Fluoxetine in the Treatment of Premenstrual Dysphoria (original) (raw)

Neuropsychopharmacology volume 16, pages 346–356 (1997)Cite this article

Abstract

We performed a double-blind, placebo-controlled, crossover trial of fluoxetine in 17 women with prospectively confirmed PMS who also met criteria for premenstrual dysphoric disorder (PMDD). A subset of 10 women with PMDD and an additional 10 controls participated in a single-dose m-chlorophenylpiperazine (m-CPP) challenge during the follicular and luteal phases of the menstrual cycle. We evaluated the ability of the acute behavioral response to luteal phase m-CPP administration to predict therapeutic response to fluoxetine. Compared with baseline, fluoxetine, but not placebo, treatment significantly improved both emotional and physical symptoms. We identified 11 (65%) fluoxetine responders who no longer met diagnostic criteria for PMDD during fluoxetine but remained symptomatic during placebo treatment. In addition, acute symptomatic improvement also occurred following m-CPP administration in 7 of 10 women with PMDD. The small number of m-CPP nonresponders did not respond to fluoxetine either. Our findings confirm that fluoxetine is an effective treatment of PMDD.

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Authors and Affiliations

  1. From the National Institute of Mental Health, Bethesda, Maryland
    Tung-Ping Su MD, Peter J Schmidt MD, Merry A Danaceau RN, MSN, Marie B Tobin MD, Donald L Rosenstein MD, Dennis L Murphy MD & David R Rubinow MD

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  1. Tung-Ping Su MD
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  2. Peter J Schmidt MD
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  3. Merry A Danaceau RN, MSN
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  4. Marie B Tobin MD
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  5. Donald L Rosenstein MD
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  6. Dennis L Murphy MD
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  7. David R Rubinow MD
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Su, TP., Schmidt, P., Danaceau, M. et al. Fluoxetine in the Treatment of Premenstrual Dysphoria.Neuropsychopharmacol 16, 346–356 (1997). https://doi.org/10.1016/S0893-133X(96)00245-X

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