Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis (original) (raw)

• Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000;80:1107–213.
  CAS PubMed Google Scholar
• Tscholl P, Alonso JM, Dolle G, et al. The use of drugs and nutritional supplements in top-level track and field athletes. Am J Sports Med. 2010;38:133–40.
  Article PubMed Google Scholar
• Lanhers C, Pereira B, Naughton G, et al. Creatine supplementation and lower limb strength performance: asystematic review and meta-analyses. Sports Med. 2015;45:1285–94.
  Article PubMed Google Scholar
• Gastin PB. Energy system interaction and relative contribution during maximal exercise. Sports Med. 2001;31:725–41.
  Article CAS PubMed Google Scholar
• Pollo A, Carlino E, Benedetti F. Placebo mechanisms across different conditions: from the clinical setting to physical performance. Philos Trans R Soc Lond B Biol Sci. 2011;366:1790–8.
  Article PubMed PubMed Central Google Scholar
• Moher D, Hopewell S, Schulz KF, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c869.
  Article PubMed PubMed Central Google Scholar
• DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.
  Article CAS PubMed Google Scholar
• Cohen J. Statistical power analysis for the behavioral sciences. Mahwah: Lawrence Erlbaum; 1988.
  Google Scholar
• Aguiar AF, Januario RSB, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013;113:987–96.
  Article CAS PubMed Google Scholar
• Bemben MG, Witten MS, Carter JM, et al. The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men. J Nutr Health Aging. 2010;14:155–9.
  Article CAS PubMed Google Scholar
• Candow DG, Little JP, Chilibeck PD, et al. Low-dose creatine combined with protein during resistance training in older men. Med Sci Sports Exerc. 2008;40:1645–52.
  Article CAS PubMed Google Scholar
• Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA. 1996;276:637–9.
  Article CAS PubMed Google Scholar
• Azizi M. The effect of a short-term creatine supplementation on some of the anaerobic performance and sprint swimming records of female competitive swimmers. Procedia Soc Behav Sci. 2011;15:1626–9.
  Article Google Scholar
• Brenner M, Rankin JW, Sebolt D. The effect of creatine supplementation during resistance training in women. J Strength Cond Res. 2000;14:207–13.
  Google Scholar
• Ferguson TB, Syrotuik DG. Effects of creatine monohydrate supplementation on body composition and strength indices in experienced resistance trained women. J Strength Cond Res. 2006;20:939–46.
  PubMed Google Scholar
• Gualano B, Macedo AR, Alves CR, et al. Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. Exp Gerontol. 2014;53:7–15.
  Article CAS PubMed Google Scholar
• Hamilton KL, Meyers MC, Skelly WA, et al. Oral creatine supplementation and upper extremity anaerobic response in females. Int J Sport Nutr Exerc Metab. 2000;10:277–89.
  Article CAS PubMed Google Scholar
• Larson-Meyer DE, Hunter GR, Trowbridge CA, et al. The effect of creatine supplementation on muscle strength and body composition during off-season training in female soccer players. J Strength Cond Res. 2000;14:434–42.
  Google Scholar
• Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1985;83:2055–63.
  Google Scholar
• Burke DG, Silver S, Holt LE, et al. The effect of continuous low dose creatine supplementation on force, power, and total work. Int J Sport Nutr Exerc Metab. 2000;10:235–44.
  Article CAS PubMed Google Scholar
• Burke DG, Chilibeck PD, Parise G, et al. Effect of creatine and weight training on muscle creatine and performance in vegetarians. Med Sci Sports Exerc. 2003;35:1946–55.
  Article CAS PubMed Google Scholar
• Stout JR, Graves BS, Cramer JT, et al. Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64–6 years). J Nutr Health Aging. 2007;11:459–64.
  CAS PubMed Google Scholar
• Camic CL, Housh TJ, Zuniga JM, et al. The effects of polyethylene glycosylated creatine supplementation on anaerobic performance measures and body composition. J Strength Cond Res. 2014;28:825–33.
  Article PubMed Google Scholar
• Peeters BM, Lantz CD, Mayhew JL. Effect of oral creatine monohydrate and creatine phosphate supplementation on maximal strength indices, dody composition, and blood pressure. J Strength Cond Res. 1999;13:3–9.
  Google Scholar
• Pluim BM, Ferrauti A, Broekhof F, et al. The effects of creatine supplementation on selected factors of tennis specific training. Br J Sports Med. 2006;40:507–12.
  Article CAS PubMed PubMed Central Google Scholar
• Volek JS, Ratamess NA, Rubin MR, et al. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur J Appl Physiol. 2004;91:628–37.
  Article CAS PubMed Google Scholar
• Noonan D, Berg K, Latin RW, et al. Effects of varying dosages of oral creatine relative to fat free body mass on strength and body composition. J Strength Cond Res. 1998;12:104–8.
  Google Scholar
• Izquierdo M, Ibanez J, Gonzalez-Badillo JJ, et al. Effects of creatine supplementation on muscle power, endurance, and sprint performance. Med Sci Sports Exerc. 2002;34:332–43.
  Article CAS PubMed Google Scholar
• Law YL, Ong WS, GillianYap TL, et al. Effects of two and five days of creatine loading on muscular strength and anaerobic power in trained athletes. J Strength Cond Res. 2009;23:906–14.
  Article PubMed Google Scholar
• Syrotuik DG, Bell GJ, Burnham R, et al. Absolute and relative strength performance following creatine monohydrate supplementation combined with periodized resistance training. J Strength Cond Res. 2000;14:182–90.
  Google Scholar
• Warber JP, Tharion WJ, Patton JF, et al. The effect of creatine monohydrate supplementation on obstacle course and multiple bench press performance. J Strength Cond Res. 2002;16:500–8.
  PubMed Google Scholar
• Bermon S, Venembre P, Sachet C, et al. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand. 1998;164:147–55.
  Article CAS PubMed Google Scholar
• del Favero S, Roschel H, Artioli G, et al. Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance. Amino Acids. 2012;42:2299–305.
  Article CAS PubMed Google Scholar
• Earnest CP, Snell PG, Rodriguez R, et al. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand. 1995;153:207–9.
  Article PubMed Google Scholar
• Gotshalk LA, Volek JS, Staron RS, et al. Creatine supplementation improves muscular performance in older men. Med Sci Sports Exerc. 2002;34:537–43.
  Article CAS PubMed Google Scholar
• Stout J, Eckerson J, Noonan D, et al. Effects of 8 weeks of creatine supplementation on exercise performance and fat-free weight in football players during training. Nutr Res. 1999;19:217–25.
  Article CAS Google Scholar
• Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol. 1999;80:139–44.
  Article CAS PubMed Google Scholar
• Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults-a meta-analysis. Med Sci Sports Exerc. 2014;46:1194–203.
  Article CAS PubMed Google Scholar
• Candow DG, Chilibeck PD, Forbes SC. Creatine supplementation and aging musculoskeletal health. Endocrine. 2014;45:354–61.
  Article CAS PubMed Google Scholar
• Villanueva MG, He J, Schroeder ET. Periodized resistance training with and without supplementation improve body composition and performance in older men. Eur J Appl Physiol. 2014;114:891–905.
  Article CAS PubMed Google Scholar
• da Silveira CL, de Souza TS, Batista GR, et al. Is long term creatine and glutamine supplementation effective in enhancing physical performance of military police officers? J Hum Kinet. 2014;43:131–8.
  PubMed PubMed Central Google Scholar
• de Salles Painelli V, Alves VT, Ugrinowitsch C, et al. Creatine supplementation prevents acute strength loss induced by concurrent exercise. Eur J Appl Physiol. 2014;114:1749–55.
  Article Google Scholar
• Brose A, Parise G, Tarnopolsky MA. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci. 2003;58:11–9.
  Article PubMed Google Scholar
• Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003;17:822–31.
  PubMed Google Scholar
• Becque MD, Lochmann JD, Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc. 2000;32:654–8.
  Article CAS PubMed Google Scholar
• Chilibeck PD, Magnus C, Anderson M. Effect of in-season creatine supplementation on body composition and performance in rugby union football players. Appl Physiol Nutr Metab. 2007;32:1052–7.
  Article PubMed Google Scholar
• Burke LM, Pyne DB, Telford RD. Effect of oral creatine supplementation on single-effort sprint performance in elite swimmers. Int J Sport Nutr. 1996;6:222–33.
  Article CAS PubMed Google Scholar
• Pearson DR, Russel DGHW, Harris T. Long-term effects of creatine monohydrate on strength and power. J Strength Cond Res. 1999;13:187–92.
  Google Scholar
• Volek JS, Duncan ND, Mazzetti SA, et al. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc. 1999;31:1147–56.
  Article CAS PubMed Google Scholar
• Volek JS, Kraemer WJ, Bush JA, et al. Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc. 1997;97:765–70.
  Article CAS PubMed Google Scholar
• Chrusch MJ, Chilibeck PD, Chad KE, et al. Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc. 2001;33:2111–7.
  Article CAS PubMed Google Scholar
• Kelly V, Jenkins DG. Effect of oral creatine supplementation on near-maximal strength and repeated sets of high-intensity bench press exercise. J Strength Cond Res. 1998;12:109–15.
  Google Scholar
• Selsby JT, DiSilvestro RA, Devor ST. Mg2+-creatine chelate and a low-dose creatine supplementation regimen improve exercise performance. J Strength Cond Res. 2004;18:311–5.
  PubMed Google Scholar
• Herda TJ, Beck TW, Ryan ED, et al. Effects of creatine monohydrate and polyethylene glycosylated creatine supplementation on muscular strength, endurance, and power output. J Strength Cond Res. 2009;23:818–26.
  Article PubMed Google Scholar
• Stone MH, Sanborn K, Smith LL, et al. Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr. 1999;9:146–65.
  Article CAS PubMed Google Scholar
• Zuniga JM, Housh TJ, Camic CL, et al. The effects of creatine monohydrate loading on anaerobic performance and one-repetition maximum strength. J Strength Cond Res. 2012;26:1651–6.
  Article PubMed Google Scholar
• LeLorier J, Gregoire G, Benhaddad A, et al. Discrepancies between meta-analyses and subsequent large randomized, controlled trials. N Engl J Med. 1997;337:536–42.
  Article CAS PubMed Google Scholar
• Bogdanis GC, Nevill ME, Lakomy HKA, et al. The effects of oral creatine supplementation on power output during repeated treadmill sprinting. J Sports Sci. 1996;14:65–6.
  Google Scholar
• Urbanski RL, Vincent WJ, Yaspelkis BB. Creatine supplementation differentially affects maximal isometric strength and time to fatigue in large and small muscle groups. Int J Sport Nutr. 1999;9:136–45.
  Article CAS PubMed Google Scholar
• Dempsey RL, Mazzone MF, Meurer LN. Does oral creatine supplementation improve strength? A meta-analysis. J Fam Pract. 2002;51:945–51.
  PubMed Google Scholar
• Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003;13:198–226.
  Article CAS PubMed Google Scholar
• Nissen SL, Sharp RL. Effect of dietary supplements on lean mass and strength gains with resistance exercise: a meta-analysis. J Appl Physiol. 1985;2003(94):651–9.
  Google Scholar