Using the EuroQol EQ-5D in Swiss Cancer Patients, Which Value Set Should be Applied? (original) (raw)

Abstract

Background

The European Quality of Life–5 Dimensions (EQ-5D) instrument combines questionnaire responses into a single utility estimate using country-specific value sets. Countries without a national value set are advised to select one based on geographic proximity. In the absence of a Swiss value set, we used foreign value sets to gain insights into their appropriateness for use with Swiss cancer patients.

Methods

EQ-5D health states and visual analogue scale (VAS) ratings were collected in one German and three Swiss oncology trials. Utilities were calculated based on the United Kingdom (UK), German (GE), French (FR) and European Union (EU) value sets. Resulting differences and Pearson partial correlation coefficients with corresponding VAS ratings were assessed.

Results

In total, 202 Swiss and 154 German patients undergoing cancer treatment completed at least two EQ-5D forms. The mean difference between GE-based and FR-, UK- or EU-based utilities was significantly larger than the differences between the latter. The absolute mean difference between utilities and VAS ratings was highest for GE-based utilities, for Swiss (0.170, 95 % confidence interval [CI] 0.146–0.194) and German patients (0.174, 95 % CI 0.145–0.202). The correlation between GE-based utilities and VAS ratings was the lowest (r = 0.36, 95 % CI 0.33–0.40); the highest was between FR-based utilities and VAS ratings (r = 0.43, 95 % CI 0.39–0.46).

Conclusion

For Switzerland, utility calculations based on the German or French value set would be an obvious choice. Our results suggest that the German value set may not be the most appropriate for use with Swiss cancer patients. The French and EU value sets may be relevant alternatives and improve international comparability.

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Acknowledgments

The authors would like to thank the principal investigators Prof. Dr. med Christoph Rochlitz (SAKK 24/09), Prof. Dr. med Thomas Ruhstaller (SAKK 75/08), Prof. Dr. med Jean-François Dufour (SAKK 77/09) and Dr. med Markus Jörger (CEPAC-TDM) for providing the EQ-5D data for this study.

Source of financial support

This study was funded by the Swiss State Secretariat for Education, Research and Innovation. The Health economic sub-project of the SAKK Trial 75/08 was funded by a grant from the Swiss Cancer Research Foundation.

Conflict of interest

The authors declare no conflicts of interest.

Authors’ contribution

Klazien Matter-Walstra was the main person responsible for planning and conducting the study, performing statistical analyses and writing the manuscript.

Dirk Klingbiel gave statistical support and reviewed the manuscript.

Matthias Schwenkglenks contributed to the planning of the study and interpretation of results, and reviewed the manuscript.

Thomas Szucs, Bernhard Pestalozzi gave support on content and reviewed the manuscript.

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Authors and Affiliations

  1. Institute of Pharmaceutical Medicine/ECPM, University of Basel, Klingelbergstrasse 61, 4056, Basel, Switzerland
    Klazien Matter-Walstra, Thomas Szucs & Matthias Schwenkglenks
  2. Swiss Group for Clinical Cancer Research Coordinating Center, Effingerstrasse 40, 3008, Bern, Switzerland
    Klazien Matter-Walstra & Dirk Klingbiel
  3. Department of Medical Oncology, University Hospital, Rämistrasse 100, 8006, Zurich, Switzerland
    Bernhard C. Pestalozzi

Authors

  1. Klazien Matter-Walstra
  2. Dirk Klingbiel
  3. Thomas Szucs
  4. Bernhard C. Pestalozzi
  5. Matthias Schwenkglenks

Corresponding author

Correspondence toKlazien Matter-Walstra.

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Matter-Walstra, K., Klingbiel, D., Szucs, T. et al. Using the EuroQol EQ-5D in Swiss Cancer Patients, Which Value Set Should be Applied?.PharmacoEconomics 32, 591–599 (2014). https://doi.org/10.1007/s40273-014-0151-0

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