Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date (original) (raw)
Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci. 2011;12(9):524–38. ArticleCASPubMed Google Scholar
Ludwig M, Leng G. Dendritic peptide release and peptide-dependent behaviours. Nat Rev Neurosci. 2006;7(2):126–36. ArticleCASPubMed Google Scholar
Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81(2):629–83. CASPubMed Google Scholar
Stoop R. Neuromodulation by oxytocin and vasopressin in the central nervous system as a basis for their rapid behavioral effects. Curr Opin Neurobiol. 2014;29:187–93. ArticleCASPubMed Google Scholar
Pinol RA, Bateman R, Mendelowitz D. Optogenetic approaches to characterize the long-range synaptic pathways from the hypothalamus to brain stem autonomic nuclei. J Neurosci Methods. 2012;210(2):238–46. ArticlePubMedPubMed Central Google Scholar
Ross HE, Young LJ. Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Front Neuroendocrinol. 2009;30(4):534–47. ArticleCASPubMedPubMed Central Google Scholar
Neumann ID, Maloumby R, Beiderbeck DI, Lukas M, Landgraf R. Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice. Psychoneuroendocrinology. 2013;38(10):1985–93. ArticleCASPubMed Google Scholar
Beets I, Janssen T, Meelkop E, Temmerman L, Suetens N, Rademakers S, et al. Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans. Science. 2012;338(6106):543–5. ArticleCASPubMed Google Scholar
Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H. Structure and expression of a human oxytocin receptor. Nature. 1992;356(6369):526–9. ArticleCASPubMed Google Scholar
Lee HJ, Macbeth AH, Pagani JH, Young WS 3rd. Oxytocin: the great facilitator of life. Prog Neurobiol. 2009;88(2):127–51. CASPubMedPubMed Central Google Scholar
Smith AL, Freeman SM, Stehouwer JS, Inoue K, Voll RJ, Young LJ, et al. Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors. Bioorg Med Chem. 2012;20(8):2721–38. ArticleCASPubMedPubMed Central Google Scholar
Manning M, Stoev S, Chini B, Durroux T, Mouillac B, Guillon G. Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473–512. ArticleCASPubMed Google Scholar
Pedersen CA, Ascher JA, Monroe YL, Prange AJ Jr. Oxytocin induces maternal behavior in virgin female rats. Science. 1982;216(4546):648–50. ArticleCASPubMed Google Scholar
Pedersen CA, Prange AJ Jr. Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin. Proc Natl Acad Sci USA. 1979;76(12):6661–5. ArticleCASPubMedPubMed Central Google Scholar
Williams JR, Insel TR, Harbaugh CR, Carter CS. Oxytocin administered centrally facilitates formation of a partner preference in female prairie voles (Microtus ochrogaster). J Neuroendocrinol. 1994;6(3):247–50. ArticleCASPubMed Google Scholar
Insel TR, Shapiro LE. Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proc Natl Acad Sci USA. 1992;89(13):5981–5. ArticleCASPubMedPubMed Central Google Scholar
Liu Y, Wang ZX. Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles. Neuroscience. 2003;121(3):537–44. ArticleCASPubMed Google Scholar
Melis MR, Melis T, Cocco C, Succu S, Sanna F, Pillolla G, et al. Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats. Eur J Neurosci. 2007;26(4):1026–35. ArticlePubMed Google Scholar
Wei D, Lee D, Cox CD, Karsten CA, Penagarikano O, Geschwind DH, et al. Endocannabinoid signaling mediates oxytocin-driven social reward. Proc Natl Acad Sci USA. 2015;112(45):14084–9. ArticleCASPubMed Google Scholar
Tracy LM, Georgiou-Karistianis N, Gibson SJ, Giummarra MJ. Oxytocin and the modulation of pain experience: implications for chronic pain management. Neurosci Biobehav Rev. 2015;55:53–67. ArticleCASPubMed Google Scholar
Knobloch HS, Charlet A, Hoffmann LC, Eliava M, Khrulev S, Cetin AH, et al. Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron. 2012;73(3):553–66. ArticleCASPubMed Google Scholar
Arletti R, Bertolini A. Oxytocin acts as an antidepressant in two animal models of depression. Life Sci. 1987;41(14):1725–30. ArticleCASPubMed Google Scholar
Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, et al. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci. 2009;29(7):2259–71. ArticleCASPubMed Google Scholar
Burkett JP, Young LJ. The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. Psychopharmacology. 2012;224(1):1–26. ArticleCASPubMedPubMed Central Google Scholar
Liu Y, Young KA, Curtis JT, Aragona BJ, Wang Z. Social bonding decreases the rewarding properties of amphetamine through a dopamine D1 receptor-mediated mechanism. J Neurosci. 2011;31(22):7960–6. ArticleCASPubMedPubMed Central Google Scholar
Liu Y, Aragona BJ, Young KA, Dietz DM, Kabbaj M, Mazei-Robison M, et al. Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species. Proc Natl Acad Sci USA. 2010;107(3):1217–22. ArticleCASPubMedPubMed Central Google Scholar
Hostetler CM, Ryabinin AE. Social partners prevent alcohol relapse behavior in prairie voles. Psychoneuroendocrinology. 2014;39:152–7. ArticlePubMed Google Scholar
Anacker AM, Ahern TH, Hostetler CM, Dufour BD, Smith ML, Cocking DL, et al. Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles. Proc Natl Acad Sci USA. 2014;111(16):6052–7. ArticleCASPubMedPubMed Central Google Scholar
McCullough ME, Churchland PS, Mendez AJ. Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted? Neurosci Biobehav Rev. 2013;37(8):1485–92. ArticleCASPubMed Google Scholar
Johns JM, Caldwell JD, Pedersen CA. Acute cocaine treatment decreases oxytocin levels in the rat hippocampus. Neuropeptides. 1993;24(3):165–9. ArticleCASPubMed Google Scholar
Meyers RA, Zavala AR, Neisewander JL. Dorsal, but not ventral, hippocampal lesions disrupt cocaine place conditioning. Neuroreport. 2003;14(16):2127–31. ArticlePubMed Google Scholar
Sarnyai Z, Kovacs GL. Role of oxytocin in the neuroadaptation to drugs of abuse. Psychoneuroendocrinology. 1994;19(1):85–117. ArticleCASPubMed Google Scholar
Georgiou P, Zanos P, Ehteramyan M, Hourani S, Kitchen I, Maldonado R, et al. Differential regulation of mGlu5 R and MuOPr by priming- and cue-induced reinstatement of cocaine-seeking behaviour in mice. Addict Biol. 2015;20(5):902–12. ArticleCASPubMed Google Scholar
Zanos P, Wright SR, Georgiou P, Yoo JH, Ledent C, Hourani SM, et al. Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A2A receptor-independent mechanism. Pharmacol Biochem Behav. 2014;119:72–9. ArticleCASPubMed Google Scholar
Light KC, Grewen KM, Amico JA, Boccia M, Brownley KA, Johns JM. Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy. Addict Behav. 2004;29(8):1541–64. ArticlePubMedPubMed Central Google Scholar
You ZD, Li JH, Song CY, Wang CH, Lu CL. Chronic morphine treatment inhibits oxytocin synthesis in rats. Neuroreport. 2000;11(14):3113–6. ArticleCASPubMed Google Scholar
Zanos P, Georgiou P, Wright SR, Hourani SM, Kitchen I, Winsky-Sommerer R, et al. The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice. Neuropsychopharmacology. 2014;39(4):855–65. ArticleCASPubMedPubMed Central Google Scholar
Lynn JM. Intravenous alcohol infusion for premature labor. J Am Osteopath Assoc. 1970;70(2):167–70. CASPubMed Google Scholar
Marchesi C, Chiodera P, Brusamonti E, Volpi R, Coiro V. Abnormal plasma oxytocin and beta-endorphin levels in alcoholics after short and long term abstinence. Prog Neuropsychopharmacol Biol Psychiatry. 1997;21(5):797–807. ArticleCASPubMed Google Scholar
Sivukhina EV, Dolzhikov AA, Morozov IuE, Jirikowski GF, Grinevich V. Effects of chronic alcoholic disease on magnocellular and parvocellular hypothalamic neurons in men. Horm Metab Res. 2006;38(6):382–90. ArticleCASPubMed Google Scholar
Butovsky E, Juknat A, Elbaz J, Shabat-Simon M, Eilam R, Zangen A, et al. Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas. Mol Cell Neurosci. 2006;31(4):795–804. ArticleCASPubMed Google Scholar
Dumont GJ, Sweep FC, van der Steen R, Hermsen R, Donders AR, Touw DJ, et al. Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. Soc Neurosci. 2009;4(4):359–66. ArticleCASPubMed Google Scholar
Broadbear JH, Tunstall B, Beringer K. Examining the role of oxytocin in the interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) using a drug discrimination paradigm in the rat. Addict Biol. 2011;16(2):202–14. ArticleCASPubMed Google Scholar
van Nieuwenhuijzen PS, Long LE, Hunt GE, Arnold JC, McGregor IS. Residual social, memory and oxytocin-related changes in rats following repeated exposure to gamma-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology. 2010;212(4):663–74. ArticlePubMed Google Scholar
Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, et al. Addiction as a stress surfeit disorder. Neuropharmacology. 2014;76(Pt B):370–82.
Hoge EA, Pollack MH, Kaufman RE, Zak PJ, Simon NM. Oxytocin levels in social anxiety disorder. CNS Neurosci Ther. 2008;14(3):165–70. ArticleCASPubMed Google Scholar
Taylor SE, Saphire-Bernstein S, Seeman TE. Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair-bond relationships? Psychol Sci. 2010;21(1):3–7. ArticlePubMed Google Scholar
Bohus B, Kovacs GL, de Wied D. Oxytocin, vasopressin and memory: opposite effects on consolidation and retrieval processes. Brain Res. 1978;157(2):414–7. ArticleCASPubMed Google Scholar
Carson DS, Cornish JL, Guastella AJ, Hunt GE, McGregor IS. Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats. Neuropharmacology. 2010;58(1):38–43. ArticleCASPubMed Google Scholar
Carson DS, Hunt GE, Guastella AJ, Barber L, Cornish JL, Arnold JC, et al. Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus. Addict Biol. 2010;15(4):448–63. ArticleCASPubMed Google Scholar
Qi J, Yang JY, Song M, Li Y, Wang F, Wu CF. Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice. Naunyn Schmiedebergs Arch Pharmacol. 2008;376(6):441–8. ArticleCASPubMed Google Scholar
Qi J, Yang JY, Wang F, Zhao YN, Song M, Wu CF. Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement. Neuropharmacology. 2009;56(5):856–65. ArticleCASPubMed Google Scholar
Bahi A. The oxytocin receptor impairs ethanol reward in mice. Physiol Behav. 2015;139:321–7. ArticleCASPubMed Google Scholar
Baracz SJ, Cornish JL. Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus. Horm Behav. 2013;63(2):370–5. ArticleCASPubMed Google Scholar
Baracz SJ, Rourke PI, Pardey MC, Hunt GE, McGregor IS, Cornish JL. Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference. Behav Brain Res. 2012;228(1):185–93. ArticleCASPubMed Google Scholar
Han WY, Du P, Fu SY, Wang F, Song M, Wu CF, et al. Oxytocin via its receptor affects restraint stress-induced methamphetamine CPP reinstatement in mice: involvement of the medial prefrontal cortex and dorsal hippocampus glutamatergic system. Pharmacol Biochem Behav. 2014;119:80–7. ArticleCASPubMed Google Scholar
Manbeck KE, Shelley D, Schmidt CE, Harris AC. Effects of oxytocin on nicotine withdrawal in rats. Pharmacol Biochem Behav. 2014;116:84–9. ArticleCASPubMed Google Scholar
Kovacs GL, Sarnyai Z, Izbeki F, Szabo G, Telegdy G, Barth T, et al. Effects of oxytocin-related peptides on acute morphine tolerance: opposite actions by oxytocin and its receptor antagonists. J Pharmacol Exp Ther. 1987;241(2):569–74. CASPubMed Google Scholar
Kovacs GL, Izbeki F, Horvath Z, Telegdy G. Effects of oxytocin and a derivative (_Z_-prolyl-d-leucine) on morphine tolerance/withdrawal are mediated by the limbic system. Behav Brain Res. 1984;14(1):1–8. ArticleCASPubMed Google Scholar
Kovacs GL, Horvath Z, Sarnyai Z, Faludi M, Telegdy G. Oxytocin and a C-terminal derivative (_Z_-prolyl-d-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain. Neuropharmacology. 1985;24(5):413–9. ArticleCASPubMed Google Scholar
Sarnyai Z, Viski S, Krivan M, Szabo G, Kovacs GL, Telegdy G. Endogenous oxytocin inhibits morphine tolerance through limbic forebrain oxytocin receptors. Brain Res. 1988;463(2):284–8. ArticleCASPubMed Google Scholar
Kovacs GL, Faludi M, Telegdy G. Oxytocin diminishes heroin tolerance in mice. Psychopharmacology. 1985;86(3):377–9. ArticleCASPubMed Google Scholar
Kovacs GL, Borthaiser Z, Telegdy G. Oxytocin reduces intravenous heroin self-administration in heroin-tolerant rats. Life Sci. 1985;37(1):17–26. ArticleCASPubMed Google Scholar
Ibragimov R, Kovacs GL, Szabo G, Telegdy G. Microinjection of oxytocin into limbic-mesolimbic brain structures disrupts heroin self-administration behavior: a receptor-mediated event? Life Sci. 1987;41(10):1265–71. ArticleCASPubMed Google Scholar
Moaddab M, Hyland BI, Brown CH. Oxytocin enhances the expression of morphine-induced conditioned place preference in rats. Psychoneuroendocrinology. 2015;53:159–69. ArticleCASPubMed Google Scholar
Bicknell RJ, Leng G, Lincoln DW, Russell JA. Naloxone excites oxytocin neurones in the supraoptic nucleus of lactating rats after chronic morphine treatment. J Physiol. 1988;396:297–317. ArticleCASPubMedPubMed Central Google Scholar
Sarnyai Z, Szabo G, Kovacs GL, Telegdy G. Opposite actions of oxytocin and vasopressin in the development of cocaine-induced behavioral sensitization in mice. Pharmacol Biochem Behav. 1992;43(2):491–4. ArticleCASPubMed Google Scholar
Sarnyai Z, Biro E, Babarczy E, Vecsernyes M, Laczi F, Szabo G, et al. Oxytocin modulates behavioural adaptation to repeated treatment with cocaine in rats. Neuropharmacology. 1992;31(6):593–8. ArticleCASPubMed Google Scholar
Kovacs GL, Sarnyai Z, Barbarczi E, Szabo G, Telegdy G. The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity. Neuropharmacology. 1990;29(4):365–8. ArticleCASPubMed Google Scholar
Sarnyai Z, Szabo G, Kovacs GL, Telegdy G. Oxytocin attenuates the cocaine-induced exploratory hyperactivity in mice. Neuroreport. 1990;1(3–4):200–2. ArticleCASPubMed Google Scholar
Sarnyai Z, Babarczy E, Krivan M, Szabo G, Kovacs GL, Barth T, et al. Selective attenuation of cocaine-induced stereotyped behaviour by oxytocin: putative role of basal forebrain target sites. Neuropeptides. 1991;19(1):51–6. ArticleCASPubMed Google Scholar
De Groot AN, Vree TB, Hekster YA, Pesman GJ, Sweep FC, Van Dongen PJ, et al. Bioavailability and pharmacokinetics of sublingual oxytocin in male volunteers. J Pharm Pharmacol. 1995;47(7):571–5. ArticlePubMed Google Scholar
Mens WB, Witter A, van Wimersma Greidanus TB. Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Res. 1983;262(1):143–9. ArticleCASPubMed Google Scholar
Zhou L, Sun WL, Young AB, Lee K, McGinty JF, See RE. Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function. Int J Neuropsychopharmacol. 2014. doi:10.1093/ijnp/pyu009(Epub 2014 Oct 31). Google Scholar
Qi J, Han WY, Yang JY, Wang LH, Dong YX, Wang F, et al. Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain. Addict Biol. 2012;17(4):758–69. ArticleCASPubMed Google Scholar
Morales-Rivera A, Hernandez-Burgos MM, Martinez-Rivera A, Perez-Colon J, Rivera R, Montalvo J, et al. Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats. Psychopharmacology. 2014;231(21):4145–55. ArticleCASPubMed Google Scholar
Baracz SJ, Everett NA, Cornish JL. The involvement of oxytocin in the subthalamic nucleus on relapse to methamphetamine-seeking behaviour. PloS One. 2015;10(8):e0136132. ArticlePubMedPubMed Central Google Scholar
Baracz SJ, Everett NA, McGregor IS, Cornish JL. Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine-seeking behaviour in rats. Addict Biol. 2014. doi:10.1111/adb.12198
Bowen MT, Peters ST, Absalom N, Chebib M, Neumann ID, McGregor IS. Oxytocin prevents ethanol actions at delta subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats. Proc Natl Acad Sci USA. 2015;112(10):3104–9. ArticleCASPubMedPubMed Central Google Scholar
Szabo G, Kovacs GL, Szekeli S, Telegdy G. The effects of neurohypophyseal hormones on tolerance to the hypothermic effect of ethanol. Alcohol. 1985;2(4):567–74. ArticleCASPubMed Google Scholar
Szabo G, Kovacs GL, Telegdy G. Intraventricular administration of neurohypophyseal hormones interferes with the development of tolerance to ethanol. Acta Physiol Hung. 1989;73(1):97–103. CASPubMed Google Scholar
Hoffman PL, Ritzmann RF, Walter R, Tabakoff B. Arginine vasopressin maintains ethanol tolerance. Nature. 1978;276(5688):614–6. ArticleCASPubMed Google Scholar
Szabo G, Kovacs GL, Telegdy G. Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal. Alcohol Alcohol. 1987;22(1):71–4. CASPubMed Google Scholar
Peters S, Slattery DA, Flor PJ, Neumann ID, Reber SO. Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice. Addict Biol. 2013;18(1):66–77. ArticleCASPubMed Google Scholar
McGregor IS, Bowen MT. Breaking the loop: oxytocin as a potential treatment for drug addiction. Horm Behav. 2012;61(3):331–9. ArticleCASPubMed Google Scholar
Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL. Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci. 2002;5(6):514–6. ArticleCASPubMed Google Scholar
Striepens N, Kendrick KM, Hanking V, Landgraf R, Wullner U, Maier W, et al. Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans. Sci Rep. 2013;3:3440. ArticlePubMedPubMed Central Google Scholar
Dal Monte O, Noble PL, Turchi J, Cummins A, Averbeck BB. CSF and blood oxytocin concentration changes following intranasal delivery in macaque. PloS One. 2014;9(8):e103677.
Pedersen CA, Smedley KL, Leserman J, Jarskog LF, Rau SW, Kampov-Polevoi A, et al. Intranasal oxytocin blocks alcohol withdrawal in human subjects. Alcohol Clin Exp Res. 2013;37(3):484–9. ArticleCASPubMedPubMed Central Google Scholar
McRae-Clark AL, Baker NL, Maria MM, Brady KT. Effect of oxytocin on craving and stress response in marijuana-dependent individuals: a pilot study. Psychopharmacology. 2013;228(4):623–31. ArticleCASPubMedPubMed Central Google Scholar
Flanagan JC, Baker NL, McRae-Clark AL, Brady KT, Moran-Santa Maria MM. Effects of adverse childhood experiences on the association between intranasal oxytocin and social stress reactivity among individuals with cocaine dependence. Psychiatry Res. 2015;229(1–2):94–100. ArticleCASPubMed Google Scholar
Kirkpatrick MG, Lee R, Wardle MC, Jacob S, de Wit H. Effects of MDMA and Intranasal oxytocin on social and emotional processing. Neuropsychopharmacology. 2014;39(7):1654–63. ArticleCASPubMedPubMed Central Google Scholar
Lee MR, Glassman M, King-Casas B, Kelly DL, Stein EA, Schroeder J, et al. Complexity of oxytocins effects in a chronic cocaine dependent population. Eur Neuropsychopharmacol. 2014;24(9):1483–91. ArticleCASPubMed Google Scholar
Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Childress AR, et al. Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci. 2006;26(24):6583–8. ArticleCASPubMed Google Scholar
Liberzon I, Trujillo KA, Akil H, Young EA. Motivational properties of oxytocin in the conditioned place preference paradigm. Neuropsychopharmacology. 1997;17(6):353–9. ArticleCASPubMed Google Scholar
MacDonald E, Dadds MR, Brennan JL, Williams K, Levy F, Cauchi AJ. A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research. Psychoneuroendocrinology. 2011;36(8):1114–26. ArticleCASPubMed Google Scholar
Laszlo K, Kovacs A, Zagoracz O, Ollmann T, Peczely L, Kertes E, et al. Positive reinforcing effect of oxytocin microinjection in the rat central nucleus of amygdala. Behav Brain Res. 2016;296:279–85. ArticleCASPubMed Google Scholar
Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry. 2003;54(12):1389–98. ArticleCASPubMed Google Scholar
Bowen MT, Carson DS, Spiro A, Arnold JC, McGregor IS. Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats. PloS One. 2011;6(11):e27237. ArticleCASPubMedPubMed Central Google Scholar
Hicks C, Cornish JL, Baracz SJ, Suraev A, McGregor IS. Adolescent pre-treatment with oxytocin protects against adult methamphetamine-seeking behavior in female rats. Addict Biol. 2014. doi:10.1111/adb.12197
Windle RJ, Kershaw YM, Shanks N, Wood SA, Lightman SL, Ingram CD. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. J Neurosci. 2004;24(12):2974–82.
Ibragimov R, Kovacs G. Effect of oxytocin microinjections into the lateral septal nucleus on intravenous heroin self-administration in heroin-tolerant rats [in Russian]. Fiziologicheskii Zh SSSR Im I M Sechenova. 1987;73(12):1625–9. CAS Google Scholar
Tirelli E, Jodogne C, Legros JJ. Oxytocin blocks the environmentally conditioned compensatory response present after tolerance to ethanol-induced hypothermia in mice. Pharmacol Biochem Behav. 1992;43(4):1263–7. ArticleCASPubMed Google Scholar