Fluoxetine in the Treatment of Premenstrual Dysphoria (original) (raw)
- Original Article
- Published: 01 May 1997
- Peter J Schmidt MD1,
- Merry A Danaceau RN, MSN1,
- Marie B Tobin MD1,
- Donald L Rosenstein MD1,
- Dennis L Murphy MD1 &
- …
- David R Rubinow MD1
Neuropsychopharmacology volume 16, pages 346–356 (1997)Cite this article
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Abstract
We performed a double-blind, placebo-controlled, crossover trial of fluoxetine in 17 women with prospectively confirmed PMS who also met criteria for premenstrual dysphoric disorder (PMDD). A subset of 10 women with PMDD and an additional 10 controls participated in a single-dose m-chlorophenylpiperazine (m-CPP) challenge during the follicular and luteal phases of the menstrual cycle. We evaluated the ability of the acute behavioral response to luteal phase m-CPP administration to predict therapeutic response to fluoxetine. Compared with baseline, fluoxetine, but not placebo, treatment significantly improved both emotional and physical symptoms. We identified 11 (65%) fluoxetine responders who no longer met diagnostic criteria for PMDD during fluoxetine but remained symptomatic during placebo treatment. In addition, acute symptomatic improvement also occurred following m-CPP administration in 7 of 10 women with PMDD. The small number of m-CPP nonresponders did not respond to fluoxetine either. Our findings confirm that fluoxetine is an effective treatment of PMDD.
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- From the National Institute of Mental Health, Bethesda, Maryland
Tung-Ping Su MD, Peter J Schmidt MD, Merry A Danaceau RN, MSN, Marie B Tobin MD, Donald L Rosenstein MD, Dennis L Murphy MD & David R Rubinow MD
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- Tung-Ping Su MD
You can also search for this author inPubMed Google Scholar - Peter J Schmidt MD
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Su, TP., Schmidt, P., Danaceau, M. et al. Fluoxetine in the Treatment of Premenstrual Dysphoria.Neuropsychopharmacol 16, 346–356 (1997). https://doi.org/10.1016/S0893-133X(96)00245-X
- Received: 08 April 1996
- Revised: 24 September 1996
- Accepted: 17 October 1996
- Published: 01 May 1997
- Issue Date: 01 May 1997
- DOI: https://doi.org/10.1016/S0893-133X(96)00245-X