Effect of ethanolic leaf extract of Trianthema portulacastrum L. On aflatoxin induced hepatic damage in rats (original) (raw)

Abstract

The aim of this study was to investigate the ethanolic leaf extract of Trianthema portulacastrum L. (Family: Aizoaceae) on aflatoxin induced hepatic damage in rats. Aflatoxin intoxication in rats significantly (p < 0.001) elevated the levels of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), and total bilirubin, which indicated acute hepatocellular damage and biliary obstruction. Ethanolic leaf extract of T. portulacastrum showed dose dependent decrease in the levels of SGPT, SGOT, ALP and total bilirubin. Minimum effective dose of extract was found to be 100 mg/kg body weight. Results obtained from histopathological studies also supported hepatoprotective activity against aflatoxin-induced hepatotoxicity. Thus the study demonstrates that T. portulacastrum possess antihepatotoxic effect against aflatoxin.

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Authors and Affiliations

  1. Centre for Biotechnology, Muthayammal College of Arts and Sciences, Kakkaveri, Rasipuram, Namakkal, Tamilnadu, 637408, India
    G. Sharmila Banu
  2. Department of Biochemistry, Selvamm Arts and Science College, Namakkal, Tamilnadu, 637003, India
    G. Kumar
  3. Division of Industrial Toxicology and Pollution control, Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Sciences, Alwarkurichi, Tamilnadu, 627412, India
    A. G. Murugesan

Authors

  1. G. Sharmila Banu
  2. G. Kumar
  3. A. G. Murugesan

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Correspondence toG. Kumar.

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Sharmila Banu, G., Kumar, G. & Murugesan, A.G. Effect of ethanolic leaf extract of Trianthema portulacastrum L. On aflatoxin induced hepatic damage in rats.Indian J Clin Biochem 24, 414–418 (2009). https://doi.org/10.1007/s12291-009-0074-2

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