In vitro expansion of U87-MG human glioblastoma cells under hypoxic conditions affects glucose metabolism and subsequent in vivo growth (original) (raw)

• Vaupel P, Thews O, Hoeckel M. Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol. 2001;18(4):243–59.
  Article CAS PubMed Google Scholar
• Nordsmark M, Hoyer M, Keller J, Nielsen OS, Jensen OM, Overgaard J. The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 1996;35(4):701–8.
  Article CAS PubMed Google Scholar
• Selvendiran K, Bratasz A, Kuppusamy ML, Tazi MF, Rivera BK, Kuppusamy P. Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. Int J Cancer. 2009;125(9):2198–204.
  Article CAS PubMed PubMed Central Google Scholar
• Pelicano H, Martin DS, Xu R-H, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene. 2006;25(34):4633–46.
  Article CAS PubMed Google Scholar
• Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature. 2006;441(7092):437–43.
  Article CAS PubMed Google Scholar
• Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol. 2009;19(1):12–6.
  Article CAS PubMed Google Scholar
• Chiche J, Le Fur Y, Vilmen C, Frassineti F, Daniel L, Halestrap AP, et al. In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH. Int J Cancer. 2012;130:1511–20.
  Article CAS PubMed Google Scholar
• Bourseau-Guilmain E, Lemaire L, Griveau A, Hervouet E, Vallette F, Berger F, et al. In vitro expansion of human glioblastoma cells at non-physiological oxygen tension irreversibly alters subsequent in vivo aggressiveness and AC133 expression. Int J Oncol. 2012;40(4):1220–9.
  CAS PubMed Google Scholar
• Yu C, Xue J, Zhu W, Jiao Y, Zhang S, Cao J. Warburg meets non-coding RNAs: the emerging role of ncRNA in regulating the glucose metabolism of cancer cells. Tumor Biol. 2015;36(1):81–94.
  Article CAS Google Scholar
• Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998;394(6692):485–90.
  Article CAS PubMed Google Scholar
• Semenza GL. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J. 2007;405(1):1–9.
  Article CAS PubMed Google Scholar
• Griffiths JR, McSheehy PM, Robinson SP, Troy H, Chung YL, Leek RD, et al. Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway. Cancer Res. 2002;62(3):688–95.
  CAS PubMed Google Scholar
• Stubbs M, Griffiths JR. The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. Adv Enzyme Regul. 2010;50(1):44–55.
  Article PubMed Google Scholar
• Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard 3rd WA, et al. Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science. 2012;337(6097):975–80.
  Article CAS PubMed PubMed Central Google Scholar
• Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashima T, et al. Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. NMR Biomed. 2012;25(12):1177–86.
  Article CAS PubMed PubMed Central Google Scholar
• Wise DR, Ward PS, Shay JES, Cross JR, Gruber JJ, Sacdeva UM, et al. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A. 2011;108(49):19611–6.
  Article CAS PubMed PubMed Central Google Scholar
• Gameiro PA, Yang J, Metelo AM, Perez-Carro R, Baker R, Wang Z, et al. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metab. 2013;17(3):372–85.
  Article CAS PubMed PubMed Central Google Scholar
• Bouzier A-K, Goodwin R, Macouillard-Poulletier de Gannes F, Valeins H, Voisin P, Canioni P, et al. Compartmentation of lactate and glucose metabolism in C6 glioma cells. J Biol Chem. 1998;273(42):27162–9.
  Article CAS PubMed Google Scholar
• Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, et al. Metabolism of [U-13C]glucose in human brain tumors in vivo. NMR Biomed. 2012;25:1234–44.
  Article CAS PubMed PubMed Central Google Scholar
• Lemaire L, Seguin F, Franconi F, Bon D, Pasco A, Boildieu N, et al. High resolution nuclear magnetic resonance investigation of metabolic disturbances induced by focal traumatic brain injury in a rat model: a pilot study. J Biomed Sci Eng. 2011;4:110–8.
  Article Google Scholar
• Madhu B, Dadulescu M, Griffiths JR. Artefacts in 1H NMR-based metabolomic studies on cell cultures. Magn Reson Mater Phys. 2014. doi:10.1007/s10334-10014-10458-z.
  Google Scholar
• Lundberg P, Vogel T, Malusek A, Lundquist P-O, Cohen L. MDL. The Magnetic Resonance Metabolomics Database (mdl.imv.liu.se). 22th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology. Basel(Switzerland); 2005;S168.
• Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009;37(Database issue):D603–610.
  Article CAS PubMed Google Scholar
• Lemaire L, Franconi F, Saint-Andre JP, Roullin VG, Jallet P, Le Jeune JJ. High-field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour. NMR Biomed. 2000;13(3):116–23.
  Article CAS PubMed Google Scholar
• Guillaumond F, Leca J, Olivares O, Lavaut MN, Vidal N, Berthezene P, et al. Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2013;110(10):3919–24.
  Article CAS PubMed PubMed Central Google Scholar
• Sullivan M, Galea P, Latif S. What is the appropriate oxygen tension for in vitro culture? Mol Hum Reprod. 2006;12(11):653.
  Article PubMed Google Scholar
• Erecinska M, Silver IA. Tissue oxygen tension and brain sensitivity to hypoxia. Resp Physiol. 2001;128(3):263–76.
  Article CAS Google Scholar
• Wion D, Christen T, Barbier EL, Coles JA. PO(2) matters in stem cell culture. Cell Stem Cell. 2009;5(3):242–3.
  Article CAS PubMed Google Scholar
• Csete M. Oxygen in the cultivation of stem cells. Ann NY Acad Sci. 2005;1049:1–8.
  Article CAS PubMed Google Scholar
• Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol. 2007;72(1):29–39.
  Article CAS PubMed Google Scholar
• Clavreul A, Guette C, Faguer R, Tetaud C, Boissard A, Lemaire L, et al. Glioblastoma-associated stromal cells (GASCs) from histologically normal surgical margins have a myofibroblast phenotype and angiogenic properties. J Pathol. 2014;233(1):74–88.
  Article CAS PubMed Google Scholar
• DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A. 2007;104(49):19345–50.
  Article CAS PubMed PubMed Central Google Scholar
• El-Ashmawy NE, El-Bahrawy HA, Shamloula MM. Biochemical/metabolic changes associated with hepatocellular carcinoma development in mice. Tumor Biol. 2014;35(6):5459–66.
  Article CAS Google Scholar
• Ohka F, Ito M, Ranjit M, Senga T, Motomura A, Motomura K, et al. Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation. Tumour Biol. 2014;35(6):5911–20.
  Article CAS PubMed Google Scholar
• Romero-Garcia S, Lopez-Gonzalez JS, Baez-Viveros JL, Aguilar-Cazares D, Prado-Garcia H. Tumor cell metabolism: an integral view. Cancer Biol Ther. 2011;12(11):939–48.
  Article CAS PubMed PubMed Central Google Scholar
• DeBerardinis RJ, Sayed N, Ditsworth D, Thompson CB. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev. 2008;18(1):54–61.
  Article CAS PubMed PubMed Central Google Scholar
• Schuster S, Fell DA, Dandekar T. A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks. Nat Biotechnol. 2000;18(3):326–32.
  Article CAS PubMed Google Scholar
• Shambaugh 3rd GE. Pyrimidine biosynthesis. Am J Clin Nutr. 1979;32(6):1290–7.
  CAS PubMed Google Scholar
• Wang JA, Zhang S, Li ZF, Yang J, Huang C, Liang RR, et al. H-1-NMR-based metabolomics of tumor tissue for the metabolic characterization of rat hepatocellular carcinoma formation and metastasis. Tumor Biol. 2011;32(1):223–31.
  Article Google Scholar