RETRACTED ARTICLE: TGF-β1 −509C/T (or +869T/C) polymorphism might be not associated with hepatocellular carcinoma risk (original) (raw)

Abstract

Many studies have reported the role of transforming growth factor-β1 (TGF-β1) −509C/T or +869T/C polymorphism with hepatocellular carcinoma (HCC) risk. However, these studies have yielded conflicting results. Hence, we performed this meta-analysis to investigate the association between TGF-β1 −509C/T or +869T/C polymorphism and HCC. A total of 11 studies including 2,577 HCC cases and 4,107 controls were included in the meta-analysis. Overall, _TGF_-β1 −509C/T (or +869T/C) polymorphism was not associated with HCC risk (homogeneous co-dominant model: OR = 1.29, 95 % CI = 0.88–1.89; heterogeneous co-dominant model: OR = 1.15, 95 % CI = 0.91–1.45; dominant model: OR = 1.14, 95 % CI = 0.87–1.48; recessive model: OR = 1.15, 95 % CI = 0.89–1.49). In the subgroup analysis, _TGF_-β1 −509C/T (or +869T/C) polymorphism was significantly associated with HCC risk in Caucasians under the recessive model (OR = 1.65, 95 % CI = 1.07–2.55) but not in other genetic models. In addition, we did not observe significant association in Asians under all genetic models. In conclusion, our meta-analysis indicates that _TGF_-β1 −509C/T (or +869T/C) polymorphism was not associated with risk of HCC, although a marginal association was found for Caucasians. However, a study with the larger sample size is needed to further evaluate gene–environment interaction on the association.

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Acknowledgments

The work was funded by Zhejiang Medicine, Health, and Science (2010KYB127); Zhejiang Province Chinese Medicine Research Program (2012ZA130); and Zhejiang Gong Yi Xing Technology Application Project (2012C33025)

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Authors and Affiliations

  1. Laboratory Medicine, Zhejiang Provincial People’s Hospital, Zhejiang, China
    Weixing Li, Han Wu & Chao Song

Authors

  1. Weixing Li
  2. Han Wu
  3. Chao Song

Corresponding author

Correspondence toWeixing Li.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Li, W., Wu, H. & Song, C. RETRACTED ARTICLE: TGF-β1 −509C/T (or +869T/C) polymorphism might be not associated with hepatocellular carcinoma risk.Tumor Biol. 34, 2675–2681 (2013). https://doi.org/10.1007/s13277-013-0818-8

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