Sumatriptan-Induced Growth Hormone Release in Patients with Major Depression, Mania, and Normal Controls (original) (raw)
- Original Article
- Published: 01 October 1997
- Athanasios P Zis MD, FRCPC1,
- Raymond W Lam MD, FRCPC1,
- Edwin Tam MD, FRCPC1 &
- …
- I-Shin Shiah MD1
Neuropsychopharmacology volume 17, pages 258–263 (1997)Cite this article
- 748 Accesses
- 16 Citations
- Metrics details
Abstract
The purpose of this study was to assess serotonergic function in patients with major depression or mania using sumatriptan, a novel 5-HT1D receptor agonist, as a pharmacological probe in a neuroendocrine challenge paradigm. We studied 18 drug free patients (10 with acute unipolar major depression and 8 with acute mania) who met DSM-IV criteria, and healthy controls. Subjects presented for testing after an overnight fast. After obtaining a blood sample for baseline growth hormone (GH) levels, sumatriptan (6 mg) was given subcutaneously, and further blood samples were collected at half hour intervals for 2 hours. The results showed that GH responses to sumatriptan were blunted in depressed patients but not in manics, compared to healthy controls. There were no differences in basal GH levels between the 3 groups. The results of this study provide further support for the role of serotonergic system in pathophysiology of major depression, but not in mania.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
- From the Division of Mood Disorders, Department of Psychiatry, The University of British Columbia, Vancouver, Canada
Lakshmi N Yatham MBBS, FRCPC, MRC.Psych, DPM, (UK), Athanasios P Zis MD, FRCPC, Raymond W Lam MD, FRCPC, Edwin Tam MD, FRCPC & I-Shin Shiah MD
Authors
- Lakshmi N Yatham MBBS, FRCPC, MRC.Psych, DPM, (UK)
You can also search for this author inPubMed Google Scholar - Athanasios P Zis MD, FRCPC
You can also search for this author inPubMed Google Scholar - Raymond W Lam MD, FRCPC
You can also search for this author inPubMed Google Scholar - Edwin Tam MD, FRCPC
You can also search for this author inPubMed Google Scholar - I-Shin Shiah MD
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Yatham, L., Zis, A., Lam, R. et al. Sumatriptan-Induced Growth Hormone Release in Patients with Major Depression, Mania, and Normal Controls.Neuropsychopharmacol 17, 258–263 (1997). https://doi.org/10.1016/S0893-133X(97)00050-X
- Received: 15 August 1996
- Revised: 12 March 1997
- Accepted: 27 March 1997
- Published: 01 October 1997
- Issue Date: 01 October 1997
- DOI: https://doi.org/10.1016/S0893-133X(97)00050-X