang, L.Q., W. Wei, L.M. Chen, and S. Liu. 2006. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. Journal of Ethnopharmacology 108(1): 109–115.
  Article CAS PubMed Google Scholar
• Wang, J.L., and D.C. Fang. 1990. Effect of epiberberine on α-adrenoceptors. Yao Xue Xue Bao 4: 289–292.
  Google Scholar
• Xing, Y., F. Yan, Y. Liu, Y. Liu, and Y. Zhao. 2010. Matrine inhibits 3T3-L1 preadipocyte differentiation associated with suppression of ERK1/2 phosphorylation. Biochemical and Biophysical Research Communications 396: 691–695.
  Article CAS PubMed Google Scholar
• Xu, J., and K. Liao. 2004. Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. Journal of Biological Chemistry 279: 35914–35922.
  Article CAS PubMed Google Scholar
• Zhang, H.H., J. Huang, K. Düvel, B. Boback, S. Wu, R.M. Squillace, C.L. Wu, and B.D. Manning. 2009. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One 4: e6189.
  Article PubMed Central PubMed Google Scholar
• Zhang, M., and L. Chen. 2012. Berberine in type 2 diabetes therapy: a new perspective for an old antidiarrheal drug? Acta Pharmaceutica Sinica B 2: 379–386.
  Article CAS Google Scholar