Submucosal tumor-like lesion originating from colon tuberculosis: a case report and review of the literature (original) (raw)

Abstract

A 76-year-old male had a solitary submucosal tumor-like lesion in the sigmoid colon originating from tuberculosis. The lesion, up to 1 cm in diameter, was found incidentally during a routine colonoscopy, which revealed a protuberant submucosal growth with a shallow depression of the overlying mucosa in the center of the tumor. Histologically, the endoscopic biopsy revealed caseating granulomas and infiltration of Langhans giant cells and epithelioid cells, consistent with tuberculosis, were also observed. Five reports of similar lesions from colon tuberculosis were found in a literature review, including the present case. In all cases, the submucosal tumor-like lesions which originated from tuberculosis were small and in an active stage of tuberculosis. Five cases of submucosal tumor-like lesions from gastric tuberculosis were also reported, with characteristics very similar to those of the lesions from colon tuberculosis. Therefore, we propose that lesions originating from tuberculosis should be included in the differential diagnosis of submucosal tumor-like lesions in the colon and stomach.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Igarashi M, Katsumata T, Naito Y, et al. X-ray and endoscopic diagnosis of colonic tuberculosis. Stomach Intestine (Tokyo). 1995;30:515–24 (in Japanese).
    Google Scholar
  2. Matsumoto T, Iuda M, Nkamura M, et al. Endoscopic diagnosis of submucosal tumors of the large intestine. Stomach Intestine (Tokyo). 2004;39:457–66 (in Japanese).
    Google Scholar
  3. Kobayashi K, Ogawa T, Haruki S, et al. Endoscopic diagnosis of submucosal tumors of the large intestine. Gastroenterological Endoscopy. 2007;49:2462–73 (in Japanese).
    Google Scholar
  4. Paustian FF, Marshall JB. Intestinal tuberculosis. In: Berk JE, editor. Bockus Gastroenteroscopy. 4th ed. Philadelphia: WB Saunders; 1985. p. 2018–36.
    Google Scholar
  5. Longo DL, Fauci AS, Kasper DL, et al. Harrison’s Principles of Internal Medicine 18ed. McGraw-Hill, 2011.
  6. WHO Global Tuberculosis Country Profiles Japan, World Health Organization 2014.
  7. WHO Global Tuberculosis Report 2014, World Health Organization 2014.
  8. John H, Buckley C, Koh L, et al. Regional survey of tuberculosis risk assessment in rheumatology outpatients commencing anti-TNF-α treatment in relation to British Thoracic Society guidelines. Clin Med. 2009;9:225–30.
    Article CAS PubMed Google Scholar
  9. Sharma MP, Bhatia V. Abdominal tuberculosis. Indian J Med Res. 2004;12:305–15.
    Google Scholar
  10. Tachikawa H, Kotoyori M, Tatsuguchi A, et al. A case of intestinal tuberculosis with a submucosal tumor like lesion. Progress Digestive Endoscopy. 1993;43:231–3 (in Japanese).
    Article Google Scholar
  11. Yanagida T, Oya M, Iwase N, et al. Rectal submucosal tumor-like lesion originating from intestinal tuberculosis. J Gastroenterology. 1997;32:822–5.
    Article CAS Google Scholar
  12. Yoshino S, Hirakawa K, Taniguchi M, et al. Asymptomatic intestinal tuberculosis with multiple mucosal nodules of the colon, report of a case. Stomach Intestine (Tokyo). 2009;44:1477–82 (in Japanese).
    Google Scholar
  13. Nabajit Choudhury MS, Sumitra Hagjer MS. Masquerading mycobacterium: rectal growth or tuberculosis? Int J Med Update. 2013;8:42–4.
    Google Scholar
  14. Imabun S, Kishima H, Ishikawa H, et al. A Surgically Treated case of Gastric Tuberculosis With Multiple Submucosal Tumor. J Japan Surg Association. 1987;48:2026–30.
    Google Scholar
  15. Kano H, Mimatsu K, Kaneda H, et al. A case of gastric tuberculosis with suspected gastric submucosal tumor before operation. Japan J Gastroenterol Surgery. 2004;37:1622–6.
    Article Google Scholar
  16. Jung AD, Seo YH, Park SH, et al. A case of secondary gastric tuberculosis mimicking submucosal tumor. Chonnam Med J. 2008;44:53–6.
    Article Google Scholar
  17. Oshima N, Hosotani T. A case of gastric tuberculosis preoperatively diagnosed as a submucosal gastric tumor. J Japan Surg Association. 2009;70:1347–52.
    Article Google Scholar
  18. Hirano Y, Matsumoto H, Suda K, et al. A case of isolated gastric tuberculosis presenting an appearance of submucosal tumor. The Japan J Gastroenterol Surgery. 2011;44:117–22.
    Article Google Scholar

Download references

Acknowledgments

We would like to thank Editage (www.editage.jp) for English language editing.

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Gastroenterology, Saiseikai Imabari Hospital, Ehime, Japan
    Keiichi Shibagaki, Jirou Miyaike, Morikazu Onji, Kazuhiro Tange, Satoru Takeji, Takatoshi Murakami, Taiji Ogawa, Tomotaka Yamaguchi, Takahide Uehara, Aki Hasebe, Keitarou Kawasaki & Masaki Oomoto
  2. Deparment of Pathology, Saiseikai Imabari Hospital, Ehime, Japan
    Kenji Bandou

Authors

  1. Keiichi Shibagaki
  2. Jirou Miyaike
  3. Morikazu Onji
  4. Kazuhiro Tange
  5. Kenji Bandou
  6. Satoru Takeji
  7. Takatoshi Murakami
  8. Taiji Ogawa
  9. Tomotaka Yamaguchi
  10. Takahide Uehara
  11. Aki Hasebe
  12. Keitarou Kawasaki
  13. Masaki Oomoto

Corresponding authors

Correspondence toKeiichi Shibagaki or Morikazu Onji.

Ethics declarations

Conflict of Interest:

All authors report no conflict of interest.

Human/Animal Rights:

Please confirm that this study has been approved by the appropriate ethics committee and that there will be no problem to publish the statement below. If this study does not contain any data about human or animal subjects, edit the text in the space below.

For studies involving human subjects, please confirm that the patients/subjects have given their Informed Consent and that there will be no problem publishing the statement below. If this study does not involve human subjects and does not apply to giving Informed Consent, edit the text in the space below.

Rights and permissions

About this article

Cite this article

Shibagaki, K., Miyaike, J., Onji, M. et al. Submucosal tumor-like lesion originating from colon tuberculosis: a case report and review of the literature.Clin J Gastroenterol 8, 207–211 (2015). https://doi.org/10.1007/s12328-015-0582-y

Download citation

Keywords